Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design with feature thickness control, include: a three-dimensional modeling program configured to provide voxelized thinning based distance to medial surface processing that measures thicknesses in a three-dimensional model, and/or ramped scaling based thickness constraint application during shape and/or topology generation. The three-dimensional modeling program can be an architecture, engineering and/or construction program (e.g., building information management program), a product design and/or manufacturing program (e.g., a CAM program), and/or a media and/or entertainment production program (e.g., an animation production program).

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures using techniques that facilitate manufacturing, include: modifying a three dimensional shape, for which a corresponding physical structure is to be created using a manufacturing process, to produce a modified three dimensional shape; and providing the modified shape of the modeled object for use in manufacturing the physical structure using one or more computer-controlled manufacturing systems that employ the manufacturing process.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures using generative design processes, where the three dimensional (3D) models of the physical structures are produced in accordance with a design criterion that limits a minimum thickness of the generatively designed 3D models, include: obtaining a design space for an object to be manufactured and one or more design criteria including a thickness constraint; iteratively modifying a generatively designed 3D shape of the modeled object in the design space in accordance with the one or more design criteria, including measuring a current thickness for the 3D shape using an overall relationship of a volume of the 3D shape with respect to a surface area of the 3D shape; and providing the generatively designed model for use in manufacturing the physical structure using one or more computer-controlled manufacturing systems.

Abstract: A conjugated diene-based polymer including at least conjugated diene monomer units, and having a shrinkage factor of high molecular weight molecules of 0.4 to 0.8, a degree of adsorption of high molecular weight molecules onto silica of 75% or less, and a degree of adsorption of medium molecular weight molecules of 40 to 100%.

Abstract: A lighting assembly for a vehicle has a light source accommodated in a housing. The light source is configured to emit light. The lighting assembly has an outer lens coupled to the housing. At least a portion of the outer lens is positioned to receive light emitted from the light source and to transmit the received light to the outside. A black mask member surrounds the portion of the outer lens. The portion of the outer lens that is disposed to receive the light has an inner surface at least a part of which isformed with an integrally formed surface texture. The surface texture is configured to diffusively transmit the light received from the light source.

Abstract: An on-board toilet cubicle for an aircraft, including a front long side and a rear long side; a front short side and a rear short side, which are each connected at one end to the front long side and at their other end to the rear long side, the long sides and the short sides enclosing an interior of the on board toilet cubicle, and the front and the rear long sides each being wider than the front and the rear short sides; a toilet unit with a toilet opening; and an L-shaped door for accessing the on-board toilet cubicle, the L-shaped door having one door leg in the front long side and one door leg in the front short side, the toilet unit arranged adjacent to the rear long side, and the door leg in the front long side being wider than the door leg in the front short side.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures using generative design processes, where the 3D models of the physical structures are produced so as to facilitate manufacturing of the physical structures using 2.5-axis subtractive manufacturing systems and techniques, include: obtaining a design space for an object to be manufactured, design criteria, and load case(s); iteratively modifying a generatively designed 3D shape of the modeled object, including generating 2D profile representations (corresponding to discrete layers) of an updated version of the 3D shape, extruding the 2D profile representations along the milling direction, and forming a next version of the 3D shape of the modeled object from a combination of the 3D representations produced by the extruding; and providing the generatively designed 3D shape of the modeled object for use in manufacturing the physical structure using a 2.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures using generative design processes include: obtaining one or more design criteria, a model of an object for which a physical structure is to be manufactured, and a set of eigenmodes from a modal analysis of the model of the object; extracting a proper subset of non-zero eigenmodes from the set of eigenmodes, wherein the proper subset of non-zero eigenmodes include at least three lowest valued, non-zero eigenmodes; combining data of the proper subset of non-zero eigenmodes to form a strain energy field for the model of the object; iteratively modifying a generatively designed shape of the model of the object using the strain energy field to drive changes to the generatively designed shape of the model; and providing the generatively designed shape of the model of the object.

Abstract: The present invention relates to the fields of Biotechnology and Medicine and describes a pharmaceutical composition of recombinant human erythropoietin which is characterized by having a microheterogeneity of fucosylated N-glycans formed by bi, tri and tetra-antennary structures with mono and bi-sialylated sialic acid residues that represent 40-60% of the total glycans, trisialylated ones that represent 40-43% of the total glycans and tetrasialylated ones that represent 10-13% of the total glycans. This glycosylation pattern confers properties to said composition that allow for its use in disorders of the nervous system. The method of obtaining the pharmaceutical composition described herein is also described.

Abstract: The present invention relates to assays, including amplification assays, conducted in the presence of modulators. These assays can be used to detect the presence of particular nucleic acid sequences. In particular, these assays can allow for genotyping or other genetic analysis.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures using generative design processes, where the 3D models of the physical structures are produced so as to facilitate manufacturing of the physical structures using 2.5-axis subtractive manufacturing systems and techniques, include: obtaining a design space for an object to be manufactured, design criteria, and load case(s); iteratively modifying a generatively designed 3D shape of the modeled object, including generating 2D profile representations (corresponding to discrete layers) of an updated version of the 3D shape, extruding the 2D profile representations along the milling direction, and forming a next version of the 3D shape of the modeled object from a combination of the 3D representations produced by the extruding; and providing the generatively designed 3D shape of the modeled object for use in manufacturing the physical structure using a 2.

