Abstract: The present disclosure discloses a preparation method of fatty acid-based VC liposomes, and belongs to the field of pharmaceutical preparations. In the disclosure, a complex of industrial conjugated linoleic acid and other fatty acids with sodium dodecyl sulfate is taken as a capsule material, which is self-assembled to embed vitamin C in an aqueous phase under an acidic condition (pH<7) to form the fatty acid-based vitamin C liposome. The preparation method of the disclosure does not use organic solvents and other substances harmful to the human body, and has the characteristics of safety and health. In addition to VC encapsulation under the acidic condition, the prepared fatty acid-based liposome can play a role in slowly releasing VC.

Abstract: A push-bending forming device for titanium alloy tubes is provided, which includes a die main body, a plurality of filling balls, a differential temperature assembly and a punch. The filling balls are configured to be filled in a tube blank, and are made of a metal material, with a heat-resistance temperature over 500° C. A diameter of the filling ball is less than an inner diameter of the tube blank. The punch includes a first pushing part and a second pushing part. A push-bending forming method using such device is also provided.

Abstract: Disclosed are treatment methods and compositions developed by the method utilizing Alistipes-derived sulfonolipids in treatment of a variety of diseases, including inflammatory bowel diseases and cancers. Also disclosed are methods for determining a correlation between a gut microbe metabolite and a disease state. The method utilizes a biosynthetic enzyme-guided correlation approach to determine particular metabolites functional in human health as well as a guide for examining the functionality thereof.

Abstract: Described herein are binding moieties, such as antibodies, that specifically bind Claudin18.2, and chimeric antigen receptors comprising such binding moieties. Further provided are engineered immune cells (such as T cells) comprising anti-Claudin 18.2 chimeric antigen receptors. Also disclosed are methods of treating Claudin18.2-expressing tumor or cancers using the binding moieties, chimeric antigen receptors and engineered immune cells.

Abstract: The present disclosure relates to novel pan-KRAS glutarimide-containing compounds with KRAS degradation activities, pharmaceutical compositions containing such compounds, and their use in prevention and treatment diseases and conditions.

Abstract: A hardware accelerator comprises a PE array, an internal buffer unit, and a data scheduler. The data scheduler obtains multiple image lines from the internal buffer unit and schedules the PE array to sequentially perform MAC (multiply-accumulate) operations on the multiple image lines. There are overlapping pixel lines between adjacent image lines, and the overlapping pixel lines are subjected to MAC operations in both of their adjacent image lines to which they belong. During the MAC operations on each image line, the PEs of the PE array are scheduled to perform MAC operations in tiles on multiple tiles included in each image line. For adjacent tiles, the operation result of the overlapping portion between the previous tile and the subsequent tile is cached, and combined with the operation result of the non-overlapping portion of the subsequent tile to form the MAC operation result of the subsequent tile.

Abstract: The present disclosure relates to novel CDK inhibitors, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of diseases and conditions associated with CDK.

Abstract: A method for federated data query includes: using, by a first electronic device, a joint query statement corresponding to a federated data query to obtain at least one operator containing a joint query operator; transforming the joint query operator to a first joint security operator; determining first data for intersection on the first electronic device by executing the first joint security operator, receiving second data for intersection from a second electronic device involved in the federated data query, and performing joint computing on the first data for intersection and the second data for intersection in a form of a ciphertext to obtain a joint data table; and determining a federated data query result corresponding to the at least one operator based on the joint data table.

Abstract: Various embodiments of a system and associated method for detecting and classifying faults in a photovoltaic array using graph-based signal processing.

Abstract: Method and systems for sorting drug-responsive cell population based on single-cell RNA sequencing (scRNA-seq) data are disclosed. In some examples, the method includes: constructing a target gene regulatory network (GRN) for each of the cell populations based on scRNA-seq data of cell populations in a disease state; virtually knocking out targets in the GRN, and constructing a target-perturbed gene regulatory network (tpGRN); acquiring a low-dimensional representation of each of network nodes from the GRN in the GRN and the tpGRN through manifold alignment; calculating a Euclidean distance for each of the network nodes between the GRN and the tpGRN through a Euclidean distance; scoring a drug response of each of the cell populations by comprehensively considering changing trends of a drug target, a 2-hop node, and an edge of the 2-hop node in the GRN and the tpGRN, and determining a sorting result of the drug-responsive cell population.

Abstract: A pixel circuit comprises a drive sub-circuit (101), writing sub-circuit (102), reset sub-circuit (103), voltage stabilizing sub-circuit (104), storage sub-circuit (105) and light emitting element. The drive sub-circuit is configured to provide a driving current to the light emitting element under control of signals of a first node (N1) and a second node (N2); the writing sub-circuit is configured to write a signal from a data signal terminal (Data) to N2 under control of signal of a scan signal terminal (Gate); the storage sub-circuit is configured to store a voltage of N1; the voltage stabilizing sub-circuit is configured to stabilize a voltage of an anode terminal of light emitting element through signal of a voltage stabilizing signal terminal (V1); the reset sub-circuit is configured to reset anode terminal of light emitting element under control of signal of Gate and reset N1 under control of signal of a reset control signal terminal (Reset).

