Abstract: A pericardium puncture needle assembly comprises a puncture needle (12) and a guide wire (13) capable of sliding in the puncture needle (12); or comprises an outer sleeve (22) and a guide wire (13) capable of sliding in the outer sleeve (22); or comprises an outer sleeve (22) and a puncture needle (12) and a guide wire (13) capable of sliding in the outer sleeve (22), wherein after the puncture needle (12) is pulled out of the outer sleeve (22), the guide wire (13) is capable of sliding in the outer sleeve (22). The guide wire (13) is made of a highly elastic material and comprises a far-end bent segment (32). The far-end bent segment (32) is formed by bending the guide wire (13) and has a preset bending shape, and is suitable for being recovered from a stretching state to the preset bending shape. The tip of the far-end bent segment has a pointed structure.

Abstract: The invention provides novel inhibitors of cancer stem cells as well as cancer stem cell pathway kinase and other related kinases, pharmaceutical compositions and uses thereof in the treatment of cancer or a related disorder in a mammal, and methods of making such compounds and compositions.

Abstract: The present invention relates to novel thiazole-substituted indolin-2-ones as inhibitors of CSCPK and related kinases; to methods of inhibiting cancer stem cells by using a kinase inhibitor; to pharmaceutical compositions containing such compounds; and to methods of using such compounds in the treatment of a protein kinase related disorder in a mammal; and to processes of making such compounds and intermediates thereof.

Abstract: A method of controlling a threshold voltage is provided. The method of controlling a threshold voltage includes performing a film-thickness measuring step to measure the thickness of a film layer on a wafer to obtain a film-thickness value. Then, at least one parameter is decided, selected, or generated according to the film-thickness value. Next, an ion implantation process is performed on the wafer, wherein the ion implantation process is executed according to the parameter to form a threshold voltage adjustment region in the wafer below the film layer.

Abstract: A system that continuously monitors cardiovascular health using an electrocardiography (ECG) source synchronized to an optical (PPG) source, without requiring invasive techniques or ongoing, large-scale external scanning procedures. The system includes an ECG signal source with electrodes contacting the skin, which generates a first set of information, and a mobile device having a camera which acts as a PPG signal source that generates a second set of information. Together with the mobile device's processor, configured to receive and process the first and second sets of information, from which the time differential of the heart beat pulmonary pressure wave can be calculated, continuous data related to cardiovascular health markers such as arterial stiffness can be determined. Variations of the ECG source may include a chest strap, a plug-in adaptor for the mobile device, or electrodes built into the mobile device.

Abstract: A method for manufacturing the MIM capacitor structure is provided. A first damascene electrode layer is formed in the first opening formed in a first dielectric layer. An insulating barrier layer is formed to cover the first dielectric layer and the first damascene electrode layer. A second opening and a third opening are formed in the second dielectric layer formed on the insulating barrier layer. The second opening and the third opening are located above the first damascene electrode layer to expose a portion of the insulating barrier layer therefrom. The insulating barrier layer in the third opening is removed to expose a portion of the first damascene electrode layer. A second damascene electrode layer is formed in the second opening to be contacted with the insulating barrier layer and a dual damascene structure is formed in the third opening to be contacted with the first damascene electrode layer.

Abstract: A flexible display has a display layer, a thin-film transistor (TFT) layer and a flexible substrate. The display layer has a plurality of display units. The TFT layer has a plurality of pixel control circuits and a plurality of sensing circuits. The pixel control circuits are configured to control operations of the plurality of display units. Each of the sensing circuits is configured to generate a deformation signal according to deformation of the flexible display. The flexible substrate and the TFT layer are stacked.

Abstract: A catheter assembly comprises a first catheter including a wall with an inner surface at least partially defining a lumen. A second catheter is connected to the wall of the first catheter and is disposed outward of the inner surface of the wall. The second catheter is at least partially covered by a sheath portion of the first catheter. A first portion of the wall of the first catheter is made of a relatively low durometer elastomeric material and is relatively extensible. A second portion of the wall is formed of a relatively high durometer elastomeric material and is relatively inextensible.

Abstract: A method of controlling a threshold voltage is provided. The method of controlling a threshold voltage includes performing a film-thickness measuring step to measure the thickness of a film layer on a wafer to obtain a film-thickness value. Then, at least one parameter is decided, selected, or generated according to the film-thickness value. Next, an ion implantation process is performed on the wafer, wherein the ion implantation process is executed according to the parameter to form a threshold voltage adjustment region in the wafer below the film layer.

Abstract: A metal-insulator-metal (MIM) capacitor structure includes a first dielectric layer, a first damascene electrode layer, an insulating barrier layer, a second dielectric layer and a second damascene electrode layer. The first damascene electrode layer is formed in the first dielectric layer. The insulating barrier layer covers the first dielectric layer and the first damascene electrode layer, and is a single layer structure. The second dielectric layer is formed on the insulating barrier layer. The second damascene electrode layer is formed in the second dielectric layer and is contacted with the insulating barrier layer. The MIM capacitor structure can includes a dual damascene structure formed in the second dielectric layer and the insulating barrier layer and electrically connected to the first damascene electrode layer. A method for manufacturing the MIM capacitor structure is also provided.

