Patents by Inventor Jian J. Chen
Jian J. Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110251199Abstract: The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula I and A1, A2, A3, A4, X, Z, Z?, R1, R2, R3, R4, R5 and R6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.Type: ApplicationFiled: June 17, 2011Publication date: October 13, 2011Applicant: Amgen Inc.Inventors: Frenel F. De Morin, Jian J. Chen, Elizabeth M. Doherty, Stephen Hitchcock, Qi Huang, Joseph L. Kim, Gang Liu, Thomas Nixey, Nick A. Paras, Jeffrey Petkus, Daniel M. Retz, Adrian L. Smith, Jiawang Zhu
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Publication number: 20110251186Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, R2, R7, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.Type: ApplicationFiled: March 14, 2011Publication date: October 13, 2011Applicant: Amgen Inc.Inventors: Jian J. CHEN, Wenge ZHONG, Bryant YANG, Wenyuan QIAN, Patricia LOPEZ, Ryan WHITE, Matthew WEISS, Ted JUDD, Timothy POWERS, Yuan CHENG, Thomas DINEEN, Oleg EPSTEIN, Jonathan LOW, Isaac MARX, Ana Elena MINATTI, Michele POTASHMAN, Nick A. PARAS
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Patent number: 7989461Abstract: The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula I wherein R1 is and A1, A2, A3, A4, X, Z, Z?, R1, R2, R3, R4, R5 and R6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.Type: GrantFiled: December 20, 2006Date of Patent: August 2, 2011Assignee: Amgen Inc.Inventors: Frenel F. De Morin, Jian J. Chen, Stephen Hitchcock, Gang Liu, Nick A. Paras, Jeffrey Petkus, Adrian L. Smith, Andrew Tasker, Jiawang Zhu
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Publication number: 20110166132Abstract: The present invention provides compounds that are gamma secretase modulators and are therefore useful for the treatment of diseases treatable by modulation of gamma secretase such as Alzheimer's disease. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.Type: ApplicationFiled: December 12, 2008Publication date: July 7, 2011Applicant: Amgen Inc.Inventors: Stephen A. Hitchcock, Jian J. Chen, Mqhele Vellah Ncube, Thomas Nixey, Albert Amegadzie, Roxanne Kunz, Wenyan Qian, Ning Chen, Christopher M. Tegley, Frenel F. De Morin, Chester Chenguang Yuan, Qingyian Liu, Jiawang Zhu, Tanya A.N. Peterkin, Jeffrey A. Adams, Essa Hu, Frank Chavez, JR.
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Publication number: 20110118234Abstract: The present invention provides compounds Formula (I) that are gamma secretase modulators and are therefore useful for the treatment of diseases treatable by modulation of gamma secretase such as Alzheimer's disease. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.Type: ApplicationFiled: May 4, 2009Publication date: May 19, 2011Inventors: Kaustav Biswas, Jian J. Chen, James R. Falsey, Vijay Keshav Gore, Qingyian Liu, Vu Van Ma, Stephanie J. Mercede, Robert M. Rzasa, Christopher M. Tegley, Jiawang Zhu
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Publication number: 20100329959Abstract: A method for purifying silicon wherein silicon is crystallized from a solvent metal. The method comprises the steps of providing a molten liquid containing silicon, a solvent metal and impurities, cooling the molten liquid to form first silicon crystals and a first mother liquor, separating the first silicon crystals from the first mother liquor, contacting the first silicon crystals with compound which will dissolve the first mother liquor and separating the washed crystals from the wash solution.Type: ApplicationFiled: July 23, 2008Publication date: December 30, 2010Applicant: 6N Silicon Inc.Inventors: Scott Nichol, Jian J. Chen
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Patent number: 7662811Abstract: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.Type: GrantFiled: July 15, 2005Date of Patent: February 16, 2010Assignee: Amgen Inc.Inventors: Benny C. Askew, Jr., Toshihiro Aya, Kaustav Biswas, Guolin Cai, Jian J. Chen, Nianhe Han, Qingyian Liu, Thomas Nguyen, Nobuko Nishimura, Rana Nomak, Tanya Peterkin, Wenyuan Qian, Kevin Yang, Chester Chenguang Yuan, Jiawang Zhu, Derin C. D'Amico, Jason B. Human, Qi Huang
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Patent number: 7612060Abstract: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.Type: GrantFiled: October 11, 2005Date of Patent: November 3, 2009Assignee: Amgen Inc.Inventors: Toshihiro Aya, Guolin Cai, Jian J. Chen, Derin D'Amico, Thomas Nguyen, Wenyuan Qian
