Abstract: Disclosed are a peptide compound and an application thereof, and a composition containing the peptide compound. The present invention provides a peptide compound represented by formula (1), and a pharmaceutically acceptable salt, a tautomer, a solvate, a crystal form or a prodrug thereof. The compound has good stability and good activity for Kiss1R.

Abstract: The present disclosure provides a manufacturing method and a manufacturing apparatus for an USB interface metal casing. The manufacturing method for an USB interface metal casing includes: feeding a flat-shaped pipe blank to a lower mold (S100); closing a first upper mold and the lower mold, and performing pipe-expansion forming to a bottom of the pipe blank (S110); closing a second upper mold and the lower mold, and performing necking and chamfering to a top port of the pipe blank (S120); and closing a third upper mold and the lower mold, and modifying the pipe blank to obtain a final finished product of the USB interface metal casing (S130).

Abstract: Implants are placed in turbinate mucosal tissue using a surgical device having a proximal grip portion and a distal hollow sharp needle portion that is manipulated using the grip portion and inserted submucosally into mucosal turbinate tissue. One or more biodegradable, drug-eluting solid implants are disposed within the needle. The implants have one or more implant withdrawal-discouraging, mucosal tissue-engaging surface features along their length. An actuator disposed within the device is used to deliver one or more of the implants from the needle into the mucosal turbinate tissue and submucosally bury at least one such tissue-engaging feature therein.

Abstract: Embodiments of the present application discloses an information authentication method, which includes: generating first transaction information based on content information of first information to be published by an original information publishing end and a HASH value of the first information, wherein the first information is original information or a copy of the original information; writing the first transaction information into a central database and Blockchain, or into the Blockchain; obtaining reprinted information published by an information reprinting end, and generating a HASH value of the reprinted information; comparing the HASH value of the first information with the HASH value of the reprinted information; and returning a first credential, which indicates the reprinted information is true or has not been tampered with, to the information reprinting end, if the HASH value of the first information is equal to the HASH value of the reprinted information.

Abstract: The invention discloses a class of compounds for treating or preventing hyperuricemia or gout, which is a compound shown in general formula (I) or a pharmaceutically acceptable salt. These compounds and their pharmaceutically acceptable salts in the invention are useful for the promotion of uric acid excretion to treat or prevent hyperuricemia or gout.

Abstract: A circuit for driving an LED lighting device from an AC power source includes a rectifier and one or more strings of LEDs. Each string of LEDs includes multiple LEDs. A controller produces control signals that open and close a set of switches that corresponding with the LED groups. The controller uses a current mirror with a pair of reference branches situated between a reference voltage and ground and between the switches and ground. Each reference branch has a first-in-line resistor between the reference voltage and the current mirror which primarily set the reference current through the controller by having the highest impedances, and the control signals are produced by a set of resistors on one of the branches. Each branch also has a last-in-line resistor between the current mirror and ground with the lowest impedances. The selection of the highest impedances and lowest impedances reduces sensitivity to temperature variations.

Abstract: The invention describes novel coating agents that include a polymer, one or more latent reactive groups and one or more noncovalent linking groups, the noncovalent linking groups selected to interact with a substrate to which the coating agent is applied. The coating agents are useful for providing a coating that can be further functionalized (for example, by application of additional coating layers), or for providing desirable properties to a surface.

Abstract: A purified and sterilized polysaccharide that exhibits enhanced and extended shelf life over conventionally prepared polysaccharides for biomedical applications. The polysaccharide, upon crosslinking, forms a hydrogel that functions as a protective coating or on tissue and structures in the ears, nose, throat, limbs and spinal column.

Abstract: Methods of obtaining quantitative MRI images of a subject that includes fitting a theoretical model that accounts for tissue-specific relaxation properties and magnetization transfer effects to MRI measured data is disclosed.

