Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: Novel tools and techniques are provided for implementing split and parallelized encoding or transcoding of audio and video. In various embodiments, a computing system might split an audio-video file that is received from a content source into a single video file and a single audio file. The computing system might encode or transcode the single audio file. Concurrently, the computing system might split the single video file into a plurality of video segments. A plurality of parallel video encoders/transcoders might concurrently encode or transcode the plurality of video segments, each video encoder/transcoder encoding or transcoding one video segment of the plurality of video segments. Subsequently, the computing system might assemble the plurality of encoded or transcoded video segments with the encoded or transcoded audio file to produce an encoded or transcoded audio-video file, which may be output to a display device(s), an audio playback device(s), or the like.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: In an example, a method for forming a composite part includes, based on a part specification, cutting layers of material in a sequence and positioning the layers to form a stack. For each layer, after positioning the layer and before cutting a next layer in the sequence, the method includes (i) scanning along a length of the layer to determine an image, (ii) determining, based on the image, at least two edges of the layer, (iii) determining, based on the edges, a measured width at locations along the length of the layer, (iv) comparing the measured width at each location to a target width at the location, (v) deciding, based on the comparison, whether to adjust the production process, and (vi) if the decision is to adjust the production process, then adjusting the production process based on the comparison. The part specification specifies the target width at each location.

Abstract: An aircraft has a wing and at least a portion of a hoist system disposed within the wing. A method of hoisting an item includes disposing at least a portion of a hoist system within a wing of an aircraft and extending a cable of the hoist system through an access hole of an exterior wall of the wing.

Abstract: A pylon assembly for a tiltrotor aircraft includes a rotor assembly rotatably coupled to a fixed pylon and operable to rotate between a vertical takeoff and landing orientation and a forward flight orientation. The rotor assembly includes a proprotor operable to produce a slipstream. A wing extension is rotatably disposed to the outboard end of the fixed pylon such that the rotor assembly and the wing extension are separated by at least a portion of the fixed pylon. The wing extension has a forward edge and an outboard end. A winglet is coupled to the outboard end of the wing extension and has a forward edge. The wing extension and the winglet are configured to rotate in synchrony with the rotor assembly such that the forward edges of the wing extension and the winglet remain in the slipstream of the proprotor.

Abstract: The present disclosure provides a refrigeration system comprising a receiver for use in applications where environmentally-friendly, typically flammable refrigerants are used. The receiver is sized so that it allows for the maximum amount of refrigerant to be used when regulatory concerns restrict the total amount. The present disclosure also provides a method for selecting the size of the receiver.

Abstract: The present invention provides triazole compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

Abstract: The present invention provides ester compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: The present invention provides pyrazole compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

Abstract: Embodiments are directed to an aircraft, such as a tiltrotor, having an internal payload storage area. A rotatable deployment system is mounted within the payload storage area. The rotatable deployment system comprises a frame that is configured to rotate between a stowed position and a deployment position. Two extendible arms are attached to the frame, wherein each extendible arm is configured to move in opposite directions between a retracted position and a plurality of extended positions. Each extendible arm has a fixed end and a moving end. A payload mounting point on each moving end. The payload mounting point allows a payload to pan and tilt in azimuth and elevation.

Abstract: An electrical device having a bus side and a load side is provided. The electrical device includes a plurality of conductive line terminals disposed on the bus side of said electrical device, and a plurality of electrical connectors. Each electrical connector of the plurality of electrical connectors includes a first end coupled to a respective line terminal of the plurality of line terminals, a second end distal from the first end, and a connector clip disposed at the second end. Each connector clip is configured to engage a bus bar to electrically couple the electrical device to the bus bar, and includes a first contact segment and a second contact segment spaced apart from the first contact segment. The first and second contact segments are configured to deflect towards one another from a relaxed position to a depressed position when inserted into a connector channel defined by the bus bar.

Abstract: A tool and method of securing a clamp is provided. The tool includes a first handle having a first jaw portion on one end. An arm is pivotally coupled to the first handle, the having a second jaw portion on one end. A second handle is adjacent the first handle. A force adjustment mechanism is rotatably coupled between the arm and the second handle. The force adjustment mechanism has a biasing member operably coupled between the arm and an adjustment member, the force adjustment mechanism further having at least one bearing member disposed between the arm and the adjustment member. The second handle is arranged to rotate relative to the arm based at least in part on a force applied on the second handle by the biasing member via the at least one bearing member.

Abstract: The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

Abstract: The present invention provides compounds useful as inhibitors of Tyrosine Kinase 2 (Tyk2), solid forms and compositions thereof, methods of producing the same, and methods of using the same in the treatment of Tyk2-mediated diseases.

Abstract: The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

Abstract: Embodiments are directed to systems and methods for a sliding door in a pressurized aircraft. In one embodiment, an aircraft comprises a fuselage having a door opening, and a door configured to slide into the door opening from within the fuselage, the door held in a closed position in the door opening by excess air pressure within the fuselage during operation of the aircraft.