Abstract: A system for purifying helium gas, a method, and an application. The system includes a first gas-liquid separation device, a primary helium extraction tower, a second gas-liquid separation device, a secondary helium extraction tower, and a nitrogen removal tower, which are in sequential communication. The first gas-liquid separation device performs first treatment to convert helium-containing natural gas into a first gas and first liquid phases; the primary helium extraction tower performs first distillation on the first gas and first liquid phases to obtain a second gas and second liquid phases; the second gas-liquid separation device performs second treatment to convert the second gas phase to a third gas and third liquid phase; the secondary helium extraction tower performs second distillation on the third gas and third liquid phases to obtain crude helium and a fourth liquid phase form which nitrogen is removed by the nitrogen removal tower.

Abstract: A non-pneumatic vacuum tire includes a tread layer, a carcass ply layer and a puncture-resistant airtight layer. The tread layer is provided on the carcass ply layer and located at a crown; a pattern groove is formed in a surface of the tread layer; the puncture-resistant airtight layer is fixedly provided between the tread layer and the carcass ply layer or fixedly provided under the carcass ply layer; the puncture-resistant airtight layer includes one or more layers of canvas; a warp and a weft of the canvas each are formed by a plurality of filaments; and the canvas forms the puncture-resistant airtight layer by rubber impregnation and rubber coating; the puncture-resistant airtight layer at least covers a clinch to a shoulder; and a lower end of the puncture-resistant airtight layer extends to the clinch and forms a turn-up structure.

Abstract: The invention relates to a hybrid power drive system, comprising: an internal combustion engine having a crankshaft; a first electric motor (14), wherein the first electric motor (14) is an outer rotor electric motor, and comprises an outer rotor (14.2) that is rigidly connected to the crankshaft and rotates together with the crankshaft; a transmission (15) comprising an input shaft (20); and a clutch (18) that is provided between the first electric motor (14) and the transmission (15), and is connected to the input shaft (20) of the transmission. The clutch (18) is configured to be capable of switching between the following positions: an engagement position where the clutch (18) is engaged with the outer rotor (14.2); and a separation position where the clutch (18) is separated from the outer rotor (14.2). The present system is simple in structure, high in efficiency, and low in manufacturing and maintenance costs.

Abstract: This application provides a channel state information (CSI) feedback method including: a terminal device selects B complex coefficients from K complex coefficients according to a preset priority rule, and provides feedback, where K is a quantity of complex coefficients that the terminal device is allowed to feed back, and the preset priority rule is related to at least one of the following: an index value of each complex coefficient in the K complex coefficients, an index value of a reference signal port corresponding to each complex coefficient in the K complex coefficients in S reference signal ports, or an index value of each complex coefficient in the K complex coefficients in a plurality of complex coefficients that are allowed to be selected for a corresponding reference signal port, where S is a quantity of reference signal ports that the terminal device is allowed to select.

Abstract: Provided is a method of reconstructing multi-source long-time-series night light data and a system thereof, relating to the field of reconstructing ecological remote sensing data. Based on night light images of a first-generation satellite DMSP/OLS (Defense Meteorological Satellite Program/Operational Line-scan System) and a second-generation satellite NPP/VIIRS (National Polar-orbiting Partnership/Visible Infrared Imaging Radiometer Suite), a method of reconstructing a set of long-time-series night light data products is developed. Since satellite images that two generations of satellites have at the same time in a certain year use an inverse hyperbolic sine transform to fit NPP/VIIRS in 2013 into a data form of DMSP/OLS, and obtain an optimal fitting equation, thus producing a set of long-time-series data products from 1992 to 2021. The method can solve a fault problem between two generations of light data of DMSP/OLS and NPP/VIRS, and improve the accuracy of data reconstruction.

Abstract: Provided is a display panel. The display panel includes a base substrate and a plurality of pixel circuits disposed on the base substrate. At least two pixel circuits in a same column are coupled with a same first initial power line, such that only a small quantity of signal lines need to be disposed on the base substrate.

Abstract: Various embodiments of the teachings herein include an interface display method for industrial software. An example method includes: obtaining a present operation sequence by a user in a functional interface of industrial software; using a recurrent neural network (RNN) model to predict a next operation of the user according to the present operation sequence by the user, wherein the RNN model is obtained through history operation sequence of the user and history operation sequence of typical users in industrial domain knowledge; and highlighting a functional component of the predicted operation of the user from the functional interface and/or generating navigation corresponding to the predicted operation of the user.

Abstract: The present disclosure relates to novel pan-KRAS glutarimide-containing compounds with KRAS degradation activities, pharmaceutical compositions containing such compounds, and their use in prevention and treatment diseases and conditions.

Abstract: The present disclosure relates to at least one entity chosen from a compound of Formula (I), tautomers, stereoisomers or a mixture of stereoisomers, hydrates, and deuterated derivatives thereof, and pharmaceutically acceptable salts of any of the foregoing, and their use as epidermal growth factor receptor (EGFR) degraders for the prevention and treatment of diseases and conditions, e.g., cancer. The present disclosure also relates to pharmaceutical compositions containing such entities, and their use in treating or preventing a disease or disorder associated with EGFR.