Patents by Inventor Jim-Min Fang

Jim-Min Fang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190389898
    Abstract: Compounds for use in prevention and/or treatment of pain are disclosed. The compounds are derived by conjugation of N6-(4-hydroxybenzyl)adenosine and analogous compounds with amino acids or peptides. In one embodiment of the invention, the compound is 5?-glycylcarbonyl-N6-(4-hydroxybenzyl)adenosine (I-a1). In another embodiment of the invention, the compound is 5?-deoxy-5?-(N?-glycylureido)-N6-(4-hydroxybenzyl)adenosine (I-d1). Also disclosed are methods of making and using the same.
    Type: Application
    Filed: January 26, 2018
    Publication date: December 26, 2019
    Inventors: Chih-Cheng CHEN, Jim-Min FANG, Cheng-Han LEE, Jen-Yao CHANG
  • Patent number: 10342818
    Abstract: The present invention provides therapeutic agents for preventing and treating neurodegenerative diseases. These agents synergistically target both the adenosine A2A receptor (A2AR) and the equilibrative nucleoside transporter 1 (ENT1).
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: July 9, 2019
    Assignee: ACADEMIA SINICA
    Inventors: Yun-Lian Lin, Yijuang Chern, Jim-Min Fang, Jung-Hsing Lin, Nai-Kuei Huang
  • Patent number: 10301348
    Abstract: Compounds for use in prevention and treatment of neurodegenerative disease and pain are disclosed. In one embodiment of the invention, the compound is selected from the group consisting of N6-[(3-halothien-2-yl)methyl]adenosine, N6-[(4-halothien-2-yl)methyl]adenosine, and N6-[(5-halothien-2-yl)methyl]adenosine. In another embodiment of the invention, the compound is selected from the group consisting of N6-[(2-bromothien-3-yl)methyl]adenosine, N6-[(4-bromothien-3-yl)methyl]adenosine, N6-[(5-bromothien-3-yl)methyl]adenosine N6-[(2-chlorothien-3-yl)methyl]adenosine, N6-[(4-chlorothien-3-yl)methyl]adenosine, and N6-[(5-chlorothien-3-yl)methyl]adenosine. Also disclosed are methods of making and using the same.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: May 28, 2019
    Assignee: ACADEMIA SINICA
    Inventors: Jim-Min Fang, Yun-Lian Lin, Jung-Hsin Lin, Chun-Jung Lin, Yijuang Chern, Nai-Kuei Huang, Hung-Li Wang, Benjamin Pang-hsien Tu, Chih-Cheng Chen
  • Patent number: 10214765
    Abstract: Provided herein are compounds for use as sialidase inhibitors, including alkynyl-3-fluorosialyl fluoride. The compounds, which include the compound DFSA, function by trapping a 3-fluorosialylenzyme intermediate (reporter-inhibitor-enzyme conjugate). These compounds can be conjugated with a detectable tagging moiety for isolation and identification of sialidases.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: February 26, 2019
    Assignee: Academia Sinica
    Inventors: Chi-Huey Wong, Jim-Min Fang, Yih-Shyun E. Cheng, Chamg-Sheng Tsai
  • Publication number: 20180369249
    Abstract: The present disclosure provides compounds of Formulas (I?) and (I), and pharmaceutically acceptable salts thereof. The compounds described herein may be useful in treating and/or preventing proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, and uses thereof for treating proliferative diseases.
