Abstract: An electronic device with heat sink is provided. The heat sink includes a base and fins. One side of the base has a first placement plane and a second placement plane. The electronic device includes a circuit board, a power module and transistors. The power module includes a power body and soldering legs, and the power body is attached to the first placement plane. The transistor has a transistor body and pins, and the transistor body is attached to the second placement plane. The circuit board is disposed at one side of the base formed with the first placement plane, and soldering legs of the power module and pins of the transistor are inserted on the circuit board. Thereby the heat sinks and the space which the circuit board occupied will be reduced for increasing the power density of the heat sink.

Abstract: An inverter apparatus with overcurrent protection control includes a first terminal of a DC input terminal connected to an AC output terminal through a first switch element and a second switch element, and a second terminal of the DC input terminal connected to the AC output terminal through a fourth switch element and a third switch element. An intermediate potential terminal is connected to a fifth switch element and a sixth switch element, and connected to the AC output terminal through the fifth switch element and the second switch element, and connected to the AC output terminal through the sixth switch element and the third switch element. When the control unit determines that the inverter apparatus is in an overcurrent state, the control unit controls a sequence of turning off the inverter apparatus to be the second switch element, the first switch element, and the sixth switch element.

Abstract: A method for preparing an antibody-drug conjugate (ADC). In particular, the method mainly utilizes a combination of antibody biomolecules and an ion exchange carrier through electrostatic interaction to realize solid phase preparation of an ADC drug. Elution conditions are optimized, to control a drug-to-antibody coupling ratio (DAR) and separate a polymer-coupled drug, reduce the amount of a drug used in a coupling reaction, and enhance the targeted therapeutic effect of an ADC drug. The preparation method features fewer steps, simple operation, and programmable control, facilitating industrial scale-up production, and also realizing zero retention of reducing agents and organic solvents in the preparation process, significantly improving drug safety and reducing production costs.

Abstract: An inverter apparatus with overcurrent protection control includes a first terminal of a DC input terminal connected to an AC output terminal through a first switch element and a second switch element, and a second terminal of the DC input terminal connected to the AC output terminal through a fourth switch element and a third switch element. An intermediate potential terminal is connected to a fifth switch element and a sixth switch element, and connected to the AC output terminal through the fifth switch element and the second switch element, and connected to the AC output terminal through the sixth switch element and the third switch element. When the control unit determines that the inverter apparatus is in an overcurrent state, the control unit controls a sequence of turning off the inverter apparatus to be the second switch element, the first switch element, and the sixth switch element.

Abstract: The present invention relates to a fluid-controlled wire tension mechanism including a sealed container, a control valve, and a delivery spool. The sealed container has a space. The control valve is coupled to the sealed container to control fluid pressure in the space. The delivery spool is coupled to the sealed container with a compression end and a reel. The compression end is placed in the space, and the reel is located outside the sealed container to send out a cutting wire. Wherein, a fluid enters the space and applies pressure on the compression end. The present invention utilizes the fluid pressure to produce the rotating impedance to the delivery spool, so that the component is wear-proof, the line tension is easily controlled and the stream of the cutting wire can be stable for a long time. Therefore, the cutting effect and the shape are more precise.

Abstract: A power bypass apparatus with a current-sharing function includes at least two bypass switch assemblies and a control unit. Each bypass switch assembly includes a controllable switch, a cooling unit, and a temperature detection unit. Each the temperature detection unit, correspondingly disposed to a heat-dissipating unit, detects a temperature value of the controllable switch to produce a temperature detection signal. The control unit receives the temperature detection signals and outputs at least two switch control signals to control at least one of the controllable switches or outputs at least two cooling unit control signals to control at least one of the cooling units, thus making currents flowing through the controllable switches identical. Accordingly, it is to increase overall efficiency of a power system and implement current-sharing function of the power system providing high power.

Abstract: A method is proposed for real-time economic dispatch in power system operation, especially in systems that include renewable power sources that may cause heavy deviations from a generation schedule due to their uncertain outputs. According to the method an optimal generation schedule is obtained based on forecasted load data. This schedule has to be adjusted if the actual load and renewable energy source outputs unexpectedly deviate from the forecasted value. An algorithm employed in the method is capable of dictating generation adjustments which minimize total generation costs. The algorithm is a modification of the base point and participation factor method. It differs from existing methods in that a precise model of transmission losses is adopted in the algorithm to achieve higher accuracy in optimization. The proposed method also has significant advantage in execution speed so that it is suitable for real-time operation.

Abstract: A power converting device includes a first and a second power module electrically coupled in parallel, a loop current limiting circuit and a driving circuit. A first and a second terminal of the loop current limiting circuit are coupled to the first and the second power module respectively. A third and a fourth terminal of the loop current limiting circuit are coupled to each other. The loop current limiting circuit includes a coupled differential-mode inductor, a first inductive unit and a second inductive unit. A first winding and a second winding of the coupled differential-mode inductor are coupled to the first and the second power modules respectively. The first and the second inductive units are coupled to the first and the second power modules respectively. The driving circuit is configured to output a driving signal to the first and the second power module according to a current detecting signal.

Abstract: A power converting device includes a first and a second power module electrically coupled in parallel, a loop current limiting circuit and a driving circuit. A first and a second terminal of the loop current limiting circuit are coupled to the first and the second power module respectively. A third and a fourth terminal of the loop current limiting circuit are coupled to each other. The loop current limiting circuit includes a coupled differential-mode inductor, a first inductive unit and a second inductive unit. A first winding and a second winding of the coupled differential-mode inductor are coupled to the first and the second power modules respectively. The first and the second inductive units are coupled to the first and the second power modules respectively. The driving circuit is configured to output a driving signal to the first and the second power module according to a current detecting signal.

