Abstract: The invention relates to a method of preparing inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: An aqueous composition comprising at least 10 weight percent of a dispersed esterified cellulose ether, based on the total weight of the aqueous composition, wherein the esterified cellulose ether comprises (i) groups of the formula —C(O)—R—COOH or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent aliphatic or aromatic hydrocarbon group, and at least a part of the groups —C(O)—R—COOH are neutralized with an ammonium salt of carbonic acid, formic acid or acetic acid, and wherein d90 of the dispersed esterified cellulose ether particles is up to 10 micrometers, d90 being the diameter where 90 mass percent of the particles have a smaller equivalent diameter and the other 10 mass percent have a larger equivalent diameter, is useful for preparing coating dosage forms including tablets, capsules and others, or for the formation of capsules shells.

Abstract: This disclosure will describe a novel finding and make the claim for the first time on a group of old compounds and formulated new compounds. These compounds have superconducting property at high temperatures, i.e., 151 K or higher. Several compounds were prepared, though not well-purified, at around middle of 1900s. Their chemical, structural, electric and magnetic properties were studied and reported but their superconducting property has not been known and has never been exploited because the idea of type-II superconductivity was not proposed at that time. The experiments to further verify their high temperature superconductivity require the utilization of sophisticated facilities on synthesizing highly pure compounds and the deregulation from government security authorities on purchasing the starting materials.

Abstract: A method, a computer program product, and a computer system for identifying user preferences and changing settings of a device based on natural language processing. One or more programs running in background on the device capture an input of natural language from a user of the device, match the input of the natural language to a user frustration, map the user frustration to one or more solutions that make one or more changes of settings on the device, apply the one or more changes of settings to set user preference settings on the device, and store the user preference settings in a common store for the user.

Abstract: Embodiments of the invention include a printed circuit board (PCB) assembly that includes advanced component in cavity (ACC) technology and methods of forming such PCB assemblies. In one embodiment, the PCB assembly may include a PCB that has a cavity formed on a first surface of the PCB. A plurality of contacts may be formed in the cavity. The cavity provides a location where components may be electrically coupled to the PCB. Additionally, a package that is mounted to the PCB may extend over the cavity. Since the package passes directly over the component, the components may be used to electrically couple the package to one or more of the contacts formed in the cavity. Accordingly, embodiments of the invention allow for the surface area used for components to be reduced, and also improves electrical performance of the PCB assembly by positioning the components proximate to the package.

Abstract: Hollow motor apparatuses and associated systems and methods for manufacturing the same are disclosed herein. In representative embodiment, a hollow motor apparatus includes a rotor assembly rotatable about a rotation axis, a stator assembly positioned adjacent to the rotor assembly and coaxially with the rotor assembly relative to the rotation axis, and a bearing assembly operably coupled to the rotor assembly. The rotor assembly has an inner portion around an opening configured to receive at least a portion of a payload. The bearing assembly is disposed outside the inner portion of the rotor assembly and is configured to maintain a position of the rotor assembly relative to the stator assembly.

Abstract: The invention relates to a method of preparing inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: A process for producing an aqueous composition comprising a dispersed esterified cellulose ether comprises the steps of grinding, in the presence of an aqueous diluent an esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a N divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, blending a salt of a fatty acid with the esterified cellulose ether and choosing the amounts of aqueous diluent, esterified cellulose ether and salt of a fatty acid that the produced aqueous composition comprises at least 20 percent of the dispersed esterified cellulose ether and heating the aqueous composition to a temperature of from 37 to 80 C during or after the grinding step.

Abstract: Capsule shells and coatings can be prepared from an aqueous composition comprising a) at least 20 percent, based on the total weight of the aqueous composition, of a dispersed esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, b) from 0.05 to 20 percent of a salt of a fatty acid, based on the weight of the dispersed esterified cellulose ether, and c) from 0.01 to 10 percent of an anionic surfactant comprising a sulfate or sulfonate group, based on the weight of the dispersed esterified cellulose ether.

Abstract: Spherical carriers for an olefin polymerization catalyst, catalyst components, catalysts, and preparation methods therefor are disclosed. The method for preparing the spherical carriers comprises the following steps: (1) reacting, in the presence of at least one polymeric dispersion stabilizer, a magnesium halide with an organic compound containing active hydrogen to form a complex solution; (2) reacting said complex solution with an alkylene oxide-type compound to directly precipitate solid particles; and (3) recovering the solid particles to obtain spherical carriers. When a catalyst prepared by using the present spherical carrier is used in propylene polymerization, said catalyst exhibits high polymerization activity and high stereo-directing ability.

