Abstract: Techniques are provided for implementing a probabilistic system and architecture to predict and optimize particular user activity. In one technique, opportunity application data that indicates multiple applications to multiple opportunities is stored. Tracking data that indicates, for each opportunity, a number of reviewer actions with respect to applications to the opportunity is stored. Based on the tracking data, one or more machine learning techniques are used to learn parameters of a model that takes, as input, a number of weighted applications of an opportunity and generates, as output, a prediction of a confirmed hire for the opportunity. A particular opportunity is identified and a first number of reviewer actions with respect to the particular opportunity is determined. A second number of weighted applications for the particular opportunity is generated based on the first number. The second number is input into the model to generate a score for the particular opportunity.

Abstract: Described herein are improvements relating to IGF-1 analysis, adjustment and disease management of non-neurological and/or neurological conditions. More specifically, methods relating to the clinical application of cyclic glycine-proline (cGP) biomarker for prediction of risk and recovery of non-neurological and/or neurological conditions with IGF-1 dysfunction and the use of a cGP containing organic or plant based material such as concentrated extract of blackcurrant anthocyanins (BCA) for the treatment of same. The methods more accurately measure IGF-1 function in vivo indirectly using cGP and cGP/IGF-1 ratio along with a means to adjust cGP and cGP/IGF-1 ratio (and hence active IGF-1 concentration), and specific treatment methods for individuals with a lower or reduction of cGP level relative to a standard set of baseline data.

Abstract: A technical problem of multi-objective optimization of job applications redistribution in an online connection network system is addressed by incorporating monetary value of job applications as a signal into a ranker for ranking jobs with respect to a member profile in job search and recommendations. The monetary value of job applications is used in addition to the relevance signal and is determined by executing a machine learning model that accounts for the covariates that could impact monetary value of an application for a job.

Abstract: The present disclosure relates to systems and methods for processing traffic objects. The systems may receive detection information associated with a plurality of traffic objects within a predetermined range of a vehicle; extract feature values of a plurality of features of each of the plurality of traffic objects from the detection information; obtain a plurality of feature weights corresponding to the plurality of features of each traffic object; and determine a priority queue associated with the plurality of traffic objects based on a plurality of priority values, each corresponding to each traffic object, wherein the priority value is based on the plurality of feature weights and the feature values of each traffic object.

Abstract: In some embodiments, the disclosed subject matter involves a system and method relating to evaluating the quality of recommendations provided to a member of a recommendation service. Techniques and embodiments described herein may be applied to various recommendation services/engines. Middleware may be used to receive a member ID from a user and forward the member ID to a recommendation engine without the user having to log on as the member to access recommendations. Results of the recommendation engine may be received by the middleware and forwarded to the user for the selected member to be displayed proximate to the member profile. The user may annotate the recommendations with a relevancy rating to evaluate the quality of the recommendation engine and provide input to retrain recommendation models of the engine. Other embodiments are described and claimed.

Abstract: A nanosuspension comprising (a) a pharmaceutical active ingredient or nutraceutical active ingredient having low solubility; (b) at least one alginate selected from the group consisting of (i) sodium alginate having a viscosity of 100 mPa·s or less in a 1% solution in water at 20° C. and (ii) potassium alginate; and (c) water. Also, a drug dosage form prepared from such a nanosuspension.

Abstract: A solid dispersion comprising: (a) a pharmaceutical active ingredient or a nutraceutical active ingredient having a low solubility; and (b) sodium or potassium alginate. In addition, a drug dosage form prepared from such a solid dispersion.

Abstract: Embodiments of this invention provide methods for therapeutic use of cyclic G-2-Allyl Proline to treat symptoms of cognitive impairment associated with developmental disorders as well as manufacture of medicaments including tablets, capsules, injectable solutions that are useful for treatment of such conditions.

Abstract: Embodiments of this invention provide methods for therapeutic use of cyclic G-2-Allyl Proline to treat cognitive disorders as well as manufacture of medicaments including tablets, capsules, injectable solutions that are useful for treatment of such conditions.

Abstract: Embodiments of this invention provide methods for therapeutic use of cyclic G-2-Allyl Proline to treat cognitive disorders as well as manufacture of medicaments including tablets, capsules, injectable solutions that are useful for treatment of such conditions.

Abstract: Embodiments of this invention provide methods for therapeutic use of cyclic G-2-Allyl Proline to treat cognitive disorders as well as manufacture of medicaments including tablets, capsules, injectable solutions that are useful for treatment of such conditions.

