Patents by Inventor Jin Huh
Jin Huh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200291428Abstract: Provided herein are engineered HSV-1 vectors comprising a modified HSV-1 genome. The engineered HSV-1 vectors can be used to deliver genetic circuits (e.g., up to 100 kb) to cells in vitro or in vivo. Methods of treating or diagnosing a disease (e.g., cancer) using the engineered HSV-1 vectors described herein are also provided.Type: ApplicationFiled: January 14, 2020Publication date: September 17, 2020Applicant: Massachusetts Institute of TechnologyInventors: Ron Weiss, Maria Hottelet Foley, Jin Huh, Ross D. Jones
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Publication number: 20200283796Abstract: Provided herein, in some aspects, are antibody expression systems comprising DNA launched RNA replicons for high level antibody expression. In some embodiments, the antibody is a therapeutic antibody. In some embodiments, the antibody is an immune check point inhibitor. Methods of using the antibody expression system for treating diseases (e.g., cancer) are also provided.Type: ApplicationFiled: March 5, 2020Publication date: September 10, 2020Applicant: Massachusetts Institute of TechnologyInventors: Ron Weiss, Jin Huh, Jacob Becraft
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Publication number: 20200208127Abstract: The present invention relates to methods of treating or preventing inflammation with a peptide having anti-inflammatory activity, wherein the peptide consists of the amino acid sequence of SEQ ID NO: 101. According to the present invention, the peptide of SEQ ID NO: 101 has outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the method comprising administration of the peptide of this invention can be used in anti-inflammatory pharmaceutical or cosmetic applications, in turn, treating and preventing a variety of different types of inflammatory diseases.Type: ApplicationFiled: March 13, 2020Publication date: July 2, 2020Applicant: GemVax & KAEL Co., Ltd.Inventors: Sang Jae KIM, Kyung Hee Kim, Kyu-Yong Lee, Seong-Ho KOH, Bum Joon Kim, Hyun-Hee PARK, Sung Jin HUH, Woo Jin LEE, Hwain JANG, Jung Soon HA
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Publication number: 20200140832Abstract: The present invention relates to a peptide with anti-inflammatory activity, wherein the peptide comprises any one amino acid sequence of SEQ ID NO:1 to SEQ ID NO:161, the peptide has above 80% homology of amino acid sequence with above-mentioned sequences, or the peptide is the fragment of the above-mentioned peptides. The present invention also relates to an inflammatory composition comprising the above mentioned peptides. According to the present invention, a peptide that has at least one amino acid sequence of SEQ ID NO:1 to SEQ ID NO:161 has outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising the peptides of this invention can be used as anti-inflammatory pharmaceutical compositions or as cosmetic compositions, in turn, treating and preventing a variety of different types of inflammatory diseases.Type: ApplicationFiled: January 17, 2020Publication date: May 7, 2020Inventors: Sang Jae KIM, Kyung Hee KIM, Kyu-Yong LEE, Seong-Ho KOH, Bum Joon KIM, Hyun-Hee PARK, Sung Jin HUH, Woo Jin LEE, Hwain JANG, Jung Soon HA
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Publication number: 20200056189Abstract: Provided herein are genetic circuits and cell state classifiers for detecting the microRNA profile of a cell. The cell state classifiers of the present disclosure utilize phosphorylation state of a transcription factor to control classifier output. Kinases and phosphatase pairs that function in phosphorylating or dephosphorylating the transcription factor are integrated into the circuit, their expression tuned by the presence of microRNAs of interest (e.g., in a cell). The genetic circuits and cell state classifiers may be used in various applications (e.g., therapeutic or diagnostic applications).Type: ApplicationFiled: August 1, 2019Publication date: February 20, 2020Applicant: Massachusetts Institute of TechnologyInventors: Ron Weiss, Ross D. Jones, Jin Huh
