Patents by Inventor Jianan Li

Jianan Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210221831
    Abstract: Disclosed are a trifluoromethyl alkenylphosphonate derivative and preparation method therefor. The preparation method comprises the following steps: dissolving an acetylene derivative, an iodine compound, and a phosphorus reagent in a solvent for reaction at the temperature from the room temperature to 100° C. to obtain the trifluoromethyl alkenylphosphonate derivative. In the present invention, the acetylene derivative is used as a starting material, and the raw materials are easily available and diversified; products obtained by using the method of the present invention have various types and can be directly used and also used for other further reactions; moreover, the method disclosed in the present invention has the advantages of short steps, mild reaction conditions, simple reaction operation and post-treatment processes, and high yield, and is suitable for large-scale production.
    Type: Application
    Filed: April 9, 2021
    Publication date: July 22, 2021
    Inventors: Jianping ZOU, Chengkun LI, Dongliang ZHANG, Zekun TAO, Jianan LI
  • Publication number: 20210198699
    Abstract: A reagent and a method for repairing an FBN1T7498C mutation by using base editing. A kit for efficiently repairing the FBN1T7498C mutation is characterized by comprising a base editor and a repair re-sgRNA directed to the FBN1T7498C site. A base editing technology is used to repair the mutation of FBN1T7498C through a precise CT single base mutation, thereby providing a method for treating a Marfan syndrome caused by such mutation.
    Type: Application
    Filed: July 25, 2018
    Publication date: July 1, 2021
    Applicant: SHANGHAITECH UNIVERSITY
    Inventors: Xingxu HUANG, Guanglei LI, Jianan LI
  • Publication number: 20210163913
    Abstract: Provided are fusion proteins that include an apolipoprotein B mRNA editing enzyme catalytic subunit 3A (APOBEC3A) and a clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) protein, optionally further with uracil glycosylase inhibitor (UGI). Such a fusion protein is able to conduct base editing in DNA by deaminating cytosine to uracil, even when the cytosine is in a GpC context or is methylated.
    Type: Application
    Filed: February 22, 2019
    Publication date: June 3, 2021
    Inventors: Jia Chen, Li Yang, Xingxu Huang, Bei Yang, Xiao Wang, Jianan Li
  • Patent number: 10997464
    Abstract: Digital image layout training is described using wireframe rendering within a generative adversarial network (GAN) system. A GAN system is employed to train the generator module to refine digital image layouts. To do so, a wireframe rendering discriminator module rasterizes a refined digital training digital image layout received from a generator module into a wireframe digital image layout. The wireframe digital image layout is then compared with at least one ground truth digital image layout using a loss function as part of machine learning by the wireframe discriminator module. The generator module is then trained by backpropagating a result of the comparison.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: May 4, 2021
    Assignee: Adobe Inc.
    Inventors: Jimei Yang, Jianming Zhang, Aaron Phillip Hertzmann, Jianan Li
  • Publication number: 20200163782
    Abstract: A system and method for transmission of a signal for a powered assistive device has a sensor node with a wireless transmitter adapted for digitally transmitting a transmitted signal, the sensor node adapted for receiving and monitoring a sensor signal from a sensor attached to a user, and a master node with a controller and a wireless receiver for receiving the transmitted signal from the wireless transmitter. The master node processes the transmitted signal and communicates a control signal to the powered assistive device. The wireless transmitter transmits the transmitted signal at a first rate when the wireless transmitter adapted to transmit the transmitted signal at a first rate when the sensor signal is indicative of the rest state and to transmit the transmitted signal at a second rate when the sensor signal is indicative of the active state, the second rate being greater than the first rate.
    Type: Application
    Filed: November 27, 2019
    Publication date: May 28, 2020
    Applicant: Worcester Polytechnic Institute
    Inventors: Benjamin Edward McDonald, Todd Richard Farrell, Edward Clancy, Jianan Li, Xinming Huang
  • Publication number: 20200151508
    Abstract: Digital image layout training is described using wireframe rendering within a generative adversarial network (GAN) system. A GAN system is employed to train the generator module to refine digital image layouts. To do so, a wireframe rendering discriminator module rasterizes a refined digital training digital image layout received from a generator module into a wireframe digital image layout. The wireframe digital image layout is then compared with at least one ground truth digital image layout using a loss function as part of machine learning by the wireframe discriminator module. The generator module is then trained by backpropagating a result of the comparison.
    Type: Application
    Filed: November 9, 2018
    Publication date: May 14, 2020
    Applicant: Adobe Inc.
    Inventors: Jimei Yang, Jianming Zhang, Aaron Phillip Hertzmann, Jianan Li
  • Patent number: 10449049
    Abstract: A prosthesis (100) for preventing a valve regurgitation, comprising a fixation unit (110), a connection piece (120) and a closure assisting piece (130); the fixation unit (110) comprises a fixation piece (111) and an anchor (112); the connection piece (120) is flexible, and a distal section thereof is connected to a proximal section of the fixation piece (111), and a proximal section thereof is connected to a distal section of the closure assisting piece (130); the fixation piece (111) is fixed on the atrial wall or a valve ring of a patient via the anchor (112); the deployed width of the fixation piece (111) is less than two-thirds of the circumference of a valve tissue annulus; the closure assisting piece (130) is located between autologous valve leaflets of the patient when in a free state; the maximum width of the closure assisting piece (130) is less than the maximum deployed width of a single autologous valve leaflet; and the proximal end of the anchor (112) is provided with an anti-disengagement end (1
    Type: Grant
    Filed: January 9, 2017
    Date of Patent: October 22, 2019
    Assignee: NINGBO JENSCARE BIOTECHNOLOGY CO., LTD.
