Abstract: Provided are compositions and methods for enhanced prime editing, which include a pegRNA that encodes a target mutation in a target protein, along with one or more nearby silent or conservative mutations. These silent mutations can increase the editing efficiency, without causing a change to the target protein sequence. Also provided are compositions and methods of using the improved prime editing for preventing or treating infections by SARS-CoV or SARS-CoV-2.

Abstract: Provided are fusion proteins and related molecules useful for conducting base editing with reduced or no off-target mutations. The fusion protein may include a first fragment comprising a nucleobase deaminase or a catalytic domain thereof, a second fragment comprising a nucleobase deaminase inhibitor, and a protease cleavage site between the first fragment and the second fragment. Also provided are improved prime editing systems, including prime editing guide RNA with improved stability.

Abstract: The present invention provides a camera optical lens, including, from an object side to an image side, a first lens having a positive refractive power, a second lens having a negative refractive power, a third lens having a positive refractive power, a fourth lens having a positive refractive power, and a fifth lens having a negative refractive power. At least one of the first to fifth lenses has a free-form surface, and the camera optical lens satisfies: 2.00?f3/f?5.50; 2.00?R4/R3?23.00, where f is a focal length of the camera optical lens, f3 is a focal length of the third lens, R3 is a central curvature radius of an object side surface of the second lens, and R4 is a central curvature radius of an image side surface of the second lens. The camera optical lens satisfies requirements of a large aperture, a wide angle and ultra-thinness, and has excellent optical performance.

Abstract: Provided is a camera optical lens including, sequentially from an object side to an image side: a first lens having a negative refractive power; a second lens; a third lens having a positive refractive power; a fourth lens having a negative refractive power; a fifth lens; a sixth lens having a positive refractive power; and a seventh lens having a negative refractive power. At least one of the first to seventh lenses comprises a free-form surface. The camera optical lens can achieve high optical performance while satisfying design requirements for ultra-thin, wide-angle lenses.

Abstract: A type of Bruton's tyrosine kinase inhibitor, a preparation method therefor, and an application thereof in the field of medicine. The Bruton's tyrosine kinase inhibitor may be used for preventing and/or treating a disease related to Bruton's tyrosine kinase mediation, such as an autoimmune disease, cancer, or an inflammatory disease. Through experimental research, the provided compound has high selectivity with respect to a Bruton's tyrosine kinase target, and can exhibit a uniquely advantageous medicinal effect in an in vivo animal experiment.

Abstract: The present invention relates to the field of optical lenses, and provides a camera optical lens, including, from an object side to an image side, a first lens having a positive refractive power, a second lens a negative refractive power, a third lens having a positive refractive power, a fourth lens having a negative refractive power, and a fifth lens. At least one of the first lens to the fifth lens has a free-form surface, and the camera optical lens satisfies: 0?R7; and R10?0, where R7 denotes a central curvature radius of an object side surface of the fourth lens, and R10 denotes a central curvature radius of an image side surface of the fifth lens. The camera optical lens provided by the present invention satisfies design requirements of a long focal length and ultra-thinness while having excellent optical performance.

Abstract: Disclosed is a camera optical lens, including nine lenses, and the nine lenses from an object side to an image side are: a first lens with a negative refractive power, a second lens with a positive refractive power, a third lens with a negative refractive power, a fourth lens with a positive refractive power, a fifth lens with a negative refractive power, a sixth lens with a positive refractive power, a seventh lens with a negative refractive power, an eighth lens with a positive refractive power and an ninth lens with a negative refractive power. The camera optical lens satisfies: ?5.50?f1/f??2.00; 3.00?d11/d12?12.00. The camera optical lens has good optical performance, and meets the design requirements of a large aperture, wide-angle and ultra-thin.

Abstract: An SPUF based on combinational logic and scan chain comprises an external stimulus source, a combinational logic circuit module, a scan chain circuit module, a data processing module and n switch circuits SW0, SW1, . . . , SWn-1, n=2m, and m is an integer greater than or equal to 1; combinational logic circuit module comprises n switch circuits S0, S1, . . . , Sn-1 and a combinational logic circuit; the scan chain circuit module comprises n scan flip-flops (SFFs) SFF0, SFF1, . . . , SFFn-1; each of the n switch circuits SW0, SW1, . . . , SWn-1 and the n switch circuits S0, S1, . . . , Sn-1 is implemented by a 2-to-1 multiplexer. The SPUF based on combinational logic and scan chain has high uniqueness and randomness, requires a few clock frequency changes, and has high reliability, more bits of responses and high security.

