Patents by Inventor Jianxin Zhao

Jianxin Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250082699
    Abstract: The disclosure provides Bifidobacterium longum subsp. infantis CCFM1269 and an application thereof, and belongs to the technical field of microorganisms. The B. longum subsp. infantis CCFM1269 provided by the disclosure is a food safety strain, which has the effects of regulating the Th1/Th2 balance and the IgA content of a mammal in an early life stage, enhancing the skeletal development, improving the femur length and skeletal steady state in the early life stage and the like, and thus the strain has a huge application prospect. Only a culture medium and control of some culture conditions are needed in a culture process of the strain, so that the cost is relatively low, and industrial production is easily implemented.
    Type: Application
    Filed: November 26, 2024
    Publication date: March 13, 2025
    Inventors: Bo YANG, Wei CHEN, Mengfan DING, Bowen LI, Haiqin CHEN, Jianxin ZHAO, Hao ZHANG
  • Publication number: 20250049304
    Abstract: A reversal system for a surgical instrument including: first and second outer achromats each having, first and second lenses, and first and second inner achromats arranged between the first and second outer achromats. Each of the first and second inner achromats having first and second lenses. A first pair of the first outer achromat and the first inner achromat being arranged symmetrically with respect to a second pair of the second outer achromat and the second inner achromat.
    Type: Application
    Filed: July 15, 2024
    Publication date: February 13, 2025
    Applicant: OLYMPUS Winter & Ibe GmbH
    Inventor: Jianxin ZHAO
  • Patent number: 12207663
    Abstract: The present disclosure discloses a method for reducing the fructan content in food made of rice and flour using microwave heating and belongs to the technical field of food processing. Fermented products made of rice and flour are prepared using microwave heating and fructan in the products can be effectively degraded. Compared with traditional steaming, the method can remarkably reduce the fructan content in the fermented food, effectively alleviate the bowel stress sensitivity to the fermented rice and flour food by patients with irritable bowel syndrome (IBS), meet the daily dietary requirements of special crowds, has the advantages of simple process, green processing and environmental protection, and is suitable for large-scale industrial production.
    Type: Grant
    Filed: July 22, 2022
    Date of Patent: January 28, 2025
    Assignees: Jiangnan University, Wuxi HuashunMinsheng Food Co. Ltd., Sichuan Anjoy Food Co. Ltd., Hubei Anjoy Food Co. Ltd., Henan Anjoy Food Co. Ltd.
    Inventors: Bowen Yan, Daming Fan, Yejun Wu, Huizhang Lian, Kai Wang, Dongna Ruan, Zhongliang Hu, Chao Chen, Bowen Wang, Siyi Fang, Nana Zhang, Jianxin Zhao, Hao Zhang, Wei Chen
  • Publication number: 20250002893
    Abstract: The present disclosure discloses a method for improving acetate tolerance and lipid accumulation of an oleaginous microorganism using an acetyl-CoA synthetase (ACS) and belongs to the technical fields of genetic engineering and microbial engineering. The present disclosure overexpresses endogenous constitutive MaACS in Mortierella alpina, improves the acetate tolerance and lipid yield of the recombinant strain, and the proportion of polyunsaturated fatty acids, and further improves the lipid accumulation using a culture medium taking ammonium acetate as a nitrogen source. The present expresses a citrate lyase ACL1 while overexpressing the MaACS in a combined manner, or expresses glucose-6-phosphate dehydrogenase G6PD2 to equilibrate the supply of reducing power NADPH so as to avoid the overflow of the acetyl-CoA, or knocks down a ? subunit SNF1 ? of a sucrose non-fermenting-related protein kinase which negatively regulates lipid accumulation to improve the activity of an acetyl-CoA carboxylase 1.
