Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: The present invention provides compounds useful as inhibitors of Tyrosine Kinase 2 (Tyk2), solid forms and compositions thereof, methods of producing the same, and methods of using the same in the treatment of Tyk2-mediated diseases.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: An electrical distribution apparatus includes a bus bar assembly including a first surface. The electrical distribution apparatus also includes a backplane including a second surface. The electrical distribution apparatus further includes a plurality of engagement features and a plurality of openings for receiving the plurality of engagement features. The plurality of engagement features couple the bus bar assembly to the backplane. The plurality of engagement features extend from at least one of the first surface and the second surface. The plurality of openings are defined by at least one of the first surface and the second surface.

Abstract: One embodiment provides a device, including: an input port; a battery pack comprising one or more battery cells; a processor; and a memory that stores instructions executable by the processor to: determine that a connected power plug supplies one or more of a current and a voltage; and thereafter provide current supply from the input port to the battery pack for charging the one or more battery cells; wherein said device operates using battery power concurrent with charging of the one or more battery cells with the current supply from the input port. Other aspects are described and claimed.

Abstract: A circuit breaker is provided. The circuit breaker includes a housing, a circuit protection device disposed within the housing and operable to i) sense operating conditions associated with at least one current path through the circuit breaker and ii) selectively open the at least one current path based on the sensed operating conditions, a processing device communicatively coupled to the circuit protection device, the processing device operable to collect operating conditions data from the circuit protection device, the operating conditions data including the sensed operating conditions and a trip indication that indicates whether the circuit protection device has opened the at least one current path, and at least one communications interface communicatively coupled to the processing device, the at least one communications interface operable to receive the operating conditions data from the processing device to facilitate exporting the operating conditions data to a remote computing device.

Abstract: A pylon assembly for a tiltrotor aircraft includes a rotor assembly operable to rotate between a generally vertical orientation, in a VTOL flight mode, and a generally horizontal orientation, in a forward flight mode, and having an intermediate orientation therebetween, in a conversion flight mode. The rotor assembly includes a proprotor operable to produce a slipstream. A wing extension, positioned outboard of the rotor assembly, has a minimal dimension and an outboard end. A winglet is coupled to the outboard end of the wing extension and has a minimal dimension. The wing extension and the winglet are operable to rotate generally with the rotor assembly such that the minimal dimensions of the wing extension and the winglet remain in the slipstream of the proprotor.

Abstract: Embodiments of the present invention relate to systems and protocols for a media management application to be used by a supervisor to monitor, manage, and control what a subject is watching, listening to, or interacting with on a media delivery device. A media interaction application executes on a media delivery device and is configured to collect media interaction data based on tracked user interactions with media content on the media delivery device. A remote media management application executes on a portable electronic device and is configured to monitor the media interaction data and further configured to issue media management instructions to the media interaction application. A communications broker executes on a first network server and is configured to provide secure communications between the media interaction application and the remote media management application.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: An electrical distribution apparatus includes a backplane for supporting a plurality of electrical devices, a bus bar assembly coupled to the backplane, and a frame that supports the backplane. The electrical distribution apparatus also includes at least one positioning member that facilitates positioning the backplane relative to the frame. The at least one positioning member at least partially supports the backplane such that the backplane is positionable between a first position and a second position. The backplane contacts the frame in the second position.

Abstract: A microbial infection in an eye of a subject is treated or prevented by topically administering to the eye an effective amount of a macromolecule or a pharmaceutically acceptable salt thereof that includes a dendrimer of 1 to 8 generations with one or more sulfonic acid- or sulfonate-containing moieties attached to one or more surface groups of the outermost generation of the dendrimer. Compositions containing the macromolecule or salt are useful in these methods.

Abstract: An electrical distribution system is provided. The system includes a bus bar assembly including a neutral bus bar and a plurality of power bus bars. The system further includes a circuit breaker including a first end and a second end opposite the first end, the first end including a plurality of first conductive terminals electrically coupled to respective power bus bars, the second end including a plurality of second conductive terminals located a first distance from the plurality of power bus bars. The system further includes a neutral connection device including a first conductive terminal electrically coupled to the neutral bus bar, a second conductive terminal, and a conductive component, the neutral connection device second conductive terminal located a second distance from the neutral bus bar, the second distance one of greater than the first distance and equal to the first distance.

Abstract: The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same. Specifically, bicyclic heteroaryl derivatives containing a imidazole, thiazole or oxazole fused to a pyridinone, pyrimidinone or pyrimidindione are provided. These compounds have therapeutic utility toward treating an ACC enzyme mediated disorder such as obesity in a subject, upon administration in an effective amount to said subject.

Abstract: The present invention provides for compounds of formula I as acetyl-CoA carboxylase (ACC) inhibitors. The ACC inhibitors are useful for the prevention or treatment of metabolic syndrome, including obesity, dyslipidemia and hyperlipidemia in humans. The inhibitor compounds are also capable of inhibiting the ACC enzyme found in plants, parasites and bacteria.

Abstract: Provided herein are compounds that exhibit activity as fungicides and are useful, for example, in methods for the control of fungal pathogens in plants and can be applied to said plants in a variety of ways.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: Embodiments of the present invention relate to systems and protocols for a media management application to be used by a supervisor to monitor, manage, and control what a subject is watching, listening to, or interacting with on a media delivery device. A media interaction application executes on a media delivery device and is configured to collect media interaction data based on tracked user interactions with media content on the media delivery device. A remote media management application executes on a portable electronic device and is configured to monitor the media interaction data and further configured to issue media management instructions to the media interaction application. A communications broker executes on a first network server and is configured to provide secure communications between the media interaction application and the remote media management application.

Abstract: The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

Abstract: The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.