Abstract: Various embodiments may relate to a method of forming a two-dimensional (2D) material based structure. The method may include forming a self-assembled monolayer (SAM) on an underlying structure. The method may also include forming a two-dimensional material (2DM) film. The 2DM film may be suspended over the self-assembled monolayer (SAM), the two-dimensional (2DM) film separated from the self-assembled monolayer (SAM) by a solvent or a fluid. The method may further include bringing the two-dimensional material (2DM) film and the self-assembled monolayer (SAM) in contact with each other.

Abstract: A rolling and sliding adaptive device for guiding and fixing a drill pipe includes a mounting platform, where the mounting platform is provided with a through hole for the drill pipe to pass through. Multiple rolling and sliding support mechanisms are arranged around the through hole. The rolling and sliding support mechanisms each include a support seat. The support seat is provided with a contact element telescopic and swingable on the support seat. A telescopic drive mechanism is provided between the contact element and the support seat. The contact elements on the multiple rolling and sliding support mechanisms form a funnel-shaped structure with a large upper part and a small lower part around the through hole. The rolling and sliding adaptive device is used on a deep in-situ high-fidelity coring calibration platform for accurate positioning of an assembly process of a multi-section drill pipe bin.

Abstract: An internal blowout-prevention gas-retaining connector has a body mounted at the bottom of a drill pipe. The body includes a valve pipe section and a connecting pipe section arranged from top to bottom. The bottom of the valve pipe section is inserted into the top of the connecting pipe section. The blowout-prevention valve seat is provided at a bottom end of the valve pipe section while a blowout-prevention valve bonnet is provided on a bottom surface of the valve pipe section. The edge of the blowout-prevention valve bonnet is rotatably connected to a bottom surface edge of the valve pipe section. A torsion spring is provided on a bottom surface of the blowout-prevention valve bonnet. One end of the torsion spring is connected to the bottom surface of the blowout-prevention valve bonnet while the other end is connected to the inner wall of the connecting pipe section.

Abstract: A real-time temperature-pressure detection and rapid processing system for a calibration platform, comprises an inner return pipe, and a water supply pipe is provided therein with an inner water supply pipe. An outer wall of the inner water supply pipe is connected with an inner wall of the water supply pipe through multiple springs. An outer wall of the inner return pipe is connected with an inner wall of a return pipe through multiple springs. The return pipe and the water supply pipe are made of a thermosetting polymer material. The multiple springs, the inner water supply pipe, and the inner return pipe are covered with a heat conducting material. The system further includes a temperature-pressure detection assembly. The assembly includes multiple infrared sensors arranged at two sides of the return pipe and the water supply pipe, a booster pump, a heater, and infrared sensors connected with a control unit.

Abstract: An assembly method for a deep in-situ high-fidelity coring calibration platform includes the following steps: S1: fixing a core bin assembly subsystem on a preset ground foundation and fixing a simulator of a core bin on a mounting base plate of the core bin assembly subsystem; S2: driving a cylinder and driving the mounting base plate to move to a preset position; S3: driving a servo motor and controlling two clips to move close to each other; S4: fixing a drill pipe bin assembly subsystem on the ground foundation; S5: assembling multiple sections of a drill pipe bin in turn; aligning and connecting a bottom of the drill pipe bin to the simulator, and aligning and communicating the top of the drill pipe bin with the lower part of an adaptive drill pipe guide structure; and S6: driving the adaptive drill pipe guide structure to perform accurate positioning.

Abstract: The present disclosure provides a rolling and sliding adaptive device for guiding and fixing a drill pipe. The rolling and sliding adaptive device includes a mounting platform, where the mounting platform is provided with a through hole for the drill pipe to pass through. Multiple rolling and sliding support mechanisms are arranged around the through hole. The rolling and sliding support mechanisms each include a support seat. The support seat is provided with a contact element telescopic and swingable on the support seat. A telescopic drive mechanism is provided between the contact element and the support seat. The contact elements on the multiple rolling and sliding support mechanisms form a funnel-shaped structure with a large upper part and a small lower part around the through hole.

