Patents by Inventor Jin-Jun Liu

Jin-Jun Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Spiroindolinone derivatives
    Patent number: 7638548
    Abstract: There are provided compounds of the general formulas wherein X, Y, R1, R2, R3 and R4 are as described herein. The compounds exhibit anticancer activity.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: December 29, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jin-Jun Liu, Zhuming Zhang
  • Spiroindolinone Derivatives
    Publication number: 20090239889
    Abstract: There are provided compounds of the general formulas wherein W, X, Y, R1, R2, R3, and R4 are as described herein. The compounds exhibit anticancer activity.
    Type: Application
    Filed: February 18, 2009
    Publication date: September 24, 2009
    Inventor: Jin-Jun Liu
  • 3,3-spiroindolinone derivatives
    Patent number: 7553833
    Abstract: There are provided compounds of the general formulas wherein X, Y, R1, R2, R3, R4 and R5 are as described herein. The compounds exhibit anticancer activity.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: June 30, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jin-Jun Liu, Jefferson Wright Tilley, Zhuming Zhang
  • 7,8-disubstituted pyrazolobenzodiazepines
    Patent number: 7524840
    Abstract: The present invention provides compounds of formula I wherein R1, R2, R3, R4, and R5are described herein. The invention also provides syntheses for preparation of such compounds and pharmaceutical compositions containing them. The invention further provides methods for inhibiting kinases, in particular CDK2, for inhibiting angiogenesis, and for treating cancers, in particular breast, colon, prostate, and lung cancer.
    Type: Grant
    Filed: October 5, 2005
    Date of Patent: April 28, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jin-Jun Liu, Kin-Chun Luk, Giacomo Pizzolato, Yi Ren, Kshitij Chhabilbhai Thakkar, Peter Michael Wovkulich, Zhuming Zhang
  • Quinazoline thiazolinones
    Patent number: 7501428
    Abstract: Quinazoline thiazolinone derivatives which demonstrate CDK1 antiproliferative activity and are useful as anti-cancer agents.
    Type: Grant
    Filed: October 5, 2005
    Date of Patent: March 10, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Shaoqing Chen, Jin-Jun Liu
  • Spiroindolinone derivatives
    Patent number: 7495007
    Abstract: The present invention relates to spiroindolinone derivatives of the formula and their enantiomers and pharmaceutically acceptable salts and esters thereof wherein R1, R2, R3, R4, R5, R6, R7 and R8, are as herein described. The compounds have utility as antiproliferative agents, especially, as anticancer agents.
    Type: Grant
    Filed: August 29, 2007
    Date of Patent: February 24, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Qingjie Ding, Jin-Jun Liu, Song Yang, Zhuming Zhang
  • SPIROINDOLINONE DERIVATIVES
    Publication number: 20080293723
    Abstract: There are provided spiroindolinone derivatives of the formula and pharmaceutically acceptable salts and esters thereof wherein R1, R2, R3, R4 and R are as herein described. The compounds exhibit anticancer activity.
    Type: Application
    Filed: April 11, 2008
    Publication date: November 27, 2008
    Inventors: Jin-Jun Liu, Zhuming Zhang
  • 3,3-SPIROINDOLINONE DERIVATIVES
    Publication number: 20080287421
    Abstract: There are provided compounds of the general formulas wherein X, Y, R1, R2, R3, R4 and R5 are as described herein. The compounds exhibit anticancer activity.
    Type: Application
    Filed: April 11, 2008
    Publication date: November 20, 2008
    Inventors: Jin-Jun Liu, Jefferson Wright Tilley, Zhuming Zhang
  • SPIROINDOLINONE DERIVATIVES
    Publication number: 20080188506
    Abstract: There are provided spiroindolinones of the formula and enantiomers and pharmaceutically acceptable salts and esters thereof which have utility as antiproliferative agents, especially, as anticancer agents.
    Type: Application
    Filed: January 31, 2008
    Publication date: August 7, 2008
    Inventors: Qingjie Ding, Jin-Jun Liu, Zhuming Zhang
  • SPIROINDOLINONE DERIVATIVES
    Publication number: 20080114013
    Abstract: There are provided compounds of the general formulas wherein X, Y, R1, R2, R3 and R4 are as described herein. The compounds exhibit anticancer activity.
    Type: Application
    Filed: October 4, 2007
    Publication date: May 15, 2008
    Inventors: Jin-Jun Liu, Zhuming Zhang
  • SPIROINDOLINONE DERIVATIVES
    Publication number: 20080009486
    Abstract: The present invention relates to spiroindolinone derivatives of the formula and their enantiomers and pharmaceutically acceptable salts and esters thereof wherein R1, R2, R3, R4, R5, R6, R7 and R8, are as herein described. The compounds have utility as antiproliferative agents, especially, as anticancer agents.