    Type: Application
    Filed: September 11, 2024
    Publication date: January 2, 2025
    Inventors: Haiqin Chen, Lulu Chang, Bo Yang, Jianxin Zhao, Wei Chen
  • Publication number: 20240424037
    Abstract: The present disclosure discloses a strain of Lactobacillus pentosus capable of relieving pathological characteristics of mice infected with influenza virus and application thereof, and belongs to the field of microorganisms. The strain of L. pentosus CCFM1227 provided by the present disclosure can effectively improve the innate immune response of the mice infected with influenza virus so as to prevent and/or relieve influenza virus infection. In addition, the L. pentosus CCFM1227 of the present disclosure can be used for fermenting phloretin to produce deaminotyrosine. Therefore, the L. pentosus CCFM1227 has a great application prospect in preparation of products for preventing and/or relieving influenza virus infection.
    Type: Application
    Filed: September 10, 2024
    Publication date: December 26, 2024
    Inventors: Wenwei Lu, Qianwen Wang, Jianxin Zhao, Hongchao Wang, Shenyan Ma, Wei Chen, Hao Zhang
  • Publication number: 20240374660
    Abstract: The present disclosure relates to a Bifidobacterium longum CCFM1206 capable of producing sulforaphane and relieving inflammation, and belongs to the field of microbial technology. B. longum CCFM1206 provided by the present disclosure can convert glucoraphanin to sulforaphane, promoting the metabolism of glucoraphanin and the generation of sulforaphane in mammals. The B. longum CCFM1206 according to the present disclosure can be used alone or in combination with glucoraphanin to relieve weight loss during ulcerative colitis, reduce the release of pro-inflammatory factors from the colon, improve the colonic barrier function, relieve the splenomegaly due to systemic inflammation, reduce the levels of pro-inflammatory factors in the serum, reduce the levels of pro-inflammatory factors in the liver tissues and increase the levels of anti-inflammatory factors, and increase the levels of short-chain fatty acids.
    Type: Application
    Filed: July 23, 2024
    Publication date: November 14, 2024
    Inventors: Bingyong MAO, Jiaying Wu, Shumao Cui, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Wei Chen
  • Patent number: 12123037
    Abstract: Disclosed is linoleic acid isomerases and their application in production of conjugated linoleic acid, which belongs to the technical fields of protein engineering and microbial engineering. The linoleic acid isomerase derived from Bifidobacterium is used to produce the conjugated linoleic acid. The recombinant E. coli containing the linoleic acid isomerase of the invention is added into a reaction system containing linoleic acid and react for 3 h to produce conjugated linoleic acids. The conversion rate of the conjugated linoleic acid of the invented method ranges from 12.1% to 42.1%, and the percentage of cis9, trans11-CLA in the conjugated linoleic acid can reach 84.3% to 89.1%. The invention provides a method for using microorganisms to produce conjugated linoleic acids with high safety and yield where cis9, trans11-CLA isomer is the major form in the conjugated linoleic acid products.
    Type: Grant
    Filed: October 10, 2021
    Date of Patent: October 22, 2024
    Assignee: Jiangnan University
    Inventors: Haiqin Chen, Bo Yang, He Gao, Jianxin Zhao, Yongquan Chen, Hao Zhang, Wei Chen
  • Patent number: 12077787
    Abstract: Disclosed is a diacylglycerol acyltransferase 1, a recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1, and application thereof in production of triacylglycerol. The diacylglycerol acyltransferase 1 of the invention has a function of catalyzing synthesis of triacylglycerol. After the recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1 of the invention is subjected to induction culture for 48 h, the content of total fatty acid and triacylglycerol in the recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1 can be respectively increased by 1.94 folds and 12.09 folds as compared with those of Saccharomyces cerevisiae without the recombinant diacylglycerol acyltransferase 1. The instant invention provides a method for improving the ability of microorganisms to produce polyunsaturated fatty acids (PUFAs) by means of genetic engineering.
