Patents by Inventor Jim-Min Fang
Jim-Min Fang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240010669Abstract: Compounds for use in prevention and/or treatment of pain are disclosed. The compounds are derived by conjugation of N6-(4-hydroxybenzyl)adenosine and analogous compounds with amino acids or peptides. In one embodiment of the invention, the compound is 5?-glycylcarbonyl-N6-(4-hydroxybenzyl)adenosine (I-a1). In another embodiment of the invention, the compound is 5?-deoxy-5?-(N?-glycylureido)-N6-(4-hydroxybenzyl)adenosine (I-d1). Also disclosed are methods of making and using the same.Type: ApplicationFiled: July 28, 2023Publication date: January 11, 2024Inventors: Chih-Cheng CHEN, Jim-Min FANG, Cheng-Han LEE, Jen-Yao CHANG
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Patent number: 11753432Abstract: Compounds for use in prevention and/or treatment of pain are disclosed. The compounds are derived by conjugation of N6-(4-hydroxybenzyl)adenosine and analogous compounds with amino acids or peptides. In one embodiment of the invention, the compound is 5?-O-(glycine-N-carbonyl-N6-(4-hydroxybenzyl)adenosine (I-a1). In another embodiment of the invention, the compound is 5-deoxy-5?-(glycine-N-amido)-N6-(4-hydroxybenzyl)adenosine (I-d1). Also disclosed are methods of making and using the same.Type: GrantFiled: January 26, 2018Date of Patent: September 12, 2023Assignee: ACADEMIA SINICAInventors: Chih-Cheng Chen, Jim-Min Fang, Cheng-Han Lee, Jen-Yao Chang
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Patent number: 11439979Abstract: Provided is a method of making colloidal selenium nanoparticles. The method includes the steps as follows: Step (A): providing a reducing agent and an aqueous solution containing a selenium precursor; Step (B): mixing the aqueous solution containing the selenium precursor and the reducing agent to form a mixture solution in a reaction vessel and heating the mixture solution to undergo a reduction reaction and produce a composition containing selenium nanoparticles, residues and a gas, and guiding the gas out of the reaction vessel, wherein an amount of the residues is less than 20% by volume of the mixture solution; and Step (C): dispersing the selenium nanoparticles with a medium to obtain the colloidal selenium nanoparticles. The method has advantages of simplicity, safety, time-effectiveness, cost-effectiveness, high yield and eco-friendliness.Type: GrantFiled: July 23, 2020Date of Patent: September 13, 2022Assignee: TRIPOD NANO TECHNOLOGY CORPORATIONInventors: Chung-Jung Hung, Chun-Lun Chiu, Chia-Chi Chang, Hsin-Chang Huang, Teng-Chieh Hsu, Meng-Hsiu Chih, Jim-Min Fang
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Publication number: 20210394157Abstract: Provided is a method of making colloidal selenium nanoparticles. The method includes the steps as follows: Step (A): providing a reducing agent and an aqueous solution containing a selenium precursor; Step (B): mixing the aqueous solution containing the selenium precursor and the reducing agent to form a mixture solution in a reaction vessel and heating the mixture solution to undergo a reduction reaction and produce a composition containing selenium nanoparticles, residues and a gas, and guiding the gas out of the reaction vessel, wherein an amount of the residues is less than 20% by volume of the mixture solution; and Step (C): dispersing the selenium nanoparticles with a medium to obtain the colloidal selenium nanoparticles. The method has advantages of simplicity, safety, time-effectiveness, cost-effectiveness, high yield and eco-friendliness.Type: ApplicationFiled: July 23, 2020Publication date: December 23, 2021Inventors: Chung-Jung HUNG, Chun-Lun CHIU, Chia-Chi CHANG, Hsin-Chang HUANG, Teng-Chieh HSU, Meng-Hsiu CHIH, Jim-Min FANG
