Abstract: A nonaqueous electrolyte for a lithium ion battery includes a lithium salt, a first nonaqueous solvent, and an additive mixture comprising a first operative additive of lithium difluorophosphate and a second operative additive of either fluoro ethylene carbonate or vinylene carbonate. A lithium-ion battery includes a negative electrode, a positive electrode comprising NMC with micrometer-scale grains, a nonaqueous electrolyte having lithium ions dissolved in a first nonaqueous solvent, and an additive mixture having a first operative additive of either fluoro ethylene carbonate or vinylene carbonate and a second operative additive of either 1,3,2-dioxathiolane-2,2-dioxide, another sulfur-containing additive, or lithium difluorophosphate.

Abstract: Provided is a compound of formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, isotopic substituent, polymorph, prodrug, or metabolite thereof. Also provided is a method for preparing the compound of formula I. The compound of formula I has higher inhibitory activity against SHP2, and thus can be used to prevent or treat a disease related to SHP2.

Abstract: A chiller system includes a mechanical-cooling circuit configured to circulate a refrigerant through an evaporator of the mechanical-cooling circuit, where the evaporator is configured to cool a conditioning fluid with the refrigerant. The chiller system also includes a free-cooling circuit configured to circulate the refrigerant through a heat exchanger of the free-cooling circuit, where the heat exchanger is configured to cool the conditioning fluid with the refrigerant. The chiller system also includes a distribution header having a first inlet configured to receive the refrigerant from the mechanical-cooling circuit, a second inlet configured to receive the refrigerant from the free-cooling circuit, and an internal volume fluidly coupled to the first inlet and the second inlet. A fan coil unit of the chiller system is configured to receive the refrigerant from the internal volume of the distribution header.

Abstract: A stable dispersant and an application thereof in preparing copolymer polyols, the preparation method for the stable dispersant including the steps of 1) contacting a polyol with a dianhydride compound for reaction so as to prepare an adduct; 2) performing a ring-opening addition reaction on the adduct obtained in step 1) and an epoxy compound to prepare a stable dispersant; the dianhydride compound does not contain a double bond that may copolymerize with an olefinically unsaturated monomer, while the epoxy compound contains a double bond that may copolymerize with an olefinically unsaturated monomer, the polyol is a polyester polyol and/or a polyether polyol, preferably being a polyether polyol. The stable dispersant obtained by means of the described preparation method has a multi-active site anchoring function, and is applied to the synthesis of copolymer polyols to obtain copolymer polyols having relatively uniform particle size.

Abstract: The present disclosure provides an image denoising method, an image denoising device, an image denoising apparatus and a storage medium. The method includes: performing edge detection on a color image to obtain a preprocessed image; acquiring a depth image having the same scene as the color image; and performing a first noise reduction process on the preprocessed image according to the depth image to obtain a first image.

Abstract: The present disclosure relates to a multispecific antibody platform for targeted degradation of cell surface proteins. The disclosure relates to multispecific (e.g., bispecific or trispecific) binding molecules such as multispecific antibodies that target at least one transmembrane E3 ubiquitin ligase protein and at least one cell surface protein, for example, a cell surface protein that is intended for degradation, and methods of using the same.

Abstract: The present invention provides PD-1 monoclonal antibodies, particularly human monoclonal antibodies of PD-1, which specifically bind to PD-1 with high affinity and comprise a heavy chain and a light chain. The present invention further provides nucleic acid sequence encoding the antibodies of the invention, cloning or expression vectors, host cells and methods for expressing or isolating the antibodies. Immunoconjugates, therapeutic compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating various cancers with anti-PD-1 antibodies.

Abstract: The present invention relates to salts of a PI3Kdelta inhibitor (referred to as “Compound A” hereinafter), preferably fumarate, and the crystalline forms thereof. The present invention also relates to the process of preparation and uses of the salts and crystalline forms of Compound A.

Abstract: A semiconductor structure includes a first metal-dielectric-metal layer, a first dielectric layer, a first conductive layer, a second conductive layer, and a second dielectric layer. The first metal-dielectric-metal layer includes a plurality of first fingers, a plurality of second fingers, and a first dielectric material. The first fingers are electrically connected to a first voltage. The second fingers are electrically connected to a second voltage different from the first voltage, and the first fingers and the second fingers are arranged in parallel and staggeredly. The first dielectric material is between the first fingers and the second fingers. The first dielectric layer is over the first metal-dielectric-metal layer. The first conductive layer is over the first dielectric layer. The second conductive layer is over the first conductive layer. The second dielectric layer is between the first conductive layer and the second conductive layer.

Abstract: Novel radioactive iodide molecular traps, in which one or more metal atoms are functionalized by coordinating to an amine containing two or more nitrogens, and methods of using the molecular traps to capture radioactive iodide.

