Patents by Inventor Jianwen Gu
Jianwen Gu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250249254Abstract: Systems and methods for schedule neuromodulation therapy are disclosed. An exemplary system comprises an electrostimulator and a controller. The electrostimulator can be configured to provide electrostimulation to a neural target of a patient. The controller circuit can be operably connected to the electrostimulator. The controller circuit can be configured to determine an activity parameter based on a schedule parameter of the patient, wherein the schedule parameter is associated with a schedule of the patient; determine stimulation parameters based on the activity parameter; and deliver the electrostimulation to the neural target of the patient using the stimulation parameters.Type: ApplicationFiled: January 15, 2025Publication date: August 7, 2025Inventors: Jessica Block, Tianhe Zhang, Jianwen Gu, Satya Venkata Sandeep Avvaru
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Publication number: 20250249251Abstract: Methods and systems for stimulation of the vagus nerve of a patient using a stimulation system is described herein. The stimulation system including a control module and at least one stimulation lead coupleable to the control module, the at least one stimulation lead including a plurality of electrodes. The method includes implanting the at least one stimulation lead percutaneously or through an opening in the carotid sheath with placement of the electrodes proximate to the vagus nerve for stimulation of the vagus nerve; implanting the control module remote from the vagus nerve; generating stimulation signals using the control module; and delivering the stimulation signals from the control module through at least one of the electrodes of the at least one stimulation lead to stimulate the vagus nerve of the patient.Type: ApplicationFiled: February 3, 2025Publication date: August 7, 2025Inventors: Jianwen Gu, Rosana Esteller, Ranjan Krishna Mukhari Nageri
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Publication number: 20250242159Abstract: A multi-modal method of stimulation to provide therapy for an epilepsy patient. A neuroprotective therapy including both an electrical modulation signal and an optical modulation signal is generated on a periodic or scheduled basis. The patient is monitored, and if a trigger condition arises indicating one of potential seizure onset, seizure onset, or an ongoing seizure, a symptom modulation therapy is initiated. The neuroprotective therapy and the symptom modulation therapy may have different targets and other parameters.Type: ApplicationFiled: January 29, 2025Publication date: July 31, 2025Applicant: Boston Scientific Neuromodulation CorporationInventors: Jianwen Gu, Changfang Zhu
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Publication number: 20250222260Abstract: Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain.Type: ApplicationFiled: March 28, 2025Publication date: July 10, 2025Inventors: Que T. Doan, Jianwen Gu, Ismael Huertas Fernandez, Rosana Esteller, Michael A. Moffitt
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Publication number: 20250222259Abstract: Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain.Type: ApplicationFiled: March 14, 2025Publication date: July 10, 2025Inventors: Que T. Doan, Jianwen Gu, Ismael Huertas Fernandez, Rosana Esteller, Michael A. Moffitt
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Patent number: 12285609Abstract: Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain.Type: GrantFiled: August 16, 2024Date of Patent: April 29, 2025Assignee: Boston Scientific Neuromodulation CorporationInventors: Que T. Doan, Jianwen Gu, Ismael Huertas Fernandez, Rosana Esteller, Michael A. Moffitt
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Publication number: 20250114601Abstract: A system may be configured for treating a patient with epileptic seizures. The system may include a therapy delivery system configured to use a set of electrodes positioned adjacent to a spinal cord or dorsal column nuclei and a stimulation configuration to deliver neuromodulation energy to at least one target neural pathway in or near the spinal cord. The at least one target neural pathway includes the dorsal column nuclei or axons projecting to the dorsal column nuclei. The dorsal column nuclei and the axons are somatotopically organized and project to at least one of a cerebellum, a thalamus or a brainstem, which include somatotopically organized nuclei and project axons to different areas of a cortex. The at least one target neural pathway corresponds to at least one of the different areas of the cortex in which the epileptic seizures were located.Type: ApplicationFiled: September 23, 2024Publication date: April 10, 2025Inventors: Jianwen Gu, Rosana Esteller
