Publication number: 20240378427
Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training a neural network to perform any one or more of a variety of machine learning tasks. For example, the neural network can be configured as a generative neural network, e.g., an autoregressive generative neural network.
Type:
Application
Filed:
May 10, 2024
Publication date:
November 14, 2024
Inventors:
Slav Petrov, Yonghui Wu, Andrew M. Dai, David Richard So, Dmitry Lepikhin, Erica Ann Moreira, Gaurav Mishra, Jonathan Hudson Clark, Maxim Krikun, Melvin Jose Johnson Premkumar, Nan Du, Orhan Firat, Rohan Anil, Siamak Shakeri, Xavier Garcia, Yanping Huang, Yong Cheng, Yuanzhong Xu, Yujing Zhang, Zachary Alexander Nado, Eric Jun Jie Ni, Kefan Xiao, Vladimir Feinberg, Jin Young Sohn, Aurko Roy
Publication number: 20240378441
Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training a neural network to perform any one or more of a variety of machine learning tasks. For example, the neural network can be configured as a generative neural network, e.g., an autoregressive generative neural network.
Type:
Application
Filed:
May 10, 2024
Publication date:
November 14, 2024
Inventors:
Slav Petrov, Yonghui Wu, Andrew M. Dai, David Richard So, Dmitry Lepikhin, Erica Ann Moreira, Gaurav Mishra, Jonathan Hudson Clark, Maxim Krikun, Melvin Jose Johnson Premkumar, Nan Du, Orhan Firat, Rohan Anil, Siamak Shakeri, Xavier Garcia, Yanping Huang, Yong Cheng, Yuanzhong Xu, Yujing Zhang, Zachary Alexander Nado, Eric Jun Jie Ni, Kefan Xiao, Vladimir Feinberg, Jin Young Sohn, Aurko Roy
Patent number: 12116356
Abstract: A N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, and a pharmaceutical composition and use thereof, specifically relating to a compound as represented by formula I, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and a medical use thereof. The medical use comprises the use in treating diseases benefiting from the capsid protein assembly inhibitor, and in particular, diseases caused by hepatitis B virus infection.
Type:
Grant
Filed:
February 6, 2023
Date of Patent:
October 15, 2024
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
Inventors:
Yinsheng Zhang, Wangwei Ao, Yuan Li, Hui Wang, Hangzhou Shen, Jie Ni, Huan Zhang, Jie Wu, Li Zhang, Kai Cao, Peng Lu, Xushi Liu, Jie Wang, Tianxiao Zhao, Xingfeng Ge, Dandan Lu, Shuo Chen, Xueqin Ma, Wei Shi, Xiaojin Wang, Hongjiang Xu
Publication number: 20230183208
Abstract: A N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, and a pharmaceutical composition and use thereof, specifically relating to a compound as represented by formula I, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and a medical use thereof. The medical use comprises the use in treating diseases benefiting from the capsid protein assembly inhibitor, and in particular, diseases caused by hepatitis B virus infection.
Type:
Application
Filed:
February 6, 2023
Publication date:
June 15, 2023
Applicant:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
Inventors:
Yinsheng Zhang, Wangwei Ao, Yuan Li, Hui Wang, Hangzhou Shen, Jie Ni, Huan Zhang, Jie Wu, Li Zhang, Kai Cao, Peng Lu, Xushi Liu, Jie Wang, Tianxiao Zhao, Xingfeng Ge, Dandan Lu, Shuo Chen, Xueqin Ma, Wei Shi, Xiaojin Wang, Hongjiang Xu
Patent number: 11597716
Abstract: A N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, and a pharmaceutical composition and use thereof, specifically relating to a compound as represented by formula I, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and a medical use thereof. The medical use comprises the use in treating diseases benefiting from the capsid protein assembly inhibitor, and in particular, diseases caused by hepatitis B virus infection.
Type:
Grant
Filed:
March 29, 2019
Date of Patent:
March 7, 2023
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
Inventors:
Yinsheng Zhang, Wangwei Ao, Yuan Li, Hui Wang, Hangzhou Shen, Jie Ni, Huan Zhang, Jie Wu, Li Zhang, Kai Cao, Peng Lu, Xushi Liu, Jie Wang, Tianxiao Zhao, Xingfeng Ge, Dandan Lu, Shuo Chen, Xueqin Ma, Wei Shi, Xiaojin Wang, Hongjiang Xu
Publication number: 20220185774
Abstract: Provided is a compound of formula I or II, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and the medical uses thereof in treating diseases benefiting from the capsid protein assembly inhibitor, particularly diseases caused by hepatitis B virus infection.
Type:
Application
Filed:
September 27, 2019
Publication date:
June 16, 2022
Inventors:
Yinsheng ZHANG, Wangwei AO, Yuan LI, Hui WANG, Hangzhou SHEN, Jie NI, Huan ZHANG, Jie WU, Li ZHANG, Kai CAO, Peng LU, Xushi LIU, Jie WANG, Tianxiao ZHAO, Xingfeng GE, Dandan LU, Shuo CHEN, Xueqin MA, Wei SHI, Xiaojin WANG, Hongjiang XU
Publication number: 20210017154
Abstract: A N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, and a pharmaceutical composition and use thereof, specifically relating to a compound as represented by formula I, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and a medical use thereof. The medical use comprises the use in treating diseases benefiting from the capsid protein assembly inhibitor, and in particular, diseases caused by hepatitis B virus infection.
Type:
Application
Filed:
March 29, 2019
Publication date:
January 21, 2021
Applicant:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
Inventors:
Yinsheng ZHANG, Wangwei AO, Yuan LI, Hui WANG, Hangzhou SHEN, Jie NI, Huan ZHANG, Jie WU, Li ZHANG, Kai CAO, Peng LU, Xushi LIU, Jie WANG, Tianxiao ZHAO, Xingfeng GE, Dandan LU, Shuo CHEN, Xueqin MA, Wei SHI, Xiaojin WANG, Hongjiang XU