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Publication number: 20200040338Abstract: Provided herein are genetic circuits and cell state classifiers for detecting the microRNA profile of a cell. In some embodiments, the cell state classifiers described herein utilize an endoribonuclease and a self-amplifying RNA molecule for controlling the expression of an output molecule. In some embodiments, the cell state classifiers described herein are encoded on a single RNA transcript, which is then processed to produce individual genetic circuits that function independently. The genetic circuits and cell state classifiers described herein may be used in various applications (e.g., therapeutic or diagnostic applications).Type: ApplicationFiled: August 1, 2019Publication date: February 6, 2020Applicant: Massachusetts Institute of TechnologyInventors: Ron Weiss, Kevin J. Lebo, Jin Huh
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Patent number: 10536130Abstract: A single input multiple output plasma control system includes a splitter that receives a single input and generates multiple outputs. Each output from the splitter is provided to a load. The splitter includes branch circuits connected between selected splitter outputs. The branch circuits control voltage, current, power, frequency, or phase between each branch to enable controlling a predetermined relationship between the voltage, current, power, impedance, frequency, or phase measured at each load.Type: GrantFiled: August 24, 2018Date of Patent: January 14, 2020Assignee: MKS Instruments, inc.Inventors: David J. Coumou, Dennis M. Brown, Jeongseok Jang, Jin Huh
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Patent number: 10408424Abstract: A housing or pocket for supporting a light guide device for an illumination device, especially for a motor vehicle or an indicator device in a rearview device of a motor vehicle. The housing has a first side which is configured to support the light guiding device for exposure to the pictogram of the reflection layer. The housing also include a second side containing exposed wire connectors to connect the light guide device to a power source. One of the light guide device, the printed circuit board or both structures are fitted with an encapsulation member and secured to the housing through the use of a fixative mount.Type: GrantFiled: August 31, 2018Date of Patent: September 10, 2019Assignee: SMR Patents S.à.r.l.Inventors: Norbert Kürschner, Andreas Herrmann, Chun Seop Kwak, Ho Jin Huh
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Patent number: 10374911Abstract: The present disclosure is related to device management in a machine to machine (M2M) network. Particularly, the present disclosure relates to performing an efficient device management based on correlations between M2M devices in the M2M network.Type: GrantFiled: February 26, 2014Date of Patent: August 6, 2019Assignee: KT CORPORATIONInventors: Hwi-Jung Ryu, Mi-Kyoung Kang, Yong Kwon, Sung-Ihk Yang, Kwang-Jin Lee, Sung-Kooc Lim, Yu-Jin Huh
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Publication number: 20190192638Abstract: The present invention relates to a peptide with anti-inflammatory activity, wherein the peptide comprises at least one amino acid sequence among SEQ ID NO: 2 to SEQ ID NO: 179, the peptide has above 80% homology of amino acid sequence with above-mentioned sequences, or the peptide is the fragment of the above-mentioned peptides. The present invention also relates to an inflammatory composition comprising the above mentioned peptides. According to the present invention, the peptides that have at least one amino acid sequence of SEQ ID NO: 2 to SEQ ID NO: 179 shows outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising the peptides of this invention can be used as anti-inflammatory pharmaceutical compositions or as cosmetic compositions, in turn, treating and preventing a variety of different types of inflammatory diseases.Type: ApplicationFiled: December 21, 2018Publication date: June 27, 2019Inventors: Sang Jae Kim, Kyung Hee Kim, Kyu-Yong Lee, Seong-Ho Koh, Hyun-Hee Park, Sung Jin Huh, Woo Jin Lee, Bum Joon Kim
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Publication number: 20190068158Abstract: A single input multiple output plasma control system includes a splitter that receives a single input and generates multiple outputs. Each output from the splitter is provided to a load. The splitter includes branch circuits connected between selected splitter outputs. The branch circuits control voltage, current, power, frequency, or phase between each branch to enable controlling a predetermined relationship between the voltage, current, power, impedance, frequency, or phase measured at each load.Type: ApplicationFiled: August 24, 2018Publication date: February 28, 2019Inventors: David J. COUMOU, Dennis M. BROWN, Jeongseok JANG, Jin HUH