Abstract: A medical device sheath that includes a relatively inelastic body having a proximal end longitudinally separated from a distal end and defining a first lumen, an aperture located at the proximal end in fluid communication with the lumen and configured to admit an elongate endoscope body into the first lumen, and a transparent tip located longitudinally adjacent to an endoscope lens when the elongate endoscope body is located within the first lumen. The endoscope sheath may also include an elongate secondary tube defining a secondary lumen. A method of using the medical device sheath is also described.

Abstract: The present invention discloses an ablation electrode used in a catheter. The ablation electrode includes an electrode shell, an optional cavity inside the electrode shell and a temperature sensor. An outflow liquid pathway for the perfusion liquid is arranged on the electrode shell, and an inflow liquid pathway for the perfusion liquid is arranged in the proximal end of the electrode shell. A thermal conduction isolation structure is arranged between the temperature sensor and the liquid pathway. The thickness of the electrode shell where the temperature sensor is located is less than 0.2 mm. The present invention also provides a perfusion electrode catheter which includes the ablation electrode. The perfused electrode catheter of the present invention can provide efficient prompts on the rising ablation temperature in the ablation process.

Abstract: An illumination device including a base, a heat dissipation member, at least one flexible printed circuit board (FPC), and a plurality of light-emitting elements is provided. The heat dissipation member disposed on the base has a central axis, a plurality of holding curvy surfaces and a plurality of heat dissipation channels extending along the central axis, wherein the holding curvy surfaces and the heat dissipation channels are staggered and arranged about the central axis, and each of the holding curvy surfaces radially extends along the central axis. The flexible printed circuit board is disposed on the holding curvy surfaces. The light-emitting elements are disposed on the flexible printed circuit board. An assembling method of the illumination device is also provided.

Abstract: A server is in communication with a plurality of clients being executed by a host. The server is configured to receive a message from a first client of the plurality of clients. The message indicates that the first client currently has focus, wherein the message is transmitted by the first client with a first cookie. The server is configured to identify that a second client of the plurality of clients utilizes a second cookie that matches the first cookie, wherein the second client is currently receiving data from the server using a low-latency update mechanism. The server is also configured to downgrade the second client from the low-latency update mechanism to a high-latency update mechanism, wherein the high-latency update mechanism is configured to enable the second client to conduct a poll of the server periodically for updates.

Abstract: A method of forming an isolation structure and a through silicon via includes the following steps. First, at least a first trench and at least a second trench are formed in the substrate by a single etch step. Then, an insulating layer is formed to simultaneously fill up the first trench and cover a sidewall and a bottom of the second trench. After that, a conductive layer is formed to fill in the second trench. Subsequently, the insulating layer and the conductive layer on a front side of the substrate are removed. Later, a back side of the substrate is thinned to expose the conductive layer in the second trench. The insulating layer in the first trench serves as an insulating filling, and the insulating layer on the sidewall of the second trench serves as a liner of the through silicon via.

Abstract: A medical device sheath that includes a relatively inelastic body having a proximal end longitudinally separated from a distal end and defining a first lumen, an aperture located at the proximal end in fluid communication with the lumen and configured to admit an elongate endoscope body into the first lumen, and a transparent tip located longitudinally adjacent to an endoscope lens when the elongate endoscope body is located within the first lumen. The endoscope sheath may also include an elongate secondary tube defining a secondary lumen. A method of using the medical device sheath is also described.

Abstract: A receptacle connector (100) includes a housing (10), a front contact module (30) and a rear contact module (20) assembled in the housing. The housing has a cavity (12) opening along a horizontal direction. The cavity has a top wall (121) and a bottom wall (122) opposing to each other, the bottom wall having a tongue portion (120) at a front side of the housing. The rear contact module has a first contacts (22) and a second contacts (23) positioned on the top wall and the bottom wall respectively. The front contact module includes a one-piece insulator (31) assembled to a bottom side (13) of the housing, and a number of third contacts (32) insert-molded with the insulator.

Abstract: A multilink wireless data transmission device comprises a control module and two or more WLAN clients. The control module is configured to control said WLAN clients to enable the data transmission states of those of the WLAN clients, which are not in an idle state, to be the same. The data transmission states comprise a receiving state and a sending state. The control module is configured to control at least one of the two or more WLAN clients, which need to receive data, to switch to the receiving state when a downlink triggering condition is met. The control module is further configured to control at least one of the two or more WLAN clients, which need to send data, to switch to the sending state when an uplink triggering condition is met.

Abstract: The invention provides novel inhibitors of cancer stem cells as well as cancer stem cell pathway kinase and other related kinases, pharmaceutical compositions and uses thereof in the treatment of cancer or a related disorder in a mammal, and methods of making such compounds and compositions.

Abstract: A catheter assembly comprises a first catheter including a wall with an inner surface at least partially defining a lumen. A second catheter is connected to the wall of the first catheter and is disposed outward of the inner surface of the wall. The second catheter is at least partially covered by a sheath portion of the first catheter.