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Publication number: 20250114610Abstract: Methods and systems for modulating the neuroimmune response while monitoring biomarkers that may directly or indirectly correlate with neuroimmune function. A neuromodulation therapy may be delivered, and a biomarker level determined. Some biomarker levels are determined from bodily fluid collected from the patient, and are compared to a predetermined threshold level. A therapeutic stimulation is delivered to a patient using one or more electrode leads, and/or optical fibers.Type: ApplicationFiled: October 8, 2024Publication date: April 10, 2025Applicant: Boston Scientific Neuromodulation CorporationInventors: Jianwen Gu, Bradley Lawrence Hershey, Changfang Zhu
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Patent number: 12268875Abstract: Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain.Type: GrantFiled: March 21, 2024Date of Patent: April 8, 2025Assignee: Boston Scientific Neuromodulation CorporationInventors: Que T. Doan, Jianwen Gu, Ismael Huertas Fernandez, Rosana Esteller, Michael A. Moffitt
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Publication number: 20250082938Abstract: Methods and systems for addressing issues related to synchrony in neural tissue signals. A spectrum of neural signals in a patient may be measured while the patient is asymptomatic, and compared to signals during a symptomatic episode to determine whether neural signals should be enhanced or disrupted. Depending on the change to neural signals, either enhancing or disrupting neural therapy is generated and confirmed or adjusted.Type: ApplicationFiled: September 6, 2024Publication date: March 13, 2025Applicant: Boston Scientific Neuromodulation CorporationInventor: Jianwen Gu
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Publication number: 20250073470Abstract: An example of a system may include a processor and a memory device comprising instructions, which when executed by the processor, cause the processor to: access a patient metric of a subject; use the patient metric as an input to a machine learning algorithm, the machine learning algorithm to search a plurality of neuromodulation parameter sets and to identify a candidate neuromodulation parameter set of the plurality of neuromodulation parameter sets, the candidate neuromodulation parameter set designed to produce a non-regular waveform that varies over a time domain and a space domain; and program a neuromodulator using the candidate neuromodulation parameter set to stimulate the subject.Type: ApplicationFiled: November 18, 2024Publication date: March 6, 2025Inventors: Michael A. Moffitt, Natalie A. Brill, Jianwen Gu, Juan Gabriel Hincapie Ordonez, Changfang Zhu, Hemant Bokil, Stephen Carcieri
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Publication number: 20250058116Abstract: A multi-modal method of stimulation to the basal forebrain to enhance the neuroprotective effects of deep brain stimulation and photobiomodulation. Stimulation is generated by a lead that incorporates optical devices and electrodes placed either intracranially or intranasally. By using this combination therapy, both electrical and optical stimulation, and its therapeutic benefits, can be incorporated within one treatment regimen.Type: ApplicationFiled: August 14, 2024Publication date: February 20, 2025Applicant: Boston Scientific Neuromodulation CorporationInventors: Jianwen Gu, Changfang Zhu
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Patent number: 12226225Abstract: This document discusses, among other things, systems and methods for managing pain in a patient. A system may include sensors to sense physiological or functional signals, and a pain analyzer that generates a pain score using the sensed physiological or functional signals and a fusion model. The system includes a calibration module that calibrates the fusion model based on measurements from the sensed physiological or functional signals and a reference pain quantification corresponding to multiple pain intensities. A pain score may be generated using the calibrated fusion model. The system can additionally include a neurostimulator that controls the delivery of pain therapy by adjusting one or more stimulation parameters based on the pain score.Type: GrantFiled: July 26, 2021Date of Patent: February 18, 2025Assignee: Boston Scientific Neuromodulation CorporationInventors: Elizabeth Mary Annoni, Jianwen Gu, Pramodsingh Hirasingh Thakur, Bryan Allen Clark, Kyle Harish Srivastava
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Publication number: 20250050109Abstract: A system may be configured for treating a condition and may include at least one therapy delivery system, at least one event detector and a controller. The therapy delivery system(s) may be configured to deliver at least two therapies to at least two therapy targets including deliver a first therapy to a first therapy target and deliver a second therapy to a second therapy target. The event detector(s) may be configured to detect at least one predefined event. The controller may be configured to coordinate the therapies based on the detected predefined event(s) using at least one defined event-therapy relationship.Type: ApplicationFiled: August 5, 2024Publication date: February 13, 2025Inventors: Jianwen Gu, Rosana Esteller