Abstract: A method and circuit for driving an LED lighting device from an AC power source includes a rectifier and a plurality of strings of LEDs. Each string of LEDs includes a plurality of LEDs. A plurality of switches is controlled by a controller for opening and closing the switches. The controller is adapted to vary the number of strings conducting electricity by applying voltage from the rectifier to arrangements of the plurality of strings of LEDs selected based upon the present voltage of the output of the rectifier and the forward bias voltage of each of the strings of LEDs.

Abstract: A method and apparatus for performing storage space management for a plurality of Virtual Machines (VMs) are provided, and the method is applied to a storage system including a plurality of storage servers. The method includes: receiving a request regarding any VM of the plurality of VMs; determining a storage region in the storage system according to the request to store data of the VM into the storage region, wherein the storage region is assigned to the VM; determining another storage region in the storage system according to geolocation classification information of at least one portion of storage servers within the plurality of storage servers, wherein the storage region and the other storage region are positioned in different storage servers within the at least one portion of storage servers, respectively; and storing a replication version of the data into the other storage region.

Abstract: The invention discloses a class of compounds for treating or preventing hyperuricemia or gout, which is a compound shown in general formula (I) or a pharmaceutically acceptable salt. These compounds and their pharmaceutically acceptable salts in the invention are useful for the promotion of uric acid excretion to treat or prevent hyperuricemia or gout.

Abstract: A stent (100) that is sleeved and radially expandable, and which in an expanded state provides a breathable, generally tubular structure sized and shaped for residence in a sinus or nasal cavity or passage, and in an unexpanded state has a cross-sectional diameter suitable for insertion into such cavity or passage. The sleeve limits expansion and outward pressure exerted by the stent and thereby can prevent or reduce the incidence of headache in patients, and can provide increased surface area for improved elution of drugs to nearby mucosal tissue.

Abstract: A method for detaching, removing or otherwise disrupting bacteria or biofilm by applying with pressure an antimicrobial wash. The antimicrobial wash contains a biguanide compound or mixtures thereof.

Abstract: Methods of obtaining quantitative MRI images of a subject that includes fitting a theoretical model that accounts for tissue-specific relaxation properties and magnetization transfer effects to MRI measured data is disclosed.

Abstract: A method for detaching, removing or otherwise disrupting bacteria or biofilm by applying with pressure an antimicrobial wash. The antimicrobial wash contains a biguanide compound or mixtures thereof.

Abstract: The present disclosure provides a manufacturing method and a manufacturing apparatus for an USB interface metal casing. The manufacturing method for an USB interface metal casing includes: feeding a flat-shaped pipe blank to a lower mold (S100); closing a first upper mold and the lower mold, and performing pipe-expansion forming to a bottom of the pipe blank (S110); closing a second upper mold and the lower mold, and performing necking and chamfering to a top port of the pipe blank (S120); and closing a third upper mold and the lower mold, and modifying the pipe blankto obtain a final finished product of the USB interface metal casing (S130).

Abstract: A processing method and a processing apparatus for a metal housing are provided. The method includes: sleeving a metal flat pipe having an end face provided with a curved surface portion on a lower mold; and pressing the curved surface portion by the cooperation between an upper mold and the lower mold, thereby forming a chamfered slanted surface on the curved surface portion. The processing processes and the apparatus involved are simple, the quality of the products is improved, and thus the method may be suitable for mass production.

Abstract: Inventive concepts relate general to the field of implantable three-dimensional scaffolds. More particularly, methods of preparing and using implantable nanofibrous tissue scaffolds are described. Inventive scaffolds can be used for treatment of defects in a living organism, such as hard or soft tissue defects including bone.

Abstract: A positron emission tomography (PET) system is provided. The system includes a first detector panel including a first array of detectors, a second detector panel including a second array of detectors, said second detector panel being moveable relative to a point between the first detector panel and the second detector panel, a tracking system configured to detect a position of said second detector panel relative to the first detector panel while imaging a subject, a computing device in communication with the first detector panel, the second detector panel, and the tracking system, the computing device configured to receive coincidence data from the first and second detector panels, receive position data from the tracking system, wherein each coincidence datum of the received coincidence data is associated with a unique position datum of the received position data, and reconstruct a plurality of images based on the received coincidence data and the received position data.