Abstract: A targeted DNA demethylation method (Mini-CRISD) and a fusion protein used in the method are provided. The Mini-CRISD method can targets delivery of demethylation activity through engineered miniature dCjCas9 to deliver engineered miniature ROS1 demethylation effector to specific DNA sequences and/or specific genomic locations (such as CpG islands) to achieve targeted demethylation of specific DNA.

Abstract: A method and a system for calculating tumor neoantigen burden (TNB) are provided. The method includes: step S1: processing a normal sample and a tumor sample, sequencing a specific region and detecting somatic mutations in the sample; step S2: annotating and filtering the somatic mutations, and translating to obtain mutant peptide sequences of a patient; step S3: filtering the mutant peptide sequences to obtain neopeptide sequences based on a proteome of the normal sample; step S4, performing a human leukocyte antigen (HLA) typing analysis based on alignment data of the normal sample to obtain HLA genotypes of the sample; step S5, predicting binding affinities between the neopeptide sequences and the HLA genotypes to obtain specific neoantigens of the sample, and performing a weighted scoring on each of the specific neoantigens and calculating the TNB of the sample.

Abstract: The present disclosure discloses a molten aluminum erosion resistant casting tip paint, the casting tip paint is formed by mixing magnesia-alumina spinel, alumina, magnesia, water, sodium tripolyphosphate and sodium carboxymethyl cellulose, wherein the proportions of various raw materials for the casting tip paint are as follows: magnesia-alumina spinel of 40-50 wt %, alumina of 10-20 wt %, magnesia of 5-10 wt %, water of 20-40 wt %, sodium tripolyphosphate of 0-10 wt %, and sodium carboxymethyl cellulose of 0-10 wt %. The present disclosure also discloses a preparation method of a molten aluminum erosion resistant casting tip. The molten aluminum erosion resistant casting tip paint provided by the present disclosure can be evenly coated onto the inner wall of the casting tip, so as to form a compact molten aluminum erosion resistant coating, thereby preventing infiltration and erosion of the molten aluminum.

Abstract: A computer system can automatically analyze a video of a physical activity and provide corresponding feedback. For example, the system can receive a video file including image frames showing an entity performing a physical activity that involves a sequence of movement phases. The system can generate coordinate sets by performing image analysis on the image frames. The system can provide the coordinate sets as input to a trained model, the trained model being configured to assign scores and movement phases to the image frames based on the coordinate sets. The system can then select a particular movement phase for which to provide feedback, based on the scores and movement phases assigned to the image frames. The system can generate the feedback for the entity about their performance of the particular movement phase, which may improve the entity's future performance of that particular movement phase.

Abstract: The present invention provides a display screen with an integrated video camera optimized to capture the display screen’s information and a light source that injects colored light into the edge of the display screen. Additionally, the system comprises a color blending instrument to blend the primary colors of red, green, blue, and a combination thereof to create an unlimited variety of color combinations that are injected into the display screen.

Abstract: An improved digital teaching station, a stand, and a platform that supports a central multitouch flat-panel display screen is provided. A reflective glass mirror is affixed on top of the stand, and a computing device is connected. Moreover, a document camera is attached to a side tray. Furthermore, hardware and software enables a separate video stream to create always upright content from an upward facing electronic display screen and to interconnect with all devices and data types.

Abstract: The present invention provides an interactive display screen integrated with an image capture device optimized to capture the user, the user's correct gaze, and information inputted on or through the interactive display screen. The present invention does not require extraneous video production equipment or technical expertise to operate while providing a compact and easily transportable system. The display screen is transparent such as an organic light emitting diode (OLED) display, with an optional touchscreen. The display screen may display digital photos or other multimedia objects that a user can annotate or otherwise manipulate. The device captures the displayed multimedia information and combines it with a video stream captured from the image capture device. The present invention also implements a display screen with a display cycle that is offset by 180 degrees from the capture cycle of the image capture device.

Abstract: The present invention provides an interactive display screen integrated with a video camera optimized to capture the user, the user's correct gaze, and information inputted on or through the interactive display screen. A presenter writes or draws information on the display screen while facing an audience. The display screen displays digital photos or other multimedia objects that a user can annotate or otherwise manipulate. Meanwhile, the device captures the displayed multimedia information and combines it with a video stream captured from the video camera. No extraneous video production equipment or technical expertise is required to operate while providing a compact and easily transportable system.

Abstract: The present invention provides a display screen with an integrated video camera optimized to capture the display screen's information. A presenter writes or draws information on the display screen while facing an audience. The video camera is located on the side opposite from the presenter. No extraneous video production equipment or technical expertise is required to operate while providing a compact and easily transportable system.

