Abstract: The present disclosure discloses a new use of desloratadine (DLT) and pharmaceutically acceptable salts thereof in preparing a drug for treating a neurodegenerative disease related to motor dysfunction. The present disclosure shows, through a large number of experimental tests, that desloratadine and the pharmaceutically acceptable salts thereof can improve the state of motor dysfunction in an SOD1-G93A model mouse in the behavioral experimental tests of Rotarod experimental test, gait monitoring experimental test and cage experimental test, and that desloratadine and the pharmaceutically acceptable salts thereof can effectively delay the onset time and prolong the survival cycle of the SOD1-G93A model mouse, and therefore, desloratadine and the pharmaceutically acceptable salts thereof can be used to treat neurodegenerative diseases related to motor dysfunction, including amyotrophic lateral sclerosis.

Abstract: Nonlinear on-chip optical devices using AlScN are described herein. In one aspect, an optical component having nonlinear characteristics can include a first substrate defining a refractive index; and a nonlinear layer, the nonlinear layer disposed on the first substrate, the nonlinear layer comprising an amount of scandium (Sc), and the nonlinear layer defining a refractive index that is higher than the refractive index of the first substrate.

Abstract: Provided are a polymorph of an EP4 receptor antagonist, a preparation method therefor and a use thereof, relating in particular to a polymorph of an EP4 receptor antagonist (S)-4-(1-(2-(4-fluorobenzyl)-4, 7-dihydro-5H-thieno [2,3-c]pyran-3-carboxamido) ethyl) benzoic acid, a preparation method therefor and a use thereof.

Abstract: A method for preparing an entropy-stabilized ceramic thin film coating includes preparing a first layer formed by raw materials with a plurality of metal elements, and subjecting the first layer to reaction with anion thereby transforming at least a portion of the first layer to a second layer. The present invention also discloses an entropy-stabilized ceramic thin film coating and a component coated with an entropy-stabilized ceramic thin film coating.

Abstract: A method for optimizing an ultrasonic imaging system parameter based on deep learning, comprising the following steps: step 1: collecting samples for training neural networks, the samples comprising ultrasound image samples i, and a corresponding ultrasonic imaging system parameter vector sample p used by an ultrasonic imaging system when the ultrasonic image samples are collected; step 2: establishing a neural network model and training the neural networks to convergence by using the samples collected=in step 1, so as to obtain a trained neural network system onn; and step 3: taking the original ultrasonic imaging system parameter vector p or the original ultrasonic image as an input to be input into the neural network system onn trained in step 2, at this moment, a parameter obtained from an output end of onn being an optimized ultrasonic imaging system parameter vector ep=onn(p).

Abstract: Provided in the present invention is a preparation method for a nano organometallic carboxylate which effectively solves the problems of a complex washing process, and cumbersome, dangerous and uneconomical preparation of lye in traditional methods for producing organometallic carboxylates. A new method for preparing high-quality organometallic carboxylates by using a carboxylic acid, caustic soda, a metal oxide or a hydroxide as starting materials, and using ball milling to assist reaction thereof. The present invention not only efficiently utilizes lye, it also obtains high-quality organometallic carboxylates, which overcomes the technical prejudice that the prior art uses calcium chloride, sodium chloride and other salts for poor reaction efficiency. The problem in environmental pollution caused by the washing waste liquid in the existing process is fundamentally solved.

Abstract: Compositions and methods comprising polynucleotides and polypeptides having EPSP (5-enolpyruvylshikimate-3-phosphate) synthase (EPSPS) activity are provided. In specific embodiments, the sequence has an improved property, such as, but not limited to, improved catalytic capacity in the presence of the inhibitor, glyphosate. Further provided are nucleic acid constructs, plants, plant cells, explants, seeds and grain having the EPSPS sequences. Various methods of employing the EPSPS sequences are provided. Such methods include methods for producing a glyphosate tolerant plant, plant cell, explant or seed and methods of controlling weeds in a field containing a crop employing the plants and/or seeds disclosed herein.

Abstract: A method for correcting misalignments is provided. An alignment for each device of a group of devices mounted on a substrate is determined. An alignment error for the group of devices mounted on the substrate is determined based on the respective alignment for each device. One or more correction factors are calculated based on the alignment error. The alignment error is corrected based on the one or more correction factors.

Abstract: A thermoelectric element to convert thermal energy into electrical energy includes a first electrode part, a second electrode part having a different work function than the first electrode part and arranged at a distance from the first electrode part, on a same surface of a substrate as the first electrode part, and a middle part provided between the first electrode part and the second electrode part.

Abstract: A decoupled ETP model processor is configured to store power consumption data retrieved from power systems; convert the power consumption data into power activated time cycles and power non-activated time cycles; derive a thermal resistance (R) parameter and a capacitance (C) parameter for a predetermined heat flow (Q) parameter at each of the outdoor temperatures; compare the converted power activated time cycles to the actual power activated time cycles; compare the converted power non-activated time cycles to the actual power non-activated time cycles; calculate a first improved resistance-capacitance-heat flow (RCQ) parameter set and a respective first outdoor temperature for the compared and converted power activated time cycles to the actual power activated time cycles; calculate the Q parameter at each outdoor temperature during the power activated time cycles; and calculate the R parameter and the C parameter at each outdoor temperature during the power non-activated time cycles.