Abstract: A method, system, and computer program product for circuit design automation. The method identifies a set of circuit components for a proposed circuit design. A subset of circuit components is selected to generate an initial topology for the proposed circuit design. A set of subsequent topologies are iteratively generated by a heuristic search algorithm based on the subset of circuit components and the initial topology. A set of valid topologies of the set of subsequent topologies are determined by a circuit simulator based on the subset of circuit components and a set of connections within the set of subsequent topologies. The method generates the proposed circuit design from the set of valid topologies.

Abstract: The described embodiments relate generally to a camera system to enhance food and material identification. More particularly, the described embodiments relate to using a plurality of camera sensors and LED light sources, including visible image sensors, visible light source, near infrared (NIR) image sensors, two or more bands of infrared light sources, depth camera images, and synchronized light source. The visible image data, NIR image data, depth image data are processed to obtain combined image data. A machine learning algorithm is employed to automatically compute an output based on the combined image data. The output includes information about the identity and the location of the food item.

Abstract: The present application discloses a cerebral perfusion state classification apparatus and method, a device, and a storage medium. The method includes: acquiring, by a transceiving module, cervical blood flow data from an ultrasound data collecting device; determining, by a processor, cerebral perfusion data corresponding to the cervical blood flow data based on the cervical blood flow data and a mapping relationship between the cervical blood flow data and the cerebral perfusion data, and classifying cerebral perfusion states of a plurality of brain regions based on blood perfusion characteristics of the plurality of brain regions in the cerebral perfusion data.

Abstract: A secondary battery includes an electrode assembly including current collecting sections, an electrode terminal, and an adapter sheet connecting the current collecting sections to the electrode terminal. The electrode assembly includes active material layer(s), current collector(s) each including an insulating layer and first and second conductive layers sandwiching the insulating layer, and conductive structures each including first and second conductive members. A portion of the first conductive member extending beyond the second conductive member forms a current collecting section. The current collecting sections are laminated with each other, with one of the current collecting sections directly contacting the adapter sheet. Neighboring ones of the current collecting sections directly contact each other, without any second conductive member arranged therebetween.

Abstract: An electrode plate includes an active material layer, a current collector including an insulating layer and first and second conductive layers sandwiching the insulating layer, and a conductive structure. The conductive structure includes a first conductive member including a first section arranged along a side of the first conductive layer and a second section extending from the first section and beyond the current collector in a direction away from the active material layer, and a second conductive member including a first connecting section connected to the second conductive layer, a bent section connected to the first connecting section and bent towards the first conductive member relative to the first connecting section, and a second connecting section bent backward relative to the bent section to be sandwiched between the first section and the first conductive layer.

Abstract: The present application discloses a negative electrode plate including a negative electrode active material layer including a first active material layer; wherein in a first cross section in a thickness direction of the negative electrode plate, the first active material has a size a in a direction parallel to the metal conductive layer, the first active material has a size b in the thickness direction, satisfying 0.8?a/b?20; in a second cross section in the thickness direction of the negative electrode plate, the first active material has a size c in the direction parallel to the metal conductive layer, the first active material has a size d in the thickness direction, satisfying 0.8?c/d?20; and the first cross section is parallel to a first direction, the second cross section is parallel to a second direction, and the first direction intersects the second direction.

Abstract: The present disclosure relates to novel metal-organic frameworks (MOFs) comprising tetratopic ligands with small pore apertures. The present disclosure further relates to methods of utilizing the MOFs of the disclosure to separate hydrocarbons through adsorptive processes.

Abstract: This application relates to the battery field, and specifically, to a positive electrode plate, an electrochemical apparatus, and an apparatus. The positive electrode plate in this application includes a current collector and an electrode active material layer disposed on at least one surface of the current collector, where the current collector includes a support layer and a conductive layer disposed on at least one surface of the support layer. A single-sided thickness D2 of the conductive layer satisfies 30 nm?D2?3 ?m. A thickness D1 of the support layer satisfies 1 ?m?D1?30 ?m. The support layer is made of a polymer material or a polymer composite material. The electrode active material layer includes electrode active materials, a binder, and a conductive agent.

Abstract: The present disclosure describes a semiconductor structure and a method for forming the same. The method can include forming a fin structure over a substrate. The fin structure can include a channel layer and a buffer layer between the channel layer and the substrate. The method can further include forming a recess structure in the channel layer. The recess structure can include a bottom surface over the buffer layer. The method can further include forming a first epitaxial layer over the bottom surface of the recess structure. The first epitaxial layer can include a first atomic concentration of germanium. The method can further include forming a second epitaxial layer over the first epitaxial layer. The second epitaxial layer can include a second atomic concentration of germanium greater than the first atomic concentration of germanium.

Abstract: Provided are novel fully human monoclonal antibodies that bind to human LAG-3. It also provides the methods of hybridoma generation using humanized rats, the nucleic acid molecules encoding the anti-LAG-3 antibodies, expression vectors and host cells used for the expression of anti-LAG-3 antibodies. The invention further provides the methods for validating the function of antibodies in vitro. The antibodies of invention provide a potent agent for the treatment of multiple cancers via modulating human immune function.