Abstract: The invention encompasses compositions, kits and methods for modifying bacteria, preferably naturally occurring bacteria, in situ. These can be used to treat, prevent or cure microbiome-associated diseases or disorders by modulating the molecules expressed and/or secreted by bacterial populations of the microbiome in a specific manner. The genomic modifications can modify the interactions between part or all of these populations and the host in a way that decreases their deleterious potential on host health. The compositions, kits and methods of the invention do not result in the direct death of these populations or a direct significant inhibition of their growth. The invention further includes methods for screening for genetic modifications in the bacteria, for determining the efficiency of vectors at inducing these genetic mutations, and for determining the effects of these mutations on bacterial growth.

Abstract: The present invention relates to a vector, preferably included in a delivery vehicle, comprising no more than 100, preferably no more than 10, restriction sites recognized by the restriction enzymes encoded by each bacterium of a group of bacteria of interest. The invention also relates to the use of said vector, preferably included in a delivery vehicle, as a drug, especially in the treatment of a disease in a patient in need thereof.

Abstract: The present disclosure relates generally to bacterial delivery vehicles and their use in efficient transfer of a desired payload into a target bacterial cell of the microbiota of a subject. More specifically, the present disclosure relates to bacterial delivery vehicles with desired host ranges that can be used to efficiently transfer the desired payload in vivo to one or more target bacterial cells of the microbiota of a subject.

Abstract: A new transactional, constraint-based system is provided to define and maintain authorization policies. Constraints are expressed as user-defined, domain-specific programs that operate on authoritative representations of entities and administrative hierarchies.

Abstract: The present invention relates to a vector, preferably included in a delivery vehicle, comprising no more than 100, preferably no more than 10, restriction sites recognized by the restriction enzymes encoded by each bacterium of a group of bacteria of interest. The invention also relates to the use of said vector, preferably included in a delivery vehicle, as a drug, especially in the treatment of a disease in a patient in need thereof.

Abstract: The present invention relates to a vector, preferably included in a delivery vehicle, comprising no more than 100, preferably no more than 10, restriction sites recognized by the restriction enzymes encoded by each bacterium of a group of bacteria of interest. The invention also relates to the use of said vector, preferably included in a delivery vehicle, as a drug, especially in the treatment of a disease in a patient in need thereof.

Abstract: The present disclosure relates generally to methods and compositions for transferring a genetic circuit from one prokaryotic cell (“donor cell”) to another prokaryotic cell (“recipient cell” or “target cell” which are used interchangeably herein). More specifically, the present disclosure relates to prokaryotic donor cells comprising (i) a genetic circuit of interest and (ii) one or more expressed transcriptional repressor proteins and the use of said donor cells in the efficient transfer of the genetic circuit into a prokaryotic recipient cell. The genetic circuit includes nucleic acid sequences encoding a RNA molecule or protein of interest.

Abstract: The present disclosure relates generally to bacterial delivery vehicles for use in efficient transfer of a desired payload into a target bacterial cell. More specifically, the present disclosure relates to bacterial delivery vehicles with desired host ranges based on the presence of a chimeric receptor binding protein (RBP) composed of a fusion between the N-terminal region of a RBP derived from a lambda-like bacteriophage and the C-terminal region of a different RBP.

Abstract: A photovoltaic system or installation, for generating electricity, which includes auxiliary charging modules for each solar tracker of the photovoltaic system to charge or supply energy to an auxiliary power supply device such as a battery, in order to power the photovoltaic system during the initial stages of the set-up process of the electric energy generation plant or during incidences in the normal operation of the photovoltaic system or installation. In addition to the auxiliary charging modules, the photovoltaic system comprises: one or more solar trackers, wherein each solar tracker comprises a plurality of photovoltaic panels, a DC/AC inverter to transform the DC electricity generated into AC electricity which is then supplied to an electric grid or an electric power distribution system, and a solar tracker controller, for each solar tracker, which controls several aspects of the one or more solar trackers of the photovoltaic system.

Abstract: The present invention relates to a vector, preferably included in a delivery vehicle, comprising no more than (100), preferably no more than (10), restriction sites recognized by the restriction enzymes encoded by each bacterium of a group of bacteria of interest. The invention also relates to the use of said vector, preferably included in a delivery vehicle, as a drug, especially in the treatment of a disease in a patient in need thereof.

Abstract: A job that receives as input a data stream is executed. For the job, it is iteratively determined a backlog growth over a first period of time; a backlog volume; and whether to adjust a quantity of processing resources. For each iteration for which the quantity of processing resources allocated to the job are determined to be adjusted, adjusting the quantity of processing resources allocated to the job. For each iteration for which the quantity of processing resources allocated to the job are determined not to be adjusted, maintaining the quantity of processing resources allocated to the job.

