Patents by Inventor Jianbing Chen
Jianbing Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150272965Abstract: The invention provides a biodegradable drug-eluting particle useful for the delivery of diagnostic or therapeutic agents. In certain embodiments, the drug-eluting particle of the invention comprises a biodegradable porous silicon body, a reservoir formed within the porous silicon body having at least one opening to an exterior of the body, wherein the reservoir contains a therapeutic or diagnostic agent, and an agent-permeable seal disposed over the at least one opening. The invention further provides a method for treating a patient to obtain a desired local or systemic physiological or pharmacological effect comprising administering a sustained release drug delivery particle of the invention.Type: ApplicationFiled: April 7, 2015Publication date: October 1, 2015Inventors: Paul Ashton, Hong Guo, Jianbing Chen, Leigh T. Canham
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Publication number: 20150224442Abstract: The present disclosure provides a method for processing an acid gas, comprising: using a processor 1 for receiving and processing the acid gas to obtain a gas phase stream 1 and a liquid phase stream 2, wherein the stream 2 is partially or completely recycled to the processor 1; using a processor 2 for processing the stream 1 from the processor 1 to obtain a gas phase stream 3 and a liquid phase stream 4; using a processor 3 for processing the stream 3 from the processor 2 to obtain a gas phase stream 5 and a liquid phase stream 6; and using a processor 4 for receiving the stream 43 from the processor 2 and using the stream 43 as a processing solution for processing the stream 5 from the processor 3 to obtain a gas phase stream 7 and a liquid phase stream 8, which can be divided into two sub-streams including a stream 81 and a stream 82. The present disclosure further provides an apparatus for processing an acid gas.Type: ApplicationFiled: October 30, 2014Publication date: August 13, 2015Inventors: Deqiang PENG, Zejun ZUO, Huimin QI, Luyao WANG, Fanfei MENG, Jianbing CHEN, Xin CHEN
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Patent number: 9023896Abstract: The invention provides a biodegradable drug-eluting particle useful for the delivery of diagnostic or therapeutic agents. In certain embodiments, the drug-eluting particle of the invention comprises a biodegradable porous silicon body, a reservoir formed within the porous silicon body having at least one opening to an exterior of the body, wherein the reservoir contains a therapeutic or diagnostic agent, and an agent-permeable seal disposed over the at least one opening. The invention further provides a method for treating a patient to obtain a desired local or systemic physiological or pharmacological effect comprising administering a sustained release drug delivery particle of the invention. The invention also provides methods of fabricating a drug-eluting particle for releasing therapeutic agents.Type: GrantFiled: May 4, 2010Date of Patent: May 5, 2015Assignee: pSivida US, Inc.Inventors: Paul Ashton, Hong Guo, Jianbing Chen, Leigh Canham
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Publication number: 20140363482Abstract: The present invention relates to sustained release drug delivery systems, medical devices incorporating said systems, and methods of use and manufacture thereof. The inventive systems feature bioerodible drug delivery devices that include biocompatible solid and biocompatible fluid compositions to achieve desired sustained release drug delivery.Type: ApplicationFiled: July 1, 2014Publication date: December 11, 2014Inventors: Hong Guo, Jianbing Chen, Dongling Su, Paul Ashton
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Publication number: 20140336278Abstract: The invention provides liquid controlled-release drug delivery compositions which gel upon injection into the body to form, in situ, controlled-release drug implants. The compositions of the invention feature a gel-forming polymer that is insoluble in water, a polyethylene glycol solvent in which the polymer is dissolved, and the drug substance to be delivered.Type: ApplicationFiled: July 28, 2014Publication date: November 13, 2014Inventors: Dongling Su, Paul Ashton, Jianbing Chen
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Patent number: 8815284Abstract: The present invention relates to sustained release drug delivery systems, medical devices incorporating said systems, and methods of use and manufacture thereof. The inventive systems feature bioerodible drug delivery devices that include biocompatible solid and biocompatible fluid compositions to achieve desired sustained release drug delivery.Type: GrantFiled: June 25, 2004Date of Patent: August 26, 2014Assignee: pSivida US, Inc.Inventors: Hong Guo, Jianbing Chen, Dongling Su, Paul Ashton
