Patents by Inventor Jian Ni
Jian Ni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20050042667Abstract: The present invention relates to 36 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: September 8, 2004Publication date: February 24, 2005Applicant: Human Genome Sciences, Inc.Inventors: David LaFleur, Daniel Soppet, Henrik Olsen, Steven Ruben, Jian Ni, Craig Rosen, Laurie Brewer, Roxanne Duan, Reinhard Ebner
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Publication number: 20050037966Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.Type: ApplicationFiled: July 29, 2004Publication date: February 17, 2005Applicant: Human Genome Sciences, Inc.Inventors: Steven Ruben, Pablo Jimenez, Roxanne Duan, Mark Rampy, Donna Mendrick, Jun Zhang, Jian Ni, Paul Moore, Timothy Coleman, Joachim Gruber, Patrick Dillon, Reiner Gentz
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Publication number: 20050032168Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: July 23, 2004Publication date: February 10, 2005Applicant: Human Genome Sciences, Inc.Inventors: Craig Rosen, George Komatsoulis, Kevin Baker, Charles Birse, Daniel Soppet, Henrik Olsen, Paul Moore, Ping Wei, Reinhard Ebner, D. Duan, Yanggu Shi, Gil Choi, Michele Fiscella, Jian Ni, Steven Ruben, Steven Barash
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Publication number: 20050026179Abstract: The invention relates to hESF I, II and III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.Type: ApplicationFiled: April 8, 2004Publication date: February 3, 2005Applicant: Human Genome Sciences, Inc.Inventors: Jian Ni, Guo-Liang Yu, Reiner Gentz
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Publication number: 20050019866Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: July 6, 2004Publication date: January 27, 2005Applicant: Human Genome Sciences, Inc.Inventors: Jian Ni, Kevin Baker, Charles Birse, Michele Fiscella, George Komatsoulis, Craig Rosen, Daniel Soppet, Paul Young, Reinhard Ebner, D. Duan, Henrik Olsen, David La Fleur, Paul Moore, Yanggu Shi, Ping Wei, Kimberly Florence
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Publication number: 20050019834Abstract: Human chemokine Alpha-3 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, sepsis, wound healing and psoriasis and to stimulate stem cell mobilization. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, ARDS and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides.Type: ApplicationFiled: September 8, 2004Publication date: January 27, 2005Applicant: Human Genome Sciences, Inc.Inventors: Jian Ni, Haodong Li, Jeffrey Su
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Publication number: 20050010042Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: August 17, 2004Publication date: January 13, 2005Applicant: Human Genome Sciences, Inc.Inventors: Steven Ruben, Charles Birse, Roxanne Duan, Daniel Soppet, Craig Rosen, Yanggu Shi, David LaFleur, Henrik Olsen, Reinhard Ebner, Kimberly Florence, Jian Ni, Paul Young
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Publication number: 20050009141Abstract: A human epidermal differentiation factor polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating and/or preventing skin diseases. Diagnostic assays for detecting mutations in a nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.Type: ApplicationFiled: August 11, 2004Publication date: January 13, 2005Applicants: The University of Antwerp, Human Genome Sciences, Inc.Inventors: Jian Ni, Ping Feng, Patrick Dillon, Reiner Gentz, Joseph Merregaert, Patrick Smits
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Publication number: 20040253672Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: December 4, 2003Publication date: December 16, 2004Inventors: Steven M. Ruben, Adam Bell, Charles E. Birse, George A. Komatsoulis, Gil H. Choi, Henrik S. Olsen, Jian Ni, Kevin P. Baker
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Publication number: 20040253684Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: July 7, 2004Publication date: December 16, 2004Applicant: Human Genome Sciences, Inc.Inventors: Steven M. Ruben, Reinhard Ebner, Craig A. Rosen, Gregory A. Endress, Daniel R. Soppet, Jian Ni, Roxanne D. Duan, Paul A. Moore, Yanggu Shi, David W. LaFleur, Henrik S. Olsen, Kimberly A. Florence