Abstract: A real-time temperature-pressure detection and rapid processing system for a calibration platform, comprises an inner return pipe, and a water supply pipe is provided therein with an inner water supply pipe. An outer wall of the inner water supply pipe is connected with an inner wall of the water supply pipe through multiple springs. An outer wall of the inner return pipe is connected with an inner wall of a return pipe through multiple springs. The return pipe and the water supply pipe are made of a thermosetting polymer material. The multiple springs, the inner water supply pipe, and the inner return pipe are covered with a heat conducting material. The system further includes a temperature-pressure detection assembly. The assembly includes multiple infrared sensors arranged at two sides of the return pipe and the water supply pipe, a booster pump, a heater, and infrared sensors connected with a control unit.

Abstract: An assembly method for a deep in-situ high-fidelity coring calibration platform includes the following steps: S1: fixing a core bin assembly subsystem on a preset ground foundation and fixing a simulator of a core bin on a mounting base plate of the core bin assembly subsystem; S2: driving a cylinder and driving the mounting base plate to move to a preset position; S3: driving a servo motor and controlling two clips to move close to each other; S4: fixing a drill pipe bin assembly subsystem on the ground foundation; S5: assembling multiple sections of a drill pipe bin in turn; aligning and connecting a bottom of the drill pipe bin to the simulator, and aligning and communicating the top of the drill pipe bin with the lower part of an adaptive drill pipe guide structure; and S6: driving the adaptive drill pipe guide structure to perform accurate positioning.

Abstract: Disclosed is a continuous conduit apparatus based on guiding and injecting integrated mechanism, which comprises a straightening apparatus and a pair of sprocket and chain clamping assemblies. The pair of sprocket and chain clamping assemblies are configured to clamp the conduit and pull the conduit to go downwards a well or upwards a lifting direction. Between the pair of sprocket and chain clamping assemblies, a conduit guide channel applied for the conduit to passing through is formed. An inlet and an outlet of the conduit guide channel are not situated in a straight line, and the straightening apparatus are configured to straighten the conduit. Each of the two sprocket and chain clamping assemblies comprises a sprocket set, a chain, a plurality of clamping blocks mounted on the chain, and a pushing plate configured to press the clamping blocks.

Abstract: Disclosed is a continuous conduit operation apparatus, which comprises a folding frame and a guiding and injecting integrated mechanism configured to pull the conduit to go downwards a well or upwards a lifting direction. The folding frame comprises a base, a mounting frame connected to the base in a movable connection, and a telescopic mechanism configured to rotate the mounting frame in a vertical plane around a position of the movable connection. One end of the telescopic mechanism is movably connected to the base, another end of the telescopic mechanism is movably connected to the mounting frame. The guiding and injecting integrated mechanism is arranged on the mounting frame. The present disclosure integrates the guiding function and the injection function to reduce the height of the apparatus and is suitable for operation environment with limited space and height.

Abstract: Provided are fusion proteins that include an apolipoprotein B mRNA editing enzyme catalytic subunit 3A (APOBEC3A) and a clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) protein, optionally further with uracil glycosylase inhibitor (UGI). Such a fusion protein is able to conduct base editing in DNA by deaminating cytosine to uracil, even when the cytosine is in a GpC context or is methylated.

Abstract: Disclosed are a trifluoromethyl alkenylphosphonate derivative and preparation method therefor. The preparation method comprises the following steps: dissolving an acetylene derivative, an iodine compound, and a phosphorus reagent in a solvent for reaction at the temperature from the room temperature to 100° C. to obtain the trifluoromethyl alkenylphosphonate derivative. In the present invention, the acetylene derivative is used as a starting material, and the raw materials are easily available and diversified; products obtained by using the method of the present invention have various types and can be directly used and also used for other further reactions; moreover, the method disclosed in the present invention has the advantages of short steps, mild reaction conditions, simple reaction operation and post-treatment processes, and high yield, and is suitable for large-scale production.

Abstract: Provided are fusion proteins that include an apolipoprotein B mRNA editing enzyme catalytic subunit 3A (APOBEC3A) and a clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) protein, optionally further with uracil glycosylase inhibitor (UGI). Such a fusion protein is able to conduct base editing in DNA by deaminating cytosine to uracil, even when the cytosine is in a GpC context or is methylated.

