Abstract: Disclosed herein is a method of determining subject sensitivity to a WEE1 inhibitor, comprising obtaining or having obtained a biological sample from the subject, and performing or having performed at least one assay on the biological sample to determine if the subject has an altered function of CCNE1. Also disclosed are methods of treating cancer with a WEE1 inhibitor, comprising identifying a subject having (a) the cancer and (b) endogenous or altered function of CCNE1; and administering an effective amount of the WEE1 inhibitor, or a pharmaceutically acceptable salt thereof, to the subject.

Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer.

Abstract: Provided in the present disclosure is a preparation method of paeoniflorin-6?-O-benzene sulfonate. The method uses crude paeoniflorin instead of paeoniflorin as a raw material, which more complies with actual requirements of an industrial production process of paeoniflorin-6?-O-benzene sulfonate, and uses an organometallic catalyst, an acid-binding agent and chemically active benzenesulfonyl chloride to react with paeoniflorin. Compared with the prior art, the method significantly increases the yield of crude paeoniflorin-6?-O-benzene sulfonate which is separated and purified by means of column chromatography and then refined to obtain paeoniflorin-6?-O-benzenesulfonate with a content of at least 98%, thereby realizing industrial production of the paeoniflorin-6?-O-benzene sulfonate.

Abstract: Disclosed are a signal filtering method and apparatus, a storage medium, and an electronic device. The signal filtering method may include: performing a Fourier transform on time-domain data acquired by M microphones to convert the time-domain data into frequency-domain signals of M channels of a current frame, M is a natural number greater than 1; separating the frequency-domain signals of the M channels to obtain a target signal and an interference signal of the current frame; determining a signal-to-interference ratio between a smooth energy of the target signal and a smooth energy of the interference signal; determining a threshold for the current frame based on the target signal and the interference signal; and filtering the target signal based on the threshold for the current frame and the signal-to-interference ratio between the smooth energies to obtain a pure target signal.

Abstract: Disclosed herein are compounds and combinations of compounds for treating a disease or condition, such as cancer.

Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a SERD inhibitor and a WEE1 inhibitor, along with pharmaceutically acceptable salts of any of the foregoing.

Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a WEE1 inhibitor, and a SERD or SERM inhibitor, along with pharmaceutically acceptable salts of any of the foregoing.

Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a SERD inhibitor and a Bcl-2 inhibitor, along with pharmaceutically acceptable salts of any of the foregoing.

Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a SERD inhibitor and another inhibitor (such as a CDK4/6 inhibitor, a selective aromatase inhibitor, a non-selective aromatase inhibitor, a mTOR inhibitor, a PI3K inhibitor, an ERK or a MEK inhibitor, AKT inhibitor, a BET inhibitor and an Aurora inhibitor), along with pharmaceutically acceptable salts of any of the foregoing.

Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a Bcl-2 inhibitor and a WEE1 inhibitor, along with pharmaceutically acceptable salts of any of the foregoing.

Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a SERD inhibitor and a WEE1 inhibitor, along with pharmaceutically acceptable salts of any of the foregoing.

Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a WEE1 inhibitor and a Bcl-2 inhibitor, along with pharmaceutically acceptable salts of any of the foregoing.

Abstract: Uses and methods that include an effective amount of Compound (A), or a pharmaceutically acceptable salt thereof, are described herein for treating breast cancer in a subject in need thereof, wherein the breast cancer has at least one point mutation within the Estrogen Receptor 1 (ESR1) that encodes Estrogen receptor alpha (ER?).

Abstract: Uses and methods that include an effective amount of Compound (A), or a pharmaceutically acceptable salt thereof, are described herein for treating breast cancer in a subject in need thereof, wherein the breast cancer has at least one point mutation within the Estrogen Receptor 1 (ESR1) that encodes Estrogen receptor alpha (ER?).

Abstract: Uses and methods that include an effective amount of Compound (A), or a pharmaceutically acceptable salt thereof, are described herein for treating breast cancer in a subject in need thereof, wherein the breast cancer has at least one point mutation within the Estrogen Receptor 1 (ESR1) that encodes Estrogen receptor alpha (ER?).

Abstract: System and methods of managing reference frame adaptively for video communication under a network are provided. The system adaptively decides the interval between each I frame, the bitrate of the encoded bit steams, and the resolution of the encoded video to achieve quick connection. The system may set the appropriate reference frame(s) for the current frame, manage the reference frame(s) in the DPB to be long/short term reference frame(s) or mark them as unused for reference; mark the current frame to be a long term reference frame, a short term reference frame, unused for reference or skip encoding the current frame; adaptively change the ratio of long term reference frame(s) with respect to the short term reference frame(s) in the DPB; adaptively change the frequency ratio of marking the current frame as long term reference frame and marking the current frame as short term reference frame.

Abstract: A decoding method includes: decoding from the video bitstream a prediction status parameter indicative of whether SOP is enabled; if the SOP is enabled, determining a SOP type indicative of a specific operation for predicting a current picture of the video bitstream; and determining a predicted picture by applying the specific operation to at least one of a reference picture for the current picture and the current picture, in which the specific operation includes at least one of rotation and zoom. An encoding method includes: if SOP is enabled, determining SOP data indicative of a specific operation for predicting a current picture of a video sequence; determining a predicted picture by applying the specific operation to at least one of a reference picture for the current picture and the current picture, in which the specific operation includes at least one of rotation and zoom; and encoding the SOP data.

Abstract: Embodiments of the disclosure provide methods and systems for adjusting road conditions. The system includes a communication interface configured to receive driving information indicative of vehicle driving records on a road. The road includes first and second direction lanes. The system includes a storage configured to store preset parameters. The system includes a processor configured to divide the road into road segments and determine a first traffic congestion index and a second traffic congestion index for the first direction lane and the second direction lane, respectively, based on the driving information associated with each road segment and the preset parameters. The processor is configured to determine a directional imbalance index for the road based on the first and second traffic congestion indices. The processor is configured to provide an instruction to adjust the first direction lane and/or the second direction lane of the road based on the directional imbalance index.

Abstract: A decoding method includes: decoding from the video bitstream a prediction status parameter indicative of whether SOP is enabled; if the SOP is enabled, determining a SOP type indicative of a specific operation for predicting a current picture of the video bitstream; and determining a predicted picture by applying the specific operation to at least one of a reference picture for the current picture and the current picture, in which the specific operation includes at least one of rotation and zoom. An encoding method includes: if SOP is enabled, determining SOP data indicative of a specific operation for predicting a current picture of a video sequence; determining a predicted picture by applying the specific operation to at least one of a reference picture for the current picture and the current picture, in which the specific operation includes at least one of rotation and zoom; and encoding the SOP data.

Abstract: Systems and methods of a safety belt to be worn by individuals in the course of physical activities such as walking, running, biking, etc. Safety belts of the inventive subject matter include one or more sensors that are used to develop a kinematic status of the individual wearing the safety belt. Kinematic status information can be broadcast out wirelessly, and it can be used to determine whether to generate an alert. Some embodiments of the safety belt can detect the presence of a hazard in the vicinity of an individual wearing the safety belt.