Abstract: The present disclosure relates to novel quinolinone-8-carbonitrile based compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions. The compounds disclosed herein exhibit androgen receptor degradation activity.

Abstract: Provided are an interaction method and apparatus in a live streaming room, and a device and a storage medium. The method comprises: in response to a trigger operation for a preset duet entry on a live streaming room page, jumping from the live streaming room page to a camera capture page, wherein a host portrait cutout corresponding to the live streaming room page is displayed on the camera capture page and a capture control is provided on the camera capture page acquiring multimedia information captured by a camera, in response to a trigger operation for the capture control on the camera capture page, wherein the multimedia information comprises an image or a video; and synthesizing the multimedia information with the host portrait cutout to obtain a duet multimedia product.

Abstract: The present disclosure relates to novel compounds that inhibit glucose-induced degradation-deficient (GID) E3 ligase, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions.

Abstract: Provided are catechol nanoparticles, catechol protein nanoparticles, and a preparation method and use thereof. The method includes: adding a tannin compound-containing natural herb medicine into water to obtain a mixture, and subjecting the mixture to heating reflux extraction to obtain a herb medicine extract and subjecting the herb medicine extract to fractionation to obtain the catechol nanoparticles.

Abstract: A vehicle positioning method via data fusion and a system using the same are disclosed. The method is performed in a processor electrically connected to a self-driving-vehicle controller and multiple electronic systems. The method is to perform a delay correction according to a first real-time coordinate, a second real-time coordinate, real-time lane recognition data, multiple vehicle dynamic parameters, and multiple vehicle information received from the multiple electronic systems with their weigh values, to generate a fusion positioning coordinate, and to determine confidence indexes. Then, the method is to output the first real-time coordinate, the second real-time coordinate, and the real-time lane recognition data that are processed by the delay correction, the fusion positioning coordinate, and the confidence indexes to the self-driving-vehicle controller for a self-driving operation.

Abstract: A vehicle positioning method via data fusion and a system using the same are disclosed. The method is performed in a processor electrically connected to a self-driving-vehicle controller and multiple electronic systems. The method is to perform a delay correction according to a first real-time coordinate, a second real-time coordinate, real-time lane recognition data, multiple vehicle dynamic parameters, and multiple vehicle information received from the multiple electronic systems with their weigh values, to generate a fusion positioning coordinate, and to determine confidence indexes. Then, the method is to output the first real-time coordinate, the second real-time coordinate, and the real-time lane recognition data that are processed by the delay correction, the fusion positioning coordinate, and the confidence indexes to the self-driving-vehicle controller for a self-driving operation.

Abstract: The present invention discloses a MEMS gravimeter comprising: a spring-mass system, a displacement sensing structure, a displacement detecting circuit, a cavity body and a level adjustment base; the spring-mass system is disposed inside the cavity body and includes: a negative-stiffness spring, a positive-stiffness spring, a proof mass and an outer frame; the proof mass is connected to the outer frame by the negative-stiffness spring and the positive-stiffness spring, the negative-stiffness spring and the positive-stiffness spring are symmetrically disposed with respect to the proof mass, and the outer frame is fixedly connected to the cavity body; the displacement sensing structure is located on a surface of the proof mass, and the displacement detecting circuit is configured to detect a displacement signal from the displacement sensing structure; the spring-mass system realizes reduction in resonant frequency by matching of the positive and negative stiffness springs; and change in gravitational acceleratio

Abstract: The present invention discloses a MEMS gravimeter comprising: a spring-mass system, a displacement sensing structure, a displacement detecting circuit, a cavity body and a level adjustment base; the spring-mass system is disposed inside the cavity body and includes: a negative-stiffness spring, a positive-stiffness spring, a proof mass and an outer frame; the proof mass is connected to the outer frame by the negative-stiffness spring and the positive-stiffness spring, the negative-stiffness spring and the positive-stiffness spring are symmetrically disposed with respect to the proof mass, and the outer frame is fixedly connected to the cavity body; the displacement sensing structure is located on a surface of the proof mass, and the displacement detecting circuit is configured to detect a displacement signal from the displacement sensing structure; the spring-mass system realizes reduction in resonant frequency by matching of the positive and negative stiffness springs; and change in gravitational acceleratio

Abstract: A supporting device is used in hair dying so as to avoid polluting the body of the user. The supporting device comprises: a supporting plate having a receiving hole; a lateral side of the receiving hole having a slot; a surface of the supporting plate being a smooth surface; a double face tape being stuck on the smooth surface of the supporting plate; the double face tape being tearable from the supporting plate; and a replacing layer adhered above the double face tape; the replacing layer being made of one of unweave cloth and disposable materials, if the replacing layer being dirt, it can be deserted and updated; the replacing layer having a receiving hole coupled to that of the supporting plate.

Abstract: The invention provides methods and compositions related to oligonucleotides that silence target genes within a cell. The oligonucleotides include an oligonucleotide methylator segment that has a first strand and a second strand complementary to the first strand. The first strand can include at least one m5CG sequence which is paired with an unmethylated CG sequence on the second strand. Alternatively, the first strand can include at least one m5CNIG sequence paired with an unmethylated CN2G sequence on the second strand, wherein N1 is any nucleotide, and N2 is a nucleotide that pairs with N1. The oligonucleotides also include a single-stranded DNA binding segment that is complementary to a nucleotide sequence in the target gene. The DNA binding segment includes at least one m5CG sequence m5CG or at least one 5CN3G sequence, wherein N3 is any nucleotide.

Abstract: A spill preventing paper holder for use during hair dye application that straddles the shoulders of the user and is comprised of a main panel and extension members assembled to the lateral ends of the main panel. The main panel has a recess formed into its upper extent that provides for the placement of a cloth towel or a disposable paper towel, a cutaway is formed at the center between the lateral ends of the main panel for posturing around the neck, and an arch-shaped straddle frame is disposed on the bottom end of the main panel for placement on the shoulders of the user. Various types of extension members can be pivotably conjoined at the two sides of the cutaway as required by the particular situation of usage to construct a folding-type, a pull-type, a turning-type, or an alignment-type paper holder, with each type of paper holder remaining foldable to decrease storage space requirements.