    Type: Grant
    Filed: September 9, 2021
    Date of Patent: September 3, 2024
    Assignee: Jiangnan University
    Inventors: Haiqin Chen, Wei Chen, Xin Tang, Jun Cao, Jianxin Zhao, Yongquan Chen, Hao Zhang
  • Publication number: 20240277784
    Abstract: The present disclosure discloses a strain of highly organic zinc-enriched Bifidobacterium animalis capable of promoting growth and reproductive development, belonging to the technical field of microorganisms. The B. animalis CCFM1230 screened by the present disclosure can efficiently enrich inorganic zinc and convert same into organic zinc, which is better absorbed and utilized by organisms, and effectively promotes growth and reproductive development. Animal experiments have proved that zinc-rich B. animalis can promote the growth and reproductive development of male rat pups, exert higher biological activity than inorganic zinc, and meet the physiological requirements of zinc supplementation. According to the present disclosure, the B. animalis CCFM1230 can efficiently enrich inorganic zinc for the preparation of a probiotic preparation capable of promoting growth and reproductive development, and thus has great application prospects in the field of food or medicine.
    Type: Application
    Filed: April 30, 2024
    Publication date: August 22, 2024
    Inventors: Bingyong MAO, Shumao Cui, Xinran Han, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Wei Chen
  • Publication number: 20240268640
    Abstract: An endoscope including: an optical filter arrangement having: a holder; and an optical filter having one of different filter properties in different directions or multiple optical filters with different filter properties, the optical filter being arranged in the holder to rotate about an axis of rotation in at least one beam path of the endoscope in a direction of light incidence in or behind an objective of the endoscope and in front of an image capturing unit or an eyepiece; wherein the optical filter arrangement is configured to change from a first filter property to a second filter property when the optical filter is rotated by 90° about the axis of rotation from a first target rotational position to a second target rotational position.
    Type: Application
    Filed: April 26, 2024
    Publication date: August 15, 2024
    Applicant: OLYMPUS WINTER & IBE GMBH
    Inventor: Jianxin ZHAO
  • Publication number: 20240268638
    Abstract: Attachment optics for use with a camera head for fluorescence imaging in open surgery. The attachment optics including: an optical system comprising, in progression from distal to proximal: a distal group of first and second meniscus lenses, is the first meniscus lens having a negative meniscus and the second meniscus lens having a positive meniscus, a biplanar glass rod; and a third meniscus lens. Where the first and second meniscus lenses of the distal group are made from different glass types having Abbé numbers ?1, ?2 with ? "\[LeftBracketingBar]" ? 1 - ? 2 ? "\[RightBracketingBar]" < 20 , and refractive indexes n1, n2 with 0.02 < ? "\[LeftBracketingBar]" n 1 - n 2 ? "\[RightBracketingBar]" < 0.07 and where the ratio of a focal length F of the optical system to the maximum outer diameter D of the first and second meniscus lenses of the distal group is F/D>10.
    Type: Application
    Filed: November 13, 2023
    Publication date: August 15, 2024
    Applicant: OLYMPUS Winter & Ibe GmbH
    Inventor: Jianxin ZHAO
  • Patent number: 12041952
    Abstract: The present invention discloses a microwave and conduction combined heating method for improving the gel strength of surimi products, belonging to the technical field of food processing. According to the present invention, surimi is first fully gelatinized by conduction heating, and then heated by microwave heating so that surimi gel can pass through a gel cracking zone quickly. This kind of microwave and conduction combined heating way can not only increase the gel strength of the surimi to achieve the desired elasticity, but also can save a lot of time and improve the production efficiency. Compared with ordinary microwave heating, the microwave and conduction combined heating method of the conduction and microwave heat preservation, i.e.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: July 23, 2024
    Assignees: JIANGNAN UNIVERSITY, ANJOY FOODS GROUP CO., LTD.
