Abstract: Bivalent compounds composition comprises one or more of the bivalent compounds. The bivalent compound comprises a cyclic-AMP response element binding protein (CBP) and/or adenoviral EA binding protein of 300 kDa (P300) ligand (CBP/P3000 ligand) conjugated to a degradation tag. The method of using the bivalent compounds is treating certain disease in a subject in need thereof. The method of identifying such bivalent compounds is disclosed.

Abstract: Exemplary methods of semiconductor processing may include delivering a carbon-containing precursor and a hydrogen-containing precursor to a processing region of a semiconductor processing chamber. The methods may include generating a plasma of the carbon-containing precursor and the hydrogen-containing precursor within the processing region of the semiconductor processing chamber. The methods may include forming a layer of graphene on a substrate positioned within the processing region of the semiconductor processing chamber. The substrate may be maintained at a temperature below or about 600° C. The methods may include halting flow of the carbon-containing precursor while maintaining the plasma with the hydrogen-containing precursor.

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

Abstract: The present disclosure relates to the field of tissue dissection. Specifically, the present disclosure relates to medical devices that lift and retract tissue during a dissection procedure to improve visualization of the target tissue and mitigate obstructions for dissection tools. In particular, the present disclosure relates to devices that transition from a constrained to an unconstrained bowed configuration to immobilize and retract the dissected portion of target tissue during a dissection procedure.

Abstract: Exemplary methods of semiconductor processing may include delivering a carbon-containing precursor and a hydrogen-containing precursor to a processing region of a semiconductor processing chamber. The methods may include generating a plasma of the carbon-containing precursor and the hydrogen-containing precursor within the processing region of the semiconductor processing chamber. The methods may include forming a layer of graphene on a substrate positioned within the processing region of the semiconductor processing chamber. The substrate may be maintained at a temperature below or about 600° C. The methods may include halting flow of the carbon-containing precursor while maintaining the plasma with the hydrogen-containing precursor.

Abstract: A casting and outputting system is provided. The system includes a casting machine, a disc body, a transfer device, a special fixture, a cooling tank, a collection device and a waste plate rack. The transfer device is configured to drive the special fixture to take out anode plates cast on the disc body, place a qualified one of the anode plates in the cooling tank, place an unqualified one of the anode plates on the waste plate rack, lift the anode plate cooled in the cooling tank, and place the cooled anode plate on the collection device for stacking.

Abstract: A horizontal drilling machine with an in-situ detection device, including a support frame, an armored cable, a steel pipe-straightening mechanism, a steel pipe-feeding mechanism, a motor, a power head, a drill pipe, a rotating chuck, a damper, a non-core drilling tool, the in-situ detection device, a fishing device and a thrust cylinder. The steel pipe-straightening mechanism, the steel pipe-feeding mechanism, the rotating chuck and the damper are sequentially fixed on the support frame from left to right. One end of the thrust cylinder is hinged with the support frame, and the other end is connected to the power head. The active drill pipe of the power head is connected to the drill pipe. An end of the armored cable is connected to the fishing device in the drill pipe, and the fishing head of the fishing device is connected to the spearhead of the non-core drilling tool.

Abstract: The present disclosure relates to the field of tissue dissection. Specifically, the present disclosure relates to medical devices which lift and retract tissue during a dissection procedure to improve visualization of the target tissue and mitigate obstruction of dissection tools. In particular, the present disclosure relates to a tissue retraction device which moves from a constrained to relaxed configuration to immobilize and retract the dissected portion of target tissue during a dissection procedure.

Abstract: The present disclosure relates to the field of tissue dissection. Specifically, the present disclosure relates to medical devices which lift and retract tissue during a dissection procedure to improve visualization of the target tissue and mitigate obstruction of dissection tools. In particular, the present disclosure relates to a tissue retraction device which moves from a constrained to relaxed configuration to immobilize and retract the dissected portion of target tissue during a dissection procedure.

Abstract: A long-distance core drilling method suitable for a horizontal geological core drilling rig. (1) An active drill rod is connected to a drill rod, which is connected to a wireline-coring outer-tube drilling tool. (2) A steel-pipe string is connected to a fishing device, and the fishing device is connected to a spearhead on a core tube, which is placed to a designated position through a pipe-feeding mechanism. (3) A washing pump is started. (4) A core drilling is carried out. (5) A core is pulled out. (6) The steel-pipe string and the fishing device are reconnected. (7) The core tube is salvaged. (8) The core tube and drill pipe are replaced. (9) A hole is swept. (10) Steps (1)-(9) are repeated until the hole is drilled to a designated depth. (11) The core tube and the wireline-coring outer-tube drilling tool are recovered.

