Patents by Inventor Jin-Jun Liu

Jin-Jun Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyrrolidine-2-carboxamides
    Patent number: 9371280
    Abstract: There are provided compounds of the formula wherein X, Y, Z, R1, R2 and R3 are as described herein and enantiomers and pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: June 21, 2016
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: David Joseph Bartkovitz, Xin-Jie Chu, George Kenneth Ehrlich, Jin-Jun Liu, Hanspeter Michel, Binh Thanh Vu, Chunlin Zhao
  • PYRAZOLOPYRIMIDONE AND PYRAZOLOPYRIDONE INHIBITORS OF TANKYRASE
    Publication number: 20130345215
    Abstract: There are provided compounds of the formula or a pharmaceutically acceptable salt thereof, wherein Q, R1 and R2 are as defined herein. The compounds of formula I are useful in the treatment of cancer.
    Type: Application
    Filed: June 6, 2013
    Publication date: December 26, 2013
    Inventors: Jianwen Feng, Nancy-Ellen Haynes, Johannes Cornelius Hermann, Kyungjin Kim, Jin-Jun Liu, Nathan Robert Scott, Lin Yi, Mark Edward Zak, Guiling Zhao
  • SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES
    Publication number: 20130324531
    Abstract: There are provided compounds of the formula wherein X, Y, Z, R1, R2 and R3 are as described herein and enantiomers and pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.
    Type: Application
    Filed: May 29, 2013
    Publication date: December 5, 2013
    Applicant: Hoffmann-La Roche Inc.
    Inventors: David Joseph Bartkovitz, Xin-Jie Chu, George Kenneth Ehrlich, Jin-Jun Liu, Hanspeter Michel, Binh Thanh Vu, Chunlin Zhao
  • SUBSTITUTED HETEROARYL 2',3',7',7A'-TETRAHYDROSPIRO[PYRROLE-3,6'-PYRROLO[1,2-C]IMIDAZOLE]-1',2(1H,5'H)-DIONE
    Publication number: 20130053410
    Abstract: There are provided compounds of the formula wherein A, B, V, W, R1, R2, R3, R4 and R5 are described herein together with the enantiomers and pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.
    Type: Application
    Filed: February 20, 2012
    Publication date: February 28, 2013
    Inventors: David Joseph Bartkovitz, Xin-Jie Chu, Qingjie Ding, Nan Jiang, Jin-Jun Liu, Zhuming Zhang
  • Substituted pyrrolidine-2-carboxamides
    Patent number: 8354444
    Abstract: There are provided compounds of the formula wherein X, Y, R1, R2, R3, R3, R4, R5, R6 and R7 are as described herein and enantiomers and pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: January 15, 2013
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Joseph Bartkovitz, Xin-Jie Chu, Qingjie Ding, Nan Jiang, Jin-Jun Liu, Tina Morgan Ross, Jing Zhang, Zhuming Zhang
  • Substituted spiroindolinones
    Patent number: 8288431
    Abstract: There is provided a compound of the formula wherein X, Y, W, R1, R2 and R3 are as described herein. The compounds have activity as anticancer agents.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: October 16, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jin-Jun Liu, Jing Zhang, Zhuming Zhang
  • NOVEL N-SUBSTITUTED 5-HYDROXYPYROLLINDES AS INHIBITORS OF MDM2-P53 INTERACTIONS
    Publication number: 20120149660
    Abstract: There are provided compounds of formula I or a pharmaceutically acceptable salt thereof, wherein X, Y, R1, R2, R3, R4, R5 are as defined herein. The compounds exhibit activity as anticancer agents.
    Type: Application
    Filed: December 9, 2011
    Publication date: June 14, 2012
    Inventors: Jin-Jun Liu, Tina Morgan Ross
  • Substituted Spiro[3H-Indole-3,6'(5'H)-[1H]Pyrrolo[1,2c]Imidazole-1',2(1H,2'H)-diones
    Publication number: 20120071499
    Abstract: There are provided compounds of the formula wherein X, Y, R1, R1?, R2, R2?, R3, R4, R5 and R6 are as described herein and enantiomers or a pharmaceutically acceptable salt or ester thereof. The compounds are useful as anticancer agents.
    Type: Application
    Filed: August 18, 2011
    Publication date: March 22, 2012
    Inventors: Xin-Jie Chu, Qingjie Ding, Nan Jiang, Jin-Jun Liu, Jing Zhang, Zhuming Zhang
  • SUBSTITUTED HEXAHYDROPYRROLO[1,2-C]IMIDAZOLONES
    Publication number: 20120065210
    Abstract: There are provided compounds of formula I or a pharmaceutically acceptable salt thereof, wherein X, Y, R1, R1?, R2, R2?, R3, R4, R5 are as defined herein. The compounds exhibit activity as anticancer agents.
    Type: Application
    Filed: September 7, 2011
    Publication date: March 15, 2012
    Inventors: Xin-Jie Chu, Qingjie Ding, Nan Jiang, Jin-Jun Liu, Tina Morgan Ross, Zhuming Zhang
  • Substituted Heteroaryl Spiropyrrolidine MDM2 Antagonists
    Publication number: 20120046306
    Abstract: There are provided compounds of the general formula wherein A, B, V, W, R1, R2, R3, R3, and R4, are as described herein and enantiomers and pharmaceutically acceptable salts thereof. The compounds are useful as anticancer agents.