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Patent number: 10206981Abstract: A peptide with anti-inflammatory activity is described, wherein the peptide comprises at least one amino acid sequence among SEQ ID NO: 2 to SEQ ID NO: 179, the peptide has above 80% homology of amino acid sequence with above-mentioned sequences, or the peptide is the fragment of the above-mentioned peptides. The peptides that have at least one amino acid sequence of SEQ ID NO: 2 to SEQ ID NO: 179 shows outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising those peptides can be used as anti-inflammatory pharmaceutical compositions or as cosmetic compositions, in turn, treating and preventing a variety of different types of inflammatory diseases.Type: GrantFiled: November 17, 2016Date of Patent: February 19, 2019Assignee: GemVax & KAEL Co., Ltd.Inventors: Sang Jae Kim, Kyung Hee Kim, Kyu-Yong Lee, Seong-Ho Koh, Hyun-Hee Park, Sung Jin Huh, Woo Jin Lee, Bum Joon Kim
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Publication number: 20190030137Abstract: A peptide with anti-inflammatory activity, wherein the peptide comprises SEQ ID NO: 1, the peptide has above 80% homology of amino acid with above-mentioned sequence, or the peptide is the fragment of the above-mentioned peptides is described. An anti-inflammatory composition comprising the above mentioned peptides is described. According to the present invention, a peptide comprising a sequence of SEQ ID NO: 1 has outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising the peptide of this invention can be used as anti-inflammatory pharmaceutical composition or as cosmetic composition, in turn, treating and preventing a variety of different types of inflammatory diseases.Type: ApplicationFiled: July 2, 2018Publication date: January 31, 2019Applicant: GemVax & KAEL Co., Ltd.Inventors: Sang Jae Kim, Kyung Hee Kim, Kyu-Yong Lee, Seong-Ho Koh, Hyun-Hee Park, Sung Jin Huh, Woo Jin Lee, Bum Joon Kim
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Publication number: 20190032141Abstract: Provided herein are genetic circuits and cell state classifiers for detecting the microRNA profile of a cell. The cell state classifiers of the present disclosure are designed to incorporate multiple genetic circuits integrated together by transcriptional or translational control. Multiple inputs can be sensed simultaneously by coupling their detection to different portions of the genetic circuit such that the output molecule is produced only when the correct input profile of miRNAs is detected. The genetic circuits and cell state classifiers may be used in various applications (e.g., therapeutic or diagnostic applications).Type: ApplicationFiled: July 31, 2017Publication date: January 31, 2019Inventors: Ron Weiss, Jin Huh
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Publication number: 20180372299Abstract: A housing or pocket for supporting a light guide device for an illumination device, especially for a motor vehicle or an indicator device in a rearview device of a motor vehicle. The housing has a first side which is configured to support the light guiding device for exposure to the pictogram of the reflection layer. The housing also include a second side containing exposed wire connectors to connect the light guide device to a power source. One of the light guide device, the printed circuit board or both structures are fitted with an encapsulation member and secured to the housing through the use of a fixative mount.Type: ApplicationFiled: August 31, 2018Publication date: December 27, 2018Applicant: SMR Patents S.à.r.l.Inventors: Norbert Kürschner, Andreas Herrmann, Chun Seop Kwak, Ho Jin Huh
