Abstract: The present disclosure relates to bifunctional chemical epigenetic modifiers, and methods of making, kits and using the bifunctional chemical epigenetic modifiers. The bifunctional chemical epigenetic modifiers can include a FK506 molecule or derivative thereof, a linker and a bifunctional ligand. The bifunctional ligand can be a histone deacetylase inhibitor.

Abstract: The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.

Abstract: The present disclosure provides a display panel and a display device. The display panel has a display area and a non-display area surrounding the display area. The display panel includes: at least one barrier portion located in the non-display area, the at least one barrier portion including a first barrier portion and a second barrier portion, and the second barrier portion being located at a side of the first barrier portion that is away from the display area; a first signal line for applying a first signal; and at least one electrostatic discharge unit arranged between the first barrier portion and the second barrier portion. The at least one electrostatic discharge unit includes a first electrostatic discharge unit. The first electrostatic discharge unit is connected to the first signal line and configured to discharge static electricity on the first signal line.

Abstract: A protection film, a method of manufacturing the protection film are provides, a display panel and a display device. The protection film includes a main portion and at least one cover surrounded by the main portion. The cover is at least partially connected to the main portion. At least part of an edge of the cover is a first edge, and the first edge and the main portion are not fixed.

Abstract: Heterobifunctional small molecules including anaplastic lymphoma kinase (ALK) ligand conjugated to a degradation/disruption tag through a linker, which selectively degrade/disrupt ALK, ALK fusion proteins, and/or ALK mutant proteins, and compositions and methods of using such degraders/disruptors to treat ALK-mediated cancer are provided.

Abstract: An amino pyrimidine compound for inhibiting protein tyrosine kinase activity, a pharmaceutical composition thereof, preparation therefor, and an application thereof. Specifically, an amino pyrimidine compound represented by formula (I), R1, R2, L, Y, R6, W, A, m, and n being defined in the specification, and a pharmaceutically acceptable salt, a stereoisomer, a solvent compound, a hydrate, a polymorphism, a prodrug, or an isotope variant thereof. The compound can be used for treating and/or preventing protein tyrosine kinase-related diseases such as cell proliferative diseases, cancers, and immune diseases.

Abstract: Disclosed are protein arginine methyltransferase 5 (PRMT5) degradation/disruption compounds including a PRMT5 ligand, a degradation/disruption tag and a linker, and methods for use of such compounds in the treatment of PRMT5-mediated diseases. The PRMT5 degraders disclosed herein offer a novel mechanism for treating PRMT5-mediated diseases compared to small molecule inhibitors of PRMT5 activity.

Abstract: A reference imaging system including a planar reference piece. The reference imaging system further includes a three-axis gantry for positioning the planar reference piece at a plurality of points in a 3D coordinate system. Additionally, the reference imaging system includes a yaw actuator for adjusting the yaw angle of the object. Furthermore, the reference imaging system includes a pitch actuator for adjusting the pitch of the object. Moreover, the reference imaging system includes a computer processing unit for controlling the 3D position, pitch and yaw of the planar reference piece.

Abstract: Use of genomic NW_006882077.1 in CHO cell for stably expressing a protein is disclosed. The certain site in CHO cell genome for stably expressing a protein is positioned at a base of No. 691045 in a CHO cell gene NW_006882077.1; a sequence of 5? NNNNNNNNNNNNNNNNNNNNNGG3? that can be identified by CRISPR/Cas9 technology and positioned in a base range of No. 690980-691090 around the certain site is a target sequence. Various of protein genes are introduced into a fixed site in CHO cell genome, and expressed stably in the present disclosure.

Abstract: Use of genomic NW_006880285.1 in CHO cell for stably expressing a protein is disclosed. The certain site in CHO cell genome for stably expressing a protein is positioned at a base of No. 1235357 in a CHO cell gene NW_006880285.1; a sequence of 5? NNNNNNNNNNNNNNNNNNNNNGG3? that can be identified by CRISPR/Cas9 technology and positioned in a base range of No. 1235284-1235429 around the certain site is a target sequence. Various of protein genes are introduced into a fixed site in CHO cell genome, and expressed stably in the present disclosure.

Abstract: The present disclosure provides a flexible display device including a flexible display panel, a flexible printed circuit board, and a reel. The flexible printed circuit board includes a first binding area provided with a first pad and an element area provided with an integrated circuit. The flexible display panel includes a display area, and a second binding area provided with a second pad. The first pad is bound to the second pad. The reel has a cavity, and the reel includes an inner surface facing towards the cavity and an outer surface facing away from the cavity. The inner surface includes a first surface, and the first surface is flat. The element area of the flexible printed circuit board is provided on the first surface, and the display area of the flexible display panel is rollable along the outer surface of the reel.

