Abstract: Systems and methods of a safety belt to be worn by individuals in the course of physical activities such as walking, running, biking, etc. Safety belts of the inventive subject matter include one or more sensors that are used to develop a kinematic status of the individual wearing the safety belt. Kinematic status information can be broadcast out wirelessly, and it can be used to determine whether to generate an alert. Some embodiments of the safety belt can detect the presence of a hazard in the vicinity of an individual wearing the safety belt.

Abstract: System and methods of managing reference frame adaptively for video communication under a network are provided. For connection process, based on the network types of all clients and network conditions the system adaptively decides the interval between each I frame, the bitrate of the encoded bit steams, and the resolution of the encoded video to achieve quick connection. Based on the feedback of other clients and network conditions, the system may decide to re-enter the connection stage.

Abstract: Systems and methods of a safety belt to be worn by individuals in the course of physical activities such as walking, running, biking, etc. Safety belts of the inventive subject matter include one or more sensors that are used to develop a kinematic status of the individual wearing the safety belt. Kinematic status information can be broadcast out wirelessly, and it can be used to determine whether to generate an alert. Some embodiments of the safety belt can detect the presence of a hazard in the vicinity of an individual wearing the safety belt.

Abstract: A frame loss compensation method and apparatus for audio signals are disclosed. The method includes: when a first frame immediately following a correctly received frame is lost, judging a frame type of the first lost frame, and when the first lost frame is a non-multi-harmonic frame, calculating MDCT coefficients of the first lost frame by using MDCT coefficients of one or more frames prior to the first lost frame; obtaining an initially compensated signal of the first lost frame according to the MDCT coefficients of the first lost frame; and performing a first class of waveform adjustment on the initially compensated signal of the first lost frame and taking an adjusted time-domain signal as a time-domain signal of the first lost frame. The apparatus includes a frame type judgment module, an MDCT coefficient acquisition module, an initial compensation signal acquisition module and an adjustment module.

Abstract: The audio coding method and system of lattice vector quantization is provided in the invention. The method comprises: dividing frequency domain coefficients of an audio signal for which a modified discrete cosine transform (MDCT) has been performed into a plurality of coding sub-bands, and quantizing and coding an amplitude envelope value of each coding sub-band to obtain coded bits of amplitude envelopes; performing bit allocation on each coding sub-band, and performing normalization, quantization and coding respectively on vectors in a low bit coding sub-band with pyramid lattice vector quantization and on vectors in a high bit coding sub-band with sphere lattice vector quantization to obtain coded bits of the frequency domain coefficients; multiplexing and packing the coded bits of the amplitude envelope and the coded bits of the frequency domain coefficients of each coding sub-band, then sending them to a decoding side.

Abstract: The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.

Abstract: A frame loss compensation method and apparatus for audio signals are disclosed. The method includes: when a first frame immediately following a correctly received frame is lost, judging a frame type of the first lost frame, and when the first lost frame is a non-multi-harmonic frame, calculating MDCT coefficients of the first lost frame by using MDCT coefficients of one or more frames prior to the first lost frame; obtaining an initially compensated signal of the first lost frame according to the MDCT coefficients of the first lost frame; and performing a first class of waveform adjustment on the initially compensated signal of the first lost frame and taking an adjusted time-domain signal as a time-domain signal of the first lost frame. The apparatus includes a frame type judgment module, an MDCT coefficient acquisition module, an initial compensation signal acquisition module and an adjustment module.

Abstract: Hierarchical audio coding and decoding method and system and hierarchical audio coding and decoding method for transient signals are provided. In the present invention, by introducing a processing method for transient signal frames in the hierarchical audio coding and decoding methods, a segmented time-frequency transform is performed on the transient signal frames, and then the frequency-domain coefficients obtained by transformation are rearranged respectively within the core layer and within the extended layer, so as to perform the same subsequent coding processes, such as bit allocation, frequency-domain coefficient coding, etc., as those on the steady-state signal frames, thus enhancing the coding efficiency of the transient signal frames and improving the quality of the hierarchical audio coding and decoding.

