Patents by Inventor Ji Zhu

Ji Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220184411
    Abstract: Methods of the present invention comprise photoinactivation of catalase in combination with low-concentration peroxide solutions and/or ROS generating agents to provide antibacterial effects.
    Type: Application
    Filed: March 3, 2022
    Publication date: June 16, 2022
    Inventors: Pu-Ting Dong, Jie Hui, Ji-Xin Cheng, Yifan Zhu
  • Patent number: 11357626
    Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: June 14, 2022
    Assignee: JC Medical, Inc.
    Inventors: Ji Zhang, Brandon G. Walsh, Cheng Yong Yang, Jinhua Zhu
  • Publication number: 20210391166
    Abstract: A gas mixture for treating a substrate in a substrate processing system includes hydrogen fluoride gas, a vapor of an alcohol, an additive consisting of a base, and a carrier gas. The gas mixture can be used to treat high aspect ratio (HAR) structures arranged on a surface of a substrate. A surface of the substrate may be spin rinsed using a first rinsing liquid. The first rinsing liquid is spun off from the surface of the substrate. The gas mixture is directed onto the surface of the substrate after the first rinsing liquid is dispensed.
    Type: Application
    Filed: September 26, 2019
    Publication date: December 16, 2021
    Inventors: Ji ZHU, Gerome Michel Dominique MELAET, Nathan LAVDOVSKY, Rafal DYLEWICZ, David MUI
  • Publication number: 20210340593
    Abstract: The present invention provides haloalkane substrates, and linkers for connecting such substrates to functional elements (e.g., tags, labels, surfaces, etc.). Substrates and linkers described herein find use, for example, in labeling, detection, and immobilization of proteins, cells, and molecules. In particular, the linkers provided herein find use within substrates for dehalogenase variants that form covalent bonds with their haloalkane substrates.
    Type: Application
    Filed: July 13, 2021
    Publication date: November 4, 2021
    Inventors: Carolyn W. Hitko, Thomas Kirkland, Sergiy Levin, Poncho Meisenheimer, Rachel Friedman Ohana, Harry Tetsuo Uyeda, Ji Zhu
  • Publication number: 20210249274
    Abstract: A method for treating a substrate includes arranging a substrate in a processing chamber. At least one of a vaporized solvent and a gas mixture including the solvent is supplied to the processing chamber to form a conformal liquid layer of the solvent on exposed surfaces of the substrate. The at least one of the vaporized solvent and the gas mixture is removed from the processing chamber. A reactive gas including a halogen species is supplied to the processing chamber. The conformal liquid layer adsorbs the reactive gas to form a reactive liquid layer that etches the exposed surfaces of the substrate.
    Type: Application
    Filed: June 7, 2019
    Publication date: August 12, 2021
    Inventors: Ji ZHU, Mark KAWAGUCHI, Nathan MUSSELWHITE
  • Patent number: 11072812
    Abstract: The present invention provides haloalkane substrates, and linkers for connecting such substrates to functional elements (e.g., tags, labels, surfaces, etc.). Substrates and linkers described herein find use, for example, in labeling, detection, and immobilization of proteins, cells, and molecules. In particular, the linkers provided herein find use within substrates for dehalogenase variants that form covalent bonds with their haloalkane substrates.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: July 27, 2021
    Assignee: PROMEGA CORPORATION
    Inventors: Carolyn W. Hitko, Thomas Kirkland, Poncho Meisenheimer, Rachel Friedman Ohana, Harry Tetsuo Uyeda, Ji Zhu
  • Patent number: 11072811
    Abstract: The present invention provides haloalkane substrates, and linkers for connecting such substrates to functional elements (e.g., tags, labels, surfaces, etc.). Substrates and linkers described herein find use, for example, in labeling, detection, and immobilization of proteins, cells, and molecules. In particular, the linkers provided herein find use within substrates for dehalogenase variants that form covalent bonds with their haloalkane substrates.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: July 27, 2021
    Assignee: PROMEGA CORPORATION
    Inventors: Carolyn W. Hitko, Thomas Kirkland, Poncho Meisenheimer, Rachel Friedman Ohana, Harry Tetsuo Uyeda, Ji Zhu
  • Patent number: 10976312
    Abstract: The present invention provides compositions and methods for capture and identification of the cellular targets of a bioactive agent. In particular, provided herein are bioactive agents tethered to capture ligand, cellular targets (optionally tagged with a reporter), capture proteins (optionally present as capture fusions), surfaces (e.g., displaying, capture ligands, capture proteins, or capture fusions), and methods of capturing and identifying the cellular targets of a bioactive agent therewith.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: April 13, 2021
    Assignee: Promega Corporation
    Inventors: Carolyn W. Hitko, Robin Hurst, Thomas Kirkland, Dieter Klaubert, Poncho Meisenheimer, Nidhi Nath, Rachel Friedman Ohana, Paul Otto, Marjeta Urh, Harry Tetsuo Uyeda, Keith Wood, Ji Zhu
  • Publication number: 20200231187
    Abstract: A bogie wheelset radial mechanism with a structure of adjustable rigidity, composing two secondary frames (21) which are pin-connected via two connecting rods (22) arranged in a crosswise manner. The connecting rods (22) are pin-connected to the secondary frames (21) with round pins (24). Joints between the round pins (24) and the connecting rods (22) and/or joints between the round pins and the secondary frames (21) are provided with replaceable elastic materials. The materials can be made into rings. End portions of the connecting rods (22) are embedded into mounting grooves (25) located in the secondary frames (21) and are connected to the same with the round pins (24).