    Type: Application
    Filed: February 3, 2017
    Publication date: December 27, 2018
    Applicants: Academia Sinica, National Taiwan University
    Inventors: Chi-Huey Wong, Pan-Chyr Yang, Jim-Min Fang, Szu-Hua Pan, Ting-Jen R. Cheng, Ling-Wei Li
  • Patent number: 10130714
    Abstract: Novel dual-targeted, bifunctional anti-influenza drugs formed by conjugation with anti-inflammatory agents are disclosed. Exemplary drugs according to the invention include caffeic acid (CA)-bearing zanamivir (ZA) conjugates ZA-7-CA (1), ZA-7-CA-amide (7) and ZA-7-Nap (43) for simultaneous inhibition of influenza virus neuraminidase and suppression of proinflammatory cytokines. Synthetic methods for preparation of these enhanced anti-influenza conjugate drugs are provided. The synthetic bifunctional ZA conjugates act synergistically towards protection of mice lethally infected by H1N1 or H5N1 influenza viruses. The efficacy of ZA-7-CA, ZA-7-CA-amide and ZA-7-Nap conjugates is much greater than the combination therapy of ZA with anti-inflammatory agents.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 20, 2018
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Jim-Min Fang, Kung-Cheng Liu, Jia-Tsrong Jan, Yih-Shyun E. Cheng, Ting-Jen R. Cheng
  • Patent number: 10117890
    Abstract: Methods for treating pain such as fibromyalgia, comprising administering to a subject in need thereof an effective amount of an adenosine analog, wherein the adenosine analog may be a compound of Formula (I): (I), or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising the adenosine analog for use in treating pain (e.g., fibromyalgia), optionally further comprising Substance P (SP), are also provided.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: November 6, 2018
    Assignee: Academia Sinica
    Inventors: Chih-Cheng Chen, Yun-Lian Lin, Jim-Min Fang, Yijuang Chern, Chia-Ching John Lin, Wei-Nan Chen, Chun-Jung Lin
  • Patent number: 10119972
    Abstract: Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide-alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: November 6, 2018
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Jim-Min Fang, Jiun-Jie Shie
  • Patent number: 10099191
    Abstract: Provided is a method of making colloidal metal nanoparticles. The method includes the steps of: mixing a metal aqueous solution and a reducing agent to form a mixture solution in a reaction tank; heating the mixture solution and undergoing a reduction reaction to produce a composition containing metal nanoparticles, residues and gas, wherein the amount of the residues is less than 20% by volume of the mixture solution, and guiding the gas out of the reaction tank; dispersing the metal nanoparticles with a medium to obtain colloidal metal nanoparticles. By separating the reduction reaction step and the dispersion step, the method of making colloidal metal nanoparticles is simple, safe, time-effective, cost-effective, and has the advantage of high yield.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: October 16, 2018
    Assignee: TRIPOD TECHNOLOGY CORPORATION
    Inventors: Lin Lu, Kuei-Sheng Fan, Chen-Hsiang Wang, Chun-Lun Chiu, Ta-Wei Chang, Cheng-Ding Wang, Jim-Min Fang
  • Patent number: 10046976
    Abstract: A method of making the inorganic gold compound, such as tetrachloroauric acid, sodium tetrachloroaurate, potassium tetrachloroaurate, sodium tetracyanoaurate, and potassium tetracyanoaurate, includes the step of: treating gold with a halogen-containing oxidizing agent in a hydrochloric acid to obtain the inorganic gold compound, wherein the halogen-containing oxidizing agent excludes chlorine gas. The method of making the inorganic gold compound is simple, safe, time-effective, cost-effective, and environment-friendly, and has the advantage of high yield.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: August 14, 2018
    Assignee: TRIPOD TECHNOLOGY CORPORATION
    Inventors: Lin Lu, Chen-Hsiang Wang, Kuei-Sheng Fan, Cheng-Ding Wang, Jim-Min Fang
  • Publication number: 20180208476
    Abstract: A method of making the inorganic gold compound, such as tetrachloroauric acid, sodium tetrachloroaurate, potassium tetrachloroaurate, sodium tetracyanoaurate, and potassium tetracyanoaurate, includes the step of: treating gold with a halogen-containing oxidizing agent in a hydrochloric acid to obtain the inorganic gold compound, wherein the halogen-containing oxidizing agent excludes chlorine gas. The method of making the inorganic gold compound is simple, safe, time-effective, cost-effective, and environment-friendly, and has the advantage of high yield.
    Type: Application
    Filed: January 25, 2017
    Publication date: July 26, 2018
    Applicant: TRIPOD TECHNOLOGY CORPORATION
    Inventors: Lin LU, Chen-Hsiang WANG, Kuei-Sheng FAN, Cheng-Ding WANG, Jim-Min FANG
  • Publication number: 20180155761
    Abstract: Provided herein are novel irreversible sialidase inhibitors. These compounds can be conjugated with a detectable tagging moiety such as azide-annexed biotin via CuAAC for isolation and identification of sialidases. The provided compounds and the corresponding detectable conjugates are useful for detecting sialidase-containing pathogens and imaging in situ sialidase activities under physiological conditions.
