Abstract: A wireless data telemetry system for use in a drilling system can include a drill head wireless transmitter and at least one data link transceiver. The drill head wireless transmitter can be in a drill head of the drilling system, the drill head wireless transmitter configured to generate and transmit one or more data signals associated with a drilling process. The at least one data link transceiver can be wirelessly coupled to at least one of the drill head wireless transmitter or another data link transceiver, with the drill head wireless transmitter and the at least one data link transceiver configured to be physically coupled within a drill string and spaced apart from one another. The drill head wireless transmitter and the at least one data link transceiver together configured to wirelessly communicate the one or more data signals beyond a transmission range of the drill head wireless transmitter.

Abstract: A method for storing and reading cached data and a device are provided. The method for storing and reading cached data includes: in response to receiving to-be-cached data, segmenting the to-be-cached data sequentially into at least two pieces of first fragmented data; writing the first fragmented data sequentially into first storage particles of at least two storage blocks in a time division multiplexing manner, and ensuring that the first fragmented data written into the respective first storage particles are different from each other. The fragmented data are stored and read in the time division multiplexing manner, and the fragmented data corresponding to a complete data are stored in different storage blocks, so a plurality of data can be stored and read in a complete data storage and read process, thereby reducing read and write time overhead during the execution of a large number of buffered data storage and read tasks.

Abstract: Disclosed are Hematopoietic Progenitor Kinase 1 (HPK1) degradation/disruption compounds including a HPK1 ligand, a degradation/disruption tag and a linker, and methods for use of such compounds in the treatment of HPK1-mediated diseases.

Abstract: Disclosed are a consensus method and device, and a blockchain system. A primary node directly broadcasts a transaction hash list including a hash value of at least one unverified transaction in the system, so that a backup node and the primary node simultaneously verify the at least one unverified transaction, and the backup node stores a first verification result obtained by verification and a first hash value of the at least one unverified transaction. The primary node broadcasts an obtained second verification result and a second hash value of the at least one unverified transaction in a pre-preparation message after completing the verification, so that the backup node searches for the first verification result based on the second hash value, and broadcast a preparation message when the second verification result is the same as the searched first verification result, to enter a subsequent consensus stage, and complete the consensus processing.

Abstract: Provided are an electronic paper display panel and a display device. The electronic paper display panel includes a first substrate and a second substrate opposite to each other and a plasma layer between the first substrate and the second substrate. The plasma layer includes an electrophoretic fluid and first-type charged particles. The first-type charged particles have charges with a first electrical property. The first-type charged particles include first charged subparticles and second charged subparticles. The particle size of a first charged subparticle is D1. The particle size of a second charged subparticle is D2. The charge quantity carried by the first charged subparticle is q1. The charge quantity carried by the second charged subparticle is q2. (D1-D2)×(q1-q2)>0.

Abstract: Methods for designing bivalent compounds which selectively degrade/disrupt EZH2 and compositions and methods of using such degraders/disruptors to treat EZH2-mediated cancer are provided.

Abstract: The invention a solvent-resistant polymeric nanofiltration membrane and preparation method thereof. The method includes subjecting a diamine monomer and a dianhydride monomer to cyclization imidization in a first polar organic solvent at 160 to 230° C., to form a polyimide, wherein the diamine monomer includes a diamine monomer with a carboxyl group and a diamine monomer without a carboxyl group; dissolving the polyimide in a second polar organic solvent, to form a membrane-forming solution; performing phase inversion to obtain an intermediate membrane; treating the intermediate membrane with an organic solution of a metal salt, so that the metal ion is coordinated and cross-linked with the carboxyl group in the polyimide, to obtain a solvent-resistant polymeric nanofiltration membrane, wherein the metal salt is a divalent and/or a multi-valent metal salt. The invention also discloses use of the solvent-resistant polymeric nanofiltration membrane in the separation and/or purification of a compound.

Abstract: A portable locator device includes a display for providing instructions to an operator, an interface for receiving inputs from the operator, a positioning system receiver for receiving locating signals, and a controller operatively coupled with the display and communicatively coupled with the interface and the positioning system receiver. The controller is configured to determine a first position of the portable locator device, receive a first input from the interface indicative of an ending position proximate to the first position, determine a second position of the portable locator device, receive a second input from the interface indicative of a starting position proximate to the second position, determine a virtual drop-line between the starting position and the ending position, and provide instructions via the display for moving from the starting position to the ending position along the virtual drop-line.

Abstract: A support assembly and a display apparatus are provided. The support assembly includes first and second support units. The first support unit includes a first recessing portion. The second support unit includes a first embedding portion. The first support unit includes first and second surfaces that are opposite to each other. The second support unit includes a third surface and a fourth surface that are opposite to each other. Operating states of the support assembly include a first state and a second state. In the first state, the first embedding portion is embedded in the first recessing portion. In the second state, the first surface and the third surface are disposed in a same horizontal plane, the first surface and the third surface abut against each other, and the second surface and the fourth surface are located at a same side of the support assembly.

