Abstract: The present disclosure relates to a polypeptide membrane fusion inhibitor against Paramyxoviridae and/or Pneumoviridae viruses, and a preparation method and application thereof. Provided in the present disclosure are a compound, a pharmaceutically acceptable salt or derivative thereof, a pharmaceutical composition and formulation product containing same, and applications thereof for preparation of drugs for preventing and/or treating diseases caused by Paramyxoviridae and/or Pneumoviridae viruses.

Abstract: A first image frame and a second image frame are captured using first and second under-display cameras positioned under an LED display. The second image frame is globally aligned to the first image frame to generate a globally-aligned second image frame. An optical flow map based on the first image frame and the globally-aligned second image frame is generated, and an occlusion map based on the first image frame and the globally-aligned second image frame is generated. The globally-aligned second image frame is warped based on the optical flow map and the occlusion map to generate a warped image frame. The first image frame and the warped image frame are blended to generate an output image.

Abstract: This disclosure provides compounds containing 6-(pyrimidin-4-yl)quinoline structure, the use thereof for selectively inhibiting the activity of CDK4, and pharmaceutical compositions comprising the compounds as treatment of various diseases including cancer.

Abstract: A parking lot management device that identifies, from among a plurality of parking frames provided in a parking lot, a parking frame to which a user who desires to use the parking lot is guided, the parking lot management device includes a processor configured to: acquire attribute information indicating an attribute of a vehicle of the user; identify, by referring to a storage that stores parking statistical information including attribute information of a vehicle parked in a past in each of the plurality of parking frames, a parking frame in which a similar vehicle that is similar to the vehicle of the user is parked in the past as the parking frame to which the user is guided based on the acquired attribute information of the user; and perform guidance for the user to the identified parking frame.

Abstract: This application discloses a condensing device and a heat pump system including the same. The condensing device includes: a shell; and at least two sets of heat exchange tube bundles, where each set of heat exchange tube bundles includes a condensing tube bundle and a subcooling tube bundle, and the subcooling tube bundle is arranged below the corresponding condensing tube bundle, where the at least two sets of heat exchange tube bundles are configured to circulate the cooling medium independently, to enable the cooling medium in each set of heat exchange tube bundles to perform heat exchange with the refrigerant in the heat exchange accommodating cavity independently. Two subcoolers are arranged in a same shell of the condensing device of this application, where one subcooler may be used in an independent refrigeration mode, and the other subcooler may be used in a water heating mode. In the independent refrigeration mode, the subcooler can improve the refrigeration performance of the heat pump system.

Abstract: A display substrate, a display panel and a display device, including: a first base substrate, a first polarizer located on one side of the first base substrate, a data line located on a side, away from the first polarizer, of the first base substrate, and the extension direction of the data line is substantially perpendicular to the absorption axis of the first polarizer.

Abstract: This application discloses a bus network technology-based packet forwarding method and apparatus, and a readable storage medium, and belongs to the field of computer communication technologies. A computer system includes a bus switch, a plurality of processors, and a plurality of NICs. The bus switch is connected to the plurality of processors, and the bus switch is further connected to the plurality of NICs. The bus switch obtains a packet generated by a first processor in the plurality of processors, determines that a destination IP address of the packet is an IP address of a first NIC in the plurality of NICs, and forwards the packet to a second processor according to a routing rule. The second processor is a processor that is in the plurality of processors and that corresponds to the first NIC.

Abstract: Provided herein are Cas9 nickase mutations with enhanced prime editing activity relative to wild type for use in prime editing using a prime editing guide RNA.

Abstract: A method for preventing, alleviating and/or treating graft versus host disease caused by hematopoietic stem cell transplantation, which comprises administering an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt, ester, stereoisomer, polymorph, solvate, N-oxide, isotope-labeled compound, metabolite or prodrug thereof to an individual in need thereof.

