Patents by Inventor Jian Ni

Jian Ni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • T1 receptor-like ligand II polypeptides
    Patent number: 6667032
    Abstract: The present invention concerns a novel T1R-like ligand II protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand II protein. T1R-like ligand II polypeptides are also provided, as are recombinant vectors and host cells for expressing the same.
    Type: Grant
    Filed: May 25, 1999
    Date of Patent: December 23, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reiner L. Gentz, Steven M. Ruben
  • 186 human secreted proteins
    Publication number: 20030225248
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: June 10, 2002
    Publication date: December 4, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Carrie L. Fischer, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, David W. LaFleur, Yi Li, Zhizhen Zeng, Hla Kyaw
  • 29 human secreted proteins
    Publication number: 20030220489
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: October 9, 2002
    Publication date: November 27, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Craig A. Rosen, Steven M. Ruben, Reinhard Ebner, Roxanne D. Duan, Jian Ni, Daniel R. Soppet, Paul A. Moore, Yanggu Shi, David W. LaFleur, Henrik Olsen, Charles E. Birse, George A. Komatsoulis
  • Human CCV polypeptides
    Patent number: 6653445
    Abstract: The present invention relates to novel human proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells and recombinant methods for producing the proteins of the invention. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Grant
    Filed: January 21, 1998
    Date of Patent: November 25, 2003
    Assignees: Human Genome Sciences, Inc., Auckland Uniservices, Limited
    Inventors: Jian Ni, Craig A. Rosen, Reiner Gentz, Jeffrey Y. Su, Geoffrey W. Krissansen, Ping Feng
  • Human IRAK-2
    Patent number: 6653452
    Abstract: The present invention relates to a novel IRAK-2 protein which is a member of the IL-1 signaling pathway. In particular, isolated nucleic acid molecules are provided encoding the human IRAK-2 protein. IRAK-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for detecting IRAK-2 related disorders and therapeutic methods for treating IRAK-2 related disorders.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: November 25, 2003
    Assignees: Human Genome Sciences, Inc., The Regents of the University of Michigan
    Inventors: Jian Ni, Ping Feng, Marta Muzio, Vishva M. Dixit
  • Pancreas-derived plasminogen activator inhibitor
    Patent number: 6649738
    Abstract: The present invention relates to a novel member of the plasminogen activator inhibitor protein family. In particular, isolated nucleic acid molecules are provided encoding the pancreas-derived plasminogen activator inhibitor protein. Pancreas-derived plasminogen activator inhibitor polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to methods for treating physiologic and pathologic disease conditions, including breast cancer, and diagnostic methods for detecting pathologic disorders.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: November 18, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reiner L. Gentz, Steven M. Ruben
  • Interferon receptor HKAEF92
    Publication number: 20030211578
    Abstract: The present invention relates to a novel Interferon receptor “INFR-HKAEF92” protein which is a member of the Interferon/IL-10 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human INFR-HKAEF92 protein. INFR-HKAEF92 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of INFR-HKAEF92 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Application
    Filed: February 5, 2003
    Publication date: November 13, 2003
    Inventors: Jian Ni, Steven M. Ruben
  • 125 human secreted proteins
    Publication number: 20030211472
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: March 28, 2001
    Publication date: November 13, 2003
    Inventors: Ping Feng, Steven M. Ruben, Craig A. Rosen, Reinhard Ebner, Henrik S. Olsen, Jian Ni, Ying-Fei Wei, Daniel R. Soppet, Paul A. Moore, Hla Kyaw, David W. LaFleur, Yanggu Shi, Fouad Janat, Gregory A. Endress, Kenneth C. Carter
  • B7-like polypeptides and polynucleotides
    Publication number: 20030208058
    Abstract: The present invention relates to novel human B7-like polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human B7-like polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human B7-like polypeptides.
    Type: Application
    Filed: December 20, 2001
    Publication date: November 6, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Michele Fiscella, Jian Ni, Steven M. Ruben
  • Galectin 11
    Publication number: 20030208044
    Abstract: The present invention relates to novel galectin 11 proteins which are members of the galectin superfamily. In particular, isolated nucleic acid molecules are provided encoding the human galectin 11 proteins. Galectin 11 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of galectin 11 activity. Also provided are diagnostic and therapeutic methods.
