Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: In an embodiment, a method includes: collecting usage and maintenance data for a rotorcraft at a computer of the rotorcraft; sending the usage and maintenance data to a fleet management server; generating individualized equipment data for the rotorcraft according to the usage and maintenance data at the fleet management server, the individualized equipment data including a lightweight digital representation of the rotorcraft and technical publications for the rotorcraft, the lightweight digital representation including mesh-based 3D visualizations of each component of the rotorcraft, the technical publications having views referencing the mesh-based 3D visualizations; sending the individualized equipment data to the computer of the rotorcraft; and persisting the individualized equipment data at the computer of the rotorcraft.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: A system, device, and method for predicting an active set of compounds that bind to a biomolecular target is disclosed. The system and device contain modules allowing for the prediction of an active set of compounds. A core identification module can identify the core of an initial lead compound. A core hopping module is used to identify potential lead compounds having different cores compared to the core of an initial lead compound. A scoring module can use computational techniques to calculate the relative binding free energy of each identified potential lead compound. An activity prediction module can use the relative binding free energy calculations to predict an active set of compounds that bind to the biomolecular target. Empirical analysis can be used to inform the accuracy and completeness of the predicted active set of compounds.

Abstract: The present invention achieves technical advantages as an aircraft having an augmented reality flight control system integrated with and operable from the pilot seat and an associated pilot headgear unit, wherein the flight control system is supplemented by flight-assisting artificial intelligence and geo-location systems. The present invention includes an augmented reality flight control system incorporating real-world objects with virtual elements to provide relevant data to a pilot during aircraft flight. A translucent substrate is disposed in the pilot's field of view such that the pilot can see therethrough, and observe virtual elements displayed on the substrate. The system includes a headgear that is worn by the pilot. A flight assistance module is configured to receive ii data related to the aircraft and provide predictive assistance to the pilot during flight based on the received data based in part on a pilot profile having preferences related to the pilot.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: One embodiment provides an information handling device, including: an electronic component; and a tape strip comprising: a top surface; and a bottom surface; wherein each of the top surface and the bottom surface comprise alternating sections of adhesive areas and non-adhesive areas; wherein the electronic component is adhered to the top surface of the tape strip via an adhesive connection between the adhesive areas located on the top surface of the tape strip and a bottom surface of the electronic component and wherein the tape strip is adhered to the information handling device via another adhesive connection between the adhesive areas. Other aspects are described and claimed.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: The present invention provides compounds of formula I useful as inhibitors of Tyrosine Kinase 2 (Tyk2) solid forms and compositions thereof, methods of producing the same, and methods of using the same in the treatment of Tyk2-mediated diseases.

Abstract: The present invention provides compounds of formula I: or pharmaceutically acceptable salts and/or pharmaceutical compositions thereof. The present invention also provides methods for the inhibition of HPK1 and methods for the treatment of HPK1-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: Novel tools and techniques are provided for implementing split and parallelized encoding or transcoding of audio and video. In various embodiments, a computing system might split an audio-video file that is received from a content source into a single video file and a single audio file. The computing system might encode or transcode the single audio file. Concurrently, the computing system might split the single video file into a plurality of video segments. A plurality of parallel video encoders/transcoders might concurrently encode or transcode the plurality of video segments, each video encoder/transcoder encoding or transcoding one video segment of the plurality of video segments. Subsequently, the computing system might assemble the plurality of encoded or transcoded video segments with the encoded or transcoded audio file to produce an encoded or transcoded audio-video file, which may be output to a display device(s), an audio playback device(s), or the like.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: Embodiments of the present invention relate to systems and protocols for a media management application to be used by a supervisor to monitor, manage, and control what a subject is watching, listening to, or interacting with on a media delivery device. A media interaction application executes on a media delivery device and is configured to collect media interaction data based on tracked user interactions with media content on the media delivery device. A remote media management application executes on a portable electronic device and is configured to monitor the media interaction data and further configured to issue media management instructions to the media interaction application. A communications broker executes on a first network server and is configured to provide secure communications between the media interaction application and the remote media management application.

Abstract: A computer-implemented method for training a machine learning model to identify one or more network events associated with a network and representing a network security threat, the one or more network events being within a population comprising a plurality of network events, the method comprising: obtaining a dataset comprising data representative of the plurality of network events; defining a machine learning model associated with a type of network event and having an associated first feature vector; generating a training dataset comprising a fraction of the dataset, the fraction associated with network events corresponding to the type of network event; and training the machine learning model using the training dataset to produce a trained machine learning model.

Abstract: In an embodiment, a method includes: collecting usage and maintenance data for a rotorcraft at a computer of the rotorcraft; sending the usage and maintenance data to a fleet management server; generating individualized equipment data for the rotorcraft according to the usage and maintenance data at the fleet management server, the individualized equipment data including a lightweight digital representation of the rotorcraft and technical publications for the rotorcraft, the lightweight digital representation including mesh-based 3D visualizations of each component of the rotorcraft, the technical publications having views referencing the mesh-based 3D visualizations; sending the individualized equipment data to the computer of the rotorcraft; and persisting the individualized equipment data at the computer of the rotorcraft.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: In an embodiment, a method includes: adjusting a first flight control device of a rotorcraft to control flight around a first axis of the rotorcraft, the first flight control device exercising flight control authority around the first axis of the rotorcraft; detecting a failure of the first flight control device; transitioning at least a portion of the flight control authority around the first axis of the rotorcraft from the first flight control device to a second flight control device of the rotorcraft, the transitioning being performed automatically in response to detecting the failure of the first flight control device; and adjusting the second flight control device to control flight around the first axis of the rotorcraft, the second flight control device being adjusted by a first control process when the rotorcraft is in a first flight mode, the second flight control device being adjusted by a second control process when the rotorcraft is in a second flight mode.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.