Abstract: Methods, systems, devices and computer implemented methods of prognosing or classifying patients using a biomarker comprising a plurality of subnetwork modules are disclosed. In some embodiments, the method comprises determining an activity of a plurality of genes in a test sample of a patient, wherein the plurality of genes are associated with the plurality of subnetwork modules. An expression profile is constructed using the activity of the plurality of genes. The dysregulation of each of the plurality of subnetwork modules is determined by calculating a score proportional to a degree of dysregulation in each of the plurality of subnetwork modules from the expression profile. The patient is prognosed or classified by inputting each dysregulation score into a model for predicting patient outcomes for patients having a disease, and inputting a clinical indicator of the patient into the model, to obtain a risk associated with the disease.

Abstract: A multichannel constant current LED driving circuit can include: (i) a power stage circuit having a power switching transistor, an inductor, and a rectifier circuit, where the power stage circuit is configured to receive a DC bus voltage, and to generate a pseudo-constant output signal to drive a plurality of LED strings; (ii) a current control unit configured to control an average current of each of the plurality of LED strings in accordance with a corresponding one of a plurality of dimming signals; and (iii) the current control unit being configured to control the power switching transistor in accordance with a current feedback signal that represents a current flowing through the LED strings, where the plurality of LED strings are coupled in series to receive the pseudo-constant output signal.

Abstract: A multichannel constant current LED controlling circuit can include: (i) a control loop configured to generate a first control signal in accordance with a current feedback signal that represents a driving current flowing through an LED load, where the LED load comprises a plurality of LED strings coupled in series; (ii) a loop steady state network comprising a plurality of steady state holding components configured to hold a plurality of steady state control signals that correspond to a plurality of load states of the LED load, where when a state of the LED load varies, at least one of the steady state holding components is selected by the control loop to generate the first control signal; and (iii) a power switching transistor of a power stage circuit configured to generate a pseudo-constant output current to drive the LED load.

Abstract: In one embodiment, a control circuit configured to control a power stage circuit of a primary-controlled flyback converter, can include: (i) a current sense circuit that generates a current sense signal by sampling a primary current; (ii) a voltage sense circuit that generates a voltage sense signal by sampling an auxiliary voltage after a blanking time has elapsed; (iii) a control signal generator that generates a switch control signal according to the voltage sense signal and the current sense signal; and (iv) the switch control signal being configured to control a power switch of the power stage circuit, where the switch control signal is active during a constant on time.

Abstract: A computer-implemented method is provided to detect a compromised Certificate Authority (CA). Over time reports are received containing data describing certificate authority certificates captured from messages exchanged between clients and servers. These reports may be received by a central computing entity. Metadata and statistics for certificates contained in the reports are stored. It is determined whether a certificate authority has been compromised based on the metadata and statistics.

Abstract: A low-back-pressure penetrating arc welding apparatus and a welding method using the same are disclosed. Through vacuuming a central vacuum chamber of a low-back-pressure protection device by a suction device, a plume of a penetrating arc located in the central vacuum chamber, as well as a back side of a keyhole molten pool, are maintained in a negative-pressure vacuum state relative to an argon gas ambience. A pressure gradient in the keyhole molten pool is thus generated that points from a front side of the keyhole molten pool to the back side of the keyhole molten pool. The pressure gradient thus further enhances a stiffness of the front side of the keyhole molten pool as well as a stability of the penetrating arc, resulting in an enhancement in the piercing capability of the penetrating arc, without changing a force distribution and a temperature gradient of the keyhole molten pool.

Abstract: In one embodiment, a control circuit configured to control a power stage circuit of a primary-controlled flyback converter, can include: (i) a current sense circuit that generates a current sense signal by sampling a primary current; (ii) a voltage sense circuit that generates a voltage sense signal by sampling an auxiliary voltage after a blanking time has elapsed; (iii) a control signal generator that generates a switch control signal according to the voltage sense signal and the current sense signal; and (iv) the switch control signal being configured to control a power switch of the power stage circuit, where the switch control signal is active during a constant on time.

Abstract: The present disclosure relates to LED driving circuit and method using a single inductor. A constant current controller controls a power stage circuit to provide a constant output signal, and thus to provide a constant current signal for an LED load. A dimming controller regulates luminance of the LED load. A constant voltage generating circuit receives the current signal at an output terminal of the power stage circuit and a reserve supply voltage for providing a supply voltage for the dimming controller. Compared with the prior art, the present disclosure does not need an independent power supply chip, and reduces components such as inductors and rectifying transistors. Thus, a peripheral circuit is simplified, and an overall size of the system is reduced.

Abstract: The present disclosure relates to an LED driving circuit and method using a single inductor. A constant current controller controls a power stage circuit to provide a constant output signal, and thus to provide a constant current signal for an LED load. A dimming controller regulates luminance of the LED load. A constant voltage generating circuit receives the current signal at an output terminal of the power stage circuit and a reserve supply voltage for providing a supply voltage for the dimming controller. Compared with the prior art, the present disclosure does not need an independent power supply chip, and reduces components such as inductors and rectifying transistors. Thus, a peripheral circuit is simplified, and an overall size of the system is reduced.

Abstract: An LED driving circuit for driving an LED load including N LED strings, where N is a positive integer no less than 2, can include: (i) a power converter having a power switch; (ii) a constant current control circuit that controls a switching operation of the power switch such that the power converter generates a driving current for the LED load; (iii) N control switches respectively coupled in series to the N LED strings; (iv) a PWM signal generator configured to generate N color tuning PWM signals; and (v) a color tuning control circuit configured to output N switching control signals according to the N color tuning PWM signals, to control switching operations of the N control switches, to regulate a ratio of a current through each LED string of the LED load to the driving current, and to regulate the color temperature of the LED load.