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Patent number: 11179781Abstract: Provided is a method of making colloidal platinum nanoparticles. The method includes three consecutive steps: dissolving platinum powders by a halogen-containing oxidizing agent in HCl to obtain an inorganic platinum solution containing an inorganic platinum compound; adding a reducing agent into the same reaction vessel to form a mixture solution and heating the mixture solution to undergo a reduction reaction and produce a composition containing platinum nanoparticles, residues and a gas, and guiding the gas out of the reaction vessel, wherein the amount of the residues is less than 15% by volume of the mixture solution; and adding a medium into the same reaction vessel to disperse the platinum nanoparticles to obtain colloidal platinum nanoparticles. The method is simple, safe, time-effective, cost-effective, and has the advantage of high yield.Type: GrantFiled: April 23, 2019Date of Patent: November 23, 2021Assignee: TRIPOD NANO TECHNOLOGY CORPORATIONInventors: Lin Lu, Kuei-Sheng Fan, Chun-Lun Chiu Chiu, Han-Wu Yen, Hao-Chan Hsu, Chia-Yi Lin, Chi-Jiun Peng, Cheng-Ding Wang, Jim-Min Fang
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Patent number: 10865121Abstract: Provided is a method of making an inorganic platinum compound. The method includes the steps of: Step (A): providing a platinum material and a halogen-containing oxidizing agent; and Step (B): treating the platinum material with the halogen-containing oxidizing agent in a hydrochloric acid aqueous solution to obtain the inorganic platinum compound, including chloroplatinic acid or chloroplatinate salt; wherein the halogen-containing oxidizing agent excludes chlorine gas. The method of making an inorganic platinum compound is simple, safe, time-effective, cost-effective, and environment-friendly, and has the advantage of high yield.Type: GrantFiled: February 19, 2019Date of Patent: December 15, 2020Assignee: TRIPOD NANO TECHNOLOGY CORPORATIONInventors: Lin Lu, Kuei-Sheng Fan, Chun-Lun Chiu, Han-Wu Yen, Chi-Jiun Peng, Cheng-Ding Wang, Jim-Min Fang
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Patent number: 10765681Abstract: The present disclosure provides compounds of Formulas (I?) and (I), and pharmaceutically acceptable salts thereof. The compounds described herein may be useful in treating and/or preventing proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, and uses thereof for treating proliferative diseases.Type: GrantFiled: February 3, 2017Date of Patent: September 8, 2020Assignees: Academia Sinica, National Taiwan UniversityInventors: Chi-Huey Wong, Pan-Chyr Yang, Jim-Min Fang, Szu-Hua Pan, Ting-Jen R. Cheng, Ling-Wei Li
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Publication number: 20200180976Abstract: Provided is a method of making an inorganic platinum compound. The method includes the steps of: Step (A): providing a platinum material and a halogen-containing oxidizing agent; and Step (B): treating the platinum material with the halogen-containing oxidizing agent in a hydrochloric acid aqueous solution to obtain the inorganic platinum compound, including chloroplatinic acid or chloroplatinate salt; wherein the halogen-containing oxidizing agent excludes chlorine gas. The method of making an inorganic platinum compound is simple, safe, time-effective, cost-effective, and environment-friendly, and has the advantage of high yield.Type: ApplicationFiled: February 19, 2019Publication date: June 11, 2020Inventors: Lin LU, Kuei-Sheng FAN, Chun-Lun CHIU, Han-Wu YEN, Chi-Jiun PENG, Cheng-Ding WANG, Jim-Min FANG
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Publication number: 20200114429Abstract: Provided is a method of making colloidal platinum nanoparticles. The method includes three consecutive steps: dissolving platinum powders by a halogen-containing oxidizing agent in HCl to obtain an inorganic platinum solution containing an inorganic platinum compound; adding a reducing agent into the same reaction vessel to form a mixture solution and heating the mixture solution to undergo a reduction reaction and produce a composition containing platinum nanoparticles, residues and a gas, and guiding the gas out of the reaction vessel, wherein the amount of the residues is less than 15% by volume of the mixture solution; and adding a medium into the same reaction vessel to disperse the platinum nanoparticles to obtain colloidal platinum nanoparticles. The method is simple, safe, time-effective, cost-effective, and has the advantage of high yield.Type: ApplicationFiled: April 23, 2019Publication date: April 16, 2020Inventors: Lin LU, Kuei-Sheng FAN, Chun-Lun CHIU CHIU, Han-Wu YEN, Hao-Chan HSU, Chia-Yi LIN, Chi-Jiun PENG, Cheng-Ding WANG, Jim-Min FANG
