Patents by Inventor Jerome Feige

Jerome Feige has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USES OF MYOSTATIN ANTAGONISTS, COMBINATIONS CONTAINING THEM AND USES THEREOF
    Publication number: 20200254090
    Abstract: The present invention relates to myostatin antagonists, for the treatment of cancer cachexia, and cancer cachexia due to chemotherapeutic treatment. In particular, the myostatin antagonist bimagrumab was found to be beneficial in the treatment of cancer cachexia by reducing body weight loss. The present invention also relates to combinations and uses of a myostatin antagonist and an mTOR inhibitor for treating cancer cachexia by reducing, maintaining or increasing body weight loss or for use in treating age-related conditions.
    Type: Application
    Filed: November 9, 2016
    Publication date: August 13, 2020
    Inventors: Shinji Hatakeyama, Ronenn Roubenoff, Estelle Trifilirff, Jerome Feige, Lloyd B Klickstein
  • METHOD FOR DETERMINING VITAMIN B12 UPTAKE
    Publication number: 20200141955
    Abstract: A method for determining a level of intestinal uptake of vitamin B12 in a subject can include: determining a level of the cubam complex or a component thereof in an isolated sample from the subject; and comparing the level of the cubam complex or a component thereof to reference levels; wherein the level of the cubam complex or a component thereof compared to the reference levels is indicative of the level intestinal uptake of vitamin B12.
    Type: Application
    Filed: November 14, 2019
    Publication date: May 7, 2020
    Inventors: Jerome Feige, Alice Pannerec
  • IN VITRO PRODUCTION OF MUSCLE STEM CELLS
    Publication number: 20190365821
    Abstract: An in vitro method of producing a population of muscle stem cells comprising co-culturing pluripotent stem cells, embryonic fibroblast cells and endothelial cells in 3D cell culture.
    Type: Application
    Filed: November 3, 2017
    Publication date: December 5, 2019
    Inventors: Omid Mashinchian, Jerome Feige, Conrad Florian Bentzinger
  • METHODS FOR TREATING SARCOPENIA AND MUSCLE INJURY
    Publication number: 20190255149
    Abstract: Wnt-inducible signalling protein 1 (WISP1) or a fragment or variant thereof for use in maintaining or increasing muscle function and/or mass in a subject, and/or substantially preventing or reducing muscle wasting in a subject.
    Type: Application
    Filed: June 1, 2017
    Publication date: August 22, 2019
    Inventors: Jerome Feige, Laura Lukjanenko
  • METHODS FOR TREATING SARCOPENIA AND FRAILTY
    Publication number: 20180353534
    Abstract: Neuregulin-1 (NRG1) or a fragment thereof or vitamin B12 for use in maintaining or increasing muscle function and/or mass in an ageing subject, and/or substantially preventing or reducing muscle wasting in an ageing subject.
    Type: Application
    Filed: December 8, 2016
    Publication date: December 13, 2018
    Inventors: Alice PANNEREC, Jerome FEIGE
  • METHOD FOR DETERMINING VITAMIN B12 UPTAKE
    Publication number: 20170254819
    Abstract: The present invention relates to a method for determining a level of intestinal uptake of vitamin B12 in a subject comprising: —determining a level of the cubam complex or a component thereof in an isolated sample from the subject; and —comparing the level of the cubam complex or a component thereof to reference levels; wherein the level of the cubam complex or a component thereof compared to the reference levels is indicative of the level intestinal uptake of vitamin B12.
    Type: Application
    Filed: September 14, 2015
    Publication date: September 7, 2017
    Inventors: Jerome Feige, Alice Pannerec
  • Method for treating metabolic disorders by administration of an anti-ActRIIB antibody
    Patent number: 9365651
    Abstract: The present invention relates to compositions comprising anti-ActRIIB antibodies and use thereof for increasing brown fat in vertebrate, including rodents and primates, and particularly in humans without significantly affecting hematological parameters.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: June 14, 2016
    Assignee: Novartis AG
    Inventors: Jerome Feige, David Glass, Shinji Hatakeyama, Brian Peter Richardson, Estelle Trifilieff
  • Method for Treating Metabolic Disorders
    Publication number: 20140328848
    Abstract: The present invention relates to compositions comprising anti-ActRIIB antibodies and use thereof for increasing brown fat in vertebrate, including rodents and primates, and particularly in humans without significantly affecting hematological parameters.
    Type: Application
    Filed: June 29, 2012
    Publication date: November 6, 2014
    Applicant: NOVARTIS AG
    Inventors: Jerome Feige, David Glass, Shinji Hatakeyama, Brian Peter Richardson, Estelle Trifilieff