Abstract: Disclosed are compounds that inhibit RNase H activity of retroviruses, for example, a compound of formula (I) wherein R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment or prevention of infection by human immunodeficiency virus (HIV).

Abstract: Embodiments of the present invention relate generally to drought tolerant transgenic plants and methods of creating the drought tolerant transgenic plants. In one embodiment, plants are transformed such that a PYL polypeptide is overexpressed in the plant. In an embodiment, the plant is transformed with a cassette or vector that comprises a polynucleotide encoding for one or more of the PYL polypeptides, which may be under the control of an inducible or constitutive promoter. In embodiments, overexpression of PYL13 results in plants having increased drought tolerance, such as a decreased transpiration rate, a decreased stomatal conductance, an increased photosynthetic rate, accelerated stress responsive gene expression, and increased water use efficiency, and/or an increased survival rate compared to a control plant. In some embodiments, other PYL proteins having the single point mutations identified in PYL13 are expressed in the plant.

Abstract: The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to a drug-eluting stent comprising said compounds and methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.

Abstract: Disclosed are pyruvate kinase M2 activators, which are, bis sulfonamide piperazinyl compounds of Formula (I) and 2,4-disubstituted 4H-thieno[3,2-b]pyrrole-2-(substituted benzyl)pyridazin-3(2H)ones of Formula (II), wherein L and R1 to R16 are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer and anemia,

Abstract: Disclosed are pyruvate kinase M2 activators, which are bis sulfonamide piperazinyl and piperidinyl compounds of Formula (I), 2,4-disubstituted 4H-thieno[3,2-c]pyrrole-2-(substituted benzyl)pyridazin-3(2H)-ones of Formula (II) and 6-(3,4-dimethylphenylaminosulfonyl)-3,4-dihydro-1H-quinolin-2-one of formula (III), wherein L, R1, R2, R11 to R16, R21 and R22 are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer and anemia.

Abstract: Disclosed are compounds that inhibit RNase H activity of retroviruses, for example, a compound of formula (I) wherein R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment or prevention of infection by human immunodeficiency virus (HIV).

Abstract: A binocular adaptive optics visual simulator and a method for binocular adaptive optics visual simulation are provided. An example method may comprise: directing beacon light to a left eye and a right eye of a subject, respectively; sensing aberrations of the left and right eyes of the subject, and sensing a deflection angle of a pupil of each of the left and right eyes; correcting the aberrations based on the sensed aberrations to achieve a desired aberration configuration between the left and right eyes; and changing a direction in which the beacon light is directed based on the sensed deflection angle in such a manner that in a case where the pupil is subjected to deflection, the beacon light is incident onto the pupil of each of the left and right eyes of the subject at a substantially identical angle before and after the deflection of the pupil.

Abstract: Disclosed are pyruvate kinase M2 activators, which are, bis sulfonamide piperazinyl compounds of Formula (I) and 2,4-disubstituted 4H-thieno[3,2-b]pyrrole-2-(substituted benzyl)pyridazin-3(2H)ones of Formula (II), wherein L and R1 to R16 are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer and anemia,

Abstract: The present invention provides a totally-enclosed integrative access system, the system adopts a die-cast case that consists of an upper cover and a lower cover, the joint face between the upper cover and the lower cover is sealed, and the peripheries of the upper cover and the lower cover are configured with cooling teeth, heating parts in the system contact closely with the inside wall of the upper cover and/or the lower cover; and the heating parts comprise: a user panel, a system control panel and a power panel. A power consumption reduction method for a totally-enclosed integrative access system is also provided in the present invention, comprising: the system control panel detects traffic on the user panel; when the traffic detected is lower than a predefined lower limit value, the system control panel enters a low frequency working mode; when the traffic detected reaches a predefined upper limit value, the system control panel restores its normal working frequency.

Abstract: The disclosure provides polynucleotides useful in generating drought resistant plants, transgenic plants comprising modified expression of such a polynucleotide and progeny thereof. Also provided are molecules useful in providing drought resistance to a plant.

Abstract: Disclosed are pyruvate kinase M2 activators, which are bis sulfonamide piperazinyl and piperidinyl compounds of Formula (I), 2,4-disubstituted 4H-thieno[3,2-c]pyrrole-2-(substituted benzyl)pyridazin-3(2H)-ones of Formula (II) and 6-(3,4-dimethylphenylaminosulfonyl)-3,4-dihydro-1H-quinolin-2-one of formula (III), wherein L, R1, R2, R11 to R16, R21 and R22 are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer and anemia.

Abstract: This invention provides variant sequences to miR398 targets in copper/zinc superoxide dismutase (CSD) genes resulting in resistance to down regulation of the CSD by the miR398.

Abstract: The present invention relates to proteins and nucleic acids related to salt tolerance in plants.

Abstract: The present invention provides new miRNAs in rice. The nucleic acids of the invention can be used to control gene expression in plants.

Abstract: The present invention provides methods and compositions for improving the drought resistance of plants. More specifically, the present invention utilizes overexpression of a molybdenum cofactor sulfurase in plants and plant cells.

Abstract: The present invention relates to a protein (Snow1), mutants thereof, and nucleic acids encoding said protein, that interacts with Ice1 and which activates CBF3 promoter activity thus regulating freezing tolerance in plants.

Abstract: A multiple-layered watermark is generated to be placed on document, to protect against counterfeiting and forgery. Hidden information embedded into each of the watermark's layers is only detectable by using a corresponding decoder. Because of the multiple-layered structure, it is difficult to reverse engineer the optical watermark. The generalized watermark structure significantly increases the “key space” of the decoder.

Abstract: The present invention provides nucleic acid constructs encoding microRNA molecules that can be used to confer salt tolerance on plants. The invention further provides transgenic plants comprising the nucleic acids, as well as methods of using them to confer salt tolerance on plants.

Abstract: The present invention provides a method of increasing salt tolerance in a plant by overexpressing a gene encoding a mutant SOS2 protein in at least one cell type in the plant. The present invention also provides for transgenic plants expressing the mutant SOS2 proteins.

Abstract: The present invention provides new miRNAs in rice. The nucleic acids of the invention can be used to control gene expression in plants.