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Publication number: 20190389898Abstract: Compounds for use in prevention and/or treatment of pain are disclosed. The compounds are derived by conjugation of N6-(4-hydroxybenzyl)adenosine and analogous compounds with amino acids or peptides. In one embodiment of the invention, the compound is 5?-glycylcarbonyl-N6-(4-hydroxybenzyl)adenosine (I-a1). In another embodiment of the invention, the compound is 5?-deoxy-5?-(N?-glycylureido)-N6-(4-hydroxybenzyl)adenosine (I-d1). Also disclosed are methods of making and using the same.Type: ApplicationFiled: January 26, 2018Publication date: December 26, 2019Inventors: Chih-Cheng CHEN, Jim-Min FANG, Cheng-Han LEE, Jen-Yao CHANG
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Patent number: 10342818Abstract: The present invention provides therapeutic agents for preventing and treating neurodegenerative diseases. These agents synergistically target both the adenosine A2A receptor (A2AR) and the equilibrative nucleoside transporter 1 (ENT1).Type: GrantFiled: September 10, 2015Date of Patent: July 9, 2019Assignee: ACADEMIA SINICAInventors: Yun-Lian Lin, Yijuang Chern, Jim-Min Fang, Jung-Hsing Lin, Nai-Kuei Huang
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Patent number: 10301348Abstract: Compounds for use in prevention and treatment of neurodegenerative disease and pain are disclosed. In one embodiment of the invention, the compound is selected from the group consisting of N6-[(3-halothien-2-yl)methyl]adenosine, N6-[(4-halothien-2-yl)methyl]adenosine, and N6-[(5-halothien-2-yl)methyl]adenosine. In another embodiment of the invention, the compound is selected from the group consisting of N6-[(2-bromothien-3-yl)methyl]adenosine, N6-[(4-bromothien-3-yl)methyl]adenosine, N6-[(5-bromothien-3-yl)methyl]adenosine N6-[(2-chlorothien-3-yl)methyl]adenosine, N6-[(4-chlorothien-3-yl)methyl]adenosine, and N6-[(5-chlorothien-3-yl)methyl]adenosine. Also disclosed are methods of making and using the same.Type: GrantFiled: October 22, 2014Date of Patent: May 28, 2019Assignee: ACADEMIA SINICAInventors: Jim-Min Fang, Yun-Lian Lin, Jung-Hsin Lin, Chun-Jung Lin, Yijuang Chern, Nai-Kuei Huang, Hung-Li Wang, Benjamin Pang-hsien Tu, Chih-Cheng Chen
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Patent number: 10214765Abstract: Provided herein are compounds for use as sialidase inhibitors, including alkynyl-3-fluorosialyl fluoride. The compounds, which include the compound DFSA, function by trapping a 3-fluorosialylenzyme intermediate (reporter-inhibitor-enzyme conjugate). These compounds can be conjugated with a detectable tagging moiety for isolation and identification of sialidases.Type: GrantFiled: January 26, 2018Date of Patent: February 26, 2019Assignee: Academia SinicaInventors: Chi-Huey Wong, Jim-Min Fang, Yih-Shyun E. Cheng, Chamg-Sheng Tsai
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Publication number: 20180369249Abstract: The present disclosure provides compounds of Formulas (I?) and (I), and pharmaceutically acceptable salts thereof. The compounds described herein may be useful in treating and/or preventing proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, and uses thereof for treating proliferative diseases.Type: ApplicationFiled: February 3, 2017Publication date: December 27, 2018Applicants: Academia Sinica, National Taiwan UniversityInventors: Chi-Huey Wong, Pan-Chyr Yang, Jim-Min Fang, Szu-Hua Pan, Ting-Jen R. Cheng, Ling-Wei Li
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Patent number: 10130714Abstract: Novel dual-targeted, bifunctional anti-influenza drugs formed by conjugation with anti-inflammatory agents are disclosed. Exemplary drugs according to the invention include caffeic acid (CA)-bearing zanamivir (ZA) conjugates ZA-7-CA (1), ZA-7-CA-amide (7) and ZA-7-Nap (43) for simultaneous inhibition of influenza virus neuraminidase and suppression of proinflammatory cytokines. Synthetic methods for preparation of these enhanced anti-influenza conjugate drugs are provided. The synthetic bifunctional ZA conjugates act synergistically towards protection of mice lethally infected by H1N1 or H5N1 influenza viruses. The efficacy of ZA-7-CA, ZA-7-CA-amide and ZA-7-Nap conjugates is much greater than the combination therapy of ZA with anti-inflammatory agents.Type: GrantFiled: March 15, 2013Date of Patent: November 20, 2018Assignee: ACADEMIA SINICAInventors: Chi-Huey Wong, Jim-Min Fang, Kung-Cheng Liu, Jia-Tsrong Jan, Yih-Shyun E. Cheng, Ting-Jen R. Cheng
