Abstract: In general, in one aspect, the invention features an article that includes a layer including a plurality of spaced-apart portions of a first material extending along a first direction. The layer transmits about 20% or more of light of wavelength ? having a first polarization state incident on the layer along a path. The layer transmits about 2% or less of light of wavelength ? having a second polarization state incident on the layer along the path, the first and second polarization states being orthogonal. For wavelength ?, the first material has a refractive index of 1.8 or more and an extinction coefficient of 1.8 or more, and ? is 300 nm or less.

Abstract: The present invention provides novel isolated compounds characterized as metabolites or derivatives of desmethylvenlafaxine including hydroxy-DV metabolites, hydroxy-DV-glucuronide metabolites, N-oxide-DV metabolites, and benzyl-hydroxy-DV metabolites. The invention includes pharmaceutical compositions comprising any of the metabolites or derivatives of the invention in combination with a pharmaceutically acceptable carrier or excipient. The invention also includes a method of treating at least one central nervous system disorder in a mammal comprising providing to a mammal in need thereof an effective amount of the compounds of the invention.

Abstract: Drug delivery is targeted to new opioid receptors using receptor-mediated internalization. Dermorphin was successfully conjugated to DSPE-PEG3400 without affecting the affinity to its receptor. The synthesized conjugate was inserted into preformed sterically stabilized liposomes to obtain dermorphin-grafted SSL. DSPE-PEG34Qo-dermorphin and dermorphin-SSL retained their affinity and selectivity for MOR. Moreover, dermorphin-SSL and encapsulated probes were taken up by CHO-hMOR cells, but not by naive CHO cells or very closely related CHO-hDOR cells. Dermorphin-SSL can be used to deliver drugs to the intracellular component of intended cells with high fidelity. Therefore, dermorphin-SSL is useful to carry pharmaceutical agents to achieve region-specific delivery of analgesics and/or to attenuate side effects associated with opioids.

Abstract: The pneumatic tool has a check valve placed inside that includes an internal and external valve base and traveling valve. The internal valve base has an inlet hole, and an enlarged slot is formed on the external end of the inlet hole. An annular oblique edge is formed between the enlarged slot and inlet hole, and an air hole is placed on the enlarged slot. The external valve base has an outlet hole that is connected to the outside of the pneumatic tool. A protruding tube is formed inside the outlet hole. Interval space is formed between the inside of the protruding tube and the inlet hole for the internal valve base; and the traveling valve can be traveling inside the interval space. The built-in check valve can avoid external force, which extends the shelf life and makes appearance of the product look neater and practical.

Abstract: In one aspect, the invention features articles that include a substrate having a first surface and a second surface contiguous with the first surface. The first and second surfaces are non-coplanar. A first multilayer film is disposed on the first surface. A second multilayer film is disposed on the second surface. The second multilayer film is contiguous with the first multilayer film.

Abstract: Antenna system and methodology for producing multiple interleaved beams using a hybrid frequency-reuse scheme. In particular, depending on the traffic demand in specific coverage areas, some beams are assigned with frequency channels in accordance with a 4-cell frequency-reuse scheme, and the other beams are assigned with frequency channels in accordance with a 7-cell frequency-reuse scheme. The antenna system has multiple feeds divided into clusters, and a number of reflectors fed by respective feed clusters and configured to form one beam for each of the feeds.

Abstract: This disclosure relates to oxide materials, as well as related articles, systems and methods.

Abstract: In accordance with the invention, a mode-locked laser comprises an optical gain medium disposed within an optical cavity formed by a first reflector and a wavelength selective second reflector to achieve mode-locking operation. Advantageously, the wavelength reflective reflector is a two-dimensional subwavelength resonant grating. The resulting laser is compact, tunable, reliable and inexpensive. It provides high side mode suppression and high output power.

Abstract: In general, in a first aspect, the invention features a method that includes depositing a first material on a surface of an article to form a layer including the first material. The surface of the article includes a plurality of protrusions and the layer including the first material forms a plurality of lenses. Each lens corresponds to a protrusion on the substrate surface.

Abstract: The pneumatic tool has a check valve placed inside that includes an internal and external valve base and traveling valve. The internal valve base has an inlet hole, and an enlarged slot is formed on the external end of the inlet hole. An annular oblique edge is formed between the enlarged slot and inlet hole, and an air hole is placed on the enlarged slot. The external valve base has an outlet hole that is connected to the outside of the pneumatic tool. A protruding tube is formed inside the outlet hole. Interval space is formed between the inside of the protruding tube and the inlet hole for the internal valve base; and the traveling valve can be traveling inside the interval space. The built-in check valve can avoid external force, which extends the shelf life and makes appearance of the product look neater and practical.

