Abstract: A casting method and cast article are provided. The casting method includes providing a casting furnace, the casting furnace including a withdrawal region in a lower end, positioning a mold within the casting furnace, positioning a molten material in the mold, partially withdrawing the mold a withdrawal distance through the withdrawal region in the casting furnace, the withdrawal distance providing a partially withdrawn portion, then reinserting at least a portion of the partially withdrawn portion into the casting furnace through the withdrawal region, and then completely withdrawing the mold from the casting furnace. The reinserting at least partially re-melts a solidified portion within the partially withdrawn portion to reduce or eliminate freckle grains. The cast article includes a microstructure and occurrence of freckle grains corresponding to being formed by a process comprising partially withdrawing, reinserting, and completely withdrawing of a mold from a casting furnace to form the cast article.

Abstract: A casting method and cast article are provided. The casting method includes providing a casting furnace, the casting furnace including a withdrawal region in a lower end, positioning a mold within the casting furnace, positioning a molten material in the mold, partially withdrawing the mold a withdrawal distance through the withdrawal region in the casting furnace, the withdrawal distance providing a partially withdrawn portion, then reinserting at least a portion of the partially withdrawn portion into the casting furnace through the withdrawal region, and then completely withdrawing the mold from the casting furnace. The reinserting partially re-melts a solidified portion within the partially withdrawn portion to fill pores formed therein with the molten material. The cast article includes a microstructure and a porosity corresponding to being formed by a process comprising partially withdrawing, reinserting, and completely withdrawing of a mold from a casting furnace to form the cast article.

Abstract: A method for filling closed regions in a drawing using a region filling tool that may appear as a paint bucket. Rather than independently selecting regions to fill or filling based on style-by-layer techniques, the user selects a seed region such that other regions of the drawing are filled if parameters of the other regions match the parameters of the seed region. Matching criteria parameters may include an exact match parameter, a shape matching parameter, a layer matching parameter, and a line weight matching parameter. The parameters may be used alone or in conjunction with other parameters. In this manner, multiple regions in the drawing that are similar to the seed region may be filled using one interaction with the region filling tool. This approach allows the user to more efficiently and intuitively fill regions in the drawing.

Abstract: The invention relates to novel bimetallic and trimetallic catalysts, their manufacture and use in both steam reforming and oxidative steam reforming of liquid fuels such as jet fuels, diesel fuels and gasoline to produce synthesis gas and/or hydrogen for fuel cell applications. The invention further relates to manufacture of synthesis gas and/or hydrogen gas for chemicals synthesis and fuel processing. The catalysts have high sulfur tolerance and carbon resistance when used in steam reforming and/or oxidative steam reforming of heavy hydrocarbon fuels.

Abstract: Systems and methods, including computer software adapted to perform certain operations, can be implemented for preventing content received from non-trusted sources from accessing protected data. A sequence of instructions and multiple permission indicators associated with the sequence of instructions are received. One or more of permission indicators are associated with a protected activity. An instruction within the sequence of instructions associated with the protected activity is identified. A determination is made whether execution of the identified instruction is permitted based, at least in part, on the one or more permission indicators, and the protected activity is performed if execution of the identified instruction is permitted.

Abstract: This invention relates to the field of immunology and more specifically relates to antiphytase monoclonal antibodies and immunoassay methods for the detection of a phytase from or derived from Aspergillus niger (phyA2) phytase, in particular, EH10a, FA7, AF9a and CC1 antiphytase antibodies. The invention further relates to hybridoma cell lines that produce antiphytase monoclonal antibodies.

Abstract: A Treponema pallidum triplet antigen construct is disclosed which includes three Treponema pallidum antigens (TP15, TP17, and TP47), as well as a ten amino acid leader sequence (tag 261) and human copper zinc superoxide dismutase (hSOD). This construct is optimized for in vitro diagnosis of syphilis infection. Plasmids containing DNA encoding the triplet antigen, host cells, production methods, detection methods, and kits are also disclosed.

Abstract: The present invention is directed to combination immunoassays, reagents and kits for simultaneous detection of HCV antigens and anti-HCV antibodies in a sample. The combination immunoassays of the present invention employ a non-ionic detergent that effectively exposes or releases the HCV core antigen from virions in a sample without interfering with the performance of other reagents such as the capture of anti-HCV antibodies by recombinant HCV antigens.

Abstract: One exemplary embodiment involves a computer-implemented method that comprises receiving, via a touch display, a touch down event on an object depicted on a user interface rendered on the touch display. The embodiment involves determining whether to provide access to a complete set of actions responsive to the touch down event based at least in part on whether the object comprises an advertisement. Additionally, the embodiment may also involve determining whether to provide access to the complete set of actions responsive to the touch down event based at least in part on whether the object is associated with one or more listeners. Then, the embodiment involves implementing one or more accessible actions responsive to the touch down event.

Abstract: A Treponema pallidum triplet antigen construct is disclosed which includes three Treponema pallidum antigens (TP15, TP17, and TP47), as well as a ten amino acid leader sequence (tag 261) and human copper zinc superoxide dismutase (hSOD). This construct is optimized for in vitro diagnosis of syphilis infection. Plasmids containing DNA encoding the triplet antigen, host cells, production methods, detection methods, and kits are also disclosed.