Abstract: The present invention provides a method and device for acquiring a similar human face picture and acquiring information about a human face picture. It mainly relates to the field of Internet technology, and mainly aims to provide the user a similar human face picture including a similar person when a similar picture is provided. The method comprising: acquiring a human face picture specified by a user; conducting human face identification to the human face picture to identify a similar human face picture of the human face picture from human face pictures that have already been collected; and displaying the similar human face picture to the user.

Abstract: A method, a computer program product, and a computer system for identifying user preferences and changing settings of a device based on natural language processing. One or more programs running in background on the device capture an input of natural language from a user of the device, match the input of the natural language to a user frustration, map the user frustration to one or more solutions that make one or more changes of settings on the device, apply the one or more changes of settings to set user preference settings on the device, and store the user preference settings in a common store for the user.

Abstract: The invention relates to a method of preparing inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: The present invention provides a catalyst component for olefin polymerization and a preparation method thereof, and a catalyst for olefin polymerization and an application thereof. The catalyst component for olefin polymerization comprises reaction products of the following components: (1) a solid component; (2) at least one titanium compound; and (3) at least two internal electron donors, wherein the solid component comprises a magnesium compound represented by formula (1) and an epoxide represented by formula (2), wherein R1 is a C1-C12 linear or branched alkyl; R2 and R3 are identical or different, and are independently hydrogen or unsubstituted or halogen-substituted C1-C5 linear or branched alkyl; X is halogen; m is in a range of from 0.1 to 1.9, n is in a range of from 0.1 to 1.9, and m+n=2.

Abstract: A polymeric capsule shell of high quality is prepared from an aqueous composition which comprises (A) at least one esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent aliphatic or aromatic hydrocarbon group, wherein at least a part of the groups —C(O)—R—COOH are neutralized with an ammonium salt of carbonic acid, formic acid or acetic acid, and (B) from 0 to 7 weight percent of a non-polymeric plasticizer, based on the weight of the esterified cellulose ether, wherein the weight of said at least one esterified cellulose ether is at least 80 percent of the total polymer weight in the aqueous composition.

Abstract: Embodiments of the present disclosure disclose a terminal, a method for decrypting a terminal and a storage medium. The method includes that: when the terminal is in an encrypted state, the terminal receives a first proximity state sequence of a first object within a first time threshold value; the terminal compares the first proximity state sequence with a preset reference proximity state sequence; and when the first proximity state sequence is as same as the preset reference proximity state sequence, the terminal is changed from the encrypted state into a decrypted state.

Abstract: This disclosure will describe a novel finding and make the claim for the first time on a group of old compounds and formulated new compounds. These compounds have superconducting property at high temperatures, i.e., 151K or higher. Several compounds were prepared, though not well-purified, at around middle of 1900s. Their chemical, structural, electric and magnetic properties were studied and reported but their superconducting property has not been known and has never been exploited because the idea of type-II superconductivity was not proposed at that time. Consequently, we claim this finding as an invention even though our invention is based on the studies of the compounds' electric and magnetic properties along with their crystallographic features from the previous publications.

Abstract: An information sharing method, device and system, and a computer storage medium are described. The method includes: a server receiving user information change data and determining information change content; inquiring at least one pre-stored group according to the information change content, determining that a group corresponding to the information change content exists, and obtaining information about a target object of the group; and sending the information change content is sent to the target object.

Abstract: Embodiments of the present disclosure provide a test circuit, a test method, a display panel and a display apparatus. Each of the signal input terminals may input a plurality of signals in a time division multiplexed manner, and in turn may be controlled by the corresponding switches to form a plurality of signal lines, a signal flow of the plurality of signal lines are totally different from each other under control of the switches. For example, one of the signal lines may function as a signal input line, and the other one of the signal lines may function as a signal input line for other specific testing, such as aging process so as to input signals different from the normal turn-on state signals. Consequently, by controlling the corresponding switches through the control signal terminals so that different input signals pass through different signal lines into the display panel to meet testing requirements of normal turn-on state testing, aging process and so on for the display panel.

Abstract: An aqueous composition comprising at least 10 weight percent of a dispersed esterified cellulose ether, based on the total weight of the aqueous composition, wherein the esterified cellulose ether comprises (i) groups of the formula —C(O)—R—COOH or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent aliphatic or aromatic hydrocarbon group, and at least a part of the groups —C(O)—R—COOH are neutralized with an ammonium salt of carbonic acid, formic acid or acetic acid, and wherein d90 of the dispersed esterified cellulose ether particles is up to 10 micrometers, d90 being the diameter where 90 mass percent of the particles have a smaller equivalent diameter and the other 10 mass percent have a larger equivalent diameter, is useful for preparing coating dosage forms including tablets, capsules and others, or for the formation of capsules shells.