Abstract: A method is proposed for real-time economic dispatch in power system operation, especially in systems that include renewable power sources that may cause heavy deviations from a generation schedule due to their uncertain outputs. According to the method an optimal generation schedule is obtained based on forecasted load data. This schedule has to be adjusted if the actual load and renewable energy source outputs unexpectedly deviate from the forecasted value. An algorithm employed in the method is capable of dictating generation adjustments which minimize total generation costs. The algorithm is a modification of the base point and participation factor method. It differs from existing methods in that a precise model of transmission losses is adopted in the algorithm to achieve higher accuracy in optimization. The proposed method also has significant advantage in execution speed so that it is suitable for real-time operation.

Abstract: Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle comprising: (a) an envelope comprising a Sindbis virus E2 glycoprotein variant; and (b) a lentiviral vector genome comprising a sequence of Interest; wherein the E2 glycoprotein variant facilitates infection of dendritic cells by the lentiviral vector particle, and wherein the E2 glycoprotein variant has reduced binding to heparan sulfate compared to a reference sequence (HR strain).

Abstract: Use of 9,10-anthraquinone compounds of formula (I) or pharmaceutical salts thereof or plant extracts containing said compounds in the preparation of anti-HCV medicaments is disclosed, in which Y1 are Y2 are independently hydrogen, hydroxyl or groups of formula (II); and R1, R2, R3, R4, R5 and R6 are independently hydrogen, hydroxyl, carboxyl, cyano group, nitro group, groups of formula (III) or groups selected from those substituted or unsubstituted groups: amino, C1-C6 aliphatic hydrocarbon, C3-C7 cyclic aliphatic hydrocarbon, C1-C6 alkoxy, C2-C7 carbalkoxy, C1-C4 acyloxy, C6-C20 aryl, or 5 to 7 members heterocyclic or benzoheterocyclic thereof; or R5 and R6 form the group of formula (IV). The compounds of present invention are cheap, safe and effective because that they mostly come from traditional Chinese medicines and have better anti-HCV effects and lighter side effects.

Abstract: Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle comprising: (a) an envelope comprising a Sindbis virus E2 glycoprotein variant; and (b) a lentiviral vector genome comprising a sequence of interest; wherein the E2 glycoprotein variant facilitates infection of dendritic cells by the lentiviral vector particle, and wherein the E2 glycoprotein variant has reduced binding to heparan sulfate compared to a reference sequence (HR strain).

Abstract: The invention provides new methods and compositions for synthesizing hydrogen fuel using simple and inexpensive materials.

Abstract: Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle comprising: (a) an envelope comprising a Sindbis virus E2 glycoprotein variant; and (b) a lentiviral vector genome comprising a sequence of interest; wherein the E2 glycoprotein variant facilitates infection of dendritic cells by the lentiviral vector particle, and wherein the E2 glycoprotein variant has reduced binding to heparan sulfate compared to a reference sequence (HR strain).

Abstract: Use of 9,10-anthraquinone compounds of formula (I) or pharmaceutical salts thereof or plant extracts containing said compounds in the preparation of anti-HCV medicaments is disclosed, in which Y1 are Y2 are independently hydrogen, hydroxyl or groups of formula (II); and R1, R2, R3, R4, R5 and R6 are independently hydrogen, hydroxyl, carboxyl, cyano group, nitro group, groups of formula (III) or groups selected from those substituted or unsubstituted groups: amino, C1-C6 aliphatic hydrocarbon, C3-C7 cyclic aliphatic hydrocarbon, C1-C6 alkoxy, C2-C7 carbalkoxy, C1-C4 acyloxy, C6-C20 aryl, or 5 to 7 members heterocyclic or benzoheterocyclic thereof; or R5 and R6 form the group of formula (IV). The compounds of present invention are cheap, safe and effective, because that they mostly conic from traditional Chinese medicines and have better anti-HCV effects and lighter side effects.

Abstract: Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle comprising: (a) an envelope comprising a Sindbis virus E2 glycoprotein variant; and (b) a lentiviral vector genome comprising a sequence of interest; wherein the E2 glycoprotein variant facilitates infection of dendritic cells by the lentiviral vector particle, and wherein the E2 glycoprotein variant has reduced binding to heparan sulfate compared to a reference sequence (HR strain).

Abstract: A method of forming a pre-molded lead frame having increased stand-offs includes the steps of attaching a first tape to a first side of the lead frame and a second tape to a second side of the lead frame. The taped lead frame is placed in a mold and a first flow of mold compound is initiated. The first flow of the mold compound fills a space between the first tape and an upper mold chase of the mold. A second flow of the mold compound then is initiated. The second flow of the mold compound fills the spaces between a die pad and leads of the lead frame. The first and second tapes then are removed from the lead frame. Improved stand-offs are provided because the first tape was depressed by the first flow of the mold compound.

Abstract: The present invention relates to a computer implemented system and method for generating and interacting with a multi-factoral patient simulation responsive to user queries and interventions.

Abstract: A semiconductor package and method of forming the package, including a substrate having an opening formed therein. Contact pads are formed about a periphery of the opening on a first side of the substrate and a second opposing side of the substrate. A flip chip die is mounted to the substrate, having an active side mounted on a first side of the substrate and in electrical communication with at least some of the contact pads formed on the first side of the substrate. At least one wire bond die is mounted through the opening, with a non-active side mounted on the active side of the flip chip die. The wire bond die is in electrical communication with at least some of the plurality of contact pads formed on the second opposing side of the substrate.