Abstract: A digital notepad is disclosed that includes an onboard computer, a base having retainers, a writing instrument having a tip that is configured to deliver ink, a plurality of sheets of paper, and a plurality of touch sensors communicatively connected to the onboard computer. The onboard computer includes one or more computer processors and a program loaded thereon configured to read information from at least one of the plurality of touch sensors. At least one of the touch sensors of the plurality of touch sensors may be integrated into the base. At least one of the plurality of sheets of paper may be retained on the base and in close proximity to the at least one of the touch sensors. The digital notepad may further include a display screen communicatively connected to the onboard computer and configured to display markings read by at least one of the plurality of touch sensors. In another embodiment, the digital notepad's writing instrument includes thermally reactive ink.

Abstract: The present invention provides an improved digital teaching station, a stand, and a platform that supports a central interactive flat-panel display screen. A reflective glass mirror is affixed on top of the stand, and a computing device is connected. Moreover, a document camera is attached to a side tray. Furthermore, hardware and software enables a separate video stream to create always upright content from an upward facing electronic display screen and to interconnect with all devices including and data types.

Abstract: Various embodiments of the present disclosure provide a system, device, apparatus, and method for detecting and registering contact made with a surface, by both conductive and non-conductive implements. The present disclosure comprises a first conductive layer comprising a plurality of first conductors, a second conductive layer comprising a plurality of second conductors and a plurality of third conductors, orientated substantially coplanar to the first conductive layer; and a dielectric layer disposed between the first conductive layer and the second conductive layer, the dielectric layer comprising a plurality of vias; each of the plurality of first conductors are arranged in a first pattern, each of the plurality of second conductors are arranged in a second pattern, the second pattern correlating to the space between each of the plurality of first conductors, and each of the plurality of the third conductors are substantially shaped and orientated in the first pattern.

Abstract: The present invention provides a new and useful hybrid digital and physical interactive writing surface. A user writes on a physical writing surface using thermal ink. Underneath the physical writing surface is a heating layer. Once the heating layer is activated, the thermal ink disappears. Meanwhile, sensors capture a user's strokes while writing, and a computing device digitally stores the captured strokes. Therefore, there is zero-time delay or lag time between writing on the physical writing surface and its appearance. Finally, there is no need to erase any writing nor use other sheets or boards after one use because the writing is automatically erased.

Abstract: Disclosed is a method and system for providing gesture-based transitions while using a digital whiteboard. The present disclosure relates to a method for gesture-based transitions for interacting with a digital whiteboard comprising the steps of receiving information relating to a first pointer down event; receiving information relating to a first pointer up event; comparing the information relating to the pointer down event to the information relating to the pointer up event; and transitioning from a first interactive mode to a second interactive mode based on the comparison.

Abstract: Disclosed is a method of acquiring an image of a target to provide an output video image that has a plurality of frame images. The method includes the steps of receiving a series of frame images from a video camera, using a processor to manipulate the series of frame images from a video camera, using a processor to manipulate the series of frame images, which includes determining a reference resolution for providing output frame images, and displaying and/or storing the manipulated series of frame images as the output video image without changing a resolution of the output frame images. Also disclosed is a document imaging apparatus that includes a digital imaging unit. The digital imaging unit contains optics that having an infinite focal length. The document imaging apparatus also includes a processor that is coupled to the digital imaging unit and that is configured to cause the digital imaging unit to zoom in or zoom out in real-time while maintaining a resolution value of stored images constant.

Abstract: A device for auricularly delivering and/or receiving medication which comprises an earcup, a drug cartridge or drug reservoir having active ingredients, and a fluid generator that generates a fluid having active ingredients and delivers the fluid to the earcup. A method for auricularly delivering medication which comprises the steps of receiving medication from a cartridge at a fluid generator, generating fluid comprising the medication, and passing the fluid to an earcup. A system for auricularly delivering medication comprising a headphone comprising at least one earcup, and a replaceable and consumable drug cartridge coupled to the headphone. A method for receiving medication which comprises the steps of placing an earcup on an ear, operating a headphone coupled to the earcup, and receiving fluid generated by a fluid generator, the fluid comprising active ingredients, wherein the fluid generator receives medication from a cartridge comprising active ingredients.

Abstract: The present disclosure, a smart measuring and dispensing apparatus, generally relates dosers that assist in measuring the amount of a given substance, liquid or solid. The present disclosure aims to reduce time, space, and effort required to measure the amount of a substance, and focuses on the measuring of foodstuffs, ingredients such as salt, pepper, herbs, spices, oils, vinegars, condiments, etc., with a handheld apparatus.