Abstract: The installation comprises: a DC-generating arrangement formed by electrical generators (PV1 . . . PVn) which are connected in series and located inside a local area, and supply a remote area with a total direct current that is the sum of the current generated by each of the electrical generators (PV1 . . . PVn); and an auxiliary power supply device (D) which is arranged inside the local area and provides the auxiliary system (E) with a supply voltage in the local area, wherein the auxiliary power supply device (D) is made up of a current-fed power converter (CP) electrically connected in series, respective input terminals (T1, T2), in the DC-generating arrangement between two connection points (p1, p2) of the electrical generators, located inside the local area.

Abstract: The present disclosure relates generally to bacterial delivery vehicles for use in efficient transfer of a desired payload into a target bacterial cell. More specifically, the present disclosure relates to bacterial delivery vehicles with desired host ranges based on the presence of a chimeric receptor binding protein (RBP) composed of a fusion between the N-terminal region of a RBP derived from a lambda-like bacteriophage and the C-terminal region of a different RBP, and/or the presence of an engineered branched receptor binding multi-subunit polypeptides (“branched-RBP”).

Abstract: The present disclosure relates generally to bacterial delivery vehicles for use in efficient transfer of a desired payload into a target bacterial cell. More specifically, the present disclosure relates to bacterial delivery vehicles with desired host ranges based on the presence of a chimeric receptor binding protein (RBP) composed of a fusion between the N-terminal region of a RBP derived from a lambda-like bacteriophage and the C-terminal region of a different RBP.

Abstract: The invention relates to the improvement of endonuclease-based antimicrobials by blocking DNA repair of double-strand break(s) (DSB(s)) in prokaryotic cells. In this respect, the invention especially concerns a method involving blocking DNA repair after a nucleic acid has been submitted to DSB, in particular by a Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated programmable double-strand endonuclease. The invention particularly relates to the use of an exogenous molecule that inhibits DNA repair, preferably a protein that binds to the ends of the double-stranded break to block DSB repair. The invention also relates to vectors, particularly phagemids and plasmids, comprising nucleic acids encoding nucleases and Gam proteins, and a pharmaceutical composition and a product containing these vectors and their application.

Abstract: A job that receives as input a data stream is executed. For the job, it is iteratively determined a backlog growth over a first period of time; a backlog volume; and whether to adjust a quantity of processing resources. For each iteration for which the quantity of processing resources allocated to the job are determined to be adjusted, adjusting the quantity of processing resources allocated to the job. For each iteration for which the quantity of processing resources allocated to the job are determined not to be adjusted, maintaining the quantity of processing resources allocated to the job.

Abstract: The present invention relates to a vector, preferably included in a delivery vehicle, comprising no more than 100, preferably no more than 10, restriction sites recognized by the restriction enzymes encoded by each bacterium of a group of bacteria of interest. The invention also relates to the use of said vector, preferably included in a delivery vehicle, as a drug, especially in the treatment of a disease in a patient in need thereof.

Abstract: Techniques for determining and reporting channel quality indicator (CQI) information are described. A user equipment (UE) may determine precoding information and channel quality information to be reported to a base station. The UE may jointly encode the precoding information and the channel quality information to obtain coded data. The UE may send the coded data to the base station.

Abstract: A photovoltaic system or installation, for generating electricity, which includes auxiliary charging modules for each solar tracker of the photovoltaic system to charge or supply energy to an auxiliary power supply device such as a battery, in order to power the photovoltaic system during the initial stages of the set-up process of the electric energy generation plant or during incidences in the normal operation of the photovoltaic system or installation. In addition to the auxiliary charging modules, the photovoltaic system comprises: one or more solar trackers, wherein each solar tracker comprises a plurality of photovoltaic panels, a DC/AC inverter to transform the DC electricity generated into AC electricity which is then supplied to an electric grid or an electric power distribution system, and a solar tracker controller, for each solar tracker, which controls several aspects of the one or more solar trackers of the photovoltaic system.

Abstract: The installation comprises: a DC-generating arrangement formed by electrical generators (PV1 . . . PVn) which are connected in series and located inside a local area, and supply a remote area with a total direct current that is the sum of the current generated by each of the electrical generators (PV 1 . . . PVn); and an auxiliary power supply device (D) which is arranged inside the local area and provides the auxiliary system (E) with a supply voltage in the local area, wherein the auxiliary power supply device (D) is made up of a current-fed power converter (CP) electrically connected in series, respective input terminals (T1, T2), in the DC-generating arrangement between two connection points (p1, p2) of the electrical generators, located inside the local area.