Abstract: A method of calibrating hyperspectral images to account for diurnal changes is disclosed which includes receiving a plurality of hyperspectral images obtained over a plurality of days from a field, deriving a plurality of spectra from the received plurality of hyperspectral images, decomposing the derived plurality of spectra into a trend component representing a trend associated with the plurality of days, subtracting the trend component from the derived plurality of spectra to thereby generate diurnal spectra for one or more wavelengths, fitting one or more mathematical functions associating spectrum to time of day to the generated diurnal spectra for each of the one or more wavelengths, generating a mode from the fitted mathematical function for each of the one or more wavelengths, and applying the model to the derived spectra at a first time to generate a calibrated spectra at a second time.

Abstract: A wireless data telemetry system for use in a drilling system can include a drill head wireless transmitter and at least one data link transceiver. The drill head wireless transmitter can be in a drill head of the drilling system, the drill head wireless transmitter configured to generate and transmit one or more data signals associated with a drilling process. The at least one data link transceiver can be wirelessly coupled to at least one of the drill head wireless transmitter or another data link transceiver, with the drill head wireless transmitter and the at least one data link transceiver configured to be physically coupled within a drill string and spaced apart from one another. The drill head wireless transmitter and the at least one data link transceiver together configured to wirelessly communicate the one or more data signals beyond a transmission range of the drill head wireless transmitter.

Abstract: Disclosed herein are WD40 repeat domain protein 5 (WDR5) degradation/disruption compounds including a WDR5 ligand, a degradation/disruption tag, and a linker, and methods of using such compounds in the treatment of WDR5-mediated diseases.

Abstract: Disclosed herein are novel drugs useful in treating Alzheimer's Disease and methods of use.

Abstract: This disclosure relates to heterobifunctional compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the heterobifunctional compounds, and to methods of use the heterobifunctional compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such heterobifunctional compounds.

Abstract: A method for storing and reading cached data and a device are provided. The method for storing and reading cached data includes: in response to receiving to-be-cached data, segmenting the to-be-cached data sequentially into at least two pieces of first fragmented data; writing the first fragmented data sequentially into first storage particles of at least two storage blocks in a time division multiplexing manner, and ensuring that the first fragmented data written into the respective first storage particles are different from each other. The fragmented data are stored and read in the time division multiplexing manner, and the fragmented data corresponding to a complete data are stored in different storage blocks, so a plurality of data can be stored and read in a complete data storage and read process, thereby reducing read and write time overhead during the execution of a large number of buffered data storage and read tasks.

Abstract: The present disclosure relates to bifunctional chemical epigenetic modifiers, and methods of making, kits and using the bifunctional chemical epigenetic modifiers. The bifunctional chemical epigenetic modifiers can include a FK506 molecule or derivative thereof, a linker and a bifunctional ligand. The bifunctional ligand can be a histone deacetylase inhibitor.

Abstract: Provided is an electrophoretic coating solution, comprising 100 parts by weight of microcapsules modified with an olefinic aldehyde compound; 1 to 20 parts by weight of a resin monomer and/or an unsaturated resin; and 50 to 100 parts by weight of a solvent. Also provided are an electrophoretic display panel and a display device. In this solution, the electrophoretic coating solution has good dispersibility, and the yield of the electrophoretic display panel is improved.

Abstract: Embodiments of the present invention provide a dual-modality bionic vision sensor. A first-type current-mode active pixel sensor (APS) circuit can simulate excitatory rod cells to perceive light intensity gradient information in a target light signal, thereby improving a dynamic arrange of an image sensed by a bionic vision sensor and its shooting speed. In addition, a first-type control switch is introduced for each of non-target first-type photosensitive devices to control the obtained light intensity gradient information, and to adjust the dynamic arrange of the image sensed by the bionic vision sensor, thereby adjusting the shooting speed and realizing a reconfigurable effect. A voltage-mode APS can simulate cone cells to output a target voltage signal representing light intensity information in the target light signal, and to perceive the light intensity information in the target light signal.

Abstract: A method for spatial analysis of leaf images is disclosed which includes acquiring one or more leaf images of plants, generating 3-dimensional (3D) images from the acquired one or more images from spectral heatmaps, identifying a stem and a plurality of veins, identifying i) one or more of valleys and ridges as regions between two consecutive veins from the plurality of veins, or ii) one or more of peaks and valleys as regions between two consecutive veins from the plurality of veins in the one or more generated 3D images, calculating average slopes in the generated 3D images between i) one or more of peak-to-valley, or ii) ridge-to-valley for the veins, calculating a nitrogen index based on the calculated average slopes, if the calculated average slope is between two thresholds, communicate to a user to add a predetermined chemical to the plants.

Abstract: The present invention provides a drive module for a GaN transistor, including: a first pull-down transistor and a gate ringing and overshoot suppression unit, where the gate ringing and overshoot suppression unit and a first end of the first pull-down transistor are directly or indirectly connected to a gate of the GaN transistor, the gate ringing and overshoot suppression unit is connected between a second end of the first pull-down transistor and the ground; the gate ringing and overshoot suppression unit is configured to: when a gate voltage of the GaN transistor drops, control the release of a gate charge of the GaN transistor with a first impedance if the gate voltage is higher than a specified threshold; and control the release of the gate charge of the GaN transistor with a second impedance if the gate voltage is less than the specified threshold, where the first impedance is less than the second impedance.