    Inventors: Yibin Li, Shiwen Lv, Zhiyun Xu, Jianan Li, Deyuan Zheng, Zhi Chen
  • Patent number: 10398547
    Abstract: An implant with anchoring device for heart valve disease comprises a cardiac valve prosthesis (1), at least two sets of anchoring needles (2) and at least two sets of anchoring needle releasing devices (3). Proximal end of the anchoring needles (2) are provided with anti-disengagement ends (23). The anchoring needle releasing devices (3) are detachably connected to the cardiac valve prosthesis (1). The anchoring needle releasing devices (3) comprise delivery tubes (31) and shafts (32). Distal sections of the anchoring needle releasing devices (3) are in preset shapes. The shafts (32) can be pushed to force the anchoring needles (2) to move toward the distal ends of the delivery tubes (31), so that the cardiac valve prosthesis (1) is fixed between autogenous tissue (6) and the anti-disengagement ends (23) to achieve accurate positioning and firm anchoring of the cardiac valve prosthesis (1).
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: September 3, 2019
    Assignee: NINGBO JENSCARE BIOTECHNOLOGY CO., LTD.
    Inventors: Jianan Li, Shiwen Lv, Zhiyun Xu, Yibin Li, Zhi Chen
  • Publication number: 20170112618
    Abstract: A prosthesis (100) for preventing a valve regurgitation, comprising a fixation unit (110), a connection piece (120) and a closure assisting piece (130); the fixation unit (110) comprises a fixation piece (111) and an anchor (112); the connection piece (120) is flexible, and a distal section thereof is connected to a proximal section of the fixation piece (111), and a proximal section thereof is connected to a distal section of the closure assisting piece (130); the fixation piece (111) is fixed on the atrial wall or a valve ring of a patient via the anchor (112); the deployed width of the fixation piece (111) is less than two-thirds of the circumference of a valve tissue annulus; the closure assisting piece (130) is located between autologous valve leaflets of the patient when in a free state; the maximum width of the closure assisting piece (130) is less than the maximum deployed width of a single autologous valve leaflet; and the proximal end of the anchor (112) is provided with an anti-disengagement end (1
    Type: Application
    Filed: January 9, 2017
    Publication date: April 27, 2017
    Applicant: NINGBO JENSCARE BIOTECHNOLOGY CO., LTD.
    Inventors: Yibin LI, Shiwen LV, ZHIYUN XU, Jianan LI, Deyuan ZHENG, Zhi CHEN
  • Publication number: 20170112622
    Abstract: An implant with anchoring device for heart valve disease comprises a cardiac valve prosthesis (1), at least two sets of anchoring needles (2) and at least two sets of anchoring needle releasing devices (3). Proximal end of the anchoring needles (2) are provided with anti-disengagement ends (23). The anchoring needle releasing devices (3) are detachably connected to the cardiac valve prosthesis (1). The anchoring needle releasing devices (3) comprise delivery tubes (31) and shafts (32). Distal sections of the anchoring needle releasing devices (3) are in preset shapes. The shafts (32) can be pushed to force the anchoring needles (2) to move toward the distal ends of the delivery tubes (31), so that the cardiac valve prosthesis (1) is fixed between autogenous tissue (6) and the anti-disengagement ends (23) to achieve accurate positioning and firm anchoring of the cardiac valve prosthesis (1).
    Type: Application
    Filed: January 5, 2017
    Publication date: April 27, 2017
    Inventors: Jianan Li, Shiwen Lv, Zhiyun Xu, Yibin Li, Zhi Chen
  • Patent number: 8142771
    Abstract: The present invention provides a novel use of coccidian, specifically relates to the use of coccidian as a vaccine live vector. The present invention further provides a live vaccine with coccidian as a vector, which is transgenic coccidian capable of expressing exogenous protein or stably transfected coccidian that contain expression vector and can express exogenous coccidian. The present coccidian vector live vaccine can induce organisms to simultaneously generate protective humoral and cellular immune responses (including the mucosal immune response), as well as generate memory responses, which can be readily carried out and has stable effect and high biological safety without generating immune tolerance.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: March 27, 2012
    Inventors: Xun Suo, Xiaojia Wang, Xianyong Liu, Tuanyuan Shi, Lili Hao, Wenchao Yan, Hongyan Wang, Jianan Li
  • Publication number: 20100183668
    Abstract: The present invention provides a novel use of coccidian, specifically relates to the use of coccidian as a vaccine live vector. The present invention further provides a live vaccine with coccidian as a vector, which is transgenic coccidian capable of expressing exogenous protein or stably transfected coccidian that contain expression vector and can express exogenous coccidian. The present coccidian vector live vaccine can induce organisms to simultaneously generate protective humoral and cellular immune responses (including the mucosal immune response), as well as generate memory responses, which can be readily carried out and has stable effect and high biological safety without generating immune tolerance.
    Type: Application
    Filed: March 28, 2008
    Publication date: July 22, 2010
    Inventors: Xun Suo, Xiaojia Wang, Xianyong Liu, Tuanyuan Shi, Lili Hao, Wenchao Yan, Hongyan Wang, Jianan Li