    Type: Application
    Filed: January 26, 2018
    Publication date: June 7, 2018
    Inventors: Chi-Huey WONG, Jim-Min FANG, Yih-Shyun E. CHENG, Chamg-Sheng TSAI
  • Patent number: 9914956
    Abstract: Provided herein are novel irreversible sialidase inhibitors. These compounds can be conjugated with a detectable tagging moiety such as azide-annexed biotin via CuAAC for isolation and identification of sialidases. The provided compounds and the corresponding detectable conjugates are useful for detecting sialidase-containing pathogens and imaging in situ sialidase activities under physiological conditions.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: March 13, 2018
    Assignee: Academia Sinica
    Inventors: Chi-Huey Wong, Jim-Min Fang, Yih-Shyun E. Cheng, Charng-Sheng Tsai
  • Patent number: 9874562
    Abstract: Methods and compositions for detection of drug resistant pathogens and treatment against infections thereof are provided. Methods for detection of oseltamivir-resistant influenza viruses by competitive binding assays utilizing non-oseltamivir influenza virus neuraminidase inhibitors and oseltamivir carboxylate are provided. Influenza virus neuraminidase inhibitors coupled to sensors and useful for employment in the methods of the invention are disclosed. Novel phosphonate compounds active as neuraminidase inhibitors against wild-type and oseltamivir-resistant influenza strains of H1N1, H5N1 and H3N2 viruses are disclosed. An enantioselective synthetic route to preparation of these phosphonate compounds via sialic acid is provided.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: January 23, 2018
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Jim-Min Fang, Yih-Shyun Edmund Cheng, Jiun-Jie Shie
  • Publication number: 20180011104
    Abstract: Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide-alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.
    Type: Application
    Filed: August 1, 2017
    Publication date: January 11, 2018
    Inventors: Chi-Huey WONG, Jim-Min FANG, Jiun-Jie SHIE
  • Patent number: 9759726
    Abstract: Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide-alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: September 12, 2017
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Jim-Min Fang, Jiun-Jie Shie
  • Publication number: 20170224716
    Abstract: The invention provides a new use of adenosine analogs for the treatment of pain through activation of neurokinin 1 (NK1) receptor signaling pathway, thereby inducing the activation of activation of M-type potassium channel to induce outward currents. A method and pharmaceutical composition for treating pain comprising an adenonsine analog that activates NK1 receptor signaling, thereby inducing outward current are also provided.
    Type: Application
    Filed: December 12, 2016
    Publication date: August 10, 2017
    Applicant: Academia Sinica
    Inventors: Chih-Cheng Chen, Yun-Lian Lin, Jim-Min Fang, Yijuang Chern, Chia-Ching John Lin, Wei-Nan Chen, Chun-Jung Lin
  • Patent number: 9662328
    Abstract: The present invention relates to novel TMPK inhibitor and their methods of use. In particular, it relates to novel TMPK inhibitor of Formula (I) and therapeutics that decrease the cellular dTTP level to suppress the growth and inhibit DNA repair in tumor cells and acts as a novel chemosensitizer, which are useful in methods for treating or preventing cancers.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: May 30, 2017
    Inventors: Zee-Fen Chang, Jim-Min Fang
  • Publication number: 20170102387
    Abstract: Methods and compositions for detection of drug resistant pathogens and treatment against infections thereof are provided. Methods for detection of oseltamivir-resistant influenza viruses by competitive binding assays utilizing non-oseltamivir influenza virus neuraminidase inhibitors and oseltamivir carboxylate are provided. Influenza virus neuraminidase inhibitors coupled to sensors and useful for employment in the methods of the invention are disclosed. Novel phosphonate compounds active as neuraminidase inhibitors against wild-type and oseltamivir-resistant influenza strains of H1N1, H5N1 and H3N2 viruses are disclosed. An enantioselective synthetic route to preparation of these phosphonate compounds via sialic acid is provided.
    Type: Application
    Filed: July 14, 2016
    Publication date: April 13, 2017
    Inventors: Chi-Huey WONG, Jim-Min FANG, Yih-Shyun Edmund CHENG, Jiun-Jie SHIE
  • Patent number: 9547009
    Abstract: Provided are benzocyclooctyne compounds of formula (I). These compounds undergo strain-promoted azide-alkyne cyclo additions (SPAAC) without presence of toxic metal catalysts. The provided compounds are useful for diagnosis and imaging of azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.
    Type: Grant
    Filed: August 21, 2013
    Date of Patent: January 17, 2017
    Assignee: Academia Sinica
    Inventors: Chi-Huey Wong, Jim-Min Fang, Jiun-Jie Shie