Abstract: The disclosure relates to bifunctional KRAS-modulating compounds having the structure K-L-T, where K is a targeting group that binds specifically to a KRAS protein (mutant or wild-type), T is an E3-ligase binding group, and L is absent or is a bivalent linking group that connects K and T together via a covalent linkage. Compounds and pharmaceutical compositions thereof can promote degradation of KRAS protein (mutant or wild-type) in a cell and are thus useful for treating, inhibiting, and preventing KRAS-associated diseases, disorders and conditions, including cancers.

Abstract: The present disclosure relates to fusion molecules and chimeric molecules which comprise two components: an Ang-2 antagonist peptide linked to a VEGF-binding moiety. Further disclosed are methods of using said chimeric molecules to treat a patient cancer, proliferative retinopathy, neovascular glaucoma, macular edema, wet age-related macular degeneration (wAMD), macular edema following retinal vein occlusion (RVO), diabetic macular edema (DME), or diabetic retinopathy (DR).

Abstract: The disclosure relates to KRAS inhibitor compounds having the structure of Formula (I), pharmaceutical compositions thereof, and methods of use thereof for inhibiting, treating, and/or preventing KRAS-associated diseases, disorders and conditions.

Abstract: A temperature sensor system in a chip and the chip are provided. The temperature sensor system in the chip includes the first temperature sensing unit and a control unit. The first temperature sensing unit senses a temperature by using a back-end-of-line metal structure formed in a back-end-of-line process of the chip to output a temperature sensing electrical signal; and the control unit is coupled with the first temperature sensing unit, and processes the temperature sensing electrical signal output by the first temperature sensing unit to output a measurement result.

Abstract: There is provided a hybrid system for electricity and water generation, that includes a thermoelectric generator (TEG) layer for converting heat to electricity, an absorber layer arranged on one side of the TEG layer for converting solar energy to heat, a cooling structure arranged on the other side of the TEG layer for dissipating a waste heat from the TEG layer, and an evaporator configured to form an interfacial cooling region with the cooling structure for water generation.

Abstract: An evaporator for solar desalination and a preparation method thereof and use thereof are provided. The evaporator has a porous skeleton, interconnected channels, and a hydrophobic decoration. The interconnected channels are formed from gaps of the porous skeleton, and the hydrophobic decoration is positioned on the surface of the porous skeleton. The evaporator is for sustainable solar water evaporation even in highly salty water. Specifically, the continuous evaporation for 24 h without salt precipitation in 20 wt % NaCl solution can be realized.

Abstract: A method and a device for controlling an air conditioner, an air conditioner and a computer-readable storage medium are provided. After the air conditioner is started and runs for a period of time, the gas phase side valve is controlled to open to switch the air conditioner to the phase separation refrigeration mode. In the phase separation refrigeration mode, the gaseous low-temperature refrigerant can be separated through the gas-liquid separation device, and be controlled to reach the heat exchanger. The refrigerant at the outlet of the condenser is heat exchanged again through the gaseous low-temperature refrigerant and the heat exchanger to increase the cooling capacity of the air conditioner.

Abstract: A filter includes a filter frame and at least two resonators. A receiving space is formed in the filter frame. The at least two resonators are disposed in the receiving space and distributed along a signal transmission path. Adjacent resonators on the signal transmission path are coupled. Each resonator includes a body part and a bending part. One end of the body part is grounded. The bending part includes a head bending part and an end bending part, the head bending part being connected to the end bending part to form a resonator structure circulating in a counterclockwise or clockwise direction.

Abstract: This application relates to the field of lighting, and discloses an LED filament. The LED filament includes an LED chip unit, a light conversion layer, and an electrode. The light conversion layer covers the LED chip unit and part of the electrode, and a color of a light emitted by the LED filament after lighting is different from a color of the light conversion layer. This application has the characteristics of uniform light emission and good heat dissipation effect.

Abstract: A method for forming a complex shape three-dimensional ceramic article by printing a first layer of a first material having a first fraction of first ceramic particles and a first fraction of a first polymeric ceramic precursor. A second layer is printed such that it is at least partially disposed on the first layer of a second material having a second fraction of second ceramic particles and a second fraction of a second polymeric ceramic precursor. A composite of the first layer and the second layer is heated at a temperature sufficient to decompose the first and second polymeric ceramic precursors and sinter the article. During the sintering process, the first and second layers with different fractions of ceramic particles undergo different degrees of shrinkage, resulting in a tuneable mismatch of the bilayer structure and accurately achieving a targeted geometry.