Abstract: A horizontal drilling machine with an impact device, including a support frame, an armored cable, a cable-straightening mechanism, a cable-feeding mechanism, a power head, a drill pipe, a rotating chuck, a damper, a fishing device with the impact device, a core tube and a thrust cylinder. One end of the thrust cylinder is hinged with the support frame, and the other end of the thrust cylinder is connected to the power head. The power head is arranged on a slid rail of the support frame. An active drill pipe of the power head is connected to the drill pipe. An end of the armored cable is connected to a control system, and the other end is connected to the fishing device in the drill pipe. A fishing head of the fishing device is connected to a spearhead of the core tube.

Abstract: Exemplary methods of semiconductor processing may include delivering a carbon-containing precursor and a hydrogen-containing precursor to a processing region of a semiconductor processing chamber. The methods may include generating a plasma of the carbon-containing precursor and the hydrogen-containing precursor within the processing region of the semiconductor processing chamber. The methods may include forming a layer of graphene on a substrate positioned within the processing region of the semiconductor processing chamber. The substrate may be maintained at a temperature below or about 600° C. The methods may include halting flow of the carbon-containing precursor while maintaining the plasma with the hydrogen-containing precursor.

Abstract: The present disclosure relates to the field of tissue dissection. Specifically, the present disclosure relates to medical devices that lift and retract tissue during a dissection procedure to improve visualization of the target tissue and mitigate obstructions for dissection tools. In particular, the present disclosure relates to devices that transition from a constrained to an unconstrained bowed configuration to immobilize and retract the dissected portion of target tissue during a dissection procedure.

Abstract: A horizontal drilling machine with an impact device, including a support frame, an armored cable, a cable-straightening mechanism, a cable-feeding mechanism, a power head, a drill pipe, a rotating chuck, a damper, a fishing device with the impact device, a core tube and a thrust cylinder. One end of the thrust cylinder is hinged with the support frame, and the other end of the thrust cylinder is connected to the power head. The power head is arranged on a slid rail of the support frame. An active drill pipe of the power head is connected to the drill pipe. An end of the armored cable is connected to a control system, and the other end is connected to the fishing device in the drill pipe. A fishing head of the fishing device is connected to a spearhead of the core tube.

Abstract: A long-distance core drilling method suitable for a horizontal geological core drilling rig. (1) An active drill rod is connected to a drill rod, which is connected to a wireline-coring outer-tube drilling tool. (2) A steel-pipe string is connected to a fishing device, and the fishing device is connected to a spearhead on a core tube, which is placed to a designated position through a pipe-feeding mechanism. (3) A washing pump is started. (4) A core drilling is carried out. (5) A core is pulled out. (6) The steel-pipe string and the fishing device are reconnected. (7) The core tube is salvaged. (8) The core tube and drill pipe are replaced. (9) A hole is swept. (10) Steps (1)-(9) are repeated until the hole is drilled to a designated depth. (11) The core tube and the wireline-coring outer-tube drilling tool are recovered.

Abstract: A horizontal drilling machine with an in-situ detection device, including a support frame, an armored cable, a steel pipe-straightening mechanism, a steel pipe-feeding mechanism, a motor, a power head, a drill pipe, a rotating chuck, a damper, a non-core drilling tool, the in-situ detection device, a fishing device and a thrust cylinder. The steel pipe-straightening mechanism, the steel pipe-feeding mechanism, the rotating chuck and the damper are sequentially fixed on the support frame from left to right. One end of the thrust cylinder is hinged with the support frame, and the other end is connected to the power head. The active drill pipe of the power head is connected to the drill pipe. An end of the armored cable is connected to the fishing device in the drill pipe, and the fishing head of the fishing device is connected to the spearhead of the non-core drilling tool.

Abstract: Medical devices and methods of using medical devices are disclosed. An example tissue retraction device includes a first engagement member having a first end and a second end, a second engagement member having a first end and a second end, a first elastic member attached to the second end of the first engagement member, and a first alignment member having a first end, a second end and a lumen extending therethrough. Further, the tissue retraction device has a first length, the first alignment member has a second length, the first elastic member extends within the lumen of the first alignment member and the second length of the first alignment member is less than or equal to the first length of the tissue retraction device.

Abstract: Bivalent compounds, compositions comprising one or more of the bivalent compounds, and methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof are provided. Methods for identifying such bivalent compounds are provided, either.

Abstract: The disclosure is directed to, in part, to BCL-2 inhibitors, pharmaceutical compositions comprising the same, as well as methods of their use and preparation.

Abstract: Apparatuses, systems, and techniques are presented to determine distance for one or more objects. In at least one embodiment, a disparity network is trained to determine distance data from input stereoscopic images using a loss function that includes at least one of a gradient loss term and an occlusion loss term.