    Type: Application
    Filed: July 12, 2011
    Publication date: February 23, 2012
    Inventors: David Joseph Bartkovitz, Xin-Jie Chu, Qingjie Ding, Prabha Saba Karnachi, Jin-Jun Liu, Sung-Sau So, Jing Zhang, Zhuming Zhang
  • N-SUBSTITUTED PYRROLIDINES
    Publication number: 20120010235
    Abstract: Compounds of formula and enantiomers and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control, amelioration or prevention of cancer.
    Type: Application
    Filed: June 30, 2011
    Publication date: January 12, 2012
    Inventors: Xin-Jie Chu, Qingjie Ding, Nan Jiang, Jin-Jun Liu, Tina Morgan Ross, Zhuming Zhang
  • N-substituted-pyrrolidines as inhibitors of MDM2-P-53 interactions
    Patent number: 8017607
    Abstract: There are provided compounds of the formula wherein X, Y, R1, R2, R3, R3, R4, and R5 are as described herein and enantiomers and pharmaceutically acceptable salts and esters thereof which are useful as anticancer agents.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: September 13, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Joseph Bartkovitz, Xin-Jie Chu, Jin-Jun Liu, Tina Morgan Ross, Zhuming Zhang
  • SUBSTITUTED SPIROINDOLINONES
    Publication number: 20110201635
    Abstract: There is provided a compound of the formula wherein X, Y, W, R1, R2 and R3 are as described herein. The compounds have activity as anticancer agents.
    Type: Application
    Filed: January 19, 2011
    Publication date: August 18, 2011
    Inventors: Jin-Jun Liu, Jing Zhang, Zhuming Zhang
  • Substituted Pyrrolidine-2-Carboxamides
    Publication number: 20110118283
    Abstract: There are provided compounds of the formula wherein R1, R2, R3, R3, R4, R5 are as described herein and enantiomers, pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.
    Type: Application
    Filed: October 6, 2010
    Publication date: May 19, 2011
    Inventors: Qingjie Ding, Nan Jiang, Jin-Jun Liu, Jing Zhang, Zhuming Zhang
  • NOVEL N-SUBSTITUTED-PYRROLIDINES AS INHIBITORS OF MDM2-P-53 INTERACTIONS
    Publication number: 20110086854
    Abstract: There are provided compounds of the formula wherein X, Y, R1, R2, R3, R3, R4, and R5 are as described herein and enantiomers and pharmaceutically acceptable salts and esters thereof which are useful as anticancer agents.
    Type: Application
    Filed: October 6, 2010
    Publication date: April 14, 2011
    Inventors: David Joseph Bartkovitz, Xin-Jie Chu, Jin-Jun Liu, Tina Morgan Ross, Zhuming Zhang
  • 4,4,5,5, tetrasubstituted imidazolines
    Patent number: 7851626
    Abstract: There is provided a compound of formula I and the pharmaceutically acceptable salts and esters thereof wherein X1, X2, R1, R2, R3, R4, R5 and R6 are herein described. The compounds exhibit activity as anticancer agents.
    Type: Grant
    Filed: November 27, 2006
    Date of Patent: December 14, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Qingjie Ding, Bradford James Graves, Norman Kong, Jin-Jun Liu, Allen John Lovey, Giacomo Pizzolato, John Lawson Roberts, Sung-Sau So, Binh Thanh Vu, Peter Michael Wovkulich
  • Spiroindolinone derivatives
    Patent number: 7834179
    Abstract: There are provided spiroindolinone derivatives of the formula and pharmaceutically acceptable salts and esters thereof wherein R1, R2, R3, R4 and R are as herein described. The compounds exhibit anticancer activity.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: November 16, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jin-Jun Liu, Zhuming Zhang
  • Substituted Pyrrolidine-2-Carboxamides
    Publication number: 20100152190
    Abstract: There are provided compounds of the formula wherein X, Y, R1, R2, R3, R3, R4, R5, R6 and R7 are as described herein and enantiomers and pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.
    Type: Application
    Filed: February 9, 2010
    Publication date: June 17, 2010
    Inventors: David Joseph Bartkovitz, Xin-Jie Chu, Qingjie Ding, Nan Jiang, Jin-Jun Liu, Tina Morgan Ross, Jing Zhang, Zhuming Zhang
  • Spiroindolinone derivatives
    Patent number: 7723372
    Abstract: There are provided compounds of the general formulas wherein W, X, Y, R1, R2, R3, and R4 are as described herein. The compounds exhibit anticancer activity.
    Type: Grant
    Filed: February 18, 2009
    Date of Patent: May 25, 2010
    Assignee: Hoffman-La Roche Inc.
    Inventor: Jin-Jun Liu
  • Substituted Pyrrolidine-2-Carboxamides
    Publication number: 20100075948
    Abstract: There are provided compounds of the formula wherein X, Y, R1, R2, R3, R3, R4, R5, R6 and R7 are as described herein and enantiomers and pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.
    Type: Application
    Filed: September 10, 2009
    Publication date: March 25, 2010
    Inventors: Qingjie Ding, Nan Jiang, Jin-Jun Liu, Tina Morgan Ross, Jing Zhang, Zhuming Zhang