Abstract: The present disclosure discloses multifunctional lactobacilli capable of relieving a toxic effect of perfluorooctanoic acid (PFOA) and use thereof, and belongs to the technical field of microorganisms.

Abstract: Described is a B. breve strain for relieving rheumatoid arthritis and application thereof, belonging to the technical field of microorganisms. Described is a B. breve strain CCFM1078 possessing the effect of relieving rheumatoid arthritis, and shown to: promote secretion of anti-inflammatory factor IL-10 from RAW264.7 cells; reduce joint thickness, clinical score, and incidence of rats with rheumatoid arthritis; decrease levels of the pro-inflammatory cytokines TNF? and IL-1? in the serum of rats with rheumatoid arthritis; regulate the content of short-chain fatty acids in the feces of rats with rheumatoid arthritis; decrease the proportion of Th17 cells in the mesenteric lymph nodes of rats with rheumatoid arthritis; and reduce secretion of pro-inflammatory factor IL-6 from synovial cells.

Abstract: Disclosed is a Lactobacillus plantarum and an application thereof in the production of urolithin A, belonging to the technical field of biology. The disclosure provides a Lactiplantibacillus plantarum CCFM1290 preserved in Guangdong Microbial Culture Collection Center (GDMCC) with a preservation number of GDMCC No: 62801 and a preservation date of Sep. 15, 2022. The L. plantarum CCFM1290 may convert ETs into various Uros represented by Uro-A. A fermented product or compound preparation provided by the disclosure may relieve muscle function damage. Compared with a control group, the fermented product and compound preparation may improve the swimming capability of Caenorhabditis elegans by 33.84% and 27.99%. Finally, Uro-type substances such as Uro-A obtained by this biosynthesis method may be applied to functional food development to achieve beneficial effects of delaying senescence, keeping muscles healthy, etc.

Abstract: The disclosure discloses a strain of Lactobacillus crispatus capable of preventing and/or treating Helicobacter pylori infection, and belongs to the technical fields of microorganisms and medicine. The disclosure provides a strain of Lactobacillus crispatus CCFM1118. The Lactobacillus crispatus CCFM1118 can inhibit Helicobacter pylori, specifically embodied in that: (1) the diameter of an inhibition zone of supernatant of the Lactobacillus crispatus CCFM1118 on Helicobacter pylori can reach 13.14 mm; and (2) the Lactobacillus crispatus CCFM1118 can significantly reduce the adhesion of Helicobacter pylori to AGS cells. Therefore, the Lactobacillus crispatus CCFM1118 has great application prospects in inhibiting Helicobacter pylori (not for the purposes of disease diagnosis and treatment) and preparing Helicobacter pylori inhibitors.

Abstract: The disclosure discloses Bifidobacterium longum with the ability to relieve atopic dermatitis and its application, and belongs to the technical fields of microorganisms and medicine. The Bifidobacterium longum of the disclosure has the effects of relieving atopic dermatitis, and the effects are specifically embodied in: (1) significantly improving the degree of ear swelling in mice with atopic dermatitis; (2) significantly improving skin pathological symptoms and inflammatory cell infiltration in mice with atopic dermatitis; (3) significantly reducing the serum IgE level in mice with atopic dermatitis; (4) significantly reducing the levels of IL-4 and IL-13 in the skin tissues of mice with atopic dermatitis; and (5) significantly reducing the level of histamine in the skin tissues of mice with atopic dermatitis. Therefore, the Bifidobacterium longum has great application prospects in the preparation of products for the prevention and/or treatment of atopic dermatitis.

Abstract: The disclosure discloses a strain of Lactobacillus rhamnosus and application thereof in inhibiting Helicobacter pylori, and belongs to the technical fields of microorganisms and medicine. The disclosure provides a strain of Lactobacillus rhamnosus CCFM1119. The Lactobacillus rhamnosus CCFM1119 can prevent and/or treat Helicobacter pylori infection, specifically embodied in that: (1) the Lactobacillus rhamnosus CCFM1119 can significantly relieve the gastrointestinal symptoms of patients with Helicobacter pylori infection; (2) the Lactobacillus rhamnosus CCFM1119 can significantly reduce the amount of colonization of Helicobacter pylori in patients with Helicobacter pylori infection; and (3) the Lactobacillus rhamnosus CCFM1119 can significantly increase the clearance rate of Helicobacter pylori in patients with Helicobacter pylori infection.