Abstract: A circuit includes: a pull down circuit including a first PFET and a second PFET connected in series between a pad of a USB circuit and ground; and a pull up circuit including a first NFET and a second NFET connected in series between the pad and a supply voltage. The circuit includes: a third PFET connected to a gate of the first PFET and a gate of the second PFET; a third NFET connected to a gate of the first NFET and a gate of the second NFET; a fourth PFET connected to the first NFET and the second NFET; and a fourth NFET connected to the first PFET and the second PFET. A pad voltage has a nominal minimum and maximum. Each of the first PFET, the second PFET, the first NFET, and the second NFET has a nominal voltage less than the pad voltage nominal maximum.

Abstract: This invention provides compounds, compositions and methods for treating a cognitive disorder or memory disorder in animals that result from aging or other neurodegenerative condition. In particular, compounds of this invention can stimulate neural cell growth, increased amounts of cells containing a key enzyme needed for production of the cholinergic neurotransmitter, and can improve memory and cognitive function in animals who have experienced a loss of memory or cognitive function.

Abstract: Embodiments of this invention provide novel cyclic compounds structurally related to diketopiperazines and methods for their therapeutic use. Such compounds are neuroprotective and have utility as therapeutic agents for treatment of diseases, injuries and other conditions characterized by neuronal degeneration and/or death. Compounds are also useful for manufacture of medicaments useful for treatment of such conditions.

Abstract: Systems, methods, and computer storage media having computer-executable instructions embodied thereon that provide insight to advertisers that participated in online advertiser auctions. A system receives data from one or more advertiser auctions and stores the data in a log. The log is queried for a sample of the data from the advertiser auctions. Data is extracted from the sample regarding advertisements submitted by the advertisers that participated in the advertiser auctions. Based on the data extracted from the sample, a report is generated that summarizes statistics and feedback regarding the advertisements that participated in the advertiser auctions. The report is displayed to a user. In embodiments, the report is automatically generated and displayed to the advertisers that participated in the advertiser auctions.

Abstract: This invention provides compounds, compositions and methods for treating a cognitive disorder or memory disorder in animals that result from aging or other neurodegenerative condition. In particular, compounds of this invention can stimulate neural cell growth, increased amounts of cells containing a key enzyme needed for production of the cholinergic neurotransmitter, and can improve memory and cognitive function in animals who have experienced a loss of memory or cognitive function.

Abstract: Embodiments of this invention provide methods for thereapeutic use of cyclic G-2-Allyl Proline to treat disorders of dopaminergic neurons, including Parkinson's disease. Cyclic G-2Allyl P is neuroprotective and has utility as a therapeutic agent for treatment of diseases and other conditions characterised by degeneration and/or death of dopaminergic neurons and the adverse symptoms of such degeneration and/or death. Such symptoms include loss of cognition and motor function. Compounds are also useful for manufacture of medicaments including tablets, capsules and injectable solutions that are useful for treatment of such conditions.

Abstract: Systems and methods are provided for generating prediction queries to help a user build and execute prediction queries. A user interface (UI) is provided that is easy to use and understand in connection with the generation of a prediction query for data mining. The UI can be instantiated from a variety of disparate sources that may request query building services. While prediction queries and relational queries are quite different, the UI enables prediction queries to be built in a manner that is similar to the way relational queries are built. In one embodiment, the main screen of the UI includes four main components: (1) a table column mapping area, (3) a selection grid area, (4) a query text display area and (5) a query result grid area. In one embodiment, the query text display area and the query result grid area are initially not presented to the user.

Abstract: This invention provides analogs and peptidomimetics of glycyl-L-prolyl-L-glutamic acid (GPE). In particular, this invention relates to GPE analogs and peptidomimetics that are anti-apoptotic, anti-necrotic and have neuroprotective effects. These agents are useful in treating neurodegeneration and behavioural disorders caused by toxins, traumatic brain injury and autoimmune disorders of the brain, such as multiple sclerosis and in reducing seizures.

Abstract: This invention provides analogs and peptidomimetics of glycyl-L-prolyl-L-glutamic acid (GPE). In particular, this invention relates to GPE analogs and peptidomimetics that are anti-apoptotic, anti-necrotic and have neuroprotective effects. These agents are useful in treating neurodegeneration and behavioural disorders caused by toxins, traumatic brain injury and autoimmune disorders of the brain, such as multiple sclerosis and in reducing seizures.