Abstract: The application relates to the technical field of biomedicine, in particular to a limited self-replicating mRNA molecular system, producing method and use. The limited self-replicating mRNA molecular system including: a first mRNA encoding a mutated alphavirus replicase; and at least one second mRNA encoding a target protein; by generating specific mutation adjustments in the nsP2 subunit of mutated replicase, this limited self-replicating mRNA molecular system can achieve limited self-replication and avoid cytotoxicity; by constructing different mRNA with mutated alphavirus replicase and different target proteins, the mutated alphavirus replicase encoded by the first mRNA can simultaneously replicate multiple different target proteins, achieving sustained expression of multiple target proteins.

Abstract: Disclosed are a multiplexing structure for a wireless antenna and a touch pad of a touch sensor, and a wireless wearable device. The multiplexing structure includes a radiating touch pad, a first conductor, a first circuit, a second circuit, and a frequency dividing circuit. The radiating touch pad is configured to receive and transmit an RF signal and receive a touch signal. The first conductor is electrically connected to the radiating touch pad. The first circuit is electrically connected to the radiating touch pad through the first conductor. The frequency dividing circuit is electrically connected to the second circuit and the first conductor, and is located between the second circuit and the first conductor. The multiplexing structure can separate the touch signal and the RF signal, and can solve the problem of mutual signal interference in the wireless wearable device caused by space limitation.

Abstract: A drug conjugate of a glucocorticoid receptor agonist, and an application thereof in medicine. Specifically, the present invention relates to an antibody-drug conjugate as represented by formula (I): Ab-(L-D)k (I), wherein Ab is an antibody or an antigen-binding fragment thereof, L is a linker covalently linking Ab to D, k is 1 to 20, and D is as represented by formula (II-A) or (II-B). The groups in the formulas are as defined in the description. The antibody-drug conjugate can effectively treat autoimmune diseases.

Abstract: The present disclosure relates to an SMTP-7 derivative and the use thereof. In particular, provided is a compound as represented by formula I or a pharmaceutically acceptable salt thereof, wherein each group is as defined in the description.

Abstract: Provided herein are a fusion protein comprising an interleukin-2 domain, a programmed cell death-1 binding domain, and a half-life-extension domain; and a pharmaceutical composition thereof. Also provided herein is a method of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

Abstract: A difference between a recorded time stamp for a first set of memory cells comprised by an open translation unit (TU) of memory cells and a current time stamp for the open TU is determined, wherein the first set of memory cells comprises a most recently programmed set of memory cells. It is determined, based on a current temperature for the open TU and the difference between the recorded time stamp and the current time stamp, that a second set of memory cells comprised by the open TU is in a coarse programming state. A programming operation is performed on the second set of memory cells using a reduced programming state verify level and a reduced programming state gate step size associated with the second set of memory cells.

Abstract: A method for storing metadata and a configuration schema for each of a plurality of capabilities, and storing a plurality of catalogs, each catalog identifying the metadata and configuration schema associated with at least one of the plurality of capabilities. The method also includes receiving a request for implementation of one of the plurality of capabilities on a pluggable system, and associating, by a lifecycle manager and based on a catalog of the plurality of catalogs related to the request, the metadata and configuration schema related to the requested one of the plurality of capabilities with a domain specific capabilities controller compatible with the pluggable system.

Abstract: The present disclosure relates to a cephalosporin antibacterial compound and a preparation method therefor. The cephalosporin antibacterial compound can exhibit antibacterial activity against Gram-negative bacteria and other bacteria.

Abstract: An apparatus includes a primary transformer circuit including a plurality of primary coils. The apparatus further includes a delta secondary transformer circuit configured to magnetically couple to the primary transformer circuit. The delta secondary transformer circuit includes a first plurality of secondary coils, a first plurality of nodes coupled to the first plurality of secondary coils, and a second plurality of secondary coils configured to magnetically couple to the plurality of primary coils. Each coil of the second plurality of secondary coils is physically coupled to a respective node of the first plurality of nodes.

Abstract: A processing unit such as a graphics processing unit (GPU) includes a plurality of vector signal processors (VSPs) that include multiply/accumulate elements. The processing unit also includes a plurality of registers associated with the plurality of VSPs. First portions of first and second matrices are fetched into the plurality of registers prior to a first round that includes a plurality of iterations. The multiply/accumulate elements perform matrix multiplication and accumulation on different combinations of subsets of the first portions of the first and second matrices in the plurality of iterations prior to fetching second portions of the first and second matrices into the plurality of registers for a second round. The accumulated results of multiplying the first portions of the first and second matrices are written into an output buffer in response to completing the plurality of iterations.

