Abstract: An apparatus includes an eyeglass frame, a first antenna, a second antenna, and a parasitic element. The eyeglass frame can include at least one rim. The first antenna can be attached to the eyeglass frame. The second antenna can be attached to the eyeglass frame. The second antenna can be disposed on a first side of the at least one rim. The parasitic element can be attached to the eyeglass frame. The parasitic element can be on a second side of the at least one rim. The second side of the at least one rim can be opposite from the first side. A distance from the first antenna to the second antenna can be greater than a distance from the first antenna to the parasitic element. The distance from the first antenna to the second antenna can be greater than a distance from the second antenna to the parasitic element.

Abstract: Solid forms of Compound (I): are disclosed. Pharmaceutical compositions comprising the same, methods of treating disorders and conditions mediated by BTK activity using the same, and methods for making Compound (I) and solid forms thereof are also disclosed.

Abstract: The present invention provides novel scaffolded HIV-1 vaccine immunogens. Some of the scaffolded immunogens contain a soluble gp140 trimer linked to the N-terminus of the nanoparticle subunit and a T-helper epitope that is fused via a short peptide spacer to the C-terminus of the nanoparticle subunit. Some other immunogens of the invention contain a soluble gp140 trimer protein that is linked to a stable nanoparticle via a short peptide spacer that is a T-helper epitope. Some of the scaffolded immunogens contain a gp140 trimer immunogen presented on a nanoparticle platform formed with I3-01 protein, E2p, or variants of protein 1VLW. Also provided in the invention are nucleic acids that encode the various vaccine immunogens described herein, and expression vectors and host cells harboring the nucleic acids. The invention further provides methods of using the scaffolded HIV-1 vaccine immunogens for preventing or treating HIV infections.

Abstract: The present invention provides methods for producing scaffolded (e.g., nanoparticle presented) or non-scaffolded vaccines that are based on viral immunogenic proteins with a glycan shielded (e.g., HIV-1 Env). The vaccines thus generated demonstrate enhanced immunogenicity and responder frequency. The methods entail (1) enzymatic digestion of glycan chain on the surface of a viral trimer protein immunogen or a self-assembling nanoparticle vaccine displaying the viral immunogen (e.g., an HIV-1 UFO trimer), or (2) expression of a construct encoding the vaccine in an expression system lacking normal glycosylation function for human proteins. Also provided in the invention are vaccine compositions produced with the described methods. The invention further provides methods of using the vaccine compositions described herein (e.g., scaffolded or non-scaffolded HIV-1 vaccines) in various therapeutic applications, e.g., for preventing or treating viral infections.

Abstract: The present invention provides methods for producing HIV-1 nanoparticle vaccines with enhanced immunogenicity. The methods entail (1) enzymatic digestion of glycan chain on the surface of a self-assembling nanoparticle vaccine displaying an HIV-1 Env derived trimer immunogen, or (2) expression of an HIV-1 nanoparticle construct in an expression system lacking normal glycosylation function for human proteins. Also provided in the invention are HIV-1 nanoparticle vaccines produced with the described methods. The invention further provides methods of using the HIV-1 nanoparticle vaccine compositions described herein in various therapeutic applications, e.g., for preventing or treating viral infections.

Abstract: Crystalline forms of Compound (I): are disclosed. Pharmaceutical compositions comprising the same, methods of inhibiting BTK using the same, and methods for making crystalline forms of Compound (I) are also disclosed.

Abstract: The technology provides for an electronic device. The electronic device includes a housing, a display cover, and a modular component configured to provide a seal between the housing to the display cover. The modular component is configured to be attached to the housing. Further, the modular component includes a first surface configured to be attached to the display cover. The modular component includes a channel extending along the first surface, where the channel is configured to hold a liquid adhesive that bonds with the display cover. The modular component further includes a radial protrusion disposed on the first surface, the radial protrusion is configured to be in contact with the display cover when the display cover is attached to the housing and to prevent the liquid adhesive from moving out of the channel.

Abstract: The technology provides for a pair of earbuds. For instance, a first earbud may include a first antenna, and a second earbud may include a second antenna. The pair of earbuds may further include one or more processors configured to receive, from the first antenna, a first signal from a beacon, and receive, from the second antenna, a second signal from the beacon. Based on the first signal and the second signal, the one or more processors may determine at least one signal strength. The one or more processors may determine a position of the user relative to the beacon based on the at least one signal strength.

Abstract: A chip module has a plurality of first ports, at least some or all of the first ports are first selection ports, and each first selection port may act as a write port or a read port. The chip module further includes a first control module. The first control module controls, based on a transmit/receive requirement of the chip module, the first selection port to be switched to a read port or a write port, to match the transmit/receive requirement of the chip module. The first selection port may selectively act as a read port or a write port, so that switching can be performed based on an operating state of the chip module, increasing a read/write bandwidth. The first control module controls an operating state of the first selection port, to flexibly adjust a quantity of read ports and a quantity of write ports of the chip module.

Abstract: The present disclosure provides an ultrasound therapy system and a dose control method. The system includes: a control device; a first ultrasound irradiation device configured to generate multiple groups of ultrasound irradiation doses driven by the control device and conduct ultrasound irradiation on a cell culture device with multiple groups of abnormally proliferating living cells; a characterization image capture device configured to capture performance characteristic data of living cells in the cell culture device, where the control device is further configured to determine an ultrasound irradiation dose corresponding to at least one group of abnormally proliferating living cells with a cell target characteristic characterization as a target ultrasound irradiation dose according to the performance characteristic data; and a second ultrasound irradiation device configured to conduct ultrasound irradiation of the target ultrasound irradiation dose on a living organism with abnormal proliferation.