Abstract: The disclosure provides Bifidobacterium longum subsp. infantis CCFM1269 and an application thereof, and belongs to the technical field of microorganisms. The B. longum subsp. infantis CCFM1269 provided by the disclosure is a food safety strain, which has the effects of regulating the Th1/Th2 balance and the IgA content of a mammal in an early life stage, enhancing the skeletal development, improving the femur length and skeletal steady state in the early life stage and the like, and thus the strain has a huge application prospect. Only a culture medium and control of some culture conditions are needed in a culture process of the strain, so that the cost is relatively low, and industrial production is easily implemented.

Abstract: A reversal system for a surgical instrument including: first and second outer achromats each having, first and second lenses, and first and second inner achromats arranged between the first and second outer achromats. Each of the first and second inner achromats having first and second lenses. A first pair of the first outer achromat and the first inner achromat being arranged symmetrically with respect to a second pair of the second outer achromat and the second inner achromat.

Abstract: The present disclosure discloses a method for reducing the fructan content in food made of rice and flour using microwave heating and belongs to the technical field of food processing. Fermented products made of rice and flour are prepared using microwave heating and fructan in the products can be effectively degraded. Compared with traditional steaming, the method can remarkably reduce the fructan content in the fermented food, effectively alleviate the bowel stress sensitivity to the fermented rice and flour food by patients with irritable bowel syndrome (IBS), meet the daily dietary requirements of special crowds, has the advantages of simple process, green processing and environmental protection, and is suitable for large-scale industrial production.

Abstract: The present disclosure discloses a method for improving acetate tolerance and lipid accumulation of an oleaginous microorganism using an acetyl-CoA synthetase (ACS) and belongs to the technical fields of genetic engineering and microbial engineering. The present disclosure overexpresses endogenous constitutive MaACS in Mortierella alpina, improves the acetate tolerance and lipid yield of the recombinant strain, and the proportion of polyunsaturated fatty acids, and further improves the lipid accumulation using a culture medium taking ammonium acetate as a nitrogen source. The present expresses a citrate lyase ACL1 while overexpressing the MaACS in a combined manner, or expresses glucose-6-phosphate dehydrogenase G6PD2 to equilibrate the supply of reducing power NADPH so as to avoid the overflow of the acetyl-CoA, or knocks down a ? subunit SNF1 ? of a sucrose non-fermenting-related protein kinase which negatively regulates lipid accumulation to improve the activity of an acetyl-CoA carboxylase 1.

Abstract: The present disclosure discloses a strain of Lactobacillus pentosus capable of relieving pathological characteristics of mice infected with influenza virus and application thereof, and belongs to the field of microorganisms. The strain of L. pentosus CCFM1227 provided by the present disclosure can effectively improve the innate immune response of the mice infected with influenza virus so as to prevent and/or relieve influenza virus infection. In addition, the L. pentosus CCFM1227 of the present disclosure can be used for fermenting phloretin to produce deaminotyrosine. Therefore, the L. pentosus CCFM1227 has a great application prospect in preparation of products for preventing and/or relieving influenza virus infection.

Abstract: The present disclosure relates to a Bifidobacterium longum CCFM1206 capable of producing sulforaphane and relieving inflammation, and belongs to the field of microbial technology. B. longum CCFM1206 provided by the present disclosure can convert glucoraphanin to sulforaphane, promoting the metabolism of glucoraphanin and the generation of sulforaphane in mammals. The B. longum CCFM1206 according to the present disclosure can be used alone or in combination with glucoraphanin to relieve weight loss during ulcerative colitis, reduce the release of pro-inflammatory factors from the colon, improve the colonic barrier function, relieve the splenomegaly due to systemic inflammation, reduce the levels of pro-inflammatory factors in the serum, reduce the levels of pro-inflammatory factors in the liver tissues and increase the levels of anti-inflammatory factors, and increase the levels of short-chain fatty acids.

Abstract: Disclosed is linoleic acid isomerases and their application in production of conjugated linoleic acid, which belongs to the technical fields of protein engineering and microbial engineering. The linoleic acid isomerase derived from Bifidobacterium is used to produce the conjugated linoleic acid. The recombinant E. coli containing the linoleic acid isomerase of the invention is added into a reaction system containing linoleic acid and react for 3 h to produce conjugated linoleic acids. The conversion rate of the conjugated linoleic acid of the invented method ranges from 12.1% to 42.1%, and the percentage of cis9, trans11-CLA in the conjugated linoleic acid can reach 84.3% to 89.1%. The invention provides a method for using microorganisms to produce conjugated linoleic acids with high safety and yield where cis9, trans11-CLA isomer is the major form in the conjugated linoleic acid products.