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Publication number: 20140128654Abstract: The present disclosure provides a reactor for at least two liquid materials, comprising an enclosed reactor housing; a feeding tube having liquid material inlets for receiving corresponding liquid materials respectively; a distribution tube communicating with the feeding tube and extending into the reactor housing, the distribution tube being provided with a plurality of distribution holes in the region thereof extending into the reactor housing; a rotating bed in form of a hollow cylinder, which is disposed in the reactor housing via a fixing mechanism, thus dividing inner cavity of the reactor housing into a central area and an outer area, the rotating bed being capable of rotating driven by a driving mechanism; and a material outlet provided in a lower portion of the reactor housing for outputting product after reaction.Type: ApplicationFiled: October 30, 2013Publication date: May 8, 2014Applicants: Fushun Research Institute of Petroleum And Petrochemicals, Sinopec, China Petroleum & Chemical CorporationInventors: Xiangchen FANG, Deqiang PENG, Huimin QI, Xin LI, Yan WANG, Jianbing CHEN, Luyao WANG, Zhiyu LIU, Xin CHEN, Shengzhong ZHANG
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Publication number: 20140037746Abstract: Disclosed is a sustained release system that includes a polymer and a pharmaceutically active agent dispersed in the polymer. The agent is in granular or particulate form, and has a rate of release from the system that is limited primarily by the rate at which the agent dissolves from the granules into the polymer matrix. Advantageously, the polymer is permeable to the agent and is non-release-rate-limiting with respect to the rate of release of the agent from the polymer.Type: ApplicationFiled: July 9, 2013Publication date: February 6, 2014Applicant: pSivida US, Inc.Inventors: Paul Ashton, Jianbing Chen, Hong Guo
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Publication number: 20130101656Abstract: The invention provides liquid controlled-release drug delivery compositions which gel upon injection into the body to form, in situ, controlled-release drug implants. The compositions of the invention feature a gel-forming polymer that is insoluble in water, a polyethylene glycol solvent in which the polymer is dissolved, and the drug substance to be delivered.Type: ApplicationFiled: September 12, 2012Publication date: April 25, 2013Inventors: Dongling Su, Paul Ashton, Jianbing Chen
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Patent number: 8303211Abstract: The present invention provides a method and pavement structure for protecting highway subgrade in frozen soil areas. The pavement structure has two or more pavement layers having gradient thermal conductivity; the thermal conductivity is layered among the pavement layers and is lowered from top to bottom, so that the pavement forms a uni-directional thermal conducting tunnel from the subgrade to the air. Heat can be easily released from the subgrade into the air, and is prevented from being transferred from the air to the subgrade. In this way, the frozen soil layer beneath the subgrade is cooled, so that the frozen soil table is made stable, and the highway subgrade in frozen soil areas is protected.Type: GrantFiled: December 31, 2009Date of Patent: November 6, 2012Assignees: CCCC First Highway Consultants Co., Ltd, Southeast UniversityInventors: Shuangjie Wang, Shengyue Wang, Jianbing Chen, Xiaofeng Zhou, Juan Zhang, Qiyang Zhu
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Publication number: 20120195934Abstract: Implantable, injectable, insertable, or otherwise administrable compositions that form hydrogels when implanted, injected, inserted, or administered into or onto living tissues comprise a pharmaceutically effective compound wherein the pharmaceutically effective compound is a codrug, or pharmaceutically acceptable salt or prodrug thereof in admixture with a hydrogel-forming compound. The pharmaceutically effective compound may be any compound that is soluble in bodily fluids, or that forms bodily fluid-soluble adducts when exposed to bodily fluids. Exemplary compounds include analgesic, anti-inflammatory and antibiotic compounds. The hydrogel-forming compound is a biologically tolerated substance that forms a hydrogel upon exposure to bodily fluids, such as the interstitial fluid surrounding or within a joint.Type: ApplicationFiled: February 9, 2012Publication date: August 2, 2012Inventors: Paul Ashton, Jianbing Chen
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Publication number: 20120045513Abstract: Disclosed is a sustained release system that includes a polymer and a pharmaceutically active agent dispersed in the polymer. The agent is in granular or particulate form, and has a rate of release from the system that is limited primarily by the rate at which the agent dissolves from the granules into the polymer matrix. Advantageously, the polymer is permeable to the agent and is non-release-rate-limiting with respect to the rate of release of the agent from the polymer.Type: ApplicationFiled: September 9, 2011Publication date: February 23, 2012Applicant: pSivida Inc.Inventors: Paul Ashton, Jianbing Chen, Hong Guo
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Publication number: 20120016467Abstract: Disclosed is a sustained release system that includes a polymer and a prodrug having a solubility less than about 1 mg/ml dispersed in the polymer. Advantageously, the polymer is permeable to the prodrug and may be non-release rate limiting with respect to the rate of release of the prodrug from the polymer. This permits improved drug delivery within a body in the vicinity of a surgery via sustained release rate kinetics over a prolonged period of time, while not requiring complicated manufacturing processes.Type: ApplicationFiled: July 19, 2011Publication date: January 19, 2012Applicant: pSivida Inc.Inventors: Jianbing Chen, Paul Ashton, Thomas J. Smith