Abstract: A transgenic soybean event XP-2 and a detection method thereof. The transgenic soybean event XP-2 utilizes the nucleotide sequence shown in SEQ ID NO:27 as the left flanking region of the exogenous genes and the nucleotide sequence shown in SEQ ID NO:28 as the right flanking region of the exogenous genes. The transgenic soybean event XP-2 co-localizes genes encoding glyphosate tolerance and flazasulfuron tolerance traits on the same DNA segment, and these genes are integrated into a single locus within the genome of the transgenic soybean event XP-2. This configuration provides enhanced breeding efficiency and enables the use of molecular markers to track the transgenic insert in breeding populations and their progeny. The specific nucleic acid sequences for detecting soybean plants allow for the unique identification of transgenic soybean event XP-2.

Abstract: This disclosure provides compounds containing 1-(1-oxo-1,2-dihydrophthalazin-6-yl)cycloalkyl-1-carboxamide derivatives, the use thereof for selectively inhibiting the activity of PRMT5 in cooperative with MTA in tumors bearing MTAPDEL mutation, and pharmaceutical compositions comprising the compounds as treatment of various diseases including cancer.

Abstract: A comprehensive management method and apparatus for application traffic, and an electric device are provided. The method includes: marking a traffic request with a label, and transmitting the traffic request with the label to a user access layer gateway; managing and configuring rules; receiving the traffic request; analyzing the traffic request based on a traffic analyzing rule; identifying and filtering the traffic request based on a traffic filtering rule; performing secondary processing on the traffic request based on a traffic processing rule; and forwarding the traffic request after secondary processing to an application proxy gateway based on a traffic forwarding rule; and performing an in-traffic proxy and an out-traffic proxy.

Abstract: Disclosed herein are heterocyclic compounds that may be used as STING modulators, process for synthesis and uses of such compounds in treatment of various diseases including cancers. In an aspect, the compounds are of Formula (I).

Abstract: Provided are compounds represented by general formula (I), which can be used for treating ATR kinase-mediated diseases, such as proliferative diseases, such as cancer. Further provided are a pharmaceutical composition of the compound represented by general formula (I), a use thereof in treating ATR kinase-mediated diseases, and a preparation thereof.

Abstract: Disclosed are an endoscopic bending section and an endoscope. The endoscopic bending section comprises a wire winding portion, the wire winding portion being provided with a mounting cavity, and a first traction wire hole, a second traction wire hole, a third traction wire hole and a fourth traction wire hole which are arranged around the mounting cavity at intervals, wherein the mounting cavity, the first traction wire hole, the second traction wire hole, the third traction wire hole and the fourth traction wire hole all extend in an axial direction of the wire winding portion; and the wire winding portion is provided with at least three wire-passage holes arranged at intervals in a circumferential direction of the wire winding portion, the wire-passage holes separately being in communication with the mounting cavity.

Abstract: A neural network processor architecture provides decompression circuitry that can exploit patterns of data in kernel weights of a convolutional neural net as flattened to a vector, the compression allowing reduced kernel data storage costs including on-chip-storage.

Abstract: Disclosed is a bile acid-metronidazole conjugate or a stereoisomer thereof, or a salt thereof, or a solvate thereof, or a prodrug thereof, or a metabolite thereof. The bile acid-metronidazole conjugate is prepared using an esterification reaction of a bile acid compound with hydroxyl group on a metronidazole structure. The synthesis process is simple and easy for industrialization. The bile acid-metronidazole conjugate can effectively inhibit the growth of anaerobic bacteria, especially the growth of Clostridioides difficile and Helicobacter pylori, so that the bile acid-metronidazole conjugate has a significantly improved therapeutic effect in the treatment of infections caused by the anaerobic bacteria.

Abstract: The invention provides a method for preparing 2-alkylsulfonyl substituted benzoic acid derivatives of formula (I) by conversion of 2-alkylthio substituted benzonitrile compound of formula (II), which are useful as intermediates in the preparation of herbicidally active compounds like pyrasulfotole or isoxaflutole.