Abstract: An antenna system for generating and configuring at least one defocused beam is provided. The antenna system includes a reflector having a focal plane and a non-parabolic curvature for forming the at least one defocused beam, and a plurality of feed antennas that illuminate the reflector. Each feed antenna is disposed in the focal plane of the reflector. The antenna system further includes at least one incoming signal dividing network that divides at least one incoming signal into a plurality of sub-signals, each corresponding to one of the feed antennas, a plurality of variable phase shifters, each receiving one of the sub-signals from the incoming signal dividing network and phase shifting the sub-signal to generate a corresponding phase-shifted sub-signal, and a plurality of fixed-amplitude amplifiers, at least one corresponding to each of the feed antennas.

Abstract: The cylinder structure for a pneumatic tool includes a first and second cylinder placed inside the pneumatic tool, and a first and second piston placed inside the first and second cylinder. The one-piece structure of the first and second cylinder are inside the pneumatic tool, and the air inlet of the first cylinder and the air inlet of the second cylinder can be connected by a first bypass. The lower air chamber of the first cylinder is connected to the second piston of the second cylinder at the bottom by a second bypass. The double cylinder of the pneumatic tool avoids being hit by external forces, which extends the life of usage. The invention makes the manufacturing process simpler and more effective, and the end product looks more unified.

Abstract: In certain aspects, the disclosure relates to articles that include a plurality of walls configured to form a grating. Each of the plurality of walls can include a layer of a first material and a layer of a second material different from the first material. The articles can retard incident radiation at wavelengths ?1 and ?2 by amounts ?1 and ?2, respectively, where |?1??2| is about 15 nm or more and ?1 is substantially equal to ?2.

Abstract: Films for optical use, articles containing such films, methods for making such films, and systems that utilize such films, are disclosed.

Abstract: The invention relates to metabolites of certain [1,4]diazepino[6,7,1-ij]quinoline derivatives and methods of preparation and use thereof. Specifically, the invention relates to compounds of formula I wherein the various substituents are defined herein. The invention also provides pharmaceutical compositions including compounds of formula I, methods of making such compounds, and methods of using such compounds.

Abstract: The present invention pertains to a package structure of multi-chips light-emitting module, wherein via the packaging technology of semiconductor, a plurality of light emitting diode chips are installed on the disposing portion of a lead frame, and the chips and the lead frame are interconnected with bond wires, and then an encapsulant is used to cover the chips, bond wires and the disposing portion to form a package structure. The light-emitting module packaged with the structure having the disposing portion can be applied to the light source of lightening, indicator and alarm, etc., and not only has high light permeability, but also has the function of diverging as well as focusing the light source.

Abstract: In accordance with the invention, a tunable subwavelength resonant grating filter comprises a liquid crystal cell having a pair of major surface walls. One wall of the cell is a coated subwavelength grating of a SRGF. The coating comprises a polymer layer to fill the grating trenches and a surfactant layer to facilitate uniform alignment of the liquid crystal material. The refractive index of the LCD material in the cell can then be electrically or thermally adjusted to tune the resonant wavelength.

Abstract: A method for panel optimization provides for optimal layout of printed circuit boards (302-306) on factory arrays (104), as well as the layout of arrays on panels (102). By using nesting algorithms to quickly simulate a large number of permutations, an optimal panelization solution can be quickly reached. The method includes the steps of collecting the necessary data (402), performing a panel dimension loop, an array length loop, and an array width loop. For every case, a total efficiency factor is calculated (422) to help determine the optimal layout.

Abstract: In accordance with the invention, a mode-locked laser comprises an optical gain medium disposed within an optical cavity formed by a first reflector and a wavelength selective second reflector to achieve mode-locking operation. Advantageously, the wavelength reflective reflector is a two-dimensional subwavelength resonant grating. The resulting laser is compact, tunable, reliable and inexpensive. It provides high side mode suppression and high output power.

Abstract: A method for fabricating LOCOS isolation having a planar surface. The method utilizes a polysilicon spacer to prevent bird beak. The method adds the steps of forming a polishing stop layer and removing said edge-protrusion portion of the local oxide by chemical mechanical polishing.