Abstract: An integrated nucleic acid loop-mediated isothermal amplification and mobile device system is provided and includes a main body and a power supply, where the 5 main body at least has a delivery unit, a heating unit and a control unit, the control unit is electrically connected to the delivery unit and the heating unit, and the power supply is electrically connected to the main body. A method for operating the integrated nucleic acid loop-mediated isothermal amplification and mobile device system is also provided.

Abstract: A camera optical lens is provided. The camera optical lens includes, from an object side to an image side, a first lens, a second lens having a negative refractive power, a third lens, a fourth lens, a fifth lens, a sixth lens, a seventh lens, an eighth lens, and a ninth lens. The camera optical lens satisfies following conditions: 0.60?f1/f?1.80; and 1.50?d11/d12?8.00, where f denotes a focal length of the camera optical lens, f1 denotes a focal length of the first lens, d11 denotes an on-axis thickness of the sixth lens, and d12 denotes an on-axis distance from an image side surface of the sixth lens to an object side surface of the seventh lens. The camera optical lens according to the present disclosure satisfies design requirements for large-aperture, wide-angle, and ultra-thin lenses while achieving good optical performance.

Abstract: The present disclosure provides a camera optical lens including eight lenses which are, from an object side to an image side in sequence: a first lens having a positive refractive power, a second lens having a positive refractive power, a third lens having a positive refractive power, a fourth lens having a negative refractive power, a fifth lens having a positive refractive power, a sixth lens having a positive refractive power, a seventh lens having a negative refractive power, and an eighth lens having a negative refractive power; the camera optical lens satisfies conditions of: 0.95?f/TTL; 2.00?f2/f?5.00; and ?0.90?(R13+R14)/(R13?R14)??0.25. The camera optical lens can achieve good optical performance while meeting the design requirements for long focal length and ultra-thinness.

Abstract: A camera optical lens includes, from an object side to an image side, a first lens having a positive refractive power, a second lens having a negative refractive power, a third lens having a positive refractive power, a fourth lens having a negative refractive power, and a fifth lens, with at least one of the first to fifth lenses having a free-form surface, and satisfies: ?3.50?f4/f??0.35; ?8.00?R10/f??1.00; and 2.00?d8/d7?8.00, where f and f4 respectively denote focal lengths of the camera optical lens and the fourth lens; R10 denotes a central curvature radius of an image side surface of the fifth lens; d7 denotes an on-axis thickness of the fourth lens; and d8 denotes an on-axis distance from an image side surface of the fourth lens to an object side surface of the fifth lens, thereby having good optical performance while satisfying design requirements of a long focal length and ultra-thinness.

Abstract: The present invention relates to the field of optical lenses, and provides a camera optical lens, including, from an object side to an image side, a first lens, a second lens, a third lens, a fourth lens, and a fifth lens. At least one of the first lens to the fifth lens has a free-form surface, and the camera optical lens satisfies: ?3.50?f2/f??1.50; ?2.00?(R5+R6)/(R5?R6)?0.20; and 1.00?f4/f?5.50, where f denotes a focal length of the camera optical lens, f2 denotes a focal length of the second lens, f4 denotes a focal length of the fourth lens, R5 denotes a central curvature radius of an object side surface of the third lens, and R6 denotes a central curvature radius of an image side surface of the third lens. The camera optical lens according to the present invention has a large aperture, a wide angle and ultra-thinness, as well as excellent optical performance.

Abstract: Provided is a camera optical lens, which includes a first lens, a second lens, a third lens, a fourth lens, a fifth lens, and a sixth lens. At least one of the first lens to the sixth lens includes a free-form surface. The camera optical lens satisfies f3/f1??1.50, ?8.50?f2/f??1.50, and 4.00?(R7+R8)/(R7?R8)?16.00, where f denotes a focal length of the camera optical lens, f1 denotes a focal length of the first lens, f2 denotes a focal length of the second lens, f3 denotes a focal length of the third lens, R7 denotes a curvature radius of an object-side surface of the fourth lens, and R8 denotes a curvature radius of an image-side surface of the fourth lens. The camera optical lens according to the present disclosure has optical performance and meet the design requirements of being ultra-thin, and having a wide-angle.