    Inventors: Daming Fan, Jianlian Huang, Hongwei Cao, Xuepeng Li, Hao Zhang, Wenguo Zhou, Bowen Yan, Xidong Jiao, Tenghui Yu, Wenhai Zhang, Weijian Ye, Jiangping Chen, Dengying Lei, Jianxin Zhao, Qingmiao Zhang, Wei Chen
  • Patent number: 11992186
    Abstract: An endoscope including: an optical filter arrangement having: a holder; and an optical filter having one of different filter properties in different directions or multiple optical filters with different filter properties, the optical filter being arranged in the holder to rotate about an axis of rotation in at least one beam path of the endoscope in a direction of light incidence in or behind an objective of the endoscope and in front of an image capturing unit or an eyepiece; wherein the optical filter arrangement is configured to change from a first filter property to a second filter property when the optical filter is rotated by 90° about the axis of rotation from a first target rotational position to a second target rotational position.
    Type: Grant
    Filed: August 26, 2020
    Date of Patent: May 28, 2024
    Assignee: OLYMPUS WINTER & IBE GMBH
    Inventor: Jianxin Zhao
  • Publication number: 20240000871
    Abstract: The present disclosure discloses Lactobacillus gasseri capable of alleviating and treating hyperuricemia, which belongs to the technical field of microorganisms. The L. gasseri CCFM1133 of the present disclosure can reduce serum uric acid levels and the activity of serum and liver xanthine oxidase (XOD) of mice with hyperuricemia, and reduce the occurrence of hyperuricemia and gout; regulate glucose and serum triglyceride (TG) levels of patients with hyperuricemia, increase the activity of liver catalase (CAT) and glutathione peroxidase (GSH-Px); increase the expression of ileum ABCG2, promote the excretion of intestinal uric acid; and increase intestinal short-chain fatty acid levels to promote health. The L. gasseri CCFM1133 of the present disclosure can be used for preparing food, functional food or medicines, and has a wide application prospect.
    Type: Application
    Filed: June 15, 2023
    Publication date: January 4, 2024
    Inventors: Gang WANG, Caixin NI, Linlin WANG, Jianxin ZHAO, Hao ZHANG, Wei CHEN
  • Publication number: 20230381254
    Abstract: The present disclosure discloses Lactobacillus reuteri CCFM1132 capable of relieving hyperuricemia and application thereof, which belongs to the technical field of microorganisms. The L. reuteri CCFM1132 can reduce serum uric acid levels of mice with hyperuricemia, inhibit the activity of serum and liver xanthine oxidase (XOD), and reduce the occurrence of hyperuricemia and gout; reduce serum creatinine levels, reduce serum total triglyceride (TG) levels, and inhibit the activity of serum alkaline phosphatase (ALP); and promote the expression of ileum uric acid transporter ABCG2. The L. reuteri CCFM1132 of the present disclosure can be used for preparing functional bacterial agents, food and medicines for relieving hyperuricemia and gout, and has a wide application prospect.
    Type: Application
    Filed: June 15, 2023
    Publication date: November 30, 2023
    Inventors: Gang WANG, Caixin NI, Yuxing ZHENG, Linlin WANG, Jianxin ZHAO, Hao ZHANG, Wei CHEN
  • Patent number: 11822957
    Abstract: The present disclosure provides a task migration method, apparatus, electronic device and storage medium, and relates to the technical field of data processing. The method may include: obtaining a task submitted by a user; in the case that the task is a Hadoop task and it is determined that task conversion is to be performed, converting Hadoop parameters in the task into parameters recognizable by a Spark; and injecting a conversion result into a predetermined kit and submitting the predetermined kit to a Spark cluster. The solution of the present disclosure may be applied to reduce the user's workload and enhance the processing efficiency etc.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: November 21, 2023
    Assignee: BAIDU ONLINE NETWORK TECHNOLOGY (BEIJING) CO., LTD.