Abstract: Provided is a cancer therapeutic agent comprising a cancer targeting molecule linked to a liver-expressed chemokine (LEC). In one embodiment, the cancer targeting molecule is an antibody that targets cancer cells or tumors in vivo. The cancer targeting molecule is associated non-covalently or covalently with LEC. The cancer therapeutic agents of the invention are useful for the treatment of cancer in an individual by reducing the size of a tumor or inhibiting the growth of cancer cells in an individual and/or by inhibiting the development of metastasis. The effectiveness of the therapy using the LEC cancer therapeutic agents can be increased by reducing the activity of immunoregulatory T cells and/or by adoptively transferring immune T cells.

Abstract: The invention provides a compensation method for audio frame loss in a MDCT domain, the method comprising: when a frame currently lost is a Pth frame, obtaining a set of frequencies to be predicted, and for each frequency in the set, using phases and amplitudes of a plurality of frames before a (P?1)th frame in a MDCT-MDST domain to predict a phase and an amplitude of the Pth frame, and using the predicted phase and amplitude to obtain a MDCT coefficient of the Pth frame at each corresponding frequency; for a frequency outside the set, using MDCT coefficients of a plurality of frames before the Pth frame to calculate a MDCT coefficient value of the Pth frame at the frequency; performing an IMDCT for the MDCT coefficients of the Pth frame to obtain a time domain signal of the Pth frame.

Abstract: The present invention relates to a method and system for audio encoding and decoding and a method for estimating a noise level, and the method for estimating a noise level in the present invention comprises: estimating a power spectrum of an audio signal to be encoded according to a frequency domain coefficient of the audio signal to be encoded; and estimating a noise level of a zero bit encoding subband audio signal according to the power spectrum obtained by calculating, and this noise level for controlling an energy proportion of noise filling to spectral band replication during decoding; wherein a zero bit encoding subband refers to an encoding subband of which allocated bit number is zero. The present invention can well reconstruct the uncoded frequency domain coefficients.

Abstract: Provided is a cancer therapeutic agent comprising a cancer targeting molecule linked to a liver-expressed chemokine (LEC). In one embodiment, the cancer targeting molecule is an antibody that targets cancer cells or tumors in vivo. The cancer targeting molecule is associated non-covalently or covalently with LEC. The cancer therapeutic agents of the invention are useful for the treatment of cancer in an individual by reducing the size of a tumor or inhibiting the growth of cancer cells in an individual and/or by inhibiting the development of metastasis. The effectiveness of the therapy using the LEC cancer therapeutic agents can be increased by reducing the activity of immunoregulatory T cells and/or by adoptively transferring immune T cells.

Abstract: A hierarchical audio coding, decoding method and system are provided. The method includes dividing frequency domain coefficients of an audio signal after MDCT into a plurality of coding sub-bands, quantizing and coding amplitude envelope values of coding sub-bands; allocating bits to each coding sub-band of the core layer, quantizing and coding core layer frequency domain coefficients to obtain coded bits of core layer frequency domain coefficients; calculating the amplitude envelope value of each coding sub-band of the core layer residual signal; allocating bits to each coding sub-band of the extended layer, quantizing and coding the extended layer coding signal to obtain coded bits of the extended layer coding signal; multiplexing and packing amplitude value envelope coded bits of each coding sub-band composed by core layer and extended layer frequency domain coefficients, core layer frequency coefficients coded bits, and extended layer coding signal coded bits, then transmitting to the decoding end.