Abstract: The present invention provides a method of in situ 4D printing of high-temperature materials including 3D printing a structure of an ink including a precursor. The structure is treated with controlled high energy flow to create a portion which has a different coefficient of thermal expansion/thermal shrinkage ratio. The structure is heated and the difference in the coefficient of thermal expansion creates an interface stress to cause a selected level of deformation. Alternatively, two structures with different coefficients of expansion/thermal shrinkage ratio may be printed. Thermal treatment of the two structures creates an interface stress to cause a selected level of deformation.

Abstract: Provided is a metal material including a plurality of metal particles arranged in a crystal structure having at least two phases; wherein the at least two phases include a crystalline phase and an amorphous phase.

Abstract: A single-layer cross-coupling filter includes a cavity in which a receiving space is formed; an integrally formed resonant structure installed in the receiving space; and at least one partition wall. The resonant structure includes at least two rows of resonant units distributed along a signal transmission path. The at least two rows of resonant units are located in a same plane of the receiving space, and each row of the resonant units includes a plurality of resonators. The resonators on a same row are coupled and connected to form signal transmission, and at least two adjacent resonators in different rows are coupled and connected to realize cross-coupling.

Abstract: Provided herein is a method of preparing a ceramic material, the method including: providing a ceramic gel including a plurality of metal salts and compressing the ceramic gel thereby inducing stress-induced mineralization of the ceramic gel and formation of the ceramic material, wherein the ceramic gel exists in isolated form.

Abstract: The present disclosure relates to sensor technology, and provides a method, an apparatus, and a system for vibration measurement for a sensor bracket as well as a movable device. The method is applied in a system for vibration measurement for the sensor bracket. The system includes the sensor bracket to be measured that is mounted on a movable device, and a marker on the sensor bracket to be measured, and a first sensor provided on the sensor bracket to be measured for collecting marker information. The method includes: collecting the marker information of the marker on the sensor bracket to be measured using the first sensor; determining a vibration measurement reference point based on the marker information, and obtaining vibration condition data of the vibration measurement reference point; and determining a vibration evaluation result for the sensor bracket based on the vibration condition data of the vibration measurement reference point.

Abstract: A hard optical film, a method for producing the same and use thereof. The film is an optical film with a nano-dual-phase structure, and features a regulable thickness, high visible light transmittance and hardness, a flat and uniform surface, and a great application prospect. The hard optical film is prepared on a surface of a substrate by magnetron sputtering, having high binding force between the obtained film and the substrate, such that the substrate has a very high hardness, a very strong abrasion resistance and certain corrosion resistance.

Abstract: A vibration energy harvester, a power accumulator and a power supplier, including: a multi-stable shell with one or more bistable regions and at least one piezoelectric element fixed on a surface of the multi-stable shell. Each of the bistable regions has two different stable configurations, and different combinations of the stable configurations of the one or more bistable regions make the multi-stable shell have a plurality of different stable configurations. The one or more bistable regions are switched between the two stable configurations thereof when being excited by vibration energy, so that the multi-stable shell is switched between the plurality of stable configurations to deform the piezoelectric element to generate electric energy.

Abstract: Disclosed are a polymer composite material and a preparation method thereof. The polymer composite material includes a polymer base layer and a metal thin film layer provided on a surface of the polymer base layer. The metal thin film layer is made of amorphous alloy. The surface of the polymer base layer is provided with a metal thin film with an amorphous structure. In this way, the arrangement of the metal thin film with amorphous structure can not only improve the mechanical properties, wear resistance and corrosion resistance of the polymer substrate material, but also can greatly improve the toughness of the polymer substrate material, to simultaneously improve the strength and toughness of the polymer material.

Abstract: A softAP bridge is created to support a mesh network that also works seamlessly with any home Wi-Fi AP routers by using Layer-3 techniques to simulate a Layer-2 bridge. With this softAP bridge, Wi-Fi chipsets with integrated special Wi-Fi MAC Layer-2 mesh network support (e.g., 802.11s), or external gateway hubs, are not required. To accomplish this solution, one of the wireless devices may be designated as a relay device for communicating IPv6 data packets between a home AP router and the remaining wireless devices designated as client devices.

Abstract: The invention discloses an electrocatalyst includes a quasi-two-dimensional metal nanosheet having a thickness ranging between 4 nm and 12 nm. The quasi-two-dimensional metal nanosheet includes platinum (Pt), nickel (Ni), and niobium (Nb). The quasi-two-dimensional metal nanosheet has a Turing structure morphology including one or more of Turing stripes and Turing spots assembled by individual metal nanocrystals having different orientations via constrained orientation attachment.