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Patent number: 10117890Abstract: Methods for treating pain such as fibromyalgia, comprising administering to a subject in need thereof an effective amount of an adenosine analog, wherein the adenosine analog may be a compound of Formula (I): (I), or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising the adenosine analog for use in treating pain (e.g., fibromyalgia), optionally further comprising Substance P (SP), are also provided.Type: GrantFiled: December 12, 2016Date of Patent: November 6, 2018Assignee: Academia SinicaInventors: Chih-Cheng Chen, Yun-Lian Lin, Jim-Min Fang, Yijuang Chern, Chia-Ching John Lin, Wei-Nan Chen, Chun-Jung Lin
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Patent number: 10119972Abstract: Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide-alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.Type: GrantFiled: August 1, 2017Date of Patent: November 6, 2018Assignee: ACADEMIA SINICAInventors: Chi-Huey Wong, Jim-Min Fang, Jiun-Jie Shie
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Patent number: 10099191Abstract: Provided is a method of making colloidal metal nanoparticles. The method includes the steps of: mixing a metal aqueous solution and a reducing agent to form a mixture solution in a reaction tank; heating the mixture solution and undergoing a reduction reaction to produce a composition containing metal nanoparticles, residues and gas, wherein the amount of the residues is less than 20% by volume of the mixture solution, and guiding the gas out of the reaction tank; dispersing the metal nanoparticles with a medium to obtain colloidal metal nanoparticles. By separating the reduction reaction step and the dispersion step, the method of making colloidal metal nanoparticles is simple, safe, time-effective, cost-effective, and has the advantage of high yield.Type: GrantFiled: June 22, 2017Date of Patent: October 16, 2018Assignee: TRIPOD TECHNOLOGY CORPORATIONInventors: Lin Lu, Kuei-Sheng Fan, Chen-Hsiang Wang, Chun-Lun Chiu, Ta-Wei Chang, Cheng-Ding Wang, Jim-Min Fang
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Patent number: 10046976Abstract: A method of making the inorganic gold compound, such as tetrachloroauric acid, sodium tetrachloroaurate, potassium tetrachloroaurate, sodium tetracyanoaurate, and potassium tetracyanoaurate, includes the step of: treating gold with a halogen-containing oxidizing agent in a hydrochloric acid to obtain the inorganic gold compound, wherein the halogen-containing oxidizing agent excludes chlorine gas. The method of making the inorganic gold compound is simple, safe, time-effective, cost-effective, and environment-friendly, and has the advantage of high yield.Type: GrantFiled: January 25, 2017Date of Patent: August 14, 2018Assignee: TRIPOD TECHNOLOGY CORPORATIONInventors: Lin Lu, Chen-Hsiang Wang, Kuei-Sheng Fan, Cheng-Ding Wang, Jim-Min Fang
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Publication number: 20180208476Abstract: A method of making the inorganic gold compound, such as tetrachloroauric acid, sodium tetrachloroaurate, potassium tetrachloroaurate, sodium tetracyanoaurate, and potassium tetracyanoaurate, includes the step of: treating gold with a halogen-containing oxidizing agent in a hydrochloric acid to obtain the inorganic gold compound, wherein the halogen-containing oxidizing agent excludes chlorine gas. The method of making the inorganic gold compound is simple, safe, time-effective, cost-effective, and environment-friendly, and has the advantage of high yield.Type: ApplicationFiled: January 25, 2017Publication date: July 26, 2018Applicant: TRIPOD TECHNOLOGY CORPORATIONInventors: Lin LU, Chen-Hsiang WANG, Kuei-Sheng FAN, Cheng-Ding WANG, Jim-Min FANG