Abstract: Provided is a cancer therapeutic agent comprising a cancer targeting molecule linked to a liver-expressed chemokine (LEC). In one embodiment, the cancer targeting molecule is an antibody that targets cancer cells or tumors in vivo. The cancer targeting molecule is associated non-covalently or covalently with LEC. The cancer therapeutic agents of the invention are useful for the treatment of cancer in an individual by reducing the size of a tumor or inhibiting the growth of cancer cells in an individual and/or by inhibiting the development of metastasis. The effectiveness of the therapy using the LEC cancer therapeutic agents can be increased by reducing the activity of immunoregulatory T cells and/or by adoptively transferring immune T cells.

Abstract: The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.

Abstract: The present invention relates to a method and system for audio encoding and decoding and a method for estimating a noise level, and the method for estimating a noise level in the present invention comprises: estimating a power spectrum of an audio signal to be encoded according to a frequency domain coefficient of the audio signal to be encoded; and estimating a noise level of a zero bit encoding subband audio signal according to the power spectrum obtained by calculating, and this noise level for controlling an energy proportion of noise filling to spectral band replication during decoding; wherein a zero bit encoding subband refers to an encoding subband of which allocated bit number is zero. The present invention can well reconstruct the uncoded frequency domain coefficients.

Abstract: The present invention relates to a method and device for spectral band replication, and a method and system for audio decoding, and the method for spectral band replication comprises: A. searching for the position of a certain tone of an audio signal in MDCT frequency domain coefficients; B. according to the tone position, determining a spectral band replication period which is a bandwidth from a 0 frequency point to a frequency point of tone position, and a source frequency segment which is a frequency segment from a frequency point of the 0 frequency point shifting copyband_offset frequency points backwards to a frequency point of the frequency point of the tone position shifting the copyband_offset frequency points backwards, wherein said offset copyband_offset is greater than or equal to 0; and C. according to the spectral band replication period, carrying out spectral band replication on zero bit encoding subbands.

Abstract: Hierarchical audio coding and decoding method and system and hierarchical audio coding and decoding method for transient signals are provided. In the present invention, by introducing a processing method for transient signal frames in the hierarchical audio coding and decoding methods, a segmented time-frequency transform is performed on the transient signal frames, and then the frequency-domain coefficients obtained by transformation are rearranged respectively within the core layer and within the extended layer, so as to perform the same subsequent coding processes, such as bit allocation, frequency-domain coefficient coding, etc., as those on the steady-state signal frames, thus enhancing the coding efficiency of the transient signal frames and improving the quality of the hierarchical audio coding and decoding.

Abstract: The audio coding method and system of lattice vector quantization is provided in the invention. The method comprises: dividing frequency domain coefficients of an audio signal for which a modified discrete cosine transform (MDCT) has been performed into a plurality of coding sub-bands, and quantizing and coding an amplitude envelope value of each coding sub-band to obtain coded bits of amplitude envelopes; performing bit allocation on each coding sub-band, and performing normalization, quantization and coding respectively on vectors in a low bit coding sub-band with pyramid lattice vector quantization and on vectors in a high bit coding sub-band with sphere lattice vector quantization to obtain coded bits of the frequency domain coefficients; multiplexing and packing the coded bits of the amplitude envelope and the coded bits of the frequency domain coefficients of each coding sub-band, then sending them to a decoding side.

Abstract: A hierarchical audio coding, decoding method and system are provided. The method includes dividing frequency domain coefficients of an audio signal after MDCT into a plurality of coding sub-bands, quantizing and coding amplitude envelope values of coding sub-bands; allocating bits to each coding sub-band of the core layer, quantizing and coding core layer frequency domain coefficients to obtain coded bits of core layer frequency domain coefficients; calculating the amplitude envelope value of each coding sub-band of the core layer residual signal; allocating bits to each coding sub-band of the extended layer, quantizing and coding the extended layer coding signal to obtain coded bits of the extended layer coding signal; multiplexing and packing amplitude value envelope coded bits of each coding sub-band composed by core layer and extended layer frequency domain coefficients, core layer frequency coefficients coded bits, and extended layer coding signal coded bits, then transmitting to the decoding end.