Abstract: A programmable control and operation system is applied in a swing pressure adsorption process. The system comprises a computer, a driving device, and a plurality of programmable control valve assemblies. The programmable control valve assembly comprises an operating valve with at least one cavity for sealing control, a valve core, a sealing ring, an operation device, a sealing control valve, and a valve position detector. The operation of the sealing control valve is dependent on the open or closed position of the valve and the process of opening and closing the valve. The sealing control valve feeds a sealing control medium at a pressure to the cavity for sealing the operating valve. The sealing control medium acts on the sealing ring to increase the pressure at the valve core to seal the operating valve. The control and operation system provide independent control of the sealing valve and operating valve to increase reliability and durability.