Abstract: Provided is an aspiration catheter having a tubular shape and used to remove an embolus or a thrombus by being inserted into a blood vessel, and more particularly, a steerable and expandable aspiration catheter which may apply an effective aspiration force to an embolus or a thrombus by steering a distal tip of the catheter in a three-dimensional direction and expanding a diameter of the tip.

Abstract: Disclosed are a cosmetic composition having increased skin contact and makeup persistence and a method of manufacturing the same. The method includes: forming a powder continuous phase by rapidly mixing a powder and a film-forming agent; and obtaining a cosmetic composition in which a surface of the powder is compounded with the film-forming agent by heating the powder continuous phase for a predetermined time. In an embodiment, the cosmetic composition is manufactured by the method. In an embodiment, the cosmetic composition includes 5 wt % to 30 wt % of a powder, 0.1 wt % to 10 wt % of a film-forming agent, 10 wt % to 30 wt % of a silicone oil, and 0.1 wt % to 10 wt % of a spherical powder.

Abstract: A method of operating a non-volatile memory device, which is configured to communicate with a storage controller includes: receiving a first request indicating a read reclaim determination and including environment information from the storage controller, performing a first on-chip read operation for generating first distribution information based on the first request, determining whether a read reclaim is required based on the first distribution information, and providing the storage controller with a determination result having a first bit value in response to determining that the read reclaim is required.

Abstract: Disclosed are a method for fabricating a microrobot for delivery of a cell therapy product and a microrobot for delivery of a cell therapy product according thereto. A method for fabricating a microrobot for delivery of a cell therapy product is configured to comprise the steps of: coating a magnetic material with a coating material capable of promoting adhesion, proliferation, and differentiation of stem cells; and internalizing or attaching the coated magnetic material into stem cells. The microrobot for delivery of a cell therapy product, fabricated by the fabrication method, is configured to comprise: a stem cell; a magnetic material attached to the surface of the stem cell or injected into the stem cell and enabling migration in response to an external magnetic field; and a coating material applied to the surface of the magnetic material and promoting attachment, proliferation, and differentiation of the stem cell.

Abstract: The present invention relates to a long-acting conjugate of an interleukin-2 analog with altered binding affinity for interleukin-2 receptors.

Abstract: A use of a fusion protein of a therapeutic enzyme and an immunoglobulin Fe region is disclosed. The fusion protein is represented by the following chemical formula 1. The fusion protein shows protective effects on peripheral sensory nerves and exhibits an extended duration in the body. Thus, the fusion protein or a composition containing the fusion protein can be used in the prevention or improvement of neuropathy.

Abstract: The present invention relates to use of a fusion protein of a therapeutic enzyme and an immunoglobulin Fc region in the prevention or improvement of renal diseases caused by or accompanied by Fabry disease.

Abstract: An archline optimization method according to the present disclosure includes generating a Spee curve based on an arc of a circle having a predetermined radius of curvature, and changing a three-dimensional archline based on the Spee curve.

Abstract: In some implementations, a substrate for coupling to an integrated circuit includes multiple layers. Each of the multiple layers has, in a particular region of the substrate, a repeating pattern of regions corresponding to power and ground. The multiple layers include (i) a top layer having, in the particular region, power contacts and ground contacts for coupling to an integrated circuit and (ii) a bottom layer having, in the particular region, power contacts and ground contacts for coupling to another device. At least one layer of the multiple layers has a repeating pattern of signal traces that extend along and are located between the regions corresponding to ground in the at least one layer.

Abstract: An image sensor is provided. The image sensor includes a substrate including a first side on which light is incident and a second side opposite the first side; a first separation pattern extending from the second side, the first separation pattern being interposed between unit pixels in the substrate of a light-receiving region and a light-shielding region provided around the light-receiving region; a second separation pattern extending from the first side and overlapping the first separation pattern, the second separation pattern being provided in the substrate of the light-receiving region; and a contact film electrically connected to the first separation pattern, the contact film being provided in the substrate of the light-shielding region. A contact trench which extends from the first side is formed in the light-shielding region of the substrate and exposes the first separation pattern, and the contact film fills at least a part of the contact trench.

Abstract: Modifications to interleukin-2 alpha receptors are disclosed. Interleukin-2 analogs with increased binding affinity for interleukin-2 beta receptors are disclosed.

Abstract: The present disclosure relates to antioxidant for a polymer electrolyte membrane fuel cell electrode catalyst, which includes cerium hydrogen phosphate (HCe2(PO4)3(H2O)) in the form of a nanofiber, and an electrode and a membrane-electrode assembly including the same. The electrode for a polymer electrolyte membrane fuel cell of the present disclosure, wherein the antioxidant is dispersed, can improve the mechanical strength of an electrode catalyst layer and can minimize deterioration of chemical durability even after long-term operation. And, a fuel cell including the same can exhibit high output performance and can operate stably even after long-term operation.

