Abstract: The present invention relates to an S-configuration-containing amino benzamide pyridazinone compound, a preparation method therefor, and a pharmaceutical composition and application thereof. Specifically, the present invention relates to a compound represented by the following general formula I or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition and application thereof. The S-configuration compound of the present application has very strong binding activity on class I histone deacetylase (HDAC1), and shows inhibitory activity on in-vitro proliferation of various tumor cells.

Abstract: Methods for the treatment of stroke, such as stroke of undetermined origin, by administration of xenon (Xe)-loaded liposome compositions are provided. In some aspects, Xe is encapsulated in echogenic liposomes and release of Xe can be enhanced by application of ultrasound stimulation. Compositions for use in treating stroke, such as liposomes loaded with Xe or Xe in combination with H2 or H2S, are also provided.

Abstract: Provided an intermittent characteristic-based demand-side resource coordination control method and system. The method includes: receiving a control request, where the control request is used for requesting control of demand-side resources having an intermittent characteristic; determining a target total control quantity of demand-side resources; determining a coordination strategy of multiple demand-side resources and an action quantity of each of the multiple demand-side resources; and performing coordinated control on the multiple demand-side resources based on the target total control quantity of demand-side resources, the coordination strategy, and the action quantity of each of the multiple demand-side resources.

Abstract: Methods, devices, and systems for generating an image for a building management system are described herein. One device includes using a computing device to import floor plan objects from computer-aided design (CAD) drawings of a building and applying a design language associated with a building management system to the floor plan objects imported from the CAD drawings. Once the design language has been applied to the floor plan objects, an image of the building is generated for use in the building management system.

Abstract: Provided herein is a novel composition for oral administration and delivery of Noble gas, such as xenon or argon. Methods of treating and preventing neuronal or cardiovascular damage with such compositions are also provided.

Abstract: Recombinant clusterin polypeptides and compositions comprising the same are provided. In some aspects, recombinant clusterin or nucleic acids encoding the same may be used for treating and preventing an abnormality of morphology and function in a mammal with disease (e.g., cardiovascular diseases or alcoholism).

Abstract: Methods, systems, and devices for annotating three-dimensional displays are described herein. One method includes displaying, by a computing device, a particular view of a 3D model of a facility, the 3D model including a plurality of objects, each object associated with a respective annotation, determining a context associated with the 3D model, and displaying a subset of the plurality of annotations associated with a respective subset of the plurality of objects based on the context.

Abstract: Methods for the treatment of stroke, such as stroke of undetermined origin, by administration of xenon (Xe)-loaded liposome compositions are provided. In some aspects, Xe is encapsulated in echogenic liposomes and release of Xe can be enhanced by application of ultrasound stimulation. Compositions for use in treating stroke, such as liposomes loaded with Xe or Xe in combination with H2 or H2S, are also provided.

Abstract: Recombinant clusterin polypeptides and compositions comprising the same are provided. In some aspects, recombinant clusterin or nucleic acids encoding the same may be used for treating and preventing an abnormality of morphology and function in a mammal with disease (e.g., cardiovascular diseases or alcoholism).

Abstract: Methods for the treatment of stroke, such as stroke of undetermined origin, by administration of xenon (Xe)-loaded liposome compositions are provided. In some aspects, Xe is encapsulated in echogenic liposomes and release of Xe can be enhanced by application of ultrasound stimulation. Compositions for use in treating stroke, such as liposomes loaded with Xe or Xe in combination with H2 or H2S, are also provided.

Abstract: Methods, systems, and devices for annotating three-dimensional displays are described herein. One method includes displaying, by a computing device, a particular view of a 3D model of a facility, the 3D model including a plurality of objects, each object associated with a respective annotation, determining a context associated with the 3D model, and displaying a subset of the plurality of annotations associated with a respective subset of the plurality of objects based on the context.

Abstract: Methods, systems, and devices for annotating three-dimensional displays are described herein. One method includes displaying, by a computing device, a particular view of a 3D model of a facility, the 3D model including a plurality of objects, each object associated with a respective annotation, determining a context associated with the 3D model, and displaying a subset of the plurality of annotations associated with a respective subset of the plurality of objects based on the context.

Abstract: Devices, methods, systems, and computer-readable media for building data consolidation are described herein. One or more embodiments include a method for building data consolidation, comprising: receiving a plurality of representative drawings that comprise a portion of a building, determining a boundary and a location of each of the plurality of representative drawings, wherein the boundary and the location correspond to the building, and stitching the plurality of representative drawings into a combined representative drawing of the building based on the boundary and the location.

Abstract: Provided herein is a novel composition for oral administration and delivery of Noble gas, such as xenon or argon. Methods of treating and preventing neuronal or cardiovascular damage with such compositions are also provided.

Abstract: Methods, devices, and systems for generating an image for a building management system are described herein. One device includes using a computing device to import floor plan objects from computer-aided design (CAD) drawings of a building and applying a design language associated with a building management system to the floor plan objects imported from the CAD drawings. Once the design language has been applied to the floor plan objects, an image of the building is generated for use in the building management system.

Abstract: Disclosed are multifunctional-echogenic immunoliposome (MF-ELIP) constructs and compositions, and their methods of use to deliver attached stem cells to a target tissue such as atheroma, to enhance one or more of survival, growth, migration, activity and differentiation of the targeted stem cells, for treating, deterring or preventing mammalian atheroma and coronary artery disease.

Abstract: Methods for the treatment of stroke, such as stroke of undetermined origin, by administration of xenon (Xe)-loaded liposome compositions are provided. In some aspects, Xe is encapsulated in echogenic liposomes and release of Xe can be enhanced by application of ultrasound stimulation. Compositions for use in treating stroke, such as liposomes loaded with Xe or Xe in combination with H2 or H2S, are also provided.

Abstract: Recombinant clusterin polypeptides and compositions comprising the same are provided. In some aspects, recombinant clusterin or nucleic acids encoding the same may be used for treating and preventing an abnormality of morphology and function in a mammal with disease (e.g., cardiovascular diseases or alcoholism).

Abstract: Methods, devices, and systems for generating an image for a building management system are described herein. One device includes using a computing device to import floor plan objects from computer-aided design (CAD) drawings of a building and applying a design language associated with a building management system to the floor plan objects imported from the CAD drawings. Once the design language has been applied to the floor plan objects, an image of the building is generated for use in the building management system.

Abstract: Recombinant clusterin polypeptides and compositions comprising the same are provided. In some aspects, recombinant clusterin or nucleic acids encoding the same may be used for treating and preventing an abnormality of morphology and function in a mammal with disease (e.g., cardiovascular diseases or alcoholism).