    Type: Application
    Filed: June 6, 2003
    Publication date: November 6, 2003
    Applicants: Human Genome Sciences, Inc., La Jolla Institute for Allergy and Immunology
    Inventors: Jian Ni, Reiner L. Gentz, Craig A. Rosen, Fu-Tong Liu
  • Fc Receptors and polypeptides
    Publication number: 20030208054
    Abstract: The present invention relates to four novel Fc receptor-like proteins which are members of the Fc Receptor family. In particular, isolated nucleic acid molecules are provided encoding the human FcR-I, FcR-II, FcR-III, and FcR-IV proteins. FcR-I, FcR-II, FcR-III, and FcR-IV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of FcR-I, FcR-II, FcR-III, and FcR-IV activities. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Application
    Filed: July 16, 2001
    Publication date: November 6, 2003
    Inventors: Henrik S. Olsen, Jian Ni, Marianne Murphy, Steven M. Ruben, Reiner L. Gentz
  • Human genes, sequences and expression products
    Publication number: 20030208043
    Abstract: Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
    Type: Application
    Filed: June 4, 2003
    Publication date: November 6, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Paul A. Moore, Reiner L. Gentz, Hongjun Ji, Jian Ni, Jing-Shan Hu
  • Transforming growth factor alpha hii
    Patent number: 6642006
    Abstract: The present invention discloses transforming growth factor alpha HII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating would healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders, and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptides and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
    Type: Grant
    Filed: January 11, 1999
    Date of Patent: November 4, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Paul S. Meissner, Jian Ni
  • 109 human secreted proteins
    Publication number: 20030204071
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: February 26, 2003
    Publication date: October 30, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Paul A. Moore, Steven M. Ruben, Kenneth C. Carter, Yanggu Shi, Craig A. Rosen, Daniel R. Soppet, Hla Kyaw, Ying-Feig Wei, Kimberly Florence, Roxanne Duan, Charles Florence, John M. Greene, Ping Feng, Ann M. Ferrie, Guo-Liang Yu, Fouad Janat, Jian Ni
  • Methods and compositions for treating inflammatory bowel diseases relating to human tumor necrosis factor-gamma-beta
    Publication number: 20030198640
    Abstract: The present invention encompasses methods for detection, diagnosis, prevention, treatment, and/or amelioration of inflammatory bowel diseases and disorders using TNF-gamma-&bgr; and its receptors DR3 and TR6. In particular the invention encompasses methods of using TNF-gamma-&bgr;, DR3 and TR6 polypeptides, as well as antibodies, and antagonists thereto, in the diagnosis, prognosis and treatment of ulcerative colitis and/or Crohn's disease. Methods of screening for antagonists of the TNF-gamma-&bgr; polypeptide, together with therapeutic uses of such antagonists are also disclosed.
    Type: Application
    Filed: December 6, 2002
    Publication date: October 23, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Jian Ni, Craig A. Rosen, Jun Zhang, Ping Wei
  • T1 receptor-like ligand II and uses thereof
    Publication number: 20030198618
    Abstract: The present invention relates to a novel T1 Receptor (T1R)-like ligand II protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand II protein. T1R-like ligand II polypeptides are also provided, as are recombinant vectors and host cells for expressing the same. This invention further relates to pharmaceutical compositions and formulations comprising T1R-like ligand II. Also provided are methods of using T1R-like ligand II polynucleotides, polypeptides, antibodies or agonists/antagonists for therapeutic and diagnostic purposes. Diagnostic kits are further provided.
    Type: Application
    Filed: May 16, 2003
    Publication date: October 23, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reiner L. Gentz, Steven M. Ruben
  • Monoclonal antibodies to membrane neutrokine-&agr;
    Patent number: 6635482
    Abstract: The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: October 21, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Reinhard Ebner, Jian Ni, Craig A. Rosen
  • Secreted protein HEMCM42
    Publication number: 20030195346
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: February 5, 2002
    Publication date: October 16, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Kenneth C. Carter, Patrick J. Dillon, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng
  • 17 human secreted proteins
    Publication number: 20030190707
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: October 23, 2002
    Publication date: October 9, 2003
    Inventors: Craig A. Rosen, George A. Komatsoulis, Kevin P. Baker, Charles E. Birse, Daniel R. Soppet, Henrik S. Olsen, Paul A. Moore, Ping Wei, Reinhard Ebner, D. Roxanne Duan, Yanggu Shi, Gil H. Choi, Michele Fiscella, Jian Ni, Steven M. Ruben, Steven C. Barash
  • Transcription factor polynucleotides, polypeptides, antibodies, and methods based thereon
    Publication number: 20030191298
    Abstract: The present invention relates to newly identified human polynucleotides and the polypeptides encoded by these polynucleotides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human antigens. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human antigens.
    Type: Application
    Filed: April 2, 2002
    Publication date: October 9, 2003
    Inventors: Steven C. Barash, Jian Ni, Steven M. Ruben, Craig A. Rosen