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Patent number: 12201838Abstract: This document discusses, among other things, systems and methods for managing pain in a subject. A system may include one or more sensors configured to sense from the subject information corresponding to emotional reaction to pain, such as emotional expression. The emotional expression includes facial or vocal expression. A pain analyzer circuit may generate a pain score using signal metrics of facial or vocal expression extracted from the sensed information. The pain score may be output to a user or a process. The system may additionally include a neurostimulator that can adaptively control the delivery of pain therapy by automatically adjusting stimulation parameters based on the pain score.Type: GrantFiled: December 20, 2022Date of Patent: January 21, 2025Assignee: Boston Scientific Neuromodulation CorporationInventors: Kyle Harish Srivastava, Bryan Allen Clark, Elizabeth Mary Annoni, Sandra Nagale, Pramodsingh Hirasingh Thakur, Jianwen Gu, David L. Perschbacher
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Patent number: 12172019Abstract: An example of a system may include a processor and a memory device comprising instructions, which when executed by the processor, cause the processor to: access a patient metric of a subject; use the patient metric as an input to a machine learning algorithm, the machine learning algorithm to search a plurality of neuromodulation parameter sets and to identify a candidate neuromodulation parameter set of the plurality of neuromodulation parameter sets, the candidate neuromodulation parameter set designed to produce a non-regular waveform that varies over a time domain and a space domain; and program a neuromodulator using the candidate neuromodulation parameter set to stimulate the subject.Type: GrantFiled: April 26, 2023Date of Patent: December 24, 2024Assignee: Boston Scientific Neuromodulation CorporationInventors: Michael A. Moffitt, Natalie A. Brill, Jianwen Gu, Juan Gabriel Hincapie Ordonez, Changfang Zhu, Hemant Bokil, Stephen Carcieri
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Publication number: 20240408394Abstract: Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain.Type: ApplicationFiled: August 16, 2024Publication date: December 12, 2024Inventors: Que T. Doan, Jianwen Gu, Ismael Huertas Fernandez, Rosana Esteller, Michael A. Moffitt
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Publication number: 20240226558Abstract: Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain.Type: ApplicationFiled: March 21, 2024Publication date: July 11, 2024Inventors: Que T. Doan, Jianwen Gu, Ismael Huertas Fernandez, Rosana Esteller, Michael A. Moffitt
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Publication number: 20240198112Abstract: This document discusses, among other things, systems and methods for managing pain of a subject. A system includes a first sensor circuit to sense a first signal indicative of a functional state of the subject, a second sensor circuit to sense a second signal different from the first signal, and a controller circuit. The controller circuit may determine an operating mode of the second sensor circuit according to the sensed first signal, trigger the second senor circuit to sense the second signal under the determined operating mode, and generate a pain score using at least the second signal sensed under the determined operating mode. The pain score may be output to a patient or used for closed-loop control of a pain therapy.Type: ApplicationFiled: February 26, 2024Publication date: June 20, 2024Inventors: Kyle Harish Srivastava, Pramodsingh Hirasingh Thakur, Dat Thanh Huynh, Bryan Allen Clark, Jianwen Gu
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Patent number: 11957912Abstract: This document discusses, among other things, systems and methods for managing pain of a subject. A system includes a first sensor circuit to sense a first signal indicative of a functional state of the subject, a second sensor circuit to sense a second signal different from the first signal, and a controller circuit. The controller circuit may determine an operating mode of the second sensor circuit according to the sensed first signal, trigger the second senor circuit to sense the second signal under the determined operating mode, and generate a pain score using at least the second signal sensed under the determined operating mode. The pain score may be output to a patient or used for closed-loop control of a pain therapy.Type: GrantFiled: August 10, 2022Date of Patent: April 16, 2024Assignee: Boston Scientific Neuromodulation CorporationInventors: Kyle Harish Srivastava, Pramodsingh Hirasingh Thakur, Dat Thanh Huynh, Bryan Allen Clark, Jianwen Gu