Abstract: Embodiments relate to a die package featuring a sputtered metal shield to reduce Electro-Magnetic Interference (EMI). According to a particular embodiment, a die featuring a top surface exposed by surrounding Molded Underfill (MUF) material, is subjected to metal sputtering. The resulting sputtered metal shield is in direct physical and thermal contact with the die, and is in electrical contact with a substrate supporting the die (e.g., to provide shield grounding). Specific embodiments may be particularly suited to reducing the EMI of a package containing an electro-optic die, to between 3-15 dB. The conformal nature and small thickness of the sputtered metal shield desirably conserves space and reduces package footprint. Direct physical contact between the shield and the die surface exposed by the MUF, enhances thermal communication (e.g., reducing junction temperature). According to certain embodiments, the sputtered metal shield comprises a stainless steel liner, copper, and a stainless steel coating.

Abstract: A CNN operates on the disparity or motion outputs of a block matching hardware module, such as a DMPAC module, to produce refined disparity or motion streams which improve operations in images having ambiguous regions. As the block matching hardware module provides most of the processing, the CNN can be small and thus able to operate in real time, in contrast to CNNs which are performing all of the processing. In one example, the CNN operation is performed only if the block hardware module output confidence level is below a predetermined amount. The CNN can have a number of different configurations and still be sufficiently small to operate in real time on conventional platforms.

Abstract: The present disclosure provides isolated monoclonal anti-CD3epsilon antibodies or antigen-binding fragments thereof comprising one or more heavy chain CDR sequences selected from the group consisting of: SEQ ID NOs: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, and 47, and/or one or more kappa light chain CDR sequences selected from the group consisting of: SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46 and 48, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the use thereof.

Abstract: Provided is a compound of formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, isotopic substituent, polymorph, prodrug, or metabolite thereof. Also provided is a method for preparing the compound of formula I. The compound of formula I has higher inhibitory activity against SHP2, and thus can be used to prevent or treat a disease related to SHP2.

Abstract: Provided are a CT scanning method and system, an electronic device, and a computer-readable storage medium. The method includes: determining a first coordinate of a mark point of a part to be imaged in a dual-camera coordinate system; converting the first coordinate into a second coordinate of the mark point in a CT coordinate system according to coordinate system transformation parameters; generating first locating information according to the second coordinate to drive a scanning table to move to a first location designated by the first locating information; obtaining projection images of the part to be scanned; determining second locating information and scanning information of the part to be scanned according to the projection images; and driving the scanning table to move to a second location designated by the second locating information according to the second locating information and performing CT scanning according to the scanning information.

Abstract: The present disclosure provides isolated monoclonal anti-CD3epsilon antibodies or antigen-binding fragments thereof comprising one or more heavy chain CDR sequences selected from the group consisting of: SEQ ID NOs: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, and 47, and/or one or more kappa light chain CDR sequences selected from the group consisting of: SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46 and 48, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the use thereof.

Abstract: A multi-targeted siRNA for treating cancers is disclosed. Specifically, an siRNA composition is provided, comprising: a first siRNA molecule that reduces the expression of the first target gene; optionally, a coding sequence targeting a peptide element; and optionally, a second siRNA molecule that reduces the expression of the second target gene, wherein the first target gene is selected from the group consisting of EGFR, KRAS, or a combination thereof, and the siRNA composition reduces the expression of two or more genes. The siRNA or vector provided can be directly injected into the body to treat cancers. A multi-targeted siRNA for treating cancers is disclosed.

Abstract: An application of a transgenic stem cell-derived exosome in preparing a medicament or whitening cosmetic is provided. In the present disclosure, miR-27b-3p is transfected into an epidermal stem cell, and a transgenic stem cell-derived exosome is harvested. It is experimentally verified that the exosome can inhibit the expression of PIK3R3 protein in melanocytes and the proliferation and migration of melanocytes; and safety experiments further demonstrate the safety of the exosome. Therefore, corresponding medicaments or cosmetics prepared from the exosome have excellent medicinal and cosmetic application prospects.

Abstract: An information processing method includes obtaining parameter information, in response to an electronic device being in a sharing scenario, displaying, based on the parameter information, a sharing identifier for sharing the source device, and in response to obtaining an input operation for the sharing identifier, sending display data of the source device obtained through a first connection channel to a server of the sharing scenario based on a second connection channel, to achieve real-time sharing of the display data of the source device by at least one sharing object in the sharing scenario. The parameter information is configured to characterize a connected source device. The source device is capable of processing and displaying information. The display data of the source device includes dynamically changing data generated by the source device for display.

