Patents by Inventor Jie Ni

Jie Ni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel guanidinobenzamides
    Publication number: 20020137939
    Abstract: Compounds of formula IA and IB are new 1
    Type: Application
    Filed: August 31, 2001
    Publication date: September 26, 2002
    Inventors: Paul A. Renhowe, Daniel Chu, Rustum S. Boyce, Zhi-Jie Ni, David Duhl, Effie Tozzo, Kirk Johnson, David C. Myles
  • Novel urea compounds, compositions and methods of use and preparation
    Publication number: 20020119962
    Abstract: Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.
    Type: Application
    Filed: December 13, 2000
    Publication date: August 29, 2002
    Inventors: Jeffrey W. Jacobs, Dinesh Patel, Jason Lewis, Zhi-Jie Ni
  • Novel succinate compounds, compositions and methods of use and preparation
    Publication number: 20020115863
    Abstract: Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.
    Type: Application
    Filed: December 13, 2000
    Publication date: August 22, 2002
    Inventors: Dinesh Patel, Jeffrey W. Jacobs, Rakesh Jain, Zhi-Jie Ni, Zhengyu Yuan
  • Methods for hard-tagging an encoded synthetic library
    Patent number: 6368874
    Abstract: Disclosed are chemical encryption methods for determining the structure of compounds formed in situ on solid supports by the use of specific amines tags which, after compound synthesis, can be deencrypted to provide the structure of the compound found on the support.
    Type: Grant
    Filed: November 17, 1999
    Date of Patent: April 9, 2002
    Assignee: Affymax, Inc.
    Inventors: Mark A. Gallop, Eric Gordon, Zhi-Jie Ni, Derek MacLean, Christopher Holmes, William Fitch, Nikhil Shah
  • Oxazolidinone combinatorial libraries, compositions and methods of preparation
    Patent number: 6239152
    Abstract: Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: May 29, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mikhail F. Gordeev, Gary W. Luehr, Dinesh V. Patel, Zhi-Jie Ni, Eric Gordon
  • Methods for hard-tagging an encoded synthetic library
    Patent number: 5846839
    Abstract: Disclosed are chemical encryption methods for determining the structure of compounds formed in situ on solid supports by the use of specific amines tags which, after compound synthesis, can be deencrypted to provide the structure of the compound found on the support.
    Type: Grant
    Filed: December 22, 1995
    Date of Patent: December 8, 1998
    Assignee: Glaxo Group Limited
    Inventors: Mark A. Gallop, Eric Gordon, Zhi-Jie Ni, Derek MacLean, Christopher Holmes, William Fitch, Nikhil Shah
  • Method and apparatus for full duplex signaling
    Patent number: 5651001
    Abstract: A network transmitter device and network receiver device is described. The network transmitter device transmits a first voltage potential, a second voltage potential, a third voltage potential and a fourth voltage potential over a first pair of output lines and a second pair of output lines in response to digital signals received over a data input. The network receiver device receives network signals of a first voltage potential, a second voltage potential, a third voltage potential, a fourth voltage potential and a fifth voltage potential over a first pair of output lines and a second pair of output lines. The network receiver device transmits digital signals corresponding to the network signals.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: July 22, 1997
    Assignee: Intel Corporation
    Inventors: Gary A. Alvstad, Jie Ni