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Publication number: 20110243659Abstract: The present invention provides a method and pavement structure for protecting highway subgrade in frozen soil areas. The pavement structure has two or more pavement layers having gradient thermal conductivity; the thermal conductivity is layered among the pavement layers and is lowered from top to bottom, so that the pavement forms a uni-directional thermal conducting tunnel from the subgrade to the air. Heat can be easily released from the subgrade into the air, and is prevented from being transferred from the air to the subgrade. In this way, the frozen soil layer beneath the subgrade is cooled, so that the frozen soil table is made stable, and the highway subgrade in frozen soil areas is protected.Type: ApplicationFiled: December 31, 2009Publication date: October 6, 2011Inventors: Shuangjie Wang, Shengyue Wang, Jianbing Chen, Xiaofeng Zhou, Juan Zhang, Qiyang Zhu
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Publication number: 20110183944Abstract: Compositions for controlled release of one or more therapeutic agents where the composition is essentially free of excipients are disclosed. In particular, compositions comprising a HMG-CoA reductase inhibitor, particularly simvastatin, and a NSAID, such as a COX-2 inhibitor, particularly celecoxib, in which greater than 90% of the weight of the composition is made up of the HMG-CoA reductase inhibitor and NSAID are provided.Type: ApplicationFiled: January 27, 2011Publication date: July 28, 2011Inventors: Paul Ashton, Hong Guo, Jianbing Chen, Tadeusz Cynkowski, Grazyna Cynkowska
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Publication number: 20110165242Abstract: The invention provides liquid controlled-release drug delivery compositions which gel upon injection into the body to form, in situ, controlled-release drug implants. The compositions of the invention feature a gel-forming polymer that is insoluble in water, a polyethylene glycol solvent in which the polymer is dissolved, and the drug substance to be delivered.Type: ApplicationFiled: August 27, 2010Publication date: July 7, 2011Applicant: pSivida Inc.Inventors: Dongling Su, Paul Ashton, Jianbing Chen
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Publication number: 20110129541Abstract: The invention relates to a novel suspension delivery system for the sustained and controlled release of pharmaceuticals. Methods of preparation and use are also disclosed.Type: ApplicationFiled: August 27, 2010Publication date: June 2, 2011Applicant: Control Delivery Systems, Inc.Inventors: Jianbing Chen, Hong Guo, Paul Ashton
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Publication number: 20100278931Abstract: The invention provides a biodegradable drug-eluting particle useful for the delivery of diagnostic or therapeutic agents. In certain embodiments, the drug-eluting particle of the invention comprises a biodegradable porous silicon body, a reservoir formed within the porous silicon body having at least one opening to an exterior of the body, wherein the reservoir contains a therapeutic or diagnostic agent, and an agent-permeable seal disposed over the at least one opening. The invention further provides a method for treating a patient to obtain a desired local or systemic physiological or pharmacological effect comprising administering a sustained release drug delivery particle of the invention.Type: ApplicationFiled: May 4, 2010Publication date: November 4, 2010Applicant: pSivida US, Inc.Inventors: Paul Ashton, Hong Guo, Jianbing Chen, Leigh Canham
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Publication number: 20100080830Abstract: The systems and methods disclosed herein provide sustained delivery of a therapeutic agent for treating a patient, e.g., human, to obtain a desired local or systemic physiological or pharmacological effect. Method includes positioning the sustained released drug delivery system at an area wherein release of the agent is desired and allowing the agent to pass through the device to the desired area of treatment. In some embodiments, the method is for treating or reducing the risk of retroviral or lentiviral infection. In certain embodiments, the method is for preventing or reducing the risk of mother-to-child transmission of HIV, wherein the therapeutic agent is an antiviral agent.Type: ApplicationFiled: December 3, 2009Publication date: April 1, 2010Applicant: pSivida Inc.Inventors: Paul Ashton, Jianbing Chen, Thomas J. Smith
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Publication number: 20090163457Abstract: The invention relates to codrugs having improved properties, methods for preparing and administering them, and methods of formulating and administering the codrugs as pharmaceutical preparations. In certain embodiments, the codrugs can be locally administered to deliver the constituent biologically active compound in a sustained-release fashion, reducing systemic concentrations of the biologically active compound.Type: ApplicationFiled: November 26, 2008Publication date: June 25, 2009Applicant: pSivida, Inc.Inventors: Paul Ashton, Jianbing Chen, Hong Guo, Grazyna Cynkowska, Tadeusz Cynkowski