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Patent number: 10039811Abstract: A peptide with anti-inflammatory activity, wherein the peptide comprises SEQ ID NO: 1, the peptide has above 80% homology of amino acid with above-mentioned sequence, or the peptide is the fragment of the above-mentioned peptides is described. An anti-inflammatory composition comprising the above mentioned peptides is described. According to the present invention, a peptide comprising a sequence of SEQ ID NO: 1 has outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising the peptide of this invention can be used as anti-inflammatory pharmaceutical composition or as cosmetic composition, in turn, treating a variety of different types of inflammatory diseases.Type: GrantFiled: November 4, 2016Date of Patent: August 7, 2018Assignee: GemVax & KAEL Co., Ltd.Inventors: Sang Jae Kim, Kyung Hee Kim, Kyu-Yong Lee, Seong-Ho Koh, Hyun-Hee Park, Sung Jin Huh, Woo Jin Lee, Bum Joon Kim
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Patent number: 9832076Abstract: The disclosure is related to managing a resource change in a machine to machine (M2M) network. Managing the resource change in M2M network by creating an abstract M2M entity object associated with a resource change, and creating an M2M entity object instance by embodying the abstract M2M entity object according to each application development environment.Type: GrantFiled: January 29, 2014Date of Patent: November 28, 2017Assignee: KT CORPORATIONInventors: Hwi-Jung Ryu, Mi-Kyoung Kang, Yong Kwon, Sung-Ihk Yang, Kwang-Jin Lee, Sung-Kooc Lim, Yu-Jin Huh
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Publication number: 20170327802Abstract: The present invention relates to a peptide with anti-inflammatory activity, wherein the peptide comprises any one amino acid sequence of SEQ ID NO: 1 to SEQ ID NO: 161, the peptide has above 80% homology of amino acid sequence with above-mentioned sequences, or the peptide is the fragment of the above-mentioned peptides. The present invention also relates to an inflammatory composition comprising the above mentioned peptides. According to the present invention, a peptide that has at least one amino acid sequence of SEQ ID NO: 1 to SEQ ID NO: 161 has outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising the peptides of this invention can be used as anti-inflammatory pharmaceutical compositions or as cosmetic compositions, in turn, treating and preventing a variety of different types of inflammatory diseases.Type: ApplicationFiled: July 31, 2017Publication date: November 16, 2017Inventors: Sang Jae KIM, Kyung Hee KIM, Kyu-Yong LEE, Seong-Ho KOH, Bum Joon KIM, Hyun-Hee PARK, Sung Jin HUH, Woo Jin LEE, Hwain JANG, Jung Soon HA
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Publication number: 20170275603Abstract: The present invention relates to a peptide with anti-inflammatory activity, wherein the peptide comprises any one amino acid sequence of SEQ ID NO:1 to SEQ ID NO: 161, the peptide has above 80% homology of amino acid sequence with above-mentioned sequences, or the peptide is the fragment of the above-mentioned peptides. The present invention also relates to an inflammatory composition comprising the above mentioned peptides. According to the present invention, a peptide that has at least one amino acid sequence of SEQ ID NO:1 to SEQ ID NO: 161 has outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising the peptides of this invention can be used as anti-inflammatory pharmaceutical compositions or as cosmetic compositions, in turn, treating and preventing a variety of different types of inflammatory diseases.Type: ApplicationFiled: April 5, 2017Publication date: September 28, 2017Inventors: Sang Jae KIM, Kyung Hee KIM, Kyu-Yong LEE, Seong-Ho KOH, Bum Joon KIM, Hyun-Hee PARK, Sung Jin HUH, Woo Jin LEE, Hwan JIANG, Jung Soon HA
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Publication number: 20170143806Abstract: A peptide with anti-inflammatory activity, wherein the peptide comprises SEQ ID NO: 1, the peptide has above 80% homology of amino acid with above-mentioned sequence, or the peptide is the fragment of the above-mentioned peptides is described. An anti-inflammatory composition comprising the above mentioned peptides is described. According to the present invention, a peptide comprising a sequence of SEQ ID NO: 1 has outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising the peptide of this invention can be used as anti-inflammatory pharmaceutical composition or as cosmetic composition, in turn, treating and preventing a variety of different types of inflammatory diseases.Type: ApplicationFiled: November 4, 2016Publication date: May 25, 2017Applicant: GemVax & KAEL Co., Ltd.Inventors: Sang Jae KIM, Kyung Hee Kim, Kyu-Yong Lee, Seong-Ho Koh, Hyun-Hee Park, Sung Jin Huh, Woo Jin Lee, Bum Joon Kim