Abstract: The present disclosure relates to a growth hormone fusion protein and a preparation method and use thereof. The growth hormone fusion protein includes: a double-stranded structure having a first constant region Fc segment and a second constant region Fc segment; and a growth hormone linked to the first constant region Fc segment, the growth hormone has no methionine at an N-terminus thereof, and the growth hormone fusion protein was expressed by a non-mammalian cell expression system. According to the present disclosure, by adopting the fusion of the growth hormone and the double-stranded structure, the in vivo half-life of the growth hormone can be prolonged, and since each double-stranded structure only carries one growth hormone, the active site of the growth hormone is not affected by steric hindrance, and stronger activity is provided, and since the N-terminus of the growth hormone has no methionine, higher safety is provided.

Abstract: Disclosed is a guiding and injecting integrated mechanism for continuous conduit, belonging to underground exploration technical field. The mechanism comprises a pair of chain wheel and chain clamping assemblies used for clamping conduit and pulling conduit to go down or out of well. A conduit guiding channel for conduit to pass through is formed between the pair of chain wheel and chain clamping assemblies, and an inlet and an outlet of the conduit guiding channel are not situated in line. The conduit guiding channel is arc-shaped and each of the two chain wheel and chain clamping assemblies comprises a chain wheel set, chains, clamping blocks mounted on the chain, and a pushing plate for pressing the clamping blocks. Further, clamping surfaces of the clamping blocks have a certain curvature with respect to guiding direction.

Abstract: A moon-based in-situ condition-preserved coring multi-stage large-depth drilling system and method therefor. The system includes a rotary plate provided inside a lander, an in-situ condition-preserved coring tool provided on a surface of the rotary plate, a space frame provided on a surface of the rotary plate, a working platform provided on a top of the space frame, a mechanical arm provided on a bottom surface of the working platform, and a camera provided on the bottom surface of the working platform, the mechanical arm is fixedly connected to the working platform, and the camera is fixedly connected to the working platform. By controlling the mechanical arm to place the in-situ condition-preserved coring tool on the moon surface, and using the in-situ condition-preserved coring tool to sample the lunar soil on the moon surface, the coring operation problem of the lunar soil is solved.

Abstract: Disclosed is a continuous conduit apparatus based on guiding and injecting integrated mechanism, which comprises a straightening apparatus and a pair of sprocket and chain clamping assemblies. The pair of sprocket and chain clamping assemblies are configured to clamp the conduit and pull the conduit to go downwards a well or upwards a lifting direction. Between the pair of sprocket and chain clamping assemblies, a conduit guide channel applied for the conduit to passing through is formed. An inlet and an outlet of the conduit guide channel are not situated in a straight line, and the straightening apparatus are configured to straighten the conduit. Each of the two sprocket and chain clamping assemblies comprises a sprocket set, a chain, a plurality of clamping blocks mounted on the chain, and a pushing plate configured to press the clamping blocks.

Abstract: An indicator light circuit configured for a micro-current comprises an indicator light module, a logic controller, and a sampling circuit. The logic controller is configured to compare a sample voltage generated by the micro-current on the sampling circuit with a first preset threshold voltage. When the sample voltage is greater than the first preset threshold voltage, the logic controller outputs a control signal to the indicator light module to drive an indicator light of the indicator light module to be turned on.

Abstract: A constant current output circuit configured for a micro-current comprises a voltage boosting module and a logic controller. An input terminal of the voltage boosting module is connected to a power source, and an output terminal of the logic controller is connected to the input terminal of the voltage boosting module. The logic controller is configured to compare a sample voltage generated by the micro-current on a sampling resistor with a first threshold voltage, and when the sample voltage is less than the first threshold voltage, the logic controller drives the voltage boosting module to boost an output voltage until the sample voltage is increased to be greater than the first threshold voltage.

Abstract: Disclosed is a continuous conduit operation apparatus, which comprises a folding frame and a guiding and injecting integrated mechanism configured to pull the conduit to go downwards a well or upwards a lifting direction. The folding frame comprises a base, a mounting frame connected to the base in a movable connection, and a telescopic mechanism configured to rotate the mounting frame in a vertical plane around a position of the movable connection. One end of the telescopic mechanism is movably connected to the base, another end of the telescopic mechanism is movably connected to the mounting frame. The guiding and injecting integrated mechanism is arranged on the mounting frame. The present disclosure integrates the guiding function and the injection function to reduce the height of the apparatus and is suitable for operation environment with limited space and height.