    Type: Application
    Filed: August 29, 2007
    Publication date: January 10, 2008
    Inventors: Li Chen, Qingjie Ding, Jin-Jun Liu, Song Yang, Zhuming Zhang
  • Substituted 1,5-naphthyridine azolinones
    Patent number: 7304074
    Abstract: Substituted 1,5-naphthyridine azolinones inhibit Cdk1 and are selective against Cdk2 and Cdk4. These compounds and their pharmaceutically acceptable salts have antiproliferative activity and are useful as anti-cancer agents.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: December 4, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Jin-Jun Liu
  • Spiroindolinone derivatives
    Publication number: 20070213341
    Abstract: The present invention relates to spiroindolinone derivatives of the formula and enantiomers and pharmaceutically acceptable salts and esters thereof which have utility as antiproliferative agents, especially, as anticancer agents.
    Type: Application
    Filed: March 1, 2007
    Publication date: September 13, 2007
    Inventors: Li Chen, Qingjie Ding, Jin-Jun Liu, Song Yang, Zhuming Zhang
  • 1,5-Naphthyridine azolinone
    Patent number: 7268231
    Abstract: 1,5-Naphthyridine azolinone derivatives are disclosed. These compounds are inhibitors of CDK1 and are useful as antiproliferative agents, such as anti-cancer agents.
    Type: Grant
    Filed: October 5, 2005
    Date of Patent: September 11, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Jin-Jun Liu
  • 4,4,5,5, Tetrasubstituted imidazolines
    Publication number: 20070129416
    Abstract: There is provided a compound of formula I and the pharmaceutically acceptable salts and esters thereof wherein X1, X2, R1, R2, R3, R4, R5 and R6 are herein described. The compounds exhibit activity as anticancer agents.
    Type: Application
    Filed: November 27, 2006
    Publication date: June 7, 2007
    Inventors: Qingjie Ding, Bradford Graves, Norman Kong, Jin-Jun Liu, Allen Lovey, Giacomo Pizzolato, John Roberts, Sung-Sau So, Binh Vu, Peter Wovkulich
  • Substituted 1,5-naphthyridine azolinones
    Publication number: 20060223843
    Abstract: Substituted 1,5-naphthyridine azolinones inhibit Cdk1 and are selective against Cdk2 and Cdk4. These compounds and their pharmaceutically acceptable salts have antiproliferative activity and are useful as anti-cancer agents.
    Type: Application
    Filed: March 6, 2006
    Publication date: October 5, 2006
    Inventor: Jin-Jun Liu
  • Pyrimido compounds having antiproliferative activity
    Patent number: 7115740
    Abstract: Disclosed are novel pyrimido compounds that are selective inhibitors of both KDR and FGFR kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds and methods of treating cancer.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: October 3, 2006
    Assignee: Hoffmann-la Roche Inc.
    Inventors: Yi Chen, Apostolos Dermatakis, Jin-Jun Liu, Kin-Chun Luk, Christophe Michoud, Pamela Loreen Rossman
  • 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
    Patent number: 7098332
    Abstract: The invention provides 5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one compounds that are selective inhibitors of KDR and FGFR kinases, and are useful in the treatment of cancers. The compounds have the generic structure I where Ar, Ar?, and R1 are as set forth in the present specification. The invention also provides pharmaceutical compositions containing these compounds and methods for their use.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: August 29, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jin-Jun Liu, Kin-Chun Luk
  • Pyrimido compounds having antiproliferative activity
    Patent number: 7084270
    Abstract: Disclosed are novel pyrimido compounds that are selective inhibitors of both KDR an FGFR kinases and are selective against LCK. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds and methods of treating cancer.
    Type: Grant
    Filed: July 21, 2003
    Date of Patent: August 1, 2006
    Assignee: Hoffman-La Roche Inc.
    Inventors: Yi Chen, Andrzej Robert Daniewski, William Harris, Marek Michal Kabat, Emily Aijun Liu, Jin-Jun Liu, Kin-Chun Luk, Christophe Michoud
  • 1,5-naphthyridine azolinone
    Publication number: 20060084673
    Abstract: 1,5-Naphthyridine azolinone derivatives are disclosed. These compounds are inhibitors of CDK1 and are useful as antiproliferative agents, such as anti-cancer agents.
    Type: Application
    Filed: October 5, 2005
    Publication date: April 20, 2006
    Inventor: Jin-Jun Liu