Abstract: The conjugated diene-based polymer of the invention comprises an aromatic vinyl unit based on an aromatic vinyl compound and a conjugated diene unit based on a conjugated diene compound, is modified with a compound containing a heteroatom, and has an SP value of 16.80 MPa1/2 to 17.10 MPa12.

Abstract: A conjugated diene copolymer has a covalent bond reversibly dissociated and added by heat, and has at least two peaks in each of curves of molecular weight distributions measured at 40° C. and 60° C. by gel permeation chromatography, wherein a change rate of the proportion of the area of the peak having the lowest molecular weight in measurement at 60° C. to the proportion of the area of the peak having the lowest molecular weight in measurement at 40° C.

Abstract: A method of receiving data transmitted by a plurality of communications devices includes receiving at each of a plurality of M antennas reference signals transmitted by each of a plurality of K communications devices, and processing by each of a plurality of antenna modules the reference signals. The processing by each of the antenna module includes estimating for each of the K detected reference signals received from the K communications devices a sample of a radio channel through which the received signals have passed, generating for each of the K samples of the radio channel a K×K partial matrix forming a part of a signal processing matrix for performing zero forcing equalisation of the received signals, and transmitting the partial matrix K×K from each of the M antenna modules to a central processing unit.

Abstract: A method of receiving data transmitted by a plurality of communications devices comprises receiving at each of a plurality of M antennas reference signals transmitted by each of a plurality of K communications devices, and processing by each of a plurality of antenna modules the reference signals, each of the antenna modules being connected to a corresponding one of the plurality of antennas. The processing by each of the antenna module includes estimating for each of the K detected reference signals received from the K communications devices a sample of a radio channel through which the received signals have passed, generating for each of the K samples of the radio channel a K×K partial matrix forming a part of a signal processing matrix for performing zero forcing equalisation of the received signals, and transmitting via a communications interface the partial matrix K×K from each of the M antenna modules to a central processing unit.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures include: obtaining a design space, design criteria, and boundary conditions for numerical simulation; defining an application of the boundary conditions to a voxelized mesh, including specifying a distribution of a load to nodes of voxels in the voxelized mesh that correspond to a surface of preserve geometry; and iteratively modifying a generatively designed three dimensional shape in the design space in accordance with the design criteria and a physical response of the modeled object determined by the numerical simulation performed using the application of the boundary conditions to the voxelized mesh, wherein the distribution of the total loading value during determination of the physical response ensures an equivalence between the total loading value and a sum of loading values distributed to the respective nodes of the voxels that correspond to the surface.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures using generative design processes, where the 3D models of the physical structures are produced so as to facilitate manufacturing of the physical structures using 2.5-axis subtractive manufacturing systems and techniques, include: obtaining a design space for an object to be manufactured, design criteria, and load case(s); iteratively modifying a generatively designed 3D shape of the modeled object, including generating 2D profile representations (corresponding to discrete layers) of an updated version of the 3D shape, extruding the 2D profile representations along the milling direction, and forming a next version of the 3D shape of the modeled object from a combination of the 3D representations produced by the extruding; and providing the generatively designed 3D shape of the modeled object for use in manufacturing the physical structure using a 2.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures using generative design processes, where the three dimensional (3D) models of the physical structures are produced in accordance with a design criterion that limits a minimum thickness of the generatively designed 3D models, include: obtaining a design space for an object to be manufactured and one or more design criteria including a thickness constraint; iteratively modifying a generatively designed 3D shape of the modeled object in the design space in accordance with the one or more design criteria, including measuring a current thickness for the 3D shape using an overall relationship of a volume of the 3D shape with respect to a surface area of the 3D shape; and providing the generatively designed model for use in manufacturing the physical structure using one or more computer-controlled manufacturing systems.

Abstract: This disclosure relates to methods, systems, computer programs and computer-readable media for the multidimensional analysis of real-time amplification data. A framework is presented that shows that the benefits of standard curves extend beyond absolute quantification when observed in a multidimensional environment. Relating to the field of Machine Learning, the disclosed method combines multiple extracted features (e.g. linear features) in order to analyse real-time amplification data using a multidimensional view. The method involves two new concepts: the multidimensional standard curve and its ‘home’, the feature space. Together they expand the capabilities of standard curves, allowing for simultaneous absolute quantification, outlier detection and providing insights into amplification kinetics.

Abstract: The present application relates to methods for detecting a first allele of a single nucleotide polymorphism (SNP) in a nucleic acid sequence under isothermal conditions using primers specific for said first allele, in particular using Loop mediated isothermal amplification (LAMP), wherein the amplification of a second allele is prevented by using blocking primers.