    Type: Application
    Filed: November 13, 2018
    Publication date: July 23, 2020
    Inventors: CHANG WU, XIANFENG ZHANG, TAO DENG, JI ZHU, YUNGUI WANG, ZHIQIANG LI, HANJIANG LUO, SHIBIN ZUO, RUI ZHANG, SONG LI
  • Publication number: 20200214990
    Abstract: A tadalafil orally dissolving film and a preparation method thereof are provided. The tadalafil orally dissolving film consisting of specific components is prepared through a conventional process. Particularly, the tadalafil orally dissolving film is prepared by tadalafil, film-forming material, plasticizer, correctant, colorant and aromatic, wherein the film-forming material includes components of: (a) at least one member selected from polysaccharide; (b) at least one member selected from organic acid; and (c) at least one member selected from hydroxyalkyl cellulose. Compared with prior art, the tadalafil orally dissolving film provided by the present invention has an easy preparation process, no specific requirement on production devices and a storing stability, and is easy to reproduce, has a low requirement on storage conditions, and is easy to package, transport and store.
    Type: Application
    Filed: April 30, 2017
    Publication date: July 9, 2020
    Inventors: Xinhua Fan, Yongrui Tu, Jintao Zhang, Tack Soo Nam, Yun He, Yueyu Zhou, Ji Zhu, Mingjie Zhang
  • Publication number: 20190051540
    Abstract: A substrate processing system to remove residual halogen species from a substrate includes a processing chamber and a substrate support arranged in the processing chamber to support a substrate. The substrate includes residual halogen species. A heater heats the substrate to a temperature in a predetermined temperature range from 100° C. to 700° C. during a processing period. A chamber pressure controller controls pressure inside the processing chamber in a predetermined pressure range greater than 10 Torr and less than 800 Torr during the processing period. A vapor generator supplies water vapor at least one of in the processing chamber or to the processing chamber during the processing period.
    Type: Application
    Filed: August 8, 2017
    Publication date: February 14, 2019
    Inventors: Ji Zhu, Jatinder Kumar, Mark Kawaguchi, lvelin Angelov, Serge Kosche
  • Patent number: 10153058
    Abstract: To predict which Hepatitis C patients are at high-risk for disease progression or adverse health outcomes, baseline characteristics are measured for patients as well as longitudinal data, including clinical, laboratory and/or biopsy results, which may be collected periodically in follow-up visits with a healthcare professional. A machine learning engine may predict whether a patient is at high-risk for disease progression or adverse health outcomes based on the baseline characteristics and the longitudinal data for the patient.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: December 11, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Monica A. Konerman, Ulysses Balis, Peter Higgins, Ji Zhu, Anna Lok, Akbar Waljee, Yiwei Zhang
  • Publication number: 20180269070
    Abstract: A substrate processing system for selectively etching a layer on a substrate includes an upper chamber region, an inductive coil arranged around the upper chamber region and a lower chamber region including a substrate support to support a substrate. A gas distribution device is arranged between the upper chamber region and the lower chamber region and includes a plate with a plurality of holes. A cooling plenum cools the gas distribution device and a purge gas plenum directs purge gas into the lower chamber. A surface to volume ratio of the holes is greater than or equal to 4. A controller selectively supplies an etch gas mixture to the upper chamber and a purge gas to the purge gas plenum and strikes plasma in the upper chamber to selectively etch a layer of the substrate relative to at least one other exposed layer of the substrate.
    Type: Application
    Filed: March 14, 2017
    Publication date: September 20, 2018
    Inventors: Kwame Eason, Dengliang Yang, Pilyeon Park, Faisal Yaqoob, Joon Hong Park, Mark Kawaguchi, Ivelin Angelov, Ji Zhu, Hsiao-Wei Chang
  • Patent number: 9802626
    Abstract: A sub-frame radial bogie comprises wheelsets, a side frame, a swing bolster, a wheelset radial device and a brake gear. Bearing adapters (41) forming the wheelset radial device are fixedly connected with the sub-frame (42) via pulling rivets (11), and each group of the bearing adapters (41) is bilaterally symmetrical in structure with a symmetry plane (A). The sub-frame (42) comprises an arm (51) and an end (52); a sub-frame connection hole (61) is arranged on the end (52); transverse positioning bosses (73) are arranged on the bearing adapters (41); and an arc groove (75) and symmetrical sub-frame connection holes (71) are arranged on a connection base (72). The bearing adapters use the same standard structure, hence, the more precise design and machining can be realized, and the cost is reduced, and meanwhile, the maintenance technique of the sub-frame is improved, and the maintenance cost is reduced.