Abstract: Methods and apparatus for generating medical records from a doctor-patient dialogue are provided. A main content portion of a written doctor-patient conversation is identified. The main content portion of the conversation is extracted from the conversation. The main content of the conversation is divided into sections according to a pre-defined set of sections, and, based on the sections and their respective content, a medical record is generated according to a pre-defined template. The pre-defined template is one of a hard medical record format or a soft medical record format.

Abstract: A processor obtains a pair including a question and an answer in natural language; determines at least one entity in the question and an entity type of each of the at least one entity consistent with the schema of a knowledge graph (KG); identifies a subset of candidate query templates based on the entity type of each of the at least one entity, wherein the candidate query templates are generated based on the schema of the KG; composes a set of queries by populating the at least one entity into each of the subset of candidate query templates; executes the set of queries on the KG to generate respective answers; identifies a first answer from the respective answers that is matching with the answer in the pair; and determines a candidate query template, from the subset of candidate query templates, corresponding to the first answer as a query template.

Abstract: A lamp has a safety circuit connected to first and second electrical connection terminals. A test is used to detect if the first and second electrical connection terminals are both connected to external power without an interfering impedance such a human body, and only then enable operation of the lamp. A time for the test is different from a time when another lamp in the system applies a test.

Abstract: A method, a system and a computer program product may evaluate reduction of disease risk. Patient data of a patient may be received. A selection of a disease outcome may be received. A risk score that the patient will experience the selected disease outcome may be determined. The determining may use the patient data. Intervention options may be generated based on the patient data and by accessing a medical record data structure. An intervention effect for each of the intervention options may be determined. The intervention effect may change the risk score. The intervention effects may be compared. A recommendation of at least one of the intervention options may be provided based on the comparing of the intervention effects.

Abstract: The present disclosure relates to trunking communication systems, servers, access networks, and trunking communication methods. One example system includes a trunking management server and an access network. The trunking management server includes a trunking call service control module and a connected trunking call media gateway module. The trunking call media gateway module is configured to receive service data sent through the access network by a trunking UE, and forward the service data according to a communication type of the service data for implementing user plane communication of the trunking UE. The trunking call service control module is configured to receive a communication request sent through the access network by a trunking UE, and perform call control and bearer management on the trunking UE according to a communication type of the communication request for implementing control plane communication of the trunking UE.

Abstract: The present disclosure provides anti-CTLA-4 antibody polypeptides, polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the uses thereof.

Abstract: This application relates to a battery comprising a positive electrode plate, a separator, and a negative electrode plate, wherein the positive electrode plate comprises a positive electrode current collector and at least two layers of positive active material coated on at least one surface of the positive electrode current collector, and wherein an underlying positive active material layer in contact with the positive electrode current collector comprises a first positive active material, a first polymer material and a first conductive material; and wherein an upper positive active material layer in contact with the underlying positive active material layer and away from the positive electrode current collector comprises a second positive active material, a second polymer material and a second conductive material, and the first polymer material comprises fluorinated polyolefin and/or chlorinated polyolefin polymer material. The battery has good safety and improved electrical properties.

Abstract: A stapler is provided, including: a main body, including a front end portion, the front end portion including a staple outlet and a plate member, the plate member including a concave adjacent to the staple outlet; a holder, switchably disposed on the main body, including a plurality of notches with different sizes and a plurality of first positioning portions; and a positioning member, disposed on the main body, releasably positioned with one of the plurality of first positioning portions so that one of the plurality of notches corresponds to the concave in a front to rear direction, for receiving a portion of a cable.

Abstract: A formation method for liquid rubber composite nodes with a tubular flow channel is provided. The formation method includes adding a middle spacer sleeve between an outer sleeve and a mandrel, bonding the middle spacer sleeve and the mandrel together through rubber vulcanization and assembling the integrated middle spacer sleeve and the mandrel into the outer sleeve; installing a tubular flow channel in the mandrel; hollowing the middle spacer sleeve to form a plurality of spaces; after vulcanization, forming a plurality of interdependent liquid cavities by using rubber and the plurality of spaces; and arranging liquid in the plurality of liquid cavities and communicating the plurality of liquid cavities through the tubular flow channel.