Abstract: The present invention discloses an inactive telomerase, which is a double mutant telomerase having double mutation sites Y707F and D868A. The present invention also discloses an adenovirus-inactive telomerase and an artificial mRNA-inactive telomerase having double mutation sites, and use thereof in the treatment of diseases associated with non-dividing cell telomere shortening. The present invention is capable of inhibiting the activity of telomerase TERT in non-dividing cells to form an inactive telomerase CI-TERT and simultaneously preventing the telomerase from leaving the nucleus. By such configuration, the telomerase can be kept in the nucleus to protect the telomeric ends from shortening and prevent telomerase from causing telomere lengthening to the extent of cell carcinogenesis, thus reducing the risk of carcinogenesis and keeping the telomerase in the nucleus to protect the telomeric ends and inhibiting the deterioration of the disease caused by telomere shortening.

Abstract: A flexible display module includes a back film, and a flexible display screen and a protective cover plate that are sequentially stacked on a side of the back film. The protective cover plate includes a cover plate body and at least one arc-shaped extension portion. An end of an arc-shaped extension portion is connected to a side face of the cover plate body. An end of the arc-shaped extension portion away from the cover plate body extends beyond an edge of the flexible display screen and an edge of the back film. An arc-shaped concave surface of the arc-shaped extension portion faces a side face of the flexible display screen and a side face of the back film that are proximate to the arc-shaped extension portion.

Abstract: A device measures a frictional force and a film thickness of a lubricating oil film in different surface velocity directions. The device includes an experiment bench. A translation stage is mounted to the experiment bench, and is linearly movable. A main shaft system is mounted to the experiment bench. A glass disc is mounted to the main shaft system and is rotatable. An arcuate guide rail is disposed on the translation stage. A rotary base is mounted to the arcuate guide rail and is movable along the arcuate guide rail. A loading system is mounted to the rotary base. A steel ball of the loading system and the glass disc are movable relative to each other. A rotary bearing in the rotary base is configured to convert a frictional force generated from the relative movement to a pressure allowed to be collected by a pressure sensor on the rotary base.

Abstract: A transparent laminated film, a display device, and a method for manufacturing a transparent laminated film are disclosed. The transparent laminated film includes a first film layer, a central film layer, and a second film layer which are sequentially stacked, each of a material of the first film layer and a material of the second film layer includes a thermoplastic plastic, and a material of the central film layer includes a thermosetting plastic.

Abstract: A systems including one or more processors and one or more non-transitory computer readable media storing computing instructions that, when executed on the one or more processors, perform: receiving in-session user activity information, the in-session user activity information comprising a user search query from a user and a ranked list of products to be displayed to the user based on the user search query, and a product of the products being part of a boost category; determining a respective content model prediction score for each of the products of the ranked list of the products; determining a respective discounted cumulative gain (DCG) score for each of the products of the ranked list of the products; analyzing the product that is part of the boost category to determine if the product is to be repositioned within the ranked list of the products based on the respective DCG score for each of the products; and in response to determining that the product that is part of the boost category is to be repositione

Abstract: A lighting module for a refrigeration appliance has a housing provided with a light outlet. The housing includes a supporting edge surrounding the light outlet and an inner frame disposed along the supporting edge. The inner frame protrudes from the supporting edge in a direction away from the light outlet. The housing further has a light source. The light source includes a light emitting element and a substrate bearing the light emitting element. The light guide plate is supported on the supporting edge and includes a first end surface protruding toward the inner frame. The housing includes a mounting portion located in a space defined by the first end surface of the light guide plate, the supporting edge, and the inner frame. The substrate is mounted on the mounting portion, so that the light emitting element and the first end surface of the light guide plate face each other.

Abstract: The present disclosure discloses an amino acid helical array film and a preparation method thereof. The amino acid helical array film comprises a substrate and an amino acid helical array uniformly deposited on the substrate. Each amino acid helix is obtained by self-assembling an amino acid with a modifying group. The amino acid is selected from one or more of twenty common natural amino acids or adjacent isomers thereof. The modifying group comprises an N-terminal protecting group and a C-terminal protecting group, wherein the N-terminal protecting group is selected from one or more of carbobenzoxy, a lipid group, t-butoxycarbonyl, and 9-fluorenylmethoxycarbonyl, and the C-terminal protecting group is selected from one or more of nitrophenyl ester, a lipoxy group, and an acylamino group.

Abstract: The present disclosure relates to a rollable display panel. The rollable display panel includes a first structure layer, a second structure layer, and a first adhesive layer stacked between the first structure layer and the second structure layer. The rollable display panel is divided into a rollable area, a strain accumulation area, and a flat area distributed in sequence along a rolling direction. A thickness of a part of the first adhesive layer located in the strain accumulation area is greater than a thickness of a part of the first adhesive layer located in the rollable area or the flat area.

Abstract: The flexible display module can be curled, and may comprise: a flexible display panel having a display side and a rear side which are provided opposite to each other in a thickness direction of the flexible display panel; a first functional film layer, formed on a display side of the flexible display panel; and a second functional film layer, formed on the rear side of the flexible display panel. The ratio of the thickness of the second functional film layer to the thickness of the first functional film layer is 0.5 to 1.5, and the ratio of the elasticity modulus of the second functional film layer to the elasticity modulus of the first functional film layer is 0.5 to 1.5. The flexible display module is not prone to peeling, losing efficacy and the like.