    Type: Grant
    Filed: April 4, 2013
    Date of Patent: October 31, 2017
    Assignee: CRRC MEISHAN CO., LTD.
    Inventors: Tao Deng, Shuping Pan, Aimin Wang, Pu Wang, Yungui Wang, Hengli Li, Xianfeng Zhang, Hanjiang Luo, Ji Zhu, Zongquan Zhou, Chengyong Liu
  • Publication number: 20170115283
    Abstract: The present invention provides compositions and methods for capture and identification of the cellular targets of a bioactive agent. In particular, provided herein are bioactive agents tethered to capture ligand, cellular targets (optionally tagged with a reporter), capture proteins (optionally present as capture fusions), surfaces (e.g., displaying, capture ligands, capture proteins, or capture fusions), and methods of capturing and identifying the cellular targets of a bioactive agent therewith.
    Type: Application
    Filed: January 10, 2017
    Publication date: April 27, 2017
    Inventors: Carolyn W. Hitko, Robin Hurst, Thomas Kirkland, Dieter Klaubert, Poncho Meisenheimer, Nidhi Nath, Rachel Friedman Ohana, Paul Otto, Marjeta Urh, Harry Tetsuo Uyeda, Keith Wood, Ji Zhu
  • Patent number: 9570320
    Abstract: A method of opening a barrier film below copper structures in a stack is provided. A pulsed gas is provided into a plasma processing chamber, wherein the providing the pulsed gas comprises providing a pulsed H2 containing gas and providing a pulsed halogen containing gas, wherein the pulsed H2 containing gas and the pulsed halogen containing gas are pulsed out of phase, and wherein the pulsed H2 containing gas has an H2 high flow period and the pulsed halogen containing gas has a halogen containing gas high flow period, wherein the H2 high flow period is greater than the halogen containing gas high flow period. The pulsed gas is formed into a plasma. The copper structures and the barrier film are exposed to the plasma, which etches the barrier film. In another embodiment, a wet and dry cyclical process may be used.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: February 14, 2017
    Assignee: Lam Research Corporation
    Inventors: Meihua Shen, Ji Zhu, Shuogang Huang, Baosuo Zhou, John Hoang, Prithu Sharma, Thorsten Lill
  • Patent number: 9551705
    Abstract: The present invention provides compositions and methods for capture and identification of the cellular targets of a bioactive agent. In particular, provided herein are bioactive agents tethered to capture ligand, cellular targets (optionally tagged with a reporter), capture proteins (optionally present as capture fusions), surfaces (e.g., displaying, capture ligands, capture proteins, or capture fusions), and methods of capturing and identifying the cellular targets of a bioactive agent therewith.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: January 24, 2017
    Assignee: Promega Corporation
    Inventors: Carolyn W. Hitko, Robin Hurst, Thomas Kirkland, Dieter Klaubert, Poncho Meisenheimer, Nidhi Nath, Rachel Friedman Ohana, Paul Otto, Marjeta Urh, Harry Tetsuo Uyeda, Keith Wood, Ji Zhu
  • Publication number: 20160104630
    Abstract: A method of opening a barrier film below copper structures in a stack is provided. A pulsed gas is provided into a plasma processing chamber, wherein the providing the pulsed gas comprises providing a pulsed H2 containing gas and providing a pulsed halogen containing gas, wherein the pulsed H2 containing gas and the pulsed halogen containing gas are pulsed out of phase, and wherein the pulsed H2 containing gas has an H2 high flow period and the pulsed halogen containing gas has a halogen containing gas high flow period, wherein the H2 high flow period is greater than the halogen containing gas high flow period. The pulsed gas is formed into a plasma. The copper structures and the barrier film are exposed to the plasma, which etches the barrier film. In another embodiment, a wet and dry cyclical process may be used.
    Type: Application
    Filed: December 22, 2014
    Publication date: April 14, 2016
    Inventors: Meihua SHEN, Ji ZHU, Shuogang HUANG, Baosuo ZHOU, John HOANG, Prithu SHARMA, Thorsten LILL
  • Publication number: 20160078184
    Abstract: To predict which Hepatitis C patients are at high-risk for disease progression or adverse health outcomes, baseline characteristics are measured for patients as well as longitudinal data, including clinical, laboratory and/or biopsy results, which may be collected periodically in follow-up visits with a healthcare professional. A machine learning engine may predict whether a patient is at high-risk for disease progression or adverse health outcomes based on the baseline characteristics and the longitudinal data for the patient.
    Type: Application
    Filed: September 11, 2015
    Publication date: March 17, 2016
    Inventors: Monica A. Konerman, Ulysses Balis, Peter Higgins, Ji Zhu, Anna Lok, Akbar Waljee, Yiwei Zhang
  • Patent number: RE49099
    Abstract: Provided are humanized antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. Methods of treatment employing these antibodies are described herein.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: June 7, 2022
    Assignee: Bayer Healthcare LLC
    Inventors: Xiao-Yan Zhao, Zhuozhi Wang, Ji-Yun Kim, Ying Zhu, Jan Tebbe