Abstract: An error associated with a read operation corresponding to a memory die of a memory sub-system is detected. In response to detecting the error, a first read throughput level of the memory sub-system is identified. A quantity of queues receiving operation requests is decreased, the decreased quantity of queues corresponding to a second read throughput level. A read retry operation associated with the memory die is initiated at the second read throughput level.

Abstract: A read operation is performed on a set of memory cells addressable by a first wordline (WL), wherein the set of memory cells is comprised by an open translation unit (TU_of memory cells of a memory device. Respective threshold voltage offset bins for each WL of a second plurality of WLs coupled to respective sets of memory cells comprised by the open TU are determined based on a threshold voltage offset bin associated with the first WL. Respective default threshold voltages for each WL of the first plurality of WLs are updated based on the respective threshold voltage offset bins for each WL of the second plurality of WLs.

Abstract: Disclosed are a system and a method for detecting a centroid of a complementary single pixel. The system includes a lens group, a single-pixel detector assembly, a Digital Micromirror Device (DMD) and an acquisition and processing unit. The acquisition and processing unit generates two-dimensional modulation matrices A and B which are loaded into the DMD; the lens group processes light reflected or transmitted from a target object, such that an image of the target object is imaged on the DMD; and the acquisition and processing unit is connected with data output ends of two single-pixel detectors in respective, to calculate the centroid of the target object. The DMD modulates an image signal of the target object according to modulation information A and B; the single-pixel detector assembly includes a first single-pixel detector and a second single-pixel detector.

Abstract: Disclosed are a system and a method for detecting a centroid of a complementary single pixel. The system includes a lens group, a single-pixel detector assembly, a Digital Micromirror Device (DMD) and an acquisition and processing unit. The acquisition and processing unit generates two-dimensional modulation matrices A and B which are loaded into the DMD; the lens group processes light reflected or transmitted from a target object, such that an image of the target object is imaged on the DMD; and the acquisition and processing unit is connected with data output ends of two single-pixel detectors in respective, to calculate the centroid of the target object. The DMID modulates an image signal of the target object according to modulation information A and B; the single-pixel detector assembly includes a first single-pixel detector and a second single-pixel detector.

Abstract: Embodiments of the present disclosure provide a puncture device and a puncture system. The puncture device includes a puncture needle mechanism, a mobile mechanism, and a clamping mechanism. The clamping mechanism is provided on the mobile mechanism and is capable of clamping or releasing the puncture needle mechanism. The puncture device enables a puncture operation to be performed remotely, ensures that image assistance is available in real-time during the puncture operation, and improves the precision, safety, and smoothness of the puncture operation.

Abstract: A system can include a memory device containing blocks made up of wordlines respectively connected to sets of memory cells, and a processing device, operatively coupled with the memory device to perform operations including responsive to receiving a read request that specifies a block, determining a value of a metric reflective of a number of programmed wordlines of the block. The operations can also include responsive to determining, based on the value of the metric, that the block is in a partially programmed state, identifying a read voltage offset corresponding to the value of the metric, and performing, using the read voltage offset, a read operation responsive to the read request.

Abstract: A system includes a memory component, and a processing device coupled with the memory component. The processing device to identify a group of management units of the memory component, wherein the group of management units is included in a set of retired groups of management units, select a management unit from the group of management units, perform a media integrity check on the management unit to determine a failed bit count of the management unit, and in response to the failed bit count of the management unit failing to satisfy a threshold criterion, remove the group of management units from the set of retired groups of management units.

Abstract: A programming operation is performed on a first set of memory cells addressable by a first wordline (WL), wherein the first set of memory cells are comprised by an open translation unit (TU) of memory cells. It is determined that a second set of memory cells comprised by the open TU are in a coarse programming state, wherein the second set of memory cells is addressable by a second WL. In response to determining that the second set of memory cells satisfies a threshold criterion, a programming state verify level associated with the second WL is reduced by a verify level offset. A programming state gate step size associated with each WL of the open TU is reduced by a predefined value. A programming operation is performed on the second set of memory cells using the reduced programming state verify level and the reduced programming state gate step size.

Abstract: The present disclosure relates to a batch sintering method for a high-property silicon nitride ceramic substrate. The batch sintering method includes: (1) silicon nitride ceramic substrate green bodies are stacked and put into a boron nitride crucible, and a layer of boron nitride powder is applied between adjacent silicon nitride ceramic substrate green bodies; (2) after step-by-step vacuumization, debinding is performed in a nitrogen atmosphere or a reducing atmosphere at 500° C. to 900° C.; (3) gas pressure sintering is then performed in a nitrogen atmosphere at 1800° C. to 2000° C., completing the batch preparation of the high-property silicon nitride ceramic substrate.

Abstract: Provided is a rectangular waveguide-to-microstrip in-phase high-isolation broadband power divider.