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Publication number: 20040241803Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: July 1, 2004Publication date: December 2, 2004Applicant: Human Genome Sciences, Inc.Inventors: Craig A. Rosen, Jian Ni, Kimberly A. Florence, Michele Fiscella, Ping Wei, Kevin P. Baker, Charles E. Birse, Paul E. Young, George A. Komatsoulis, Paul A. Moore, Daniel R. Soppet
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Patent number: 6824767Abstract: Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexperession of the TNF-gamma-alpha and TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.Type: GrantFiled: February 8, 1999Date of Patent: November 30, 2004Assignee: Human Genome Sciences, Inc.Inventors: Guo-Liang Yu, Jian Ni, Craig A. Rosen, Jun Zhang
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Patent number: 6822585Abstract: A mobile phone has a display and a keypad which comprises a plurality of keys. Each key has associated with it a plurality of different symbols. The keypad is used to enter symbols in the form of Pinyin strings (25) into the display which are then used to determine a candidate list (26) of Chinese characters which are presented in the display. Symbols are entered into the display by pressing respective keys once or more than one times in rapid succession. Selection of a symbol is only permitted if it corresponds to a valid Pinyin string (25), either in isolation or in combination with one or more symbols entered in a previous selection. Characters chosen from the candidate list are entered into a message (24) in the display.Type: GrantFiled: September 15, 2000Date of Patent: November 23, 2004Assignee: Nokia Mobile Phones, Ltd.Inventors: Jian Ni, Yong Gou, Ninghui Gao
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Publication number: 20040224387Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.Type: ApplicationFiled: December 12, 2003Publication date: November 11, 2004Applicant: Human Genome Sciences, Inc.Inventors: Steven M. Ruben, Pablo Jimenez, D. Roxanne Duan, Mark A. Rampy, Donna Mendrick, Jun Zhang, Jian Ni, Paul A. Moore, Timothy A. Coleman, Joachim R. Gruber, Patrick J. Dillon, Reiner L. Gentz
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Publication number: 20040225118Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: July 7, 2003Publication date: November 11, 2004Applicant: Human Genome Sciences, Inc.Inventors: Jian Ni, Steven M. Ruben, Craig A. Rosen, Reinhard Ebner, Kimberly A. Florence, Paul E. Young, Charles E. Birse, Kenneth C. Carter, George Komatsoulis
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Patent number: 6812327Abstract: The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.Type: GrantFiled: February 22, 2000Date of Patent: November 2, 2004Assignee: Human Genome Sciences, Inc.Inventors: Guo-Liang Yu, Reinhard Ebner, Jian Ni, Craig A. Rosen
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Patent number: 6806351Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: GrantFiled: February 1, 2001Date of Patent: October 19, 2004Assignee: Human Genome Sciences, Inc.Inventors: Steven M. Ruben, Daniel R. Soppet, Reinhard Ebner, Henrik S. Olsen, Paul E. Young, John M. Greene, Ann M. Ferrie, Guo-Liang Yu, Jian Ni, Craig A. Rosen, Laurie A. Brewer, Fouad Janat
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Publication number: 20040197870Abstract: The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.Type: ApplicationFiled: April 30, 2004Publication date: October 7, 2004Applicant: Human Genome Sciences, Inc.Inventors: Jian Ni, Guo-Liang Yu, Ping Fan, Reiner L. Gentz
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Publication number: 20040185505Abstract: The invention relates to cytostatin II growth modulatory polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.Type: ApplicationFiled: April 13, 2004Publication date: September 23, 2004Applicant: Human Genome Sciences, Inc.Inventors: Jian Ni, Guo-Liang Yu, Reiner L. Gentz
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Publication number: 20040185440Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: March 28, 2001Publication date: September 23, 2004Inventors: Ping Feng, Steven M. Ruben, Craig A. Rosen, Reinhard Ebner, Henrik S. Olsen, Jian Ni, Ying-Fei Wei, Daniel R. Soppet, Paul A. Moore, Hla Kyaw, David W. LaFleur, Yanggu Shi, Fouad Janat, Gregory A. Endress, Kenneth C. Carter