Abstract: A magnetic resonance imaging (MRI) contrast agent and a preparation method and a use thereof is provided, which belong to the technical field of Magnetic Resonance Imaging contrast agent. The MRI contrast agent is prepared by the compound having a structure of formula I; and it also may include the compound having a structure of formula II or a pharmaceutically acceptable salt thereof, wherein M1 is a divalent ion or a trivalent ion of a paramagnetic metal selected from Mn, Fe, Eu, or Dy; M2 is selected from Na+, K+ or meglumine cation; when M1 is a divalent ion, a is 2; when M1 is a trivalent ion, a is 3. The MRI contrast agent has good water solubility, high relaxivity, and low toxic and side effect.

Abstract: An equalization training method and apparatus are described. The method includes obtaining a training rate of each of a master chip and a slave chip in a target phase of equalization training. The method also includes determining a target rate threshold interval within which the training rate in the target phase falls, determining, based on a correspondence between N+1 rate threshold intervals and N+1 equalization timeout periods, a target equalization timeout period corresponding to the target rate threshold interval, and configuring the target equalization timeout period as an equalization timeout period in the target phase.

Abstract: Systems, methods, and apparatuses, including electronic devices and computer-readable storage media, for adaptively switching wireless connections between antennas of a wearable electronic device and a host electronic device. One device includes a wearable electronic device with a first and second housing, each housing including two or more antennas. The wearable electronic device is configured to establish and monitor a wireless cross-link between two antennas in different housings, or between antennas in one housing and antennas of a host electronic device. The wearable electronic device can monitor the integrity of the wireless cross-link, and establish an updated cross-link in response to the wireless cross-link not meeting a predetermined integrity threshold. The wearable electronic device can monitor a wireless cross-head link between housings of a wearable electronic device at the same time as a wireless cross-body link between the wearable electronic device and the host electronic device.

Abstract: The present disclosure provides an ultrasound therapy system and a dose control method. The system includes: a control device; a first ultrasound irradiation device configured to generate multiple groups of ultrasound irradiation doses driven by the control device and conduct ultrasound irradiation on a cell culture device with multiple groups of abnormally proliferating living cells; a characterization image capture device configured to capture performance characteristic data of living cells in the cell culture device, where the control device is further configured to determine an ultrasound irradiation dose corresponding to at least one group of abnormally proliferating living cells with a cell target characteristic characterization as a target ultrasound irradiation dose according to the performance characteristic data; and a second ultrasound irradiation device configured to conduct ultrasound irradiation of the target ultrasound irradiation dose on a living organism with abnormal proliferation.

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract: Provided is a method for manufacturing a printed circuit board with electronic component; including: mounting an electronic component on an insulating substrate; applying an insulating first coating resin to at least a part of the electronic component; curing the first coating resin; applying an insulating second coating resin to the cured first coating resin; and curing the second coating resin.

Abstract: A foldable camping chair, including a foldable supporting frame which includes a connecting unit arranged between two front supporting blocks, a rear supporting block and the two front supporting blocks defining a triangular shape, two side connecting rods, and two front connecting rods; two recessed grooves are formed on a front side of the rear supporting block; two ends of each side connecting rod are movably articulated with a corresponding recessed groove and fixedly plugged in a corresponding front supporting block respectively; two ends of each front connecting rod is movably articulated with an end of the connecting unit and a front supporting block respectively; lower and upper ends of each front supporting block are plugged with a front supporting leg and a front supporting rod respectively; lower and upper ends of the rear supporting block are plugged with a rear supporting leg and a rear supporting rod respectively.

Abstract: The present invention provides novel engineered HCV E2 polypeptide immunogens and related vaccine compositions that display the engineered E2 polypeptides. The invention also provides methods of using such immunogens and vaccine compositions in various therapeutic applications, e.g., for preventing or treating HCV infections.

Abstract: A merchant evaluation method includes: acquiring multi-dimensional evaluation index data of a merchant to be evaluated; for the multi-dimensional evaluation index data, obtaining, by calculation based on standard normal distribution, a health portrait of the merchant to be evaluated, and obtaining, by calculation based on a geometric mean, a health score of the merchant to be evaluated, wherein the health portrait is data representing at least one evaluation result of the merchant to be evaluated; and outputting the health portrait and the health score of the merchant to be evaluated.

Abstract: Systems, methods, and apparatuses, including electronic devices and computer-readable storage media, for adaptively switching wireless connections between antennas of a wearable electronic device and a host electronic device. One device includes a wearable electronic device with a first and second housing, each housing including two or more antennas. The wearable electronic device is configured to establish and monitor a wireless cross-link between two antennas in different housings, or between antennas in one housing and antennas of a host electronic device. The wearable electronic device can monitor the integrity of the wireless cross-link, and establish an updated cross-link in response to the wireless cross-link not meeting a predetermined integrity threshold. The wearable electronic device can monitor a wireless cross-head link between housings of a wearable electronic device at the same time as a wireless cross-body link between the wearable electronic device and the host electronic device.