Abstract: Disclosed are a catalyst electrode for a fuel cell, a method for fabricating the catalyst electrode, and a fuel cell including the catalyst electrode. The presence of an ionomer-ionomer support composite in the catalyst electrode prevents the porous structure of the catalyst electrode from collapsing due to oxidation of a carbon support to avoid an increase in resistance to gas diffusion and can stably secure proton channels. The presence of carbon materials with high conductivity is effective in preventing the electrical conductivity of the electrode from deterioration resulting from the use of a metal oxide in the ionomer-ionomer support composite and is also effective in suppressing collapse of the porous structure of the electrode to prevent an increase in resistance to gas diffusion in the electrode. Based on these effects, the fuel cell exhibits excellent performance characteristics and prevents its performance from deteriorating during continuous operation.

Abstract: A volumetric segmentation method is disclosed for brain region analysis, in particular but not limited to, regions of the basal ganglia such as the subthalamic nucleus (STN). This serves for visualization and localization within the sub-cortical region of the basal ganglia, as an example of prediction of a region of interest for deep brain stimulation procedures. A statistical shape model is applied for variation modes of the STN, or the corresponding regions of interest, and its predictors on high-quality training sets obtained from high-field, e.g., 7T, MR imaging. The partial least squares regression (PLSR) method is applied to induce the spatial relationship between the region to be predicted, e.g., STN, and its predictors. The prediction accuracy for validating the invention is evaluated by measuring the shape similarity and the errors in position, size, and orientation between manually segmented STN and its predicted one.

Abstract: A volumetric segmentation method is disclosed for brain region analysis, in particular but not limited to, regions of the basal ganglia such as the subthalamic nucleus (STN). This serves for visualization and localization within the sub-cortical region of the basal ganglia, as an example of prediction of a region of interest for deep brain stimulation procedures. A statistical shape model is applied for variation modes of the STN, or the corresponding regions of interest, and its predictors on high-quality training sets obtained from high-field, e.g., 7 T, MR imaging. The partial least squares regression (PLSR) method is applied to induce the spatial relationship between the region to be predicted, e.g., STN, and its predictors. The prediction accuracy for validating the invention is evaluated by measuring the shape similarity and the errors in position, size, and orientation between manually segmented STN and its predicted one.

Abstract: A wafer level fan out package includes a semiconductor die having a first surface, a second surface, and a third surface. A stiffener is disposed on the third surface of the semiconductor die. A conductive via passes through the stiffener. First and second electrically conductive patterns electrically connected to the conductive via are disposed on the first and second surfaces of the semiconductor die and stiffener. Solder balls are electrically connected to the first or second electrically conductive patterns.

Abstract: The present invention relates to changes in interleukin-2 alpha receptors and interleukin-2 analogs with increased binding affinity for interleukin-2 beta receptors.

Abstract: A photoacoustic, noninvasive, and continuous blood glucose measurement device includes: a diode laser for irradiating a living body with a pulsed laser signal having a specific wavelength; and an ultrasound transducer for measuring a photoacoustic signal in a form of ultrasonic waves generated by a reaction of the living body with the pulsed laser signal.

Abstract: Disclosed is an antioxidant for a polymer electrolyte membrane of a fuel cell including cerium hydrogen phosphate (CeHPO4). The presence of cerium hydrogen phosphate in the antioxidant enhances the dissolution stability of cerium and improves the ability to capture water, leading to an increase in proton conductivity. In addition, the cerium hydrogen phosphate has a crystal structure composed of smaller cerium particles. This crystal structure greatly improves the ability of the antioxidant to prevent oxidation of the electrolyte membrane. Also disclosed are an electrolyte membrane including the antioxidant, a fuel cell including the electrolyte membrane, a method for preparing the antioxidant, a method for producing the electrolyte membrane, and a method for fabricating the fuel cell.

Abstract: A semiconductor device with redistribution layers formed utilizing dummy substrates is disclosed and may include forming a first redistribution layer on a first dummy substrate, forming a second redistribution layer on a second dummy substrate, electrically connecting a semiconductor die to the first redistribution layer, electrically connecting the first redistribution layer to the second redistribution layer, and removing the dummy substrates. The first redistribution layer may be electrically connected to the second redistribution layer utilizing a conductive pillar. An encapsulant material may be formed between the first and second redistribution layers. Side portions of one of the first and second redistribution layers may be covered with encapsulant. A surface of the semiconductor die may be in contact with the second redistribution layer. The dummy substrates may be in panel form. One of the dummy substrates may be in panel form and the other in unit form.