Abstract: A detection device includes a substrate and a die. The substrate provides a first voltage. The die is disposed adjacent to the substrate. The die includes a plurality of resistor paths, a selection circuit, an ADC (Analog-to-Digital Converter), and a digital circuit. The selection circuit selects one of the resistor paths as a target path. The target path provides a second voltage. The ADC generates a digital signal according to the first voltage and the second voltage. The digital circuit processes the digital signal.

Abstract: The present disclosure provides a method of preparing olefins from methanol, in which methanol and phenol-like molecules are used as raw material, which is gasified and then passed into a two-stage fixed-bed catalytic reactor. The raw material reacts with a catalyst A (silica-aluminum molecular sieve) and a catalyst B (silica-aluminum or phosphorus-aluminum molecular sieve) in sequence to produce ethylene.

Abstract: The present disclosure relates to novel pan-KRAS glutarimide-containing compounds with KRAS degradation activities, pharmaceutical compositions containing such compounds, and their use in prevention and treatment diseases and conditions.

Abstract: The present disclosure relates to novel glutarimide-containing compounds with KRAS mutant form degradation activities, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of diseases and conditions.

Abstract: The present disclosure relates to novel SOS1 inhibitors, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions.

Abstract: The present disclosure relates to novel quinolinone-8-carbonitrile based compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions. The compounds disclosed herein exhibit androgen receptor degradation activity.

Abstract: The invention proposes a kind of bending bolt type anti-loosening nut, which relates to the technical field of mechanical fastening. It comprises an upper nut and a lower nut, the upper nut and the lower nut are stacked on the outside of the bolt and used to tightly connect the bolt to the connecting piece, the lower nut is arranged close to the connecting piece, the upper nut is arranged on the outer end surface of the lower nut; the adjacent end between the upper nut and lower nut is provided with an inclined surface, the inclined surface is inclined towards the interior of the upper nut, so that an inclined plane angle with deformation space between the upper nut and lower nut is formed; the invention achieves the effect of preventing nut loosening, is low in price, easy to manufacture, and suitable for small or miniature anti-loosening nuts.

Abstract: Various embodiments of the teachings herein include a method for knowledge recommendation. The method may include: obtaining current searching information of a user for certain knowledge in factory production, job characteristic information of the user, and historical feedback information of the user for at least one knowledge item and/or knowledge resource in the past; using a first prediction algorithm model for learning based on historical searching information, job feature information, and historical feedback information of the user and other users to analyze obtained information, to obtain first prediction information including a first number of knowledge items; using a second prediction algorithm model to perform fusion sorting on the first prediction information and thereby obtain second prediction information including a second number of knowledge items; providing the second number of knowledge items to a knowledge recommendation model; and recommending a knowledge resource output from the model.

Abstract: The present disclosure relates to a method, device, and system for configuring parameters, a computer device, a medium, and a product. A configuration device for configuring parameter sampling with respect to an edge device includes: one information acquiring unit, configured to acquire information related to the purpose and use environment of the edge device; one transmitting unit, configured to transmit the information to a cloud platform; and one configuration information determining unit, configured to receive configuration information for parameter sampling with respect to the edge device from the cloud platform, where the configuration information is configuration information determined as matching the information by the cloud platform utilizing a configuration model stored thereby.

Abstract: A method for specifying an object, includes: determining whether a pointing device is in a pointing mode or a control mode; determining a first position of a first locator and a second position of a second locator in the pointing device in a virtual space, when the pointing device is in the pointing mode; determining a pointing of the pointing device based on the first position of the first locator and the second position of the second locator; and determining a specified virtual object based on the pointing of the pointing device.

Abstract: The present disclosure relates to novel compounds that inhibit glucose-induced degradation-deficient (GID) E3 ligase, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions.

Abstract: The present disclosure relates to novel compounds that degrade Bruton's tyrosine kinase (BTK), pharmaceutical compositions containing such compounds, and their use in prevention and treatment of conditions modulated by BTK.

Abstract: Provided herein are monoclonal antibodies (mAbs) that bind to human Cluster of Differentiation 73 (CD73). In particular, anti-CD73 mAbs are provided that bind to and inhibit the activity of human CD73.

Abstract: A light-emitting diode for plant illumination is provided. The light-emitting diode has a multiple quantum well structure for generating a light beam with a broadband blue-violet light spectrum. The broadband blue-violet light spectrum has a first peak and a second peak within a range from 410 nm to 450 nm, a wavelength value of the second peak is greater than a wavelength value of the first peak, and a difference between the wavelength value of the second peak and the wavelength value of the first peak ranges from 5 nm to 30 nm. The broadband blue-violet light spectrum generated by the light-emitting diode can better match a photosynthetic action spectrum of plants.

Abstract: Provided is a hemostatic composition comprising trypsin and zeolite, wherein pore channels of the zeolite are micropores, the zeolite contains divalent metal cations, and the mass ratio of the trypsin to the zeolite is 1:200-4:10. In the present invention, the trypsin specifically binds to the zeolite, allowing the trypsin to maintain a certain conformation on the surface of the zeolite and to obtain a higher procoagulant activity, thereby obtaining a hemostatic composition with an excellent blood coagulation effect. The hemostatic composition of the present invention has the advantages of a simple preparation method, low cost and convenient use, and can be widely used in hemostasis during trauma and operations, especially in emergent hemostasis in hemophilia patients.

Abstract: The present disclosure describes multi-parameter dynamic sampling methods and systems. An example method includes: configuring two sampling rates for each parameter in a set of sampling parameters; selecting one of the sampling rates for each parameters to sample it; calculating a load for each parameter at the selected sampling rate, sorting the parameters according to the loads, and determining high-loaded parameters according to a sorting result; and determining whether each parameter has data loss, and if at least one of the sampling parameters has data loss, performing down-sampling on the high-loaded sampling parameters within a range of the configured at least two sampling rates.

Abstract: A light-emitting module and a light-emitting diode are provided. The light-emitting diode includes an epitaxial light-emitting structure to generate a light beam with a broadband blue spectrum. A spectrum waveform of the broadband blue spectrum has a full width at half maximum (FWHM) larger than or equal to 30 nm. The spectrum waveform has a plurality of peak inflection points, and a difference between two wavelength values to which any two adjacent ones of the peak inflection points respectively correspond is less than or equal to 18 nm.

Abstract: Disclosed are heteroaryl compounds and pharmaceutical compositions thereof, which are useful for inhibiting EGFR, as well as methods for using such compounds to treat cancer associated with an EGFR or HER2 exon 20 insertion mutation.

Abstract: This application relates to an application control method performed by an electronic device that runs a native application and a sub-application nested in the native application. The method includes: receiving, by the native application, an object creation instruction transmitted by the sub-application; in response to the object creation instruction, creating, by the native application, a native object, wherein the native object is configured for performing operation on target multimedia content in the sub-application; receiving, by the native application, an object calling instruction transmitted by the sub-application; and in response to the object calling instruction, executing, by the native application, the native object and returning an execution result of the native project to the sub-application, wherein the sub-application is configured for performing corresponding operation on target multimedia content according to the execution result.

Abstract: The disclosure provides sulfonamides based compounds and pharmaceutical compositions thereof, which are useful for inhibiting one or more mutations of EGFR, as well as methods for using such compounds to treat cancer associated with EGFR mutations.