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Publication number: 20090149468Abstract: The present invention relates to therapeutic diazobicyclo pyridines and their use in the treatment of arthritis, rheumatoid arthritis, psoriatic arthritis or osteoarthritis, organ transplant, acute transplant or heterograft and homograft rejection, ischemic and reperfusion injury, transplantation tolerance induction, multiple sclerosis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, lupus, graft vs.Type: ApplicationFiled: February 4, 2009Publication date: June 11, 2009Applicant: Amgen Inc.Inventors: Guo-Qiang Cao, Jian J. Chen, Celia Dominguez, Anthony Reed, Kelvin K.C. Sham, Maya C. Thaman, Dawei Zhang, Bradley J. Herberich
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Publication number: 20090054460Abstract: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.Type: ApplicationFiled: January 11, 2008Publication date: February 26, 2009Inventors: Jian J. Chen, Ben C. Askew, Kaustav Biswas, Jennifer N. Chau, Derin C. D'Amico, Scott Harried, Thomas Nguyen, Wenyuan Qian, Jiawang Zhu, Christopher H. Fotsch, Aiwen Li, Qingyian Liu, Nobuku Nishimura, Tanya Peterkin, Babak Riahi, Chester Chenguang Yuan, Nianhe Han, Rana Nomak, Kevin Yang
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Publication number: 20080249106Abstract: The invention encompasses novel compounds and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for treatment of diseases mediated by B1 bradykinin receptor.Type: ApplicationFiled: April 8, 2008Publication date: October 9, 2008Inventors: Benny C. Askew, Jian J. Chen, Derin C. D'Amico, Thomas Nguyen, Kevin Yang
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Patent number: 7414134Abstract: The invention encompasses novel compounds and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for treatment of diseases mediated by B1 bradykinin receptor.Type: GrantFiled: October 11, 2005Date of Patent: August 19, 2008Assignee: Amgen Inc.Inventors: Benny C. Askew, Jr., Jian J. Chen, Derin C. D'Amico, Thomas Nguyen, Kevin Yang
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Patent number: 7393852Abstract: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.Type: GrantFiled: June 21, 2004Date of Patent: July 1, 2008Assignee: Amgen Inc.Inventors: Jian J. Chen, Ben C. Askew, Kaustav Biswas, Jennifer N. Chau, Derin C. D'Amico, Scott Harried, Thomas Nguyen, Wenyuan Qian, Jiawang Zhu, Christopher H. Fotsch, Aiwen Li, Qingyian Liu, Nobuku Nishimura, Tanya Peterkin, Babak Riahi, Chester Chenguang Yuan, Nianhe Han, Rana Nomak, Kevin Yang
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Inductive plasma processor having coil with plural windings and method of controlling plasma density
Patent number: 7096819Abstract: An inductive plasma processor includes a multiple winding radio frequency coil having plural electrically parallel, spatially concentric windings (1) having different amounts of RF power supplied to them, and (2) arranged to produce electromagnetic fields having different couplings to different regions of plasma in the chamber to control plasma flux distribution incident on a processed workpiece. The coil is powered by a single radio frequency generator via a single matching network. Input and output ends of each winding are respectively connected to input and output tuning capacitors. In a first embodiment, the location of maximum inductive coupling of the radio frequency to the plasma and the current magnitude in each winding are respectively mainly determined by values of the output and input capacitors.Type: GrantFiled: March 30, 2001Date of Patent: August 29, 2006Assignee: Lam Research CorporationInventors: Jian J. Chen, Robert G. Veltrop, Thomas E. Wicker -
Patent number: 7094315Abstract: A plasma confining assembly for minimizing unwanted plasma formations in regions outside of a process region in a process chamber is disclosed. The plasma confining assembly includes a first confining element and second confining element positioned proximate the periphery of the process region. The second confining element is spaced apart from the first confining element. The first confining element includes an exposed conductive surface that is electrically grounded and the second confining element includes an exposed insulating surface, which is configured for covering a conductive portion that is electrically grounded. The first confining element and the second confining element substantially reduce the effects of plasma forming components that pass therebetween.Type: GrantFiled: December 22, 2004Date of Patent: August 22, 2006Assignee: LAM Research CorporationInventors: Jian J. Chen, Mukund Srinivasan, Eric H. Lenz