Abstract: The present disclosure discloses a band-stop filter and a radio frequency device, and the band-stop filter includes a cavity, an input port and an output port disposed on the cavity, and a transmission mainline and a plurality of resonators are disposed within the cavity, both ends of the transmission mainline are connected to the input port or the output port respectively, each resonator includes a resonant chamber and a resonant column disposed within the resonant chamber, a coupling wall is disposed between the resonant column and the corresponding transmission mainline, the coupling wall extends upwardly from the bottom wall of the cavity, the coupling wall and the transmission mainline are coupled.

Abstract: This application provides a driving switching mechanism for a stapling instrument. An actuation driving assembly includes a driving sleeve for driving an end effector to perform a closing action and a knife bar driving rod for driving the end effector to perform a stapling action. A handle driving assembly includes a driving handle and a knife bar driving assembly which includes a knife driving member and a handle driving connecting member. The handle driving connecting member is connected to a handle driving portion. The knife driving member is movably connected to the handle driving connecting member, and is movable relative to the handle driving connecting member to a driving position or a driving disengagement position. When the knife driving member is in the driving position, the knife driving member and the knife bar driving rod are engaged as the handle driving portion moves toward a second position.

Abstract: Provided in the present invention is a preparation method for a nano organometallic carboxylate which effectively solves the problems of a complex washing process, and cumbersome, dangerous and uneconomical preparation of lye in traditional methods for producing organometallic carboxylates. A new method for preparing high-quality organometallic carboxylates by using a carboxylic acid, caustic soda, a metal oxide or a hydroxide as starting materials, and using ball milling to assist reaction thereof. The present invention not only efficiently utilizes lye, it also obtains high-quality organometallic carboxylates, which overcomes the technical prejudice that the prior art uses calcium chloride, sodium chloride and other salts for poor reaction efficiency. The problem in environmental pollution caused by the washing waste liquid in the existing process is fundamentally solved.

Abstract: Network hardware devices organized in a wireless network. A controller device receives device information about each of a multiple network devices, network congestion at each device, scan data, and a station list from each of the devices. The controller device assigns a channel to each radio of the multiple network devices using the device information, the network congestion data, the scan data, and the station list and outputs a first subset of channel assignments to a first group of the network devices, a second subset of channel assignments to a second group of the network devices, and a third subset of channel assignments to a third group of the network devices.

Abstract: An LED lamp comprises a lampshade, a base connected to the lampshade, a photoelectric module comprising a light source module and a power supply module disposed in an accommodating space formed between the lampshade and the base, the photoelectric module is detachably fixed to the base through a mounting portion.

Abstract: Provided herein is a method of preparing a ceramic material, the method including: providing a ceramic gel including a plurality of metal salts and compressing the ceramic gel thereby inducing stress-induced mineralization of the ceramic gel and formation of the ceramic material, wherein the ceramic gel exists in isolated form.

Abstract: The present invention provides a method of fabricating a catalytic reaction material. A solution of a carbon precursor compound and a noble metal precursor compound is prepared; the carbon precursor compound includes a salt component. The solution is recrystallized the solution to form recrystallized complexes including both the carbon precursor compound and the noble metal precursor compound. The recrystallized complexes are calcined to create a salt template for generation of two-dimensional carbon nanosheets embedding isolated noble metal atoms. Further calcining and washing decomposes the salt template to produce two two-dimensional carbon nanosheets embedding isolated noble metal atoms, each nanosheet having a thickness of approximately 1 to approximately 10 nanometers.

Abstract: The present invention provides a method for preparing organometallic composite material, comprising: providing PVC resin, activated calcium carbonate, plant fiber, calcium stearate, barium sulfate, paraffin, sodium bicarbonate, zinc laurate, nanometre titanium dioxide, organometallic salt, shell powder, carbon nanotube, talcum powder and stabilizer; mixing and heating; subject to first cooling after extrusion and second cooling under vacuum; towing to obtain the organometallic composite material, wherein the organometallic salt is a benzoic acid metal salt mixture. The present method can significantly reduce the processing temperature of PVC composite by 20 to 50° C., and also increase the toughness and strength of the material so as to alleviate the exudation of the composite material as in the conventional technologies and extend the lifespan of the composite material.

Abstract: A catalyst including an amorphous matrix of a metallic glass including iron and phosphorous; wherein when the catalyst performs a catalytic reaction with a reactant, the metallic glass catalyst activates at least some of the reactant, and at least a portion of the catalyst at a surface of the metallic glass matrix transforms to a surface layer including a material property different from that of the metallic glass matrix being covered by the surface layer; and wherein the surface layer is arranged to maintain an amorphous structure of the metallic glass matrix and to facilitate the catalytic reaction to occur at the surface layer.