Abstract: The invention is directed to a surgical microscope and a device for switching the same among multiple working modes. The device includes an illumination rotary member and an observation rotary member that are arranged, respectively, in the illumination beam path and the observation beam path of the surgical microscope and are drivable by the same power source to rotate synchronously among multiple rotary positions corresponding to the multiple working modes. In each of the rotary positions, light from a light source of the surgical microscope passes through one or more of multiple light-through-portions of the illumination rotary member along the illumination beam path to illuminate the observed object, and then passes through one or more of multiple light-through-portions of the observation rotary member along the observation beam path to reach the eyepiece and/or an observation instrument of the surgical microscope.

Abstract: The present disclosure provides a flexible display device including a flexible display panel, a flexible printed circuit board, and a reel. The flexible printed circuit board includes a first binding area provided with a first pad and an element area provided with an integrated circuit. The flexible display panel includes a display area, and a second binding area provided with a second pad. The first pad is bound to the second pad. The reel has a cavity, and the reel includes an inner surface facing towards the cavity and an outer surface facing away from the cavity. The inner surface includes a first surface, and the first surface is flat. The element area of the flexible printed circuit board is provided on the first surface, and the display area of the flexible display panel is rollable along the outer surface of the reel.

Abstract: The present invention provides a vertical, axial flow oil pump (10). The oil pump includes: a casing (11), the casing having a cylindrical shape as a whole and being able to rotate around its own central axis (O); a suction port (12), located at a lower end of the casing in an axial direction, and configured to suck oil into the oil pump; a discharge port (13), located at an upper end of the casing in the axial direction, and configured to discharge the oil from the oil pump to outside; and an impeller (14), provided in and formed integrally with the casing. The impeller rotates together with the casing when the casing rotates, so that the oil is flowed from the suction port to the discharge port. The present invention also provides a scroll compressor having the oil pump.

Abstract: A display device including a display panel. The display panel includes a display region and a non-display region surrounding the display region. The display region includes a first pixel region, the non-display region includes a second pixel region, and the first pixel region and the second pixel region together form a pixel region. The first pixel region and the second pixel region each includes a plurality of pixels. The display device also includes a cover window disposed on a light-emitting side of the display panel. The cover window includes a viewable region and a light-shielding region surrounding the viewable region, and the light-shielding region is disposed with a light-shielding material. The area of the pixel region is larger than the area of the viewable region, the first pixel region is arranged opposite to the viewable region, and the second pixel region is arranged opposite to the light-shielding region.

Abstract: A reference imaging system including a planar reference piece. The reference imaging system further includes a three-axis gantry for positioning the planar reference piece at a plurality of points in a 3D coordinate system. Additionally, the reference imaging system includes a yaw actuator for adjusting the yaw angle of the object. Furthermore, the reference imaging system includes a pitch actuator for adjusting the pitch of the object. Moreover, the reference imaging system includes a computer processing unit for controlling the 3D position, pitch and yaw of the planar reference piece.

Abstract: The present invention provides a counterweight for a compressor, an electric motor, with the counterweight, for a compressor, and a compressor with the electric motor or the counterweight. The counterweight comprises: a first component having an annular shape; a first groove formed in a surface of the first component and having a sidewall and a bottom wall; and a second component disposed in the first groove. With the technical solution according to the present invention, for example, counterbalance requirements are met, while fluid can be prevented from being stirred to cause power loss.

Abstract: Methods of detecting the impacts on plant health attributable to the presence of one or more agronomically important polypeptides of interest in a transgenic plant are disclosed. The methods involve transforming plants or plant cells with nucleic acid sequences encoding proteins of agronomically important traits. The transformed plants or plant cells expressing the nucleic acid sequences encoding the proteins of agronomically important traits are compared to transformed plants or plant cells expressing a neutral control gene to detect the impacts on plant health attributable to the presence of the one or more agronomically important polypeptides of interest.

Abstract: A root imaging system is disclosed which includes a robotic arm, a camera coupled to the robotic arm, the robotic arm configured to insert the camera into the soil at predefined coordinates, a processor system configured to receive user-defined data about a plant of interest, define insertion points about the plant of interest based on the user-defined data, control the robotic arm to thereby insert the camera into the soil at defined insertion points, obtain images from the camera positioned at the insertion points, analyze the images for presence of roots, and identify the images having roots and combine that with image 3D location information for 3D structure reconstruction of the entire root structure.

Abstract: An imaging system for a smartphone includes a housing configured to rigidly attach to a handheld smartphone device. The system further includes an arm extending from the housing, wherein the arm is configured to be adjustable such that the arm is movable toward and away from the housing. Additionally, the system includes a sample mounting portion attached to the arm, the mounting portion having a retaining device, wherein the retaining device is configured to secure a target sample, the mounting portion configured to direct an image of the target sample to a first camera in the handheld smartphone device.