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Patent number: 6904223Abstract: In a preferred embodiment, a motorized variable optical attenuator comprises an input fiber collimator; an output fiber collimator disposed substantially along the first collimator; and a right-angle reflector movable relative to the input collimator and the output collimator along a translation direction forming a non-zero angle with a direction of a light beam emitted by the input collimator. The reflector comprises two mutually-perpendicular reflective surfaces for sequentially reflecting the light beam emitted by the input collimator to the output collimator. A variable attenuation imparted by the attenuator on the light beam is determined by a position of the reflector relative to the input collimator and the output collimator, along the translation direction. The reflector preferably comprises a right-angle prism adhered to a nut mounted on a threaded axle driven by a stepper motor. The attenuator can achieve stable, ripple-free attenuation characteristics at insertion losses beyond ?40 dB.Type: GrantFiled: April 4, 2003Date of Patent: June 7, 2005Assignee: Optiworks, Inc.Inventors: Zuyun Fang, Jianhua Wang, Jian J. Chen
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Patent number: 6872281Abstract: A plasma confining assembly for minimizing unwanted plasma formations in regions outside of a process region in a process chamber is disclosed. The plasma confining assembly includes a first confining element and second confining element positioned proximate the periphery of the process region. The second confining element is spaced apart from the first confining element. The first confining element includes an exposed conductive surface that is electrically grounded and the second confining element includes an exposed insulating surface, which is configured for covering a conductive portion that is electrically grounded. The first confining element and the second confining element substantially reduce the effects of plasma forming components that pass therebetween.Type: GrantFiled: September 28, 2000Date of Patent: March 29, 2005Assignee: Lam Research CorporationInventors: Jian J. Chen, Mukund Srinivasan, Eric H. Lenz
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Patent number: 6721474Abstract: A 1×N optical switch includes an input fiber collimator, an x-y scanning device including two perpendicular galvanometer-driven rotatable mirrors, and a 2-D array of output fiber collimators arranged over an output surface so as to be aligned with a corresponding ray extending from the x-y scanning device. Each of the output fiber collimators corresponds to a unique pair of rotation angles of the two mirrors. The output surface can have a spherical curvature, or a curvature which accounts for the dependency of optical path on the angles of the two mirrors. The switch allows improved switching speeds, accuracy, and reduced and uniform insertion losses. The architecture can be used for N×M switches and N×M cross-connects.Type: GrantFiled: March 19, 2001Date of Patent: April 13, 2004Assignee: Optiwork, Inc.Inventors: Jianhua Wang, Zuyun Fang, Jian J. Chen
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Patent number: 6714716Abstract: A mechanically-adjustable variable optical attenuator includes an azimuthally-tapering, rotatable beam attenuator. In a plane perpendicular to the light beam to be attenuated, the projection of the beam attenuator comprises a sharp distal tip, a proximal region, and a concave curved light-blocking surface narrowing from the proximal region to the distal tip. The extent of the beam attenuator obstructing the light beam is varied by rotating the beam attenuator about a rotation axis perpendicular to the light beam direction. The beam attenuator geometry allows achieving high resolutions while limiting the beam attenuator size. The attenuated light beam can be a single-mode or multi-mode light beam.Type: GrantFiled: June 28, 2002Date of Patent: March 30, 2004Assignee: Optiwork, Inc.Inventors: Jian J Chen, Jianhua Wang
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Publication number: 20040045506Abstract: An inductive plasma processor includes a multiple winding radio frequency coil having plural electrically parallel, spatially concentric windings (1) having different amounts of RF power supplied to them, and (2) arranged to produce electromagnetic fields having different couplings to different regions of plasma in the chamber to control plasma flux distribution incident on a processed workpiece. The coil is powered by a single radio frequency generator via a single matching network. Input and output ends of each winding are respectively connected to input and output tuning capacitors. In a first embodiment, the location of maximum inductive coupling of the radio frequency to the plasma and the current magnitude in each winding are respectively mainly determined by values of the output and input capacitors.Type: ApplicationFiled: August 26, 2003Publication date: March 11, 2004Applicant: LAM Research CorporationInventors: Jian J. Chen, Robert G. Veltrop, Thomas E. Wicker