Abstract: A flexible display assembly, a flexible display device and a method for preparing the flexible display device are provided.

Abstract: The present disclosure discloses a whole avian-origin reverse genetic manipulation system and its use in producing a recombinant H7N9 avian influenza vaccine. The whole avian-origin reverse genetic manipulation system is an eight-plasmid reverse genetic manipulation system based on H5N2 subtype avian influenza D7 virus strain, which is comprised of 8 recombinant plasmids respectively containing PB2, PB1, PA, HA, NP, NA, M and NS gene fragments derived from H5N2 subtype avian influenza D7 virus strain. The genome of the recombinant H7N9 subtype avian influenza vaccine of the present disclosure is comprised of an NA gene and a modified HA gene derived from a highly pathogenic H7N9 subtype avian influenza virus strain, as well as PB2, PB1, PA, NP, M and NS genes derived from H5N2 subtype avian influenza D7 virus strain.

Abstract: A refrigeration appliance has a storage compartment provided with a front opening. The storage compartment further has a top wall and a mounting slot located in the top wall. A lighting module is fastened in the mounting slot. The lighting module includes a front wall facing the front opening. The front wall includes a main part and a decorative strip connected to the main part. An upper end of the decorative strip extends into the mounting slot.

Abstract: A lighting module is provided for a refrigeration appliance. The lighting module includes: a housing, provided with a light outlet; a light source, located in the housing; a light guide plate, adapted to guide light from the light source toward the light outlet; and an elastic member, adapted to deform to maintain a position of the light guide plate with respect to the light source and/or the light outlet.

Abstract: The present disclosure discloses a whole avian-origin reverse genetic system, a recombinant H5N2 subtype avian influenza virus, a vaccine containing the virus, and a preparation method and application thereof. The genome of the recombinant virus is comprised of a modified HA gene derived from a highly pathogenic H5N6 subtype avian influenza virus strain, as well as PB2, PB1, PA, NP, NA, M and NS genes derived from H5N2 subtype avian influenza D7 virus strain. The recombinant virus is a recombinant H5N2 avian influenza virus rescued from the D7 virus strain as a backbone, which is an avirulent virus strain with the original immunogenicity, and can maintain a high virus titer during the chick embryo culture process. The recombinant virus fully meets the biological safety requirements and has a good application prospect.

Abstract: The present disclosure discloses a whole avian-origin reverse genetic manipulation system and its use in producing a recombinant H7N9 avian influenza vaccine. The whole avian-origin reverse genetic manipulation system is an eight-plasmid reverse genetic manipulation system based on H5N2 subtype avian influenza D7 virus strain, which is comprised of 8 recombinant plasmids respectively containing PB2, PB1, PA, HA, NP, NA, M and NS gene fragments derived from H5N2 subtype avian influenza D7 virus strain. The genome of the recombinant H7N9 subtype avian influenza vaccine of the present disclosure is comprised of an NA gene and a modified HA gene derived from a highly pathogenic H7N9 subtype avian influenza virus strain, as well as PB2, PB1, PA, NP, M and NS genes derived from H5N2 subtype avian influenza D7 virus strain.

Abstract: The present disclosure discloses a whole avian-origin reverse genetic system, a recombinant H5N2 subtype avian influenza virus, a vaccine containing the virus, and a preparation method and application thereof. The genome of the recombinant virus is comprised of a modified HA gene derived from a highly pathogenic H5N6 subtype avian influenza virus strain, as well as PB2, PB1, PA, NP, NA, M and NS genes derived from H5N2 subtype avian influenza D7 virus strain. The recombinant virus is a recombinant H5N2 avian influenza virus rescued from the D7 virus strain as a backbone, which is an avirulent virus strain with the original immunogenicity, and can maintain a high virus titer during the chick embryo culture process. The recombinant virus fully meets the biological safety requirements and has a good application prospect.

Abstract: A scroll-type display panel and a scroll-type display device. The scroll-type display panel comprises a display module; the display module comprises: a support layer and an array substrate; the support layer comprises a first wound portion and a second wound portion which are distributed in a winding direction; the array substrate is located on one side of the support layer, and an orthographic projection of the array substrate on the support layer is located on the first wound portion, wherein hollowed-out openings are provided on both the first wound portion and the second wound portion, and the area ratio of the hollowed-out openings to the first wound portion is greater than the area ratio of the hollowed-out openings to the second wound portion.

Abstract: An application freezing control method and device, a terminal device (1000), and a non-transitory computer-readable storage medium are disclosed. The application freezing control method may include: unfreezing, in response to a basic unfreezing moment in a basic freezing control period being reached, an application which is in a frozen state and meets an unfreezing condition (S101); and freezing, in response to a basic freezing moment in the basic freezing control period being reached, an application which is in an unfrozen state and meets a freezing condition (S102).

Abstract: A display panel, a manufacturing method thereof and a display device are disclosed. The display panel includes a display array layer, a first optical structural layer, and a first light shielding pattern. The display array layer includes a first sub-display area and a second sub-display area at least partially surrounded by the first sub-display area, the second sub-display area is configured to be able to transmit ambient light; the first optical structural layer is located at a display side of the display array layer; and the first light shielding pattern is located at a side of the first optical structural layer facing the display array layer, and the first light shielding pattern at least partially surrounds the second sub-display area and exposes at least a part of the second sub-display area.