Abstract: A card connector is disclosed having a base and a plurality of contacts. The plurality of contacts is positioned on the base. Each of the contacts has a contacting portion electrically contacting an electrical card when the electrical card inserted into the card connector. Each contact has an outer facing surface, and a supporting portion having two elastic arms extending from the base and intersecting at the contacting portion. Each of the elastic arms has a guide arm portion extending from the contacting portion at an angle of approximately 0 to 90 degrees with respect to a card insertion direction. Each guide arm portions has a smooth, ridge-shaped convex surface extending to the contacting portion and a smooth transitional surface with the outer facing surface of the contacting portion.

Abstract: A computer-implemented method is provided to detect a compromised Certificate Authority (CA). Over time reports are received containing data describing certificate authority certificates captured from messages exchanged between clients and servers. These reports may be received by a central computing entity. Metadata and statistics for certificates contained in the reports are stored. It is determined whether a certificate authority has been compromised based on the metadata and statistics.

Abstract: The disclosure relates to a control circuit, a control method and a flyback converter of primary-side feedback control including the control circuit. On the basis of the current sampling signal feedback, the flyback converter of primary-side feedback control is controlled to operate in a constant on time mode when the input voltage is large, and is controlled to operate in a peak current mode when the input voltage is close to a valley. Thus, the peak value of the primary-side current may not become too small because of a decreased input voltage, further avoiding occurrence of an error sampling after a blanking time due to excessive variations in demagnetization time.

Abstract: In one embodiment, a control circuit can include: a voltage feedback circuit configured to obtain a voltage feedback signal that represents an output voltage of the power stage circuit; a set signal generator configured to output a set signal when a secondary current crosses zero or a voltage sampling signal reaches a valley value; a reset signal generator configured to output a reset signal in a constant on time mode when the voltage feedback signal is greater than a first voltage threshold value, and to output the reset signal in a peak current mode when the voltage feedback signal is less than the first voltage threshold value; and a logic circuit configured to activate a switching control signal according to the set signal, and to deactivate the switching control signal according to the reset signal.

Abstract: A multichannel constant current LED driving circuit can include: (i) a power stage circuit having a power switching transistor, an inductor, and a rectifier circuit, where the power stage circuit is configured to receive a DC bus voltage, and to generate a pseudo-constant output signal to drive a plurality of LED strings; (ii) a current control unit configured to control an average current of each of the plurality of LED strings in accordance with a corresponding one of a plurality of dimming signals; and (iii) the current control unit being configured to control the power switching transistor in accordance with a current feedback signal that represents a current flowing through the LED strings, where the plurality of LED strings are coupled in series to receive the pseudo-constant output signal.

Abstract: A low-back-pressure penetrating arc welding apparatus and a welding method using the same are disclosed. Through vacuuming a central vacuum chamber of a low-back-pressure protection device by a suction device, a plume of a penetrating arc located in the central vacuum chamber, as well as a back side of a keyhole molten pool, are maintained in a negative-pressure vacuum state relative to an argon gas ambience. A pressure gradient in the keyhole molten pool is thus generated that points from a front side of the keyhole molten pool to the back side of the keyhole molten pool. The pressure gradient thus further enhances a stiffness of the front side of the keyhole molten pool as well as a stability of the penetrating arc, resulting in an enhancement in the piercing capability of the penetrating arc, without changing a force distribution and a temperature gradient of the keyhole molten pool.

Abstract: An electrical connector having a body having a shoulder receiving recess formed in a terminal end wall, and a plurality of contacts positioned in the body. Each contact has a pin projecting from a terminal end of the body. Each pin has a base with a pair of protruding shoulders.

Abstract: A multichannel constant current LED driving circuit can include: (i) a power stage circuit having a power switching transistor, an inductor, and a rectifier circuit, where the power stage circuit is configured to receive a DC bus voltage, and to generate a pseudo-constant output signal to drive a plurality of LED strings; (ii) a current control unit configured to control an average current of each of the plurality of LED strings in accordance with a corresponding one of a plurality of dimming signals; and (iii) the current control unit being configured to control the power switching transistor in accordance with a current feedback signal that represents a current flowing through the LED strings, where the plurality of LED strings are coupled in series to receive the pseudo-constant output signal.

Abstract: Systems and methods for a device connected to a private network to efficiently retrieve a software/firmware update. The device may retrieve an update scheme that defines an external Uniform Resource Identifier (URI) for a resource external to the private network and a primary URI for a primary resource connected to the private network. The device may compare own Internet Protocol address and the primary URI to determine whether or not the device is the primary resource. When the device is the primary resource, the device may retrieve the software/firmware update from the external URI.

Abstract: A card connector is disclosed having a base and a plurality of contacts. The plurality of contacts is positioned on the base. Each of the contacts has a contacting portion electrically contacting an electrical card when the electrical card inserted into the card connector. Each contact has an outer facing surface, and a supporting portion having two elastic arms extending from the base and intersecting at the contacting portion. Each of the elastic arms has a guide arm portion extending from the contacting portion at an angle of approximately 0 to 90 degrees with respect to a card insertion direction. Each guide arm portions has a smooth, ridge-shaped convex surface extending to the contacting portion and a smooth transitional surface with the outer facing surface of the contacting portion.