Abstract: Systems and methods, including computer software adapted to perform certain operations, can be implemented for remotely defining security data for authorizing access to data on a client device. Permission indicators are associated with a sequence of instructions, and a protected activity is associated with one or more of the permission indicators and with an instruction within the sequence of instructions. The one or more permission indicators and the sequence of instructions are provided to a remote device. The remote device determines whether execution of the instruction is permitted based, at least in part, on the one or more permission indicators, and the remote device performs the protected activity if execution of the instruction is permitted.

Abstract: Systems and methods, including computer software adapted to perform certain operations, can be implemented for remotely defining security data for authorizing access to data on a client device. Permission indicators are associated with a sequence of instructions, and a protected activity is associated with one or more of the permission indicators and with an instruction within the sequence of instructions. The one or more permission indicators and the sequence of instructions are provided to a remote device. The remote device determines whether execution of the instruction is permitted based, at least in part, on the one or more permission indicators, and the remote device performs the protected activity if execution of the instruction is permitted.

Abstract: Methods for determining the presence or amount of a complex comprising a first and second molecular entity are provided, preferably an sFlt-1:PlGF complex. A determination of the presence or amount of the complex can be used in methods for predicting, detecting, monitoring a disease, or guiding therapy in respect to a disease such as vascular, vascular-related disease, cardiac, cardiac-related disease, cancer, cancer-related disease, preeclampsia, and preeclampsia-related disease. Determining sFlt-1:angiogenic factor complex is particularly useful for predicting and detecting preeclampsia in early stages of gestation and in stages of the disease where clinical evaluation may be uninformative.

Abstract: The invention relates to a device for detecting the thickness and crown of plates and strips, belonging to the field of nuclear technology applications. The device comprises a C-frame; two ray source mounted in an upper arm of the C-frame and distributed at an interval along the width direction of a steel plate/strip; two rows of gas-pressurized ionization chamber detector arrays mounted in a lower arm of the C-frame and distributed at an interval along the moving direction of the plate/strip; collimators mounted below the two ray source, the collimators enabling the rays of each ray source to only irradiate to a corresponding row of detectors; pre-amplifier modules connected with the detector arrays; a data collector connected with the pre-amplifier modules; a data processing and displaying computer connected with the data collector; and a cooling water and pressurized air service system and a control system for ensuring system operation and monitoring.

Abstract: A casting method and cast article are provided. The casting method includes providing a casting furnace, the casting furnace including a withdrawal region in a lower end, positioning a mold within the casting furnace, positioning a molten material in the mold, partially withdrawing the mold a withdrawal distance through the withdrawal region in the casting furnace, the withdrawal distance providing a partially withdrawn portion, then reinserting at least a portion of the partially withdrawn portion into the casting furnace through the withdrawal region, and then completely withdrawing the mold from the casting furnace. The reinserting partially re-melts a solidified portion within the partially withdrawn portion to fill pores formed therein with the molten material. The cast article includes a microstructure and a porosity corresponding to being formed by a process comprising partially withdrawing, reinserting, and completely withdrawing of a mold from a casting furnace to form the cast article.

Abstract: Graft-versus-host disease (GVHD) is a lethal complication of allograft transplantation. The current strategy of using immunosuppressive agents to control GVHD may cause general immune suppression and limit the effectiveness of allograft transplantation. Adoptive transfer of regulatory T cells (Treg) can prevent GVHD in rodents, indicating the therapeutic potential of Treg for GVHD in humans. However, the clinical application of Treg-based therapy is hampered by the low frequency of human Treg and the lack of a reliable model to test their therapeutic effects in vivo. Human alloantigen-specific Treg are generated from antigenically-naïve precursors in a large scale ex vivo using allogeneic activated B cells as stimulators. Here, a human allogeneic GVHD model is established in humanized mice to mimic GVHD after allograft transplantation in humans.

Abstract: Provided is a 10-methoxycamptothecine derivate of formula (1), wherein R is selected from hydrogen, C1-6 alkyl, C1-6 haloalkyl, aryl substituted C1-6 alkyl, phosphate substituted C1-6 alkyl, amino-substituted C1-6 alkyl, carboxyl substituted C1-6 alkyl, hydroxyl substituted C1-6 alkyl, and amide-substituted C1-6 alkyl; R1 is selected from hydrogen and t-butoxycarbonyl substituted amino. Also provided in the present invention are the preparation method of the derivate and the use thereof in anti-tumor drug preparation.

Abstract: The present invention generally relates to high rate adsorbents and a method for their manufacture involving the steps of component mixing, extrusion, spheronization and calcination. The component mixing can involve both dry mixing in addition to wet mixing of an adsorbent with a binder, if required, and a fluid such as water. The paste so formed from the mixing stage is extruded to produce pellets which are optionally converted to beads by spheronization using in one embodiment, a marumerizer. The product is harvested and calcined to set any binder or binders used and/or burn out any additives or processing aids. This basic manufacturing scheme can be augmented by extra processing steps including ion exchange and activation to alter the composition of the adsorbents, as required.

Abstract: Disclosed herein are compositions and methods comprising two or more proteins in which at least one of the proteins has been altered to reduce their mutual recognition and binding. Such compositions are useful as reference, calibrators or controls in methods and assays for determining the amount of one or more of the proteins that may be present in a sample of interest or in confirming the presence of one or more of the proteins in the sample. More particularly, it relates to compositions and methods comprising altered placental growth factor-1 (PlGF-1) and soluble fms-like tyrosine kinase (sFlt-1) and methods for determining the amount or confirming the presence of sFlt-1 and/or PlGF-1 in a sample of interest.