    Inventors: Haijiao Hao, Xuguang Lv, Jianxin Zhao, Linhong Liu, Hao Li
  • Publication number: 20230346856
    Abstract: The disclosure discloses a strain of Bifidobacterium breve capable of preventing and relieving psoriasis and application thereof, belonging to the field of microbial technologies and medical technologies. The disclosure provides new uses of B. breve CCFM1078 in inhibiting the release of IL-23/Th17 axis related inflammatory factors, and relieving the psoriasis. The B. breve CCFM1078 of the disclosure can relieve the lesion skin of psoriasis-like mice, and can inhibit thickening of the skin epidermal layer, so that the IL-23 level, the IL-22 level and the IL-17 level in the skin decrease by 20.3%, 22.0% and 18.3%, respectively. The B. breve CCFM1078 has a great application prospect in the preparation of a product (such as a food, a drug or a health food) for preventing and/or treating psoriasis.
    Type: Application
    Filed: June 21, 2023
    Publication date: November 2, 2023
    Inventors: Wei CHEN, Wenwei LU, Yadan DENG, Qixiao ZHAI, Bo YANG, Shumao CUI, Bingyong MAO, Hongchao WANG, Jianxin ZHAO, Hao ZHANG
  • Patent number: 11805578
    Abstract: The disclosure discloses a microwave processing equipment for continuous flow liquids, and belongs to the technical field of microwave processing. The microwave processing equipment includes a feed preheating section, a microwave heating section and a cooling section. The microwave heating section includes a microwave generation system, a waveguide system, tuners, and a microwave absorption cavity. The waveguide system includes at least two waveguides. Each waveguide is installed at the microwave feed port formed in the outer wall of the microwave absorption cavity according to a predetermined angle greater than or equal to 15° and less than 90°.
    Type: Grant
    Filed: August 10, 2020
    Date of Patent: October 31, 2023
    Assignees: JIANGNAN UNIVERSITY, NANJING XIANOU INSTRUMENTS MANUFACTURE CO., LTD
    Inventors: Daming Fan, Wenhua Gao, Huayu Yang, Hao Zhang, Bowen Yan, Yuhao Zhang, Jianxin Zhao, Wei Chen
  • Patent number: 11766165
    Abstract: An optical system for a stereo-video endoscope, the optical system including: first and second lens system channels having first and second optical elements on first and second optical axes, respectively, the first and second optical axes being parallel to each other; wherein the first and second optical elements are each arranged symmetrically relative to each other about a plane of symmetry between the first and second lens system channels and the first and second optical elements comprise first and second D-cut lenses, respectively, each of the first and second D-cut lenses having a boundary surface which is set back relative to the plane of symmetry; and the boundary surface of each of the first and second D-cut lenses are inclined with respect of the plane of symmetry.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: September 26, 2023
    Assignee: OLYMPUS WINTER & IBE GMBH
    Inventor: Jianxin Zhao
  • Publication number: 20230263844
    Abstract: The disclosure relates to Bifidobacterium longum for preventing and/or treating essential hypertension, and belongs to the technical fields of microorganisms and medicine. The B. longum CCFM752 provided by the disclosure prevents essential hypertension, specifically including: (1) significantly decreasing the O2- level, the H2O2 level and the NADPH oxidase activity in A7R5 cells stimulated with Angiotensin II; (2) significantly increasing the CAT activity in A7R5 cells, aortas of SHRs and serum of SHRs; (3) significantly decreasing the blood pressure level of SHRs; (4) significantly decreasing the aortic wall ROS level, the aortic wall NADPH oxidase activity, the aortic wall collagen level and the aortic wall thickness index of SHRs; and (5) significantly increasing the aortic wall eNOS activity of SHRs. It can be seen that the B. longum CCFM752 has great application prospects in preparation of products (such as food or drugs) for preventing and/or treating hypertension.
    Type: Application
    Filed: March 29, 2023
    Publication date: August 24, 2023
    Inventors: Wenwei Lu, Wei Chen, Yusheng Wang, Qixiao Zhai, Jianxin Zhao, Hao Zhang