Abstract: Provided is a camera optical lens including, sequentially from an object side to an image side: a first lens having a negative refractive power; a second lens having a refractive power; a third lens having a positive refractive power; a fourth lens having a negative refractive power; a fifth lens having a refractive power; a sixth lens having a positive refractive power; and a seventh lens having a negative refractive power. At least one of the first to seventh lenses comprises a free-form surface. The camera optical lens satisfies following conditions: ?3.00?f4/f3??1.00; 2.90?d9/d10?8.50; and 2.00?d11/d12?15.00. The camera optical lens can achieve high optical performance while satisfying design requirements for ultra-thin, wide-angle lenses.

Abstract: The present invention provides a camera optical lens, including, from an object side to an image side, a first lens having a positive refractive power, a second lens a negative refractive power, a third lens having a positive refractive power, a fourth lens having a negative refractive power, and a fifth lens. At least one of the first lens to the fifth lens has a free-form surface, and the camera optical lens satisfies 0.50?f3/f?1.20; and 1.50?R7/R8, where f denotes a focal length of the camera optical lens, f3 denotes a focal length of the third lens, R7 is a central curvature radius of an object side surface of the fourth lens, and R8 is a central curvature radius of an image side surface of the fourth lens. The camera optical lens has excellent optical performance while meeting requirements of a long focal length and ultra-thinness.

Abstract: The present disclosure relates to the technical field of optical lens and discloses a camera optical lens satisfying following conditions: 0.50?f12/f?1.20; 1.50?f4/f?5.00; ?10.00?R2/R1??1.20; where f12 denotes a combined focal length of the first lens and the second lens, f denotes a focal length of the camera optical lens, f4 denotes a focal length of the fourth lens, R2 denotes a central curvature radius of an image-side surface of the first lens, and R1 denotes a central curvature radius of an object-side surface of the first lens. The camera optical lens in the present disclosure satisfies a design requirement of long focal length and ultra-thinness while having good optical functions.

Abstract: A camera optical lens includes, from an object side to an image side: a first lens with a positive refractive power; a second lens with a negative refractive power; a third lens; a fourth lens; a fifth lens with a positive refractive power; a sixth lens with a positive refractive power; a seventh lens with a negative refractive power. The camera optical lens satisfies the conditions of -8.00?f2/f?-2.50, 2.50?(R5+R6)/(R5-R6)?30.00 and R8/R7 ?-1.50. The camera optical lens of the present disclosure has excellent optical performances, and meanwhile can meet design requirements of a wide-angle, a large aperture and ultra-thin.

Abstract: A method is disclosed of manufacturing a semiconductor structure comprising an (001) oriented zincblende structure group III-nitride layer, such as GaN. The layer is formed on a 3C-SiC layer on a silicon substrate. A nucleation layer is formed, recrystallized and then the zincblende structure group III-nitride layer is formed by MOVPE at temperature T3 in the range 750-1000° C., to a thickness of at least 0.5?. There is also disclosed a corresponding semiconductor structure comprising a zincblende structure group III-nitride layer which, when characterized by XRD, shows that the substantial majority, or all, of the layer is formed of zincblende structure group III-nitride in preference to wurtzite structure group III-nitride. The present invention provides methods for producing hydrogen using a mediator that is capable of reversibly donating and accepting four or more electrons.

Abstract: Provided is a camera optical lens including, sequentially from an object side to an image side: a first lens having a negative refractive power; a second lens; a third lens having a positive refractive power; a fourth lens having a negative refractive power; a fifth lens; a sixth lens having a positive refractive power; and a seventh lens having a negative refractive power. At least one of the first to seventh lenses comprises a free-form surface. The camera optical lens satisfies following conditions: ?5.00?f1/f??1.00; and 1.50?d1/d2?7.00. The camera optical lens can achieve high optical performance while satisfying design requirements for ultra-thin, wide-angle lenses.