Patents by Inventor Jiawei Yao

Jiawei Yao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetically modified non-human animal with human or chimeric CD28
    Patent number: 11350614
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD28, and methods of use thereof.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: June 7, 2022
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Yang Bai, Yanan Guo, Meiling Zhang, Rui Huang, Chengzhang Shang, Jiawei Yao
  • Genetically modified non-human animal with human or chimeric OX40
    Patent number: 11279948
    Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric OX40, and methods of use thereof.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: March 22, 2022
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Chaoshe Guo, Yang Bai, Jiawei Yao, Meiling Zhang, Xiaofei Zhou
  • Genetically modified non-human animal with human or chimeric PD-1
    Patent number: 11272695
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) programmed cell death protein 1 (PD-1), and methods of use thereof. In one aspect, the animals have an insertion of a sequence encoding a human or humanized programmed cell death protein 1 (PD-1) at an endogenous PD-1 gene locus. This animal model can express a PD-1 protein containing a functional domain of the human PD-1 protein, and can be used as an animal model for developing therapeutics for human diseases and disorders, and assessing the toxicity and/or the efficacy of these human therapeutics.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: March 15, 2022
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Rui Huang, Xiaofei Zhou, Meiling Zhang, Jiawei Yao, Chaoshe Guo
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD137
    Publication number: 20220071185
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD137, and methods of use thereof.
    Type: Application
    Filed: September 23, 2021
    Publication date: March 10, 2022
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Lei Zhao, Rui Huang, Jiawei Yao, Meiling Zhang
  • Genetically modified non-human animal with human or chimeric IL15
    Patent number: 11234421
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL15, and methods of use thereof.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: February 1, 2022
    Assignees: Biocytogen JiangSu Co., Ltd., Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Meiling Zhang, Jiawei Yao, Chaoshe Guo, Yanan Guo, Yang Bai, Rui Huang, Lei Zhao
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC GENES
    Publication number: 20220015343
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL6R and/or IL6, and methods of use thereof.
    Type: Application
    Filed: December 17, 2019
    Publication date: January 20, 2022
    Inventors: Yuelei Shen, Meiling Zhang, Jiawei Yao, Chaoshe Guo, Yanan Guo, Yang Bai, Rui Huang, Lei Zhao, Chengzhang Shang
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC GENES
    Publication number: 20220000086
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL4R and/or IL4, and methods of use thereof.
    Type: Application
    Filed: September 23, 2021
    Publication date: January 6, 2022
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Rui Huang, Xiaofei Zhou, Chengzhang Shang, Meiling Zhang, Jiawei Yao, Chaoshe Guo
  • GENETICALLY MODIFIED ANIMAL WITH CANINE OR CHIMERIC PD-1
    Publication number: 20210400933
    Abstract: The present disclosure relates to genetically modified animals that express a canine or chimeric (e.g., caninized) programmed cell death protein 1 (PD-1), and methods of use thereof.
    Type: Application
    Filed: November 19, 2019
    Publication date: December 30, 2021
    Inventors: Yuelei Shen, Yang Bai, Rui Huang, Xiaofei Zhou, Chengzhang Shang, Meiling Zhang, Jiawei Yao, Chaoshe Guo, Yanan Guo
  • Genetically modified non-human animal with human or chimeric CD137
    Patent number: 11154040
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD137, and methods of use thereof.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: October 26, 2021
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Lei Zhao, Rui Huang, Jiawei Yao, Meiling Zhang
  • Genetically modified non-human animal with human or chimeric genes
    Patent number: 11154041
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL4R and/or IL4, and methods of use thereof.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: October 26, 2021
    Assignees: Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Biocytogen JiangSu Co., Ltd.
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Rui Huang, Xiaofei Zhou, Chengzhang Shang, Meiling Zhang, Jiawei Yao, Chaoshe Guo
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD3e
    Publication number: 20210259220
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD3e (T-cell surface glycoprotein CD3 epsilon chain), and methods of use thereof.
    Type: Application
    Filed: February 5, 2021
    Publication date: August 26, 2021
    Inventors: Yuelei Shen, Yanan Guo, Rui Huang, Xiaofei Zhou, Yang Bai, Jiawei Yao, Chaoshe Guo
  • Method of using a genetically modified mouse that expresses a humanized CTLA-4 gene
    Patent number: 11096383
    Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric CTLA-4, and methods of use thereof.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: August 24, 2021
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Jiawei Yao, Chengzhang Shang, Rui Huang
  • Genetically modified non-human animal with human or chimeric CTLA-4
    Patent number: 11071290
    Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric CTLA-4, and methods of use thereof.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: July 27, 2021
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Jiawei Yao, Chengzhang Shang, Rui Huang
  • IMMUNODEFICIENT NON-HUMAN ANIMAL
    Publication number: 20210105982
    Abstract: The present disclosure relates to the genetically modified non-human animals that have a disruption at the endogenous CD132 gene (e.g.
    Type: Application
    Filed: September 24, 2020
    Publication date: April 15, 2021
    Inventors: Yuelei Shen, Yang Bai, Meiling Zhang, Jiawei Yao, Rui Huang, Yanan Guo
  • Genetically modified non-human animal with human or chimeric CD3e
    Patent number: 10945420
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD3e (T-cell surface glycoprotein CD3 epsilon chain), and methods of use thereof.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: March 16, 2021
    Assignees: BiocytogenPharmaceuticals (Beijing) Co., Ltd., Biocytogen JiangSu Co., Ltd.
    Inventors: Yuelei Shen, Yanan Guo, Rui Huang, Xiaofei Zhou, Yang Bai, Jiawei Yao, Chaoshe Guo
  • Genetically modified non-human animal with human or chimeric GITR
    Patent number: 10945419
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) glucocorticoid-induced TNFR-related protein (GITR), and methods of use thereof.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: March 16, 2021
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Jiawei Yao, Rui Huang, Lei Zhao, Meiling Zhang
  • HUMANIZED TRANSGENIC ANIMAL
    Publication number: 20210068379
    Abstract: Provided are a humanized transgenic non-human animal, especially a rodent, in particular a transgenic mouse containing a human interleukin 17A (IL-17A) gene, a human gene 17RA (IL-17RA) and/or a human TNF-alpha gene, and a preparation method therefor and the use thereof.
    Type: Application
    Filed: November 4, 2020
    Publication date: March 11, 2021
    Inventors: Yuelei Shen, Chaoshe Guo, Yanan Guo, Yang Bai, Rui Huang, Lei Zhao, Xiaofei Zhou, Meiling Zhang, Jiawei Yao
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC IL15
    Publication number: 20210051928
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL15, and methods of use thereof.
    Type: Application
    Filed: September 4, 2020
    Publication date: February 25, 2021
    Inventors: Yuelei Shen, Meiling Zhang, Jiawei Yao, Chaoshe Guo, Yanan Guo, Yang Bai, Rui Huang, Lei Zhao
  • Genetically modified non-human animal with human or chimeric LAG-3
    Patent number: 10925264
    Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric (e.g., humanized) Lymphocyte Activation Gene 3 (LAG-3), and methods of use thereof.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: February 23, 2021
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd
    Inventors: Yuelei Shen, Yanan Guo, Chaoshe Guo, Yang Bai, Jiawei Yao, Lei Zhao, Rui Huang
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC GENES
    Publication number: 20210045367
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL4R and/or IL4, and methods of use thereof.
    Type: Application
    Filed: September 2, 2020
    Publication date: February 18, 2021
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Rui Huang, Xiaofei Zhou, Chengzhang Shang, Meiling Zhang, Jiawei Yao, Chaoshe Guo