Abstract: Disclosed is a diacylglycerol acyltransferase 1, a recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1, and application thereof in production of triacylglycerol. The diacylglycerol acyltransferase 1 of the invention has a function of catalyzing synthesis of triacylglycerol. After the recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1 of the invention is subjected to induction culture for 48 h, the content of total fatty acid and triacylglycerol in the recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1 can be respectively increased by 1.94 folds and 12.09 folds as compared with those of Saccharomyces cerevisiae without the recombinant diacylglycerol acyltransferase 1. The instant invention provides a method for improving the ability of microorganisms to produce polyunsaturated fatty acids (PUFAs) by means of genetic engineering.

Abstract: The present disclosure discloses a strain of highly organic zinc-enriched Bifidobacterium animalis capable of promoting growth and reproductive development, belonging to the technical field of microorganisms. The B. animalis CCFM1230 screened by the present disclosure can efficiently enrich inorganic zinc and convert same into organic zinc, which is better absorbed and utilized by organisms, and effectively promotes growth and reproductive development. Animal experiments have proved that zinc-rich B. animalis can promote the growth and reproductive development of male rat pups, exert higher biological activity than inorganic zinc, and meet the physiological requirements of zinc supplementation. According to the present disclosure, the B. animalis CCFM1230 can efficiently enrich inorganic zinc for the preparation of a probiotic preparation capable of promoting growth and reproductive development, and thus has great application prospects in the field of food or medicine.

Abstract: Attachment optics for use with a camera head for fluorescence imaging in open surgery. The attachment optics including: an optical system comprising, in progression from distal to proximal: a distal group of first and second meniscus lenses, is the first meniscus lens having a negative meniscus and the second meniscus lens having a positive meniscus, a biplanar glass rod; and a third meniscus lens. Where the first and second meniscus lenses of the distal group are made from different glass types having Abbé numbers ?1, ?2 with ? "\[LeftBracketingBar]" ? 1 - ? 2 ? "\[RightBracketingBar]" < 20 , and refractive indexes n1, n2 with 0.02 < ? "\[LeftBracketingBar]" n 1 - n 2 ? "\[RightBracketingBar]" < 0.07 and where the ratio of a focal length F of the optical system to the maximum outer diameter D of the first and second meniscus lenses of the distal group is F/D>10.

Abstract: An endoscope including: an optical filter arrangement having: a holder; and an optical filter having one of different filter properties in different directions or multiple optical filters with different filter properties, the optical filter being arranged in the holder to rotate about an axis of rotation in at least one beam path of the endoscope in a direction of light incidence in or behind an objective of the endoscope and in front of an image capturing unit or an eyepiece; wherein the optical filter arrangement is configured to change from a first filter property to a second filter property when the optical filter is rotated by 90° about the axis of rotation from a first target rotational position to a second target rotational position.

Abstract: The present invention discloses a microwave and conduction combined heating method for improving the gel strength of surimi products, belonging to the technical field of food processing. According to the present invention, surimi is first fully gelatinized by conduction heating, and then heated by microwave heating so that surimi gel can pass through a gel cracking zone quickly. This kind of microwave and conduction combined heating way can not only increase the gel strength of the surimi to achieve the desired elasticity, but also can save a lot of time and improve the production efficiency. Compared with ordinary microwave heating, the microwave and conduction combined heating method of the conduction and microwave heat preservation, i.e.

Abstract: An endoscope including: an optical filter arrangement having: a holder; and an optical filter having one of different filter properties in different directions or multiple optical filters with different filter properties, the optical filter being arranged in the holder to rotate about an axis of rotation in at least one beam path of the endoscope in a direction of light incidence in or behind an objective of the endoscope and in front of an image capturing unit or an eyepiece; wherein the optical filter arrangement is configured to change from a first filter property to a second filter property when the optical filter is rotated by 90° about the axis of rotation from a first target rotational position to a second target rotational position.

Abstract: The present disclosure discloses Lactobacillus gasseri capable of alleviating and treating hyperuricemia, which belongs to the technical field of microorganisms. The L. gasseri CCFM1133 of the present disclosure can reduce serum uric acid levels and the activity of serum and liver xanthine oxidase (XOD) of mice with hyperuricemia, and reduce the occurrence of hyperuricemia and gout; regulate glucose and serum triglyceride (TG) levels of patients with hyperuricemia, increase the activity of liver catalase (CAT) and glutathione peroxidase (GSH-Px); increase the expression of ileum ABCG2, promote the excretion of intestinal uric acid; and increase intestinal short-chain fatty acid levels to promote health. The L. gasseri CCFM1